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	<span class="totem_bold">Informazioni personali</span></p>
<p>
	Nadia D&rsquo;Ambrosi</p>
<p>
	Dipartimento di Biologia, Universit&agrave; degli Studi di Roma Tor Vergata</p>
<p>
	Via della Ricerca Scientifica, 1 - 00133 Roma, Italia</p>
<p>
	Telefono: +390672594244</p>
<p>
	Email: nadia.dambrosi@uniroma2.it</p>
<p>
	<span class="totem_bold">Istruzione e formazione</span></p>
<p>
	-2003-2007: Borsista Post-doc presso la Fondazione Santa Lucia, Roma, Italia</p>
<p>
	-2003: Dottorato in Neuroscienze, Facolt&agrave; di Medicina e Chirurgia, Universit&agrave; degli Studi di Roma Tor Vergata</p>
<p>
	-1998: Borsista presso il Royal Free Hospital, Autonomic Neuroscience Institute, Londra, Regno Unito</p>
<p>
	-1998: Laurea in Scienze Biologiche (110 e lode) Universit&agrave; degli Studi di Roma La Sapienza</p>
<p>
	Esperienza lavorativa</p>
<p>
	-2019-presente: Professore Associato in Biochimica (BIO/10), Dipartimento di Biologia, Universit&agrave; degli Studi di Roma Tor Vergata</p>
<p>
	-2016-2019: Ricercatore a tempo determinato (RTDB) in Biochimica (BIO/10), Dipartimento di Biologia, Universit&agrave; degli Studi di Roma Tor Vergata</p>
<p>
	-2013-2016: Ricercatore a tempo determinato (RTDA) in Biologia Applicata (BIO/13) Istituto di Anatomia Umana e Biologia Cellulare, Universit&agrave; Cattolica del Sacro Cuore, Roma, Italia</p>
<p>
	-2008-2013: Ricercatore a progetto presso Fondazione Santa Lucia/Istituto di Biologia Cellulare e Neurobiologia CNR, Roma, Italia</p>
<p>
	<span class="totem_bold">Insegnamenti</span></p>
<p>
	-2019-presente: componente della scuola di dottorato in Biologia Molecolare e Cellulare, Dipartimento di Biologia, Universit&agrave; degli Studi di Roma Tor Vergata; coordinatore del corso dell III anno &ldquo;Career Resources for PhD Students&rdquo;</p>
<p>
	- 2016-presente: Docente di Biochimica Generale, Metodologie Biochimiche e Metabolismo del sistema nervoso nella LT Biotecnologie e nella LM Biologia Cellulare Molecolare e Scienze Biomediche Universit&agrave; degli Studi di Roma Tor Vergata</p>
<p>
	- 2016-2019 Docente di Biologia e Biologia cellulare nella laurea magistrale a ciclo unico Medicine and Surgery (erogata in lingua inglese), Facolt&agrave; di Medicina, Universit&agrave; Cattolica del Sacro Cuore, Roma, Italia</p>
<p>
	<span class="totem_bold">Riconoscimenti</span></p>
<p>
	-2020-presente: componente del comitato editoriale delle riviste NeuroSci (MDPI), Cells (MDPI), Frontiers in Molecular Neuroscience</p>
<p>
	-2018-presente: Revisore per i seguenti enti finanziatori: Thierry Latran Foundation (France), MRC (Cambrigde, UK), AFM-Telethon, Fondation Maladies Rares, FWO-Research Foundation Flanders</p>
<p>
	<span class="totem_italic">Finanziamenti attuali</span></p>
<p>
	- 2024-2026 PI: FARA &ldquo;Investigating microglial phenotypes and functions in the pathogenesis of Friedreich&rsquo;s Ataxia &ldquo;</p>
<p>
	- 2023-2025 Partner: NEXTGENERATIONEU (NGEU) and founded by Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP) PRIN-PNRR 2022 P2022JKTWH</p>
<p>
	- 2022-2025 Partner: NEXTGENERATIONEU (NGEU) and founded by Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) &ndash; A Multiscale Integrated Approach to the Study of the Nervous System in Health and Disease</p>
<p>
	- 2022-2024 PI: AFM-Telethon &ldquo;TargetS-Targeting S100A4 to improve inflammation and fibrosis in Duchenne Musclular Dystrophy&rdquo;</p>
<p>
	- 2022-2024 Partner: AriSLA &ldquo;SwitchALS- Therapeutic correction of alternative splicing defects in hnRNP A2/B1 as a way to counteract Amyotrophic Lateral Sclerosis associated to FUS&rdquo;</p>
<p>
	<span class="totem_bold">Ambiti di ricerca</span></p>
<p>
	La mia attivit&agrave; di ricerca si &egrave; sempre incentrata sui meccanismi molecolari che sottendono le malattie neuromuscolari. I miei progetti in corso sono i seguenti:</p>
<p>
	- indagare come l'infiammazione cronica e la fibrosi contribuiscano alla sclerosi laterale amiotrofica (SLA) ed esplorare il potenziale di farmaci anti-infiammatori e anti-fibrotici come strategie per rallentare la progressione della malattia;</p>
<p>
	- studiare il dismetabolismo dell'RNA messaggero e la deregolazione dello splicing alterativo nella patogenesi della SLA;</p>
<p>
	- investigare il contributo della microglia nella neurodegenerazione cerebellare nell&rsquo;Atassia di Friedreich;</p>
<p>
	- esplorare il coinvolgimento della proteina pro-infiammatoria S100A4 nell'interazione tra macrofagi e cellule muscolari nella patogenesi della distrofia muscolare di Duchenne.</p>
<p>
	I progetti sono condotti integrando approcci biochimici a modelli cellulari e animali delle malattie.</p></document><document><p>
	<span class="totem_bold">Personal information</span></p>
<p>
	Nadia D&rsquo;Ambrosi</p>
<p>
	University of Rome Tor Vergata, Department of Biology</p>
<p>
	Building L, floor 1</p>
<p>
	Via della Ricerca Scientifica, 1 - 00133 Rome, Italy</p>
<p>
	Telephone: +390672594144</p>
<p>
	Email: nadia.dambrosi@uniroma2.it</p>
<p>
	<span class="totem_bold">Education and training</span></p>
<p>
	-2003-2007: Post-doc fellow at Santa Lucia Foundation, Rome, Italy</p>
<p>
	-2003: Ph. D. in Neuroscience, Faculty of Medicine and Surgery, University of Rome Tor Vergata</p>
<p>
	-1998: Junior fellow at Royal Free Hospital, Autonomic Neuroscience Institute, London, UK</p>
<p>
	-1998: Master&rsquo;s Degree in Biological Sciences, University of Rome &ldquo;La Sapienza&rdquo;</p>
<p>
	<span class="totem_bold">Employment</span></p>
<p>
	-2019-present: Associate Professor in Biochemistry (BIO/10), Department of Biology, University of Rome Tor Vergata</p>
<p>
	-2016-2019: Assistant Professor (RTDB) in Biochemistry (BIO/10), Department of Biology, University of Rome Tor Vergata</p>
<p>
	-2013-2016: Assistant Professor (RTDA) in Applied Biology (BIO/13) at Institute of Anatomy and Cell Biology, Catholic University of the Sacred Heart, Rome, Italy</p>
<p>
	-2008-2013: Senior Researcher at Santa Lucia Foundation/Institute of Cell Biology and Neurobiology CNR, Rome, Italy</p>
<p>
	<span class="totem_bold">Teaching</span></p>
<p>
	-2019-present: member of the PhD school in Molecular and Cellular Biology, Department of Biology, University of Rome Tor Vergata, Italy; Coordinator of the III year course &ldquo;Career Resources for PhD Students&rdquo;</p>
<p>
	- 2016-present: Lecturer in Biochemistry, Biochemical Methodologies and Brain Metabolism in the LT Biotechnology and the LM Cellular and Molecular Biology and Biomedical Sciences, University of Rome Tor Vergata, Italy</p>
<p>
	- 2016-2019 Lecturer in Biology and Cellular Biology in the Medicine and Surgery course (English taught), Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy</p>
<p>
	<span class="totem_bold">Honours</span></p>
<p>
	-2020-present: member of the Editorial Board of NeuroSci (MDPI), Cells (MDPI), Frontiers in Molecular Neuroscience</p>
<p>
	-2018-present: Reviewer for the following funding agencies: Thierry Latran Foundation (France), MRC (Cambrigde, UK), AFM-Telethon, Fondation Maladies Rares, FWO-Research Foundation Flanders</p>
<p>
	<span class="totem_italic">Ongoing grants:</span></p>
<p>
	- 2024-2026 PI: FARA &ldquo;Investigating microglial phenotypes and functions in the pathogenesis of Friedreich&rsquo;s Ataxia &ldquo;</p>
<p>
	- 2023-2025 Partner: NEXTGENERATIONEU (NGEU) and founded by Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP) PRIN-PNRR 2022 P2022JKTWH</p>
<p>
	- 2022-2025 Partner: NEXTGENERATIONEU (NGEU) and founded by Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) &ndash; A Multiscale Integrated Approach to the Study of the Nervous System in Health and Disease</p>
<p>
	- 2022-2024 PI: AFM-Telethon &ldquo;TargetS-Targeting S100A4 to improve inflammation and fibrosis in Duchenne Musclular Dystrophy&rdquo;</p>
<p>
	- 2022-2024 Partner: AriSLA &ldquo;SwitchALS- Therapeutic correction of alternative splicing defects in hnRNP A2/B1 as a way to counteract Amyotrophic Lateral Sclerosis associated to FUS&rdquo;</p>
<p>
	<span class="totem_bold">Research interests</span></p>
<p>
	My research interests have always been focused on molecular pathogenic mechanisms underlying neuromuscular diseases. &nbsp;My ongoing projects are:</p>
<p>
	- investigating how chronic inflammation and fibrosis contribute to amyotrophic lateral sclerosis (ALS) pathology and exploring the potential of anti-inflammatory, anti-fibrotic drugs as strategies to halt the disease progression;</p>
<p>
	- studying RNA dysmetabolism and alternative splicing deregulation in the pathogenesis of ALS;</p>
<p>
	- investigating the microglial contribution to Friedreich&rsquo;s Ataxia pathology</p>
<p>
	- exploring the involvement of the pro-inflammatory protein S100A4 in the crosstalk between macrophages and muscle cells in the pathogenesis of Duchenne Muscular Dystrophy.</p>
<p>
	The projects are conducted by integrating biochemistry with cellular and animal models of the diseases.</p></document> a:0:{}"
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