CURRICULUM VITAE ET STUDIORUM Nome: TERRINONI ALESSANDRO Nascita: Roma, 22-05-1968 e-mail: alessandro.Terrinoni@uniroma2.it Nazionalità: Italiana Lingue: Italiano, Inglese Sesso: Maschio Esperienza lavorativa Posizione attuale Professore associato presso il Dipartimento di Medicina Sperimentale dell'Università di Roma "Tor Vergata". Tel: +39.06.20902362 Profilo biografico Alessandro Terrinoni si è laureato in Biologia presso l'Università di Roma La Sapienza (1993), in Scienze e Nutrizione Umana presso l'Università di Roma Tor Vergata (2005), ha ottenuto il dottorato di ricerca presso l'Università di Roma Tor Vergata (2001). Il Prof Terrinoni ha lavorato Presso l'Università di Dundee in Scozia (prof. Irwin Mclean), presso l'University Colledge of London, Londra (prof. Martin Raff), presso l'Università di Leicester, MRC Toxicology Unit Hodgkin Building (prof. Pierluigi Nicotera). A livello scientifico ha lavorato sulla morte cellulare, in modelli oncologici e dermatologici. Ha lavorato sulla famiglia p53, in particolare su p63 e p73, di cui ha identificato parte dei meccanismi di morte cellulare, di transattivazione genica, le vie di degradazione biochimica, gli inibitori della degradazione proteosomica, i meccanismi di regolazione fisiologica (utilizzando modelli di topi transgenici sviluppati nel suo laboratorio). Ha inoltre identificato i meccanismi biochimici di morte dei cheratinociti nella pelle in vitro (ruolo delle transglutaminasi e dei loro substrati) e in vivo, sviluppando topi transgenici e studiando le patologie umane. Queste ultime ricerche hanno portato all'identificazione di una nuova malattia genetica e alla scoperta della causa molecolare di altre malattie genetiche della pelle. In particolare: (1) UNILATERAL PALMOPLANTAR VERRUCOUS NEVUS, nuova genodermatosi descritta in OMIM (144200), (2) Marie Unna Hereditary Hypotrichosis (OMIM 146550). Ha sviluppato vettori per la creazione di animali transgenici con espressione di MiR selettivamente nell'epidermide (MiR24). Ha sviluppato il sistema con luciferasi per l'analisi dell'effetto del MiR217 su Sirt-1. Attualmente nel laboratorio di Biochimica Clinica si occupa anche del ruolo di alcuni MiR nel differenziamento dei miociti, del cancro del colon-retto (CRC) e della loro analisi nella biopsia liquida di pazienti CRC.
Produzione scientifica 100 articoli pubblicati, 18 primo autore, 16 autore corrispondente Totale citazioni: 4336 (Scopus) Indice h: 32 (Scopus) Formazione 1993 Laurea in Biologia, con il massimo dei voti. 2001 Dottorato di ricerca in Biologia e Fisiopatologia degli Epiteli, con lode, Università di Roma "Tor Vergata". 2005 Laurea in Scienze della Nutrizione Umana con lode, Università di Roma Tor Vergata. Altre qualifiche -Abilitazione scientifica nazionale: Professore ordinario di Biochimica Clinica e Biologia Molecolare Clinica, bando 2020. -Abilitazione all'insegnamento della biologia (148/150). -2° corso sull'apoptosi dell'Associazione Italiana di Biologia Cellulare e Differenza. "Gran Sasso" Italia dal 3 al 5 giugno 1998 - Modelli animali di malattie umane: Modellare i tumori umani nel topo, un problema pratico. Scuola Europea di Ematologia (ESH), Eurolab. Parigi, 24-28 gennaio 2002. -Tecnologia Gene Chip di Affymetrix: Preparazione dei campioni, ibridazione e strumenti di data mining. IDI-IRCCS, Roma, 7 novembre 2003. Attività didattica attuale - Corso di Laurea in Farmacia (inglese), Università di Roma Tor Vergata, corso di Analisi del Farmaco I, 5 CFU e Biochimica Clinica, 2CFU - Corso di Laurea in Nutrizione Umana, Università di Roma Tor Vergata, corso di Biochimica Clinica 5CFU - Scuola di Specializzazione in Biochimica e Patologia Clinica. Biochimica Clinica - Scuola di Specializzazione in Endocrinologia e Malattie del Metabolismo, Biochimica Clinica. - Consiglio del Dottorato di Ricerca in Biologia Molecolare, Università di Roma Tor Vergata, Altro Comitati editoriali Comitato editoriale per la Biochimica nell'Enciclopedia delle Scienze della Vita (Wiley) Comitato di redazione per il Journal of Cytology and Tissue Biology (rivista di citologia e biologia dei tessuti) Comitato editoriale per la Rivista internazionale di scienze molecolari (MDPI)
Revisore scientifico (Referee)
Cell Death and Differentiation
Cell Death and Disease
British Journal of Dermatology
Investigative Journal of Dermatology
European Journal of Dermatology
American Journal Of Physiology – Cell Biology
Journal of Molecular Sciences (MDPI)
Nutrients
Libri
Alessandro Terrinoni, Southern e Northern Blot. Metodologie Bio-Molecolari nel Nuovo Millennio, Zanichelli 2019
Terrinoni, Alessandro, Melino, Gerry, Serra, Valeria, Alessandrini, Marco, Napolitano, Bianca, and Bruno, Ernesto (Sep 2009) Deafness. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0001453.pub2]
Candi, E, McLean, WH, Didona, B, Terrinoni, A, and Melino, G(Dec 2009) Cornification Diseases (Skin Cell Death). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0021986]
Melino, G., De Laurenzi, V., Catani, M. V., Terrinoni, A., Ciani, B., Candi, E., Marekov, L. & Steinert, P. M. 1998. The cornified envelope: a model of cell death in the skin. Results Probl Cell Differ, 24,
L’involucro corneo un modello di differenziamento e morte cellulare, Eleonora Candi, Alessandro Terrinoni, Gerry Melino, in Argomenti di biologia molecolare, SEU, 2006, ISBN: 8889548312
ISBN-13: 9788889548318
Selected publications
[1-113]
1. Terrinoni, M.; Nordqvist, S.L.; Lofstrand, M.; Nilsson, F.; Kallgard, S.; Sharma, T.; Lebens, M.R.; Holmgren, J. A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera vaccine. Vaccine 2023, 41, 3347-3357, doi:10.1016/j.vaccine.2023.04.004.
2. Terrinoni, A.; Sala, G.; Bruno, E.; Pitolli, C.; Minieri, M.; Pieri, M.; Gambacurta, A.; Campione, E.; Belardi, R.; Bernardini, S. Partial Loss of Function ABCA12 Mutations Generate Reduced Deposition of Glucosyl-Ceramide, Leading to Patchy Ichthyosis and Erythrodermia Resembling Erythrokeratodermia Variabilis et Progressiva (EKVP). Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241813962.
3. Terrinoni, A.; Micheloni, G.; Moretti, V.; Caporali, S.; Bernardini, S.; Minieri, M.; Pieri, M.; Giaroni, C.; Acquati, F.; Costantino, L., et al. OTX Genes in Adult Tissues. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms242316962.
4. Piro, M.C.; Gasperi, V.; De Stefano, A.; Anemona, L.; Cenciarelli, C.R.; Montanaro, M.; Mauriello, A.; Catani, M.V.; Terrinoni, A.; Gambacurta, A. In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241512158.
5. Nicolai, E.; Sarubbi, S.; Pelagalli, M.; Basile, V.; Terrinoni, A.; Minieri, M.; Cennamo, O.; Grelli, S.; Bernardini, S.; Pieri, M. Performance Evaluation of the New Chemiluminescence Immunoassay CL-1200i for HBV, HIV Panels. Diseases 2023, 11, doi:10.3390/diseases11020083.
6. D'Agostini, C.; Legramante, J.M.; Minieri, M.; Di Lecce, V.N.; Lia, M.S.; Maurici, M.; Simonelli, I.; Ciotti, M.; Paganelli, C.; Terrinoni, A., et al. Correlation between Chest Computed Tomography Score and Laboratory Biomarkers in the Risk Stratification of COVID-19 Patients Admitted to the Emergency Department. Diagnostics (Basel) 2023, 13, doi:10.3390/diagnostics13172829.
7. Campione, E.; Di Prete, M.; Costanza, G.; Saggini, A.; Agostinelli, S.; Terrinoni, A.; Centofanti, F.; Rapanotti, M.C.; Bianchi, L.; Ferlosio, A., et al. Increased Occurrence of Cutaneous Leiomyomas and Dermatofibromas in Patients with Uterine Leiomyomas without Fumarate Hydratase Gene Mutations. Dermatopathology (Basel) 2023, 10, 231-243, doi:10.3390/dermatopathology10030032.
8. Angeletti, S.; Legramante, J.M.; Lia, M.S.; D'Amico, L.; Fogolari, M.; Cella, E.; De Cesaris, M.; De Angelis, F.; Pieri, M.; Terrinoni, A., et al. Assessment of the Stability of Midregional Proadrenomedullin in Different Biological Matrices. Lab Med 2023, 54, 41-46, doi:10.1093/labmed/lmac066.
9. Sozio, E.; Moore, N.A.; Fabris, M.; Ripoli, A.; Rumbolo, F.; Minieri, M.; Boverio, R.; Rodriguez Mulero, M.D.; Lainez-Martinez, S.; Martinez Martinez, M., et al. Identification of COVID-19 patients at risk of hospital admission and mortality: a European multicentre retrospective analysis of mid-regional pro-adrenomedullin. Respir Res 2022, 23, 221, doi:10.1186/s12931-022-02151-1.
10. Pieri, M.; Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Tomassetti, F.; Pelagalli, M.; Minieri, M.; Terrinoni, A.; Bernardini, S. Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) rapid test for SARS-CoV-2 neutralizing antibodies. Arch Virol 2022, 167, 1285-1291, doi:10.1007/s00705-022-05422-w.
11. Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Basile, V.; Perrone, M.A.; Terrinoni, A.; Minieri, M.; Pieri, M.; Bernardini, S. Performance evaluation of the new Chemiluminescence Immunoassay CL-1200i Thyroid Panel. J. Immunoassay Immunochem. 2022, 43, 333-345, doi:10.1080/15321819.2021.2017301.
12. Minieri, M.; Di Lecce, V.N.; Lia, M.S.; Maurici, M.; Leonardis, F.; Longo, S.; Colangeli, L.; Paganelli, C.; Levantesi, S.; Terrinoni, A., et al. Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department. Diagnostics (Basel) 2022, 12, doi:10.3390/diagnostics12081971.
13. Caporali, S.; De Stefano, A.; Calabrese, C.; Giovannelli, A.; Pieri, M.; Savini, I.; Tesauro, M.; Bernardini, S.; Minieri, M.; Terrinoni, A. Anti-Inflammatory and Active Biological Properties of the Plant-Derived Bioactive Compounds Luteolin and Luteolin 7-Glucoside. Nutrients 2022, 14, doi:10.3390/nu14061155.
14. Rapanotti, M.C.; Cugini, E.; Nuccetelli, M.; Terrinoni, A.; Di Raimondo, C.; Lombardo, P.; Costanza, G.; Cosio, T.; Rossi, P.; Orlandi, A., et al. MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms222212416.
15. Pieri, M.; Pignalosa, S.; Perrone, M.A.; Russo, C.; Noce, G.; Perrone, A.; Terrinoni, A.; Massoud, R.; Bernardini, S. Evaluation of the Diesse Cube 30 touch erythrocyte sedimentation method in comparison with Alifax test 1 and the manual Westergren gold standard method. Scand. J. Clin. Lab. Invest. 2021, 81, 181-186, doi:10.1080/00365513.2021.1881996.
16. Perna, A.; Passiatore, M.; Massaro, A.; Terrinoni, A.; Bianchi, L.; Cilli, V.; D'Orio, M.; Proietti, L.; Taccardo, G.; De Vitis, R. Skin manifestations in COVID-19 patients, state of the art. A systematic review. Int. J. Dermatol. 2021, 60, 547-553, doi:10.1111/ijd.15414.
17. Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Basile, V.; Perrone, M.A.; Terrinoni, A.; Minieri, M.; Pieri, M.; Bernardini, S. Performance evaluation of the new Chemiluminescence Immunoassay CL-1200i Thyroid Panel. J. Immunoassay Immunochem. 2021, 10.1080/15321819.2021.2017301, 1-13, doi:10.1080/15321819.2021.2017301.
18. Minieri, M.; Leoni, B.D.; Bellincampi, L.; Bajo, D.; Agnoli, A.; De Angelis, A.M.; Pieri, M.; Equitani, F.; Rossi, V.; Valente, F., et al. Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation. Clin. Chim. Acta 2021, 521, 1-8, doi:10.1016/j.cca.2021.06.004.
19. De Stefano, A.; Caporali, S.; Di Daniele, N.; Rovella, V.; Cardillo, C.; Schinzari, F.; Minieri, M.; Pieri, M.; Candi, E.; Bernardini, S., et al. Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside. Int. J. Mol. Sci. 2021, 22, 1-19, doi:10.3390/ijms22031321.
20. Caporali, S.; Didona, B.; Paradisi, M.; Mauriello, A.; Campione, E.; Falconi, M.; Iacovelli, F.; Minieri, M.; Pieri, M.; Bernardini, S., et al. Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms22136901.
21. Caporali, S.; Calabrese, C.; Minieri, M.; Pieri, M.; Tarantino, U.; Marini, M.; D'Ottavio, S.; Angeletti, S.; Mauriello, A.; Cortese, C., et al. The miR-133a, TPM4 and TAp63gamma Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms22189818.
22. Campione, E.; Lanna, C.; Cosio, T.; Rosa, L.; Conte, M.P.; Iacovelli, F.; Romeo, A.; Falconi, M.; Del Vecchio, C.; Franchin, E., et al. Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence. Int. J. Environ. Res. Public Health 2021, 18, doi:10.3390/ijerph182010985.
23. Campione, E.; Lanna, C.; Cosio, T.; Rosa, L.; Conte, M.P.; Iacovelli, F.; Romeo, A.; Falconi, M.; Del Vecchio, C.; Franchin, E., et al. Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences. Front. Pharmacol. 2021, 12, 666600, doi:10.3389/fphar.2021.666600.
24. Spoto, S.; Legramante, J.M.; Minieri, M.; Fogolari, M.; Terrinoni, A.; Valeriani, E.; Sebastiano, C.; Bernardini, S.; Ciccozzi, M.; Angeletti, P.S. How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin. Biomarkers Med. 2020, 14, 549-562, doi:10.2217/bmm-2019-0414.
25. Rapanotti, M.C.; Viguria, T.M.S.; Spallone, G.; Terrinoni, A.; Rossi, P.; Costanza, G.; Campione, E.; Lombardo, P.; Pathirannehalage, C.D.; Orlandi, A., et al. Minimal Residual Disease in Melanoma:molecular characterization of in transit cutaneous metastases and Circulating Melanoma Cells recognizes an expression panel potentially related to disease progression. Cancer. Treat. Res. Commun 2020, 25, 100262, doi:10.1016/j.ctarc.2020.100262.
26. Perrone, M.A.; Viola, F.G.; Minieri, M.; Caporali, S.; Copponi, A.; Sancesario, G.; Angeletti, S.; Massoud, R.; Romeo, F.; Bernardini, S., et al. The Von Willebrand Factor Antigen Plasma Concentration: a Monitoring Marker in the Treatment of Aortic and Mitral Valve Diseases. Folia Biol. 2020, 66, 133-141.
27. Diluvio, L.; Caporali, S.; Lozzi, F.; Campione, E.; Mazzilli, S.; Lanna, C.; Bianchi, L.; Bernardini, S.; Minieri, M.; Mauriello, A., et al. Birt-Hogg-Dube syndrome, from non-invasive dermatologic assessment to gene testing, molecular and ultrastructural histologic analysis. J. Eur. Acad. Dermatol. Venereol. 2020, 34, e206-e209, doi:10.1111/jdv.16168.
28. Ciotti, M.; Ciccozzi, M.; Terrinoni, A.; Jiang, W.C.; Wang, C.B.; Bernardini, S. The COVID-19 pandemic. Crit. Rev. Clin. Lab. Sci. 2020, 57, 365-388, doi:10.1080/10408363.2020.1783198.
29. Terrinoni, A.; Palombo, R.; Pitolli, C.; Caporali, S.; De Berardinis, R.; Ciccarone, S.; Lanzillotta, A.; Mauramati, S.; Porta, G.; Minieri, M., et al. Role of the TAp63 Isoform in Recurrent Nasal Polyps. Folia Biol. 2019, 65, 170-180.
30. Terrinoni, A.; Calabrese, C.; Basso, D.; Aita, A.; Caporali, S.; Plebani, M.; Bernardini, S. The circulating miRNAs as diagnostic and prognostic markers. Clin. Chem. Lab. Med. 2019, 57, 932-953, doi:10.1515/cclm-2018-0838.
31. Spoto, S.; Fogolari, M.; De Florio, L.; Minieri, M.; Vicino, G.; Legramante, J.; Lia, M.S.; Terrinoni, A.; Caputo, D.; Costantino, S., et al. Procalcitonin and MR-proAdrenomedullin combination in the etiological diagnosis and prognosis of sepsis and septic shock. Microb. Pathog. 2019, 137, 103763, doi:10.1016/j.micpath.2019.103763.
32. Palombo, R.; Caporali, S.; Falconi, M.; Iacovelli, F.; Morozzo Della Rocca, B.; Lo Surdo, A.; Campione, E.; Candi, E.; Melino, G.; Bernardini, S., et al. Luteolin-7-O-beta-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes. Int. J. Mol. Sci. 2019, 20, doi:10.3390/ijms20112689.
33. Lozzi, F.; Lanna, C.; Mazzeo, M.; Garofalo, V.; Palumbo, V.; Mazzilli, S.; Diluvio, L.; Terrinoni, A.; Bianchi, L.; Campione, E. Investigational drugs currently in phase II clinical trials for actinic keratosis. Expert Opin. Invest. Drugs 2019, 28, 629-642, doi:10.1080/13543784.2019.1636030.
34. Terrinoni, A.; Didona, B.; Caporali, S.; Chillemi, G.; Lo Surdo, A.; Paradisi, M.; Annichiarico-Petruzzelli, M.; Candi, E.; Bernardini, S.; Melino, G. Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin. PLoS ONE 2018, 13, e0195792, doi:10.1371/journal.pone.0195792.
35. Pitolli, C.; Pietroni, V.; Marekov, L.; Terrinoni, A.; Yamanishi, K.; Mazzanti, C.; Melino, G.; Candi, E. Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis. Amino Acids 2017, 49, 635-642, doi:10.1007/s00726-016-2356-3.
36. Frezza, V.; Terrinoni, A.; Pitolli, C.; Mauriello, A.; Melino, G.; Candi, E. Transglutaminase 3 Protects against Photodamage. J. Invest. Dermatol. 2017, 137, 1590-1594, doi:10.1016/j.jid.2017.02.982.
37. Palombo, R.; Savini, I.; Avigliano, L.; Madonna, S.; Cavani, A.; Albanesi, C.; Mauriello, A.; Melino, G.; Terrinoni, A. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis. 2016, 7, e2344, doi:10.1038/cddis.2016.201.
38. Palombo, R.; Giannella, E.; Didona, B.; Annicchiarico-Petruzzelli, M.; Melino, G.; Terrinoni, A. Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease. J. Eur. Acad. Dermatol. Venereol. 2016, 30, 847-851, doi:10.1111/jdv.13153.
39. Palombo, R.; Porta, G.; Bruno, E.; Provero, P.; Serra, V.; Neduri, K.; Viziano, A.; Alessandrini, M.; Micarelli, A.; Ottaviani, F., et al. OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. Aging 2015, 7, 928-936, doi:10.18632/aging.100839.
40. Giamboi-Miraglia, A.; Cianfarani, F.; Cattani, C.; Lena, A.M.; Serra, V.; Campione, E.; Terrinoni, A.; Zambruno, G.; Odorisio, T.; Di Daniele, N., et al. The E3 ligase Itch knockout mice show hyperproliferation and wound healing alteration. FEBS J. 2015, 282, 4435-4449, doi:10.1111/febs.13514.
41. Campione, E.; Paterno, E.J.; Candi, E.; Falconi, M.; Costanza, G.; Diluvio, L.; Terrinoni, A.; Bianchi, L.; Orlandi, A. The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors. Drug Des. Dev. Ther. 2015, 9, 5843-5850, doi:10.2147/DDDT.S84849.
42. Terrinoni, A.; Giardina, E.; Pertusi, G.; Cascella, R.; Serra, V.; Bornacina, C.; Palombo, R.; Tiberio, R.; Gattoni, M.; Novelli, G., et al. Absence of filaggrin mutation in a patient affected by pachyonychia congenita and mild atopic dermatitis. Eur. J. Dermatol. 2014, 24, 703-704, doi:10.1684/ejd.2014.2446.
43. Diluvio, L.; Torti, C.; Terrinoni, A.; Candi, E.; Piancatelli, R.; Piccione, E.; Paterno, E.J.; Chimenti, S.; Orlandi, A.; Campione, E., et al. Dermoscopy as an adjuvant tool for detecting skin leiomyomas in patient with uterine fibroids and cerebral cavernomas. BMC Dermatol. 2014, 14, 7, doi:10.1186/1471-5945-14-7.
44. Campione, E.; Diluvio, L.; Terrinoni, A.; Orlandi, A.; Latino, M.P.; Torti, C.; Pietroleonardo, L.; Botti, E.; Chimenti, S.; Bianchi, L. Severe erytrodermic psoriasis in child twins: from clinical-pathological diagnosis to treatment of choice through genetic analyses: two case reports. BMC Res. Notes 2014, 7, 929, doi:10.1186/1756-0500-7-929.
45. Terrinoni, A.; Serra, V.; Bruno, E.; Strasser, A.; Valente, E.; Flores, E.R.; van Bokhoven, H.; Lu, X.; Knight, R.A.; Melino, G. Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 7300-7305, doi:10.1073/pnas.1214498110.
46. Giacobbe, A.; Bongiorno-Borbone, L.; Bernassola, F.; Terrinoni, A.; Markert, E.K.; Levine, A.J.; Feng, Z.; Agostini, M.; Zolla, L.; Agro, A.F., et al. p63 regulates glutaminase 2 expression. Cell Cycle 2013, 12, 1395-1405, doi:10.4161/cc.24478.
47. Conforti, F.; Yang, A.L.; Piro, M.C.; Mellone, M.; Terrinoni, A.; Candi, E.; Tucci, P.; Thomas, G.J.; Knight, R.A.; Melino, G., et al. PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. Oncogene 2013, 32, 4758-4765, doi:10.1038/onc.2012.497.
48. Campione, E.; Diluvio, L.; Terrinoni, A.; Di Stefani, A.; Orlandi, A.; Chimenti, S.; Bianchi, L. Progressive late-onset of cutaneous angiomatosis as possible sign of cerebral cavernous malformations. Dermatol. Online J. 2013, 19.
49. Yis, U.; Terrinoni, A. Sjogren-Larsson syndrome: report of monozygote twins and a case with a novel mutation. Turk. J. Pediatr. 2012, 54, 64-66.
50. Tucci, P.; Agostini, M.; Grespi, F.; Markert, E.K.; Terrinoni, A.; Vousden, K.H.; Muller, P.A.; Dotsch, V.; Kehrloesser, S.; Sayan, B.S., et al. Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 15312-15317, doi:10.1073/pnas.1110977109.
51. Terrinoni, A.; Serra, V.; Codispoti, A.; Talamonti, E.; Bui, L.; Palombo, R.; Sette, M.; Campione, E.; Didona, B.; Annicchiarico-Petruzzelli, M., et al. Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis. Cell Death Dis. 2012, 3, e416, doi:10.1038/cddis.2012.152.
52. Amelio, I.; Lena, A.M.; Viticchie, G.; Shalom-Feuerstein, R.; Terrinoni, A.; Dinsdale, D.; Russo, G.; Fortunato, C.; Bonanno, E.; Spagnoli, L.G., et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J. Cell Biol. 2012, 199, 347-363, doi:10.1083/jcb.201203134.
53. Vernole, P.; Muzi, A.; Volpi, A.; Terrinoni, A.; Dorio, A.S.; Tentori, L.; Shah, G.M.; Graziani, G. Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2011, 712, 40-48, doi:10.1016/j.mrfmmm.2011.03.006
10.1016/j.mrfmmm.2011.04.006.
54. Terrinoni, A.; Pagani, I.S.; Zucchi, I.; Chiaravalli, A.M.; Serra, V.; Rovera, F.; Sirchia, S.; Dionigi, G.; Miozzo, M.; Frattini, A., et al. OTX1 expression in breast cancer is regulated by p53. Oncogene 2011, 30, 3096-3103, doi:10.1038/onc.2011.31.
55. Serra, V.; Castori, M.; Paradisi, M.; Bui, L.; Melino, G.; Terrinoni, A. Functional characterization of a novel TP63 mutation in a family with overlapping features of Rapp-Hodgkin/AEC/ADULT syndromes. Am. J. Med. Genet. Part A 2011, 155A, 3104-3109, doi:10.1002/ajmg.a.34335.
56. Rufini, S.; Lena, A.M.; Cadot, B.; Mele, S.; Amelio, I.; Terrinoni, A.; Desideri, A.; Melino, G.; Candi, E. The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochem. Pharmacol. 2011, 82, 1262-1268, doi:10.1016/j.bcp.2011.07.087.
57. Browne, G.; Cipollone, R.; Lena, A.M.; Serra, V.; Zhou, H.; van Bokhoven, H.; Dotsch, V.; Merico, D.; Mantovani, R.; Terrinoni, A., et al. Differential altered stability and transcriptional activity of DeltaNp63 mutants in distinct ectodermal dysplasias. J. Cell Sci. 2011, 124, 2200-2207, doi:10.1242/jcs.079327.
58. Terrinoni, A.; Codispoti, A.; Serra, V.; Didona, B.; Bruno, E.; Nistico, R.; Giustizieri, M.; Alessandrini, M.; Campione, E.; Melino, G. Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation. Biochem. Biophys. Res. Commun. 2010, 394, 909-914, doi:10.1016/j.bbrc.2010.03.073.
59. Terrinoni, A.; Codispoti, A.; Serra, V.; Bruno, E.; Didona, B.; Paradisi, M.; Nistico, S.; Campione, E.; Napolitano, B.; Diluvio, L., et al. Connexin 26 (GJB2) mutations as a cause of the KID syndrome with hearing loss. Biochem. Biophys. Res. Commun. 2010, 395, 25-30, doi:10.1016/j.bbrc.2010.03.098.
60. Pagani, I.S.; Terrinoni, A.; Marenghi, L.; Zucchi, I.; Chiaravalli, A.M.; Serra, V.; Rovera, F.; Sirchia, S.; Dionigi, G.; Miozzo, M., et al. The mammary gland and the homeobox gene Otx1. Breast J. 2010, 16 Suppl 1, S53-56, doi:10.1111/j.1524-4741.2010.01006.x.
61. Keller, M.A.; Watschinger, K.; Golderer, G.; Maglione, M.; Sarg, B.; Lindner, H.H.; Werner-Felmayer, G.; Terrinoni, A.; Wanders, R.J.; Werner, E.R. Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal. J. Lipid Res. 2010, 51, 1554-1559, doi:10.1194/jlr.D002220.
62. Wen, Y.; Liu, Y.; Xu, Y.; Zhao, Y.; Hua, R.; Wang, K.; Sun, M.; Li, Y.; Yang, S.; Zhang, X.J., et al. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat. Genet. 2009, 41, 228-233, doi:10.1038/ng.276.
63. Vernole, P.; Muzi, A.; Volpi, A.; Dorio, A.S.; Terrinoni, A.; Shah, G.M.; Graziani, G. Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2009, 664, 39-47, doi:10.1016/j.mrfmmm.2009.02.005.
64. Menghini, R.; Casagrande, V.; Cardellini, M.; Martelli, E.; Terrinoni, A.; Amati, F.; Vasa-Nicotera, M.; Ippoliti, A.; Novelli, G.; Melino, G., et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 2009, 120, 1524-1532, doi:10.1161/CIRCULATIONAHA.109.864629.
65. Diluvio, L.; Campione, E.; Paterno, E.J.; Orlandi, A.; Terrinoni, A.; Chimenti, S. Peculiar clinical and dermoscopic remission pattern following imiquimod therapy of basal cell carcinoma in seborrhoeic areas of the face. J Dermatolog Treat 2009, 20, 124-129, doi:10.1080/09546630802441226.
66. Codispoti, A.; Colombo, E.; Zocchi, L.; Serra, V.; Pertusi, G.; Leigheb, G.; Tiberio, R.; Bornacina, G.; Zuccoli, R.; Ramponi, A., et al. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur. J. Dermatol. 2009, 19, 114-118, doi:10.1684/ejd.2008.0575.
67. Campione, E.; Diluvio, L.; Paterno, E.J.; Di Marcantonio, D.; Francesconi, A.; Terrinoni, A.; Orlandi, A.; Chimenti, S. Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia. Clin. Ther. 2009, 31, 2565-2569, doi:10.1016/j.clinthera.2009.11.018.
68. Zocchi, L.; Bourdon, J.C.; Codispoti, A.; Knight, R.; Lane, D.P.; Melino, G.; Terrinoni, A. Scotin: A new p63 target gene expressed during epidermal differentiation. Biochem. Biophys. Res. Commun. 2008, 367, 271-276, doi:10.1016/j.bbrc.2007.12.115.
69. Zocchi, L.; Terrinoni, A.; Candi, E.; Ahvazi, B.; Bagetta, G.; Corasaniti, M.T.; Lena, A.M.; Melino, G. Identification of transglutaminase 3 splicing isoforms. J. Invest. Dermatol. 2007, 127, 1791-1794, doi:10.1038/sj.jid.5700768.
70. Porzio, O.; Massa, O.; Cunsolo, V.; Colombo, C.; Malaponti, M.; Bertuzzi, F.; Hansen, T.; Johansen, A.; Pedersen, O.; Meschi, F., et al. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. Hum. Mutat. 2007, 28, 1150, doi:10.1002/humu.9511.
71. Nucci, C.; Gasperi, V.; Tartaglione, R.; Cerulli, A.; Terrinoni, A.; Bari, M.; De Simone, C.; Agro, A.F.; Morrone, L.A.; Corasaniti, M.T., et al. Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. Invest. Ophthalmol. Vis. Sci. 2007, 48, 2997-3004, doi:10.1167/iovs.06-1355.
72. Didona, B.; Codispoti, A.; Bertini, E.; Rizzo, W.B.; Carney, G.; Zambruno, G.; Dionisi-Vici, C.; Paradisi, M.; Pedicelli, C.; Melino, G., et al. Novel and recurrent ALDH3A2 mutations in Italian patients with Sjogren-Larsson syndrome. J. Hum. Genet. 2007, 52, 865-870, doi:10.1007/s10038-007-0180-z.
73. Candi, E.; Rufini, A.; Terrinoni, A.; Giamboi-Miraglia, A.; Lena, A.M.; Mantovani, R.; Knight, R.; Melino, G. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 11999-12004, doi:10.1073/pnas.0703458104.
74. Campione, E.; Terrinoni, A.; Orlandi, A.; Codispoti, A.; Melino, G.; Bianchi, L.; Mazzotta, A.; Garaci, F.G.; Ludovici, A.; Chimenti, S. Cerebral cavernomas in a family with multiple cutaneous and uterine leiomyomas associated with a new mutation in the fumarate hydratase gene. J. Invest. Dermatol. 2007, 127, 2271-2273, doi:10.1038/sj.jid.5700851.
75. Ponassi, R.; Terrinoni, A.; Chikh, A.; Rufini, A.; Lena, A.M.; Sayan, B.S.; Melino, G.; Candi, E. p63 and p73, members of the p53 gene family, transactivate PKCdelta. Biochem. Pharmacol. 2006, 72, 1417-1422, doi:10.1016/j.bcp.2006.07.031.
76. Candi, E.; Terrinoni, A.; Rufini, A.; Chikh, A.; Lena, A.M.; Suzuki, Y.; Sayan, B.S.; Knight, R.A.; Melino, G. p63 is upstream of IKK alpha in epidermal development. J. Cell Sci. 2006, 119, 4617-4622, doi:10.1242/jcs.03265.
77. Candi, E.; Rufini, A.; Terrinoni, A.; Dinsdale, D.; Ranalli, M.; Paradisi, A.; De Laurenzi, V.; Spagnoli, L.G.; Catani, M.V.; Ramadan, S., et al. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 2006, 13, 1037-1047, doi:10.1038/sj.cdd.4401926.
78. Barcaroli, D.; Bongiorno-Borbone, L.; Terrinoni, A.; Hofmann, T.G.; Rossi, M.; Knight, R.A.; Matera, A.G.; Melino, G.; De Laurenzi, V. FLASH is required for histone transcription and S-phase progression. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 14808-14812, doi:10.1073/pnas.0604227103.
79. van Steensel, M.A.; van Geel, M. Does recessive EKV exist? J. Invest. Dermatol. 2005, 124, 268-269; author reply 270-261, doi:10.1111/j.0022-202X.2004.23517.x.
80. Ramadan, S.; Terrinoni, A.; Catani, M.V.; Sayan, A.E.; Knight, R.A.; Mueller, M.; Krammer, P.H.; Melino, G.; Candi, E. p73 induces apoptosis by different mechanisms. Biochem. Biophys. Res. Commun. 2005, 331, 713-717, doi:10.1016/j.bbrc.2005.03.156.
81. Gressner, O.; Schilling, T.; Lorenz, K.; Schulze Schleithoff, E.; Koch, A.; Schulze-Bergkamen, H.; Lena, A.M.; Candi, E.; Terrinoni, A.; Catani, M.V., et al. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J. 2005, 24, 2458-2471, doi:10.1038/sj.emboj.7600708.
82. Cassidy, A.J.; van Steensel, M.A.; Steijlen, P.M.; van Geel, M.; van der Velden, J.; Morley, S.M.; Terrinoni, A.; Melino, G.; Candi, E.; McLean, W.H. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am. J. Hum. Genet. 2005, 77, 909-917, doi:10.1086/497707.
83. Terron-Kwiatkowski, A.; Terrinoni, A.; Didona, B.; Melino, G.; Atherton, D.J.; Irvine, A.D.; McLean, W.H. Atypical epidermolytic palmoplantar keratoderma presentation associated with a mutation in the keratin 1 gene. Br. J. Dermatol. 2004, 150, 1096-1103, doi:10.1111/j.1365-2133.2004.05967.x.
84. Terrinoni, A.; Ranalli, M.; Cadot, B.; Leta, A.; Bagetta, G.; Vousden, K.H.; Melino, G. p73-alpha is capable of inducing scotin and ER stress. Oncogene 2004, 23, 3721-3725, doi:10.1038/sj.onc.1207342.
85. Terrinoni, A.; Leta, A.; Pedicelli, C.; Candi, E.; Ranalli, M.; Puddu, P.; Paradis, M.; Angelo, C.; Bagetta, G.; Melino, G. A novel recessive connexin 31 (GJB3) mutation in a case of erythrokeratodermia variabilis. J. Invest. Dermatol. 2004, 122, 837-839, doi:10.1111/j.0022-202X.2004.22311.x.
86. Terrinoni, A.; Cocuroccia, B.; Gubinelli, E.; Zambruno, G.; Candi, E.; Melino, G.; Girolomoni, G. Identification of the keratin K9 R162W mutation in patients of Italian origin with epidermolytic palmoplantar keratoderma. Eur. J. Dermatol. 2004, 14, 375-378.
87. Rossi, M.; Sayan, A.E.; Terrinoni, A.; Melino, G.; Knight, R.A. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. In Annals of the New York Academy of Sciences, New York Academy of Sciences: 2004; Vol. 1028, pp 143-149.
88. Munarriz, E.; Barcaroli, D.; Stephanou, A.; Townsend, P.A.; Maisse, C.; Terrinoni, A.; Neale, M.H.; Martin, S.J.; Latchman, D.S.; Knight, R.A., et al. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol. Cell. Biol. 2004, 24, 10593-10610, doi:10.1128/MCB.24.24.10593-10610.2004.
89. Candi, E.; Paradisi, A.; Terrinoni, A.; Pietroni, V.; Oddi, S.; Cadot, B.; Jogini, V.; Meiyappan, M.; Clardy, J.; Finazzi-Agro, A., et al. Transglutaminase 5 is regulated by guanine-adenine nucleotides. Biochem. J. 2004, 381, 313-319, doi:10.1042/BJ20031474.
90. Billon, N.; Terrinoni, A.; Jolicoeur, C.; McCarthy, A.; Richardson, W.D.; Melino, G.; Raff, M. Roles for p53 and p73 during oligodendrocyte development. Development (Cambridge) 2004, 131, 1211-1220, doi:10.1242/dev.01035.
91. Marulli, G.C.; Campione, E.; Chimenti, M.S.; Terrinoni, A.; Melino, G.; Bianchi, L. Type I lamellar ichthyosis improved by tazarotene 0.1% gel. Clin. Exp. Dermatol. 2003, 28, 391-393, doi:10.1046/j.1365-2230.2003.01318.x.
92. Pucci, B.; Claudio, P.P.; Masciullo, V.; Bellincampi, L.; Terrinoni, A.; Khalili, K.; Melino, G.; Giordano, A. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 2002, 21, 5897-5905, doi:10.1038/sj.onc.1205750.
93. Candi, E.; Paradisi, A.; Terrinoni, A.; Cadot, B.; Rufini, A.; Puddu, P.; Melino, G. Role of transglutaminase 5 in epidermis. Minerva Biotecnol 2002, 14, 155-158.
94. Candi, E.; Oddi, S.; Paradisi, A.; Terrinoni, A.; Ranalli, M.; Teofoli, P.; Citro, G.; Scarpato, S.; Puddu, P.; Melino, G. Expression of transglutaminase 5 in normal and pathologic human epidermis. J. Invest. Dermatol. 2002, 119, 670-677, doi:10.1046/j.1523-1747.2002.01853.x.
95. Bernassola, F.; Federici, M.; Corazzari, M.; Terrinoni, A.; Hribal, M.L.; De Laurenzi, V.; Ranalli, M.; Massa, O.; Sesti, G.; McLean, W.H., et al. Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J. 2002, 16, 1371-1378, doi:10.1096/fj.01-0689com.
96. Terrinoni, A.; Smith, F.J.; Didona, B.; Canzona, F.; Paradisi, M.; Huber, M.; Hohl, D.; David, A.; Verloes, A.; Leigh, I.M., et al. Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. J. Invest. Dermatol. 2001, 117, 1391-1396, doi:10.1046/j.0022-202x.2001.01565.x.
97. Terrinoni, A.; Rugg, E.L.; Lane, E.B.; Melino, G.; Felix, D.H.; Munro, C.S.; McLean, W.H. A novel mutation in the keratin 13 gene causing oral white sponge nevus. J. Dent. Res. 2001, 80, 919-923, doi:10.1177/00220345010800031401.
98. Terrinoni, A.; Dell'Arciprete, R.; Fornaro, M.; Stella, M.; Alberti, S. Cyclin D1 gene contains a cryptic promoter that is functional in human cancer cells. Genes Chromosomes Cancer 2001, 31, 209-220, doi:10.1002/gcc.1137.
99. Candi, E.; Oddi, S.; Terrinoni, A.; Paradisi, A.; Ranalli, M.; Finazzi-Agro, A.; Melino, G. Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. J. Biol. Chem. 2001, 276, 35014-35023, doi:10.1074/jbc.M010157200.
100. Vernole, P.; Terrinoni, A.; Didona, B.; De Laurenzi, V.; Rossi, P.; Melino, G.; Grimaldi, P. An SRY-negative XX male with Huriez syndrome. Clin. Genet. 2000, 57, 61-66, doi:10.1034/j.1399-0004.2000.570109.x.
101. Terrinoni, A.; Puddu, P.; Didona, B.; De Laurenzi, V.; Candi, E.; Smith, F.J.; McLean, W.H.; Melino, G. A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. J. Invest. Dermatol. 2000, 114, 1136-1140, doi:10.1046/j.1523-1747.2000.00983.x.
102. Terrinoni, A.; Candi, E.; Oddi, S.; Gobello, T.; Camaione, D.B.; Mazzanti, C.; Zambruno, G.; Knight, R.; Melino, G. A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus. J. Invest. Dermatol. 2000, 114, 388-391, doi:10.1046/j.1523-1747.2000.00890.x.
103. Richard, G.; Brown, N.; Smith, L.E.; Terrinoni, A.; Melino, G.; Mackie, R.M.; Bale, S.J.; Uitto, J. The spectrum of mutations in erythrokeratodermias--novel and de novo mutations in GJB3. Hum. Genet. 2000, 106, 321-329, doi:10.1007/s004390051045.
104. De Laurenzi, V.; Rossi, A.; Terrinoni, A.; Barcaroli, D.; Levrero, M.; Costanzo, A.; Knight, R.A.; Guerrieri, P.; Melino, G. p63 and p73 transactivate differentiation gene promoters in human keratinocytes. Biochem. Biophys. Res. Commun. 2000, 273, 342-346, doi:10.1006/bbrc.2000.2932.
105. De Laurenzi, V.D.; Catani, M.V.; Terrinoni, A.; Corazzari, M.; Melino, G.; Costanzo, A.; Levrero, M.; Knight, R.A. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ. 1999, 6, 389-390, doi:10.1038/sj.cdd.4400521.
106. Melino, G.; De Laurenzi, V.; Catani, M.V.; Terrinoni, A.; Ciani, B.; Candi, E.; Marekov, L.; Steinert, P.M. The cornified envelope: a model of cell death in the skin. Results Probl Cell Differ 1998, 24, 175-212, doi:10.1007/978-3-540-69185-3_9.
107. Junakovic, N.; Terrinoni, A.; Di Franco, C.; Vieira, C.; Loevenbruck, C. Accumulation of transposable elements in the heterochromatin and on the Y chromosome of Drosophila simulans and Drosophila melanogaster. J. Mol. Evol. 1998, 46, 661-668, doi:10.1007/pl00006346.
108. De Laurenzi, V.; Costanzo, A.; Barcaroli, D.; Terrinoni, A.; Falco, M.; Annicchiarico-Petruzzelli, M.; Levrero, M.; Melino, G. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 1998, 188, 1763-1768, doi:10.1084/jem.188.9.1763.
109. Chalvet, F.; di Franco, C.; Terrinoni, A.; Pelisson, A.; Junakovic, N.; Bucheton, A. Potentially active copies of the gypsy retroelement are confined to the Y chromosome of some strains of Drosophila melanogaster possibly as the result of the female-specific effect of the flamenco gene. J. Mol. Evol. 1998, 46, 437-441, doi:10.1007/pl00006323.
110. Terrinoni, A.; Franco, C.D.; Dimitri, P.; Junakovic, N. Intragenomic distribution and stability of transposable elements in euchromatin and heterochromatin of Drosophila melanogaster: non-LTR retrotransposon. J. Mol. Evol. 1997, 45, 145-153, doi:10.1007/pl00006214.
111. Mostaccioli, S.; DeLaurenzi, V.; Terrinoni, A.; Richard, G.; Didona, B.; Cavalieri, R.; Melino, G. White sponge nevus is caused by mutations in mucosal keratins. European Journal of Dermatology 1997, 7, 405-408.
112. Junakovic, N.; Di Franco, C.; Terrinoni, A. Evidence for a host role in regulating the activity of transposable elements in Drosophila melanogaster: the case of the persistent instability of Bari 1 elements in Charolles stock. Genetica 1997, 100, 149-154, doi:10.1023/a:1018325427405.
113. Di Franco, C.; Terrinoni, A.; Dimitri, P.; Junakovic, N. Intragenomic distribution and stability of transposable elements in euchromatin and heterochromatin of Drosophila melanogaster: elements with inverted repeats Bari 1, hobo, and pogo. J. Mol. Evol. 1997, 45, 247-252, doi:10.1007/pl00006227.
CURRICULUM VITAE ET STUDIORUM
Name TERRINONI ALESSANDRO
Birth: Roma, 22-05-1968
e-mail: alessandro.Terrinoni@uniroma2.it
Nationality: Italian
Languages: Italian, English
Gender: Male
Work experience
Present position
Associate Professor at Department of Experimental Medicine, University of Roma "Tor Vergata". Tel: +39.06.20902362
Previous positions
Biographical Sketch
Alessandro Terrinoni has been, and previously He graduated in Biology at the University of Rome La Sapienza (1993) Science and Human Nutrition at the University of Rome Tor Vergata (2005) and after his PhD at the University of Rome Tor Vergata (2001). Dr Terrinoni spent time working in Dundee (Prof Irwin Mclean), London (prof Martin Raff), University of Leicester, MRC Toxicology Unit Hodgkin Building (prof. Pierluigi Nicotera).
At the scientific level he has worked on cell death, in cancer and dermatological models. It worked on the p53 family, in particular on p63 and p73, of which he identified part of the mechanisms of cell death, of gene transactivation, the biochemical degradation pathways, inhibitors of proteosomal degradation, the physiological regulatory mechanisms (using transgenic mouse models developed in his laboratory). He also identified the biochemical mechanisms of death of keratinocytes in in vitro skin (role of transglutaminase and their substrates) and in vivo, developing transgenic mice and studying human pathologies. This latest research have led to the identification of a new genetic disease and the discovery of the molecular cause of other genetic diseases of the skin. In particular: (1) UNILATERAL PALMOPLANTAR VERRUCOUS NEVUS, new genodermatosis described in OMIM (144200), (2) Marie Unna Hereditary Hypotrichosis (OMIM 146550). He developed vectors for the creation of transgenic animals with MiR expression selectively in the epidermis (MiR24). He developed the system with luciferase for the analysis of the effect of MiR217 on the 3rd minute of Sirt-1.
Currently in the Clinical Biochemistry laboratory he also deals with the role of some MiR in the differentiation of myocytes, colorectal cancer (CRC) and in their analysis in liquid biopsy of CRCpatients.
Scientific production
100 Articles published, 18 First Author, 16 Corresponding Author
Total Citations: 4336 (Scopus)
h-Index: 32 (Scopus)
Education
1993 degree in Biology, with full score.
2001 PhD in Biology and Physiopathology of Epithelia, cum laude, University of Rome "Tor Vergata".
2005 Degree in Human Nutrition Science cum Laude, University of Rome Tor Vergata.
Other qualifications
-National scientific qualification: Full professor of Clinical Biochemistry and Clinical Molecular Biology, Call 2020.
-Biology board qualification (148/150)
-2nd course on apoptosis of the Italian Association for Cell Biology and Differentition. “Gran Sasso” Italy June 3rd to 5th 1998
- Animal models of human Disease: Modelling Human Cancers in the Mouse, a Pratical Issue. European School of Haematology (ESH), Eurolab. Paris, 24-28 January 2002.
-Affymetrix Gene Chip Technology: Sample preparation, Ibridization and Data Mining Tools. IDI-IRCCS, Rome 7 November 2003.
Current teaching Activity
· Degree in Pharmacy (English), University of di Rome Tor Vergata, course of Drug Analysis I, 5 CFU and Clinical Biochemistry, 2CFU
· Degree in Nutrizione Umana, University of di Rome Tor Vergata, course of Clinical Biochemistry 5CFU
· Scuola di Specializzazione in Biochimica e Patologia Clinica. Clinical Biochemistry
· Scuola di Specializzazione in Endocrinologia e Malattie del Metabolismo, Clinical Biochemistry
· Board of the PhD program in Molecular Biology, Università di Roma Tor Vergata,
Other
Editorial Boards
Editorial Board for Biochemistryin Enciclopedia of Life Sciences (Wiley)
Editorial Board for Journal of Cytology and Tissue Biology
Editorial Board for International Journal of Molecular Sciences (MDPI)
Referee
Cell Death and Differentiation
Cell Death and Disease
British Journal of Dermatology
Investigative Journal of Dermatology
European Journal of Dermatology
American Journal Of Physiology – Cell Biology
Journal of Molecular Sciences (MDPI)
Nutrients
Others
Books
Alessandro Terrinoni, Southern e Northern Blot. Metodologie Bio-Molecolari nel Nuovo Millennio, Zanichelli 2019
Terrinoni, Alessandro, Melino, Gerry, Serra, Valeria, Alessandrini, Marco, Napolitano, Bianca, and Bruno, Ernesto (Sep 2009) Deafness. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0001453.pub2]
Candi, E, McLean, WH, Didona, B, Terrinoni, A, and Melino, G(Dec 2009) Cornification Diseases (Skin Cell Death). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0021986]
Melino, G., De Laurenzi, V., Catani, M. V., Terrinoni, A., Ciani, B., Candi, E., Marekov, L. & Steinert, P. M. 1998. The cornified envelope: a model of cell death in the skin. Results Probl Cell Differ, 24,
L’involucro corneo un modello di differenziamento e morte cellulare, Eleonora Candi, Alessandro Terrinoni, Gerry Melino, in Argomenti di biologia molecolare, SEU, 2006, ISBN: 8889548312
ISBN-13: 9788889548318
Grant Scientific Coordinator
Scientific PI of Ricerca n° 8 - Istituto Dermopatico dell’Immacolata (IDI-IRCCS), afferente al Destinatario Istituzionale n° 1 - Istituto Europeo di Oncologia (IEO), ai fini della realizzazione del progetto “Identificazione di marcatori per la predizione della risposta a nuovi farmaci antitumorali (inibitori di HDAC, tirosino chinasi e pompe ioniche)”
Scientific PI of the following research grant “Ricerca Corrente Italian Ministry of Health”
1. RC-1.1, 2009-2015: “Meccanismi genetici e molecolari che regolano lo sviluppo della cute in condizioni normali e patologiche”.
2. RC-1.3, 2009-2015: “Il differenziamento terminale dell’epidermide: meccanismi molecolari e malattie genetiche correlate”.
3. RC-3.6, 2009-2015: “Ruolo della regolazione trascrizionale e post traduzionale degli elementi della p53 family, nella cancerogenesi e nella resistenza a chemioterapici, in tumori di origine epiteliale. Valutazione di nuovi target terapeutici”.
Meetings (speaker)
Alessandro Terrinoni et al. The role of TGase3 in ultraviolet photodamage. 11th EWCD European Workshops on Cell Death. DEATH NEVER DIES FIUGGI May 6th to 11th 2018
Alessandro Terrinoni et al, Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis and inflammation in keratinocytes and in mouse psoriatic model. EWCD European Workshops on Cell Death. DEATH NEVER DIES FIUGGI APRIL 3rd to 8th 2016
Palombo R, Porta G, Bruno E, Provero P, Serra V, Neduri K, Viziano A, Alessandrini M, Micarelli A, Ottaviani F, Melino G, Terrinoni A. OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. P63 international, Ricerca e confronti Padova, 24-25 November 2015 (Speaker)
Serra V, Codispoti A, Bruno E, van Bokhoven H, Candi E, Melino G, Terrinoni A (2012) The molecular and physiological mechanism responsible of sensorineural deafness in EEC syndrome: role of the p63 transcription factor. Journal of Investigative Dermatology 132:S104-S104.
2nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR) Location: Venice, ITALY Date: SEP 07-10, 2012 (Speaker)
Alessandro Terrinoni. Involvement of p63 apoptosis/differentiation pathway in cochlear neuroepitelum. and sensorineural deafness. 20th Euroconference on Apoptosis “From Death to Eternity”. (speaker)
Valeria Serra, Alessandro Terrinoni Ernesto Bruno, Hans van Bohkoven. The role of p63 in cochlea development and in sensorineural deafness in EEC syndrome (Speaker). 5th p63/p73 Workshop in Lyon 11-14 September 2011
Terrinoni A, Serra V, van Bohkoven H, Codispoti A, Melino G (2011) The role of p63 in cochlea development and in sensorineural deafness in EEC syndrome. Journal of Investigative Dermatology 131:S67-S67. 41st Annual Meeting of the European-Society-for-Dermatological-Research Location: Barcelona, SPAIN Date: SEP 07-10, 2011
Candi E, Cipollone R, Codispoti A, Melino G, Terrinoni A (2008) Transcriptional study of p63alpha mutants found in ectodermal dysplasia syndromes. Journal of Investigative Dermatology 128:S128-S128. International Investigative Dermatology Meeting Location: Kyoto, JAPAN Date: MAY 12-17, 2008
Terrinoni A, Codispoti A, Paradisi M, Didona B, Melino G (2007) Functional characterization of different Connexin 26 mutants identified in KID Syndrome patients: impairment of membrane trafficking and connexon assembly. Journal of Investigative Dermatology 127:S83-S83.
37th Annual Meeting of the European-Society-for-Dermatological-Research Location: Zurich, SWITZERLAND Date: SEP 05-08, 2007.
Terrinoni A, Didona B, Codispoti A, Zocchi L, Melino G (2006) The novel Connexinx 26 Gly11Glu heterozygous mutation is responsible of a case of KID Syndrome, via the impairment of membrane trafficking and connexon assembly. Journal of Investigative Dermatology 126:81-81.
67th Annual Meeting of the Society-for-Investigative-Dermatology Location: Philadelphia, PA Date: MAY 03-06, 2006
Selected publications
[1-113]
1. Terrinoni, M.; Nordqvist, S.L.; Lofstrand, M.; Nilsson, F.; Kallgard, S.; Sharma, T.; Lebens, M.R.; Holmgren, J. A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera vaccine. Vaccine 2023, 41, 3347-3357, doi:10.1016/j.vaccine.2023.04.004.
2. Terrinoni, A.; Sala, G.; Bruno, E.; Pitolli, C.; Minieri, M.; Pieri, M.; Gambacurta, A.; Campione, E.; Belardi, R.; Bernardini, S. Partial Loss of Function ABCA12 Mutations Generate Reduced Deposition of Glucosyl-Ceramide, Leading to Patchy Ichthyosis and Erythrodermia Resembling Erythrokeratodermia Variabilis et Progressiva (EKVP). Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241813962.
3. Terrinoni, A.; Micheloni, G.; Moretti, V.; Caporali, S.; Bernardini, S.; Minieri, M.; Pieri, M.; Giaroni, C.; Acquati, F.; Costantino, L., et al. OTX Genes in Adult Tissues. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms242316962.
4. Piro, M.C.; Gasperi, V.; De Stefano, A.; Anemona, L.; Cenciarelli, C.R.; Montanaro, M.; Mauriello, A.; Catani, M.V.; Terrinoni, A.; Gambacurta, A. In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241512158.
5. Nicolai, E.; Sarubbi, S.; Pelagalli, M.; Basile, V.; Terrinoni, A.; Minieri, M.; Cennamo, O.; Grelli, S.; Bernardini, S.; Pieri, M. Performance Evaluation of the New Chemiluminescence Immunoassay CL-1200i for HBV, HIV Panels. Diseases 2023, 11, doi:10.3390/diseases11020083.
6. D'Agostini, C.; Legramante, J.M.; Minieri, M.; Di Lecce, V.N.; Lia, M.S.; Maurici, M.; Simonelli, I.; Ciotti, M.; Paganelli, C.; Terrinoni, A., et al. Correlation between Chest Computed Tomography Score and Laboratory Biomarkers in the Risk Stratification of COVID-19 Patients Admitted to the Emergency Department. Diagnostics (Basel) 2023, 13, doi:10.3390/diagnostics13172829.
7. Campione, E.; Di Prete, M.; Costanza, G.; Saggini, A.; Agostinelli, S.; Terrinoni, A.; Centofanti, F.; Rapanotti, M.C.; Bianchi, L.; Ferlosio, A., et al. Increased Occurrence of Cutaneous Leiomyomas and Dermatofibromas in Patients with Uterine Leiomyomas without Fumarate Hydratase Gene Mutations. Dermatopathology (Basel) 2023, 10, 231-243, doi:10.3390/dermatopathology10030032.
8. Angeletti, S.; Legramante, J.M.; Lia, M.S.; D'Amico, L.; Fogolari, M.; Cella, E.; De Cesaris, M.; De Angelis, F.; Pieri, M.; Terrinoni, A., et al. Assessment of the Stability of Midregional Proadrenomedullin in Different Biological Matrices. Lab Med 2023, 54, 41-46, doi:10.1093/labmed/lmac066.
9. Sozio, E.; Moore, N.A.; Fabris, M.; Ripoli, A.; Rumbolo, F.; Minieri, M.; Boverio, R.; Rodriguez Mulero, M.D.; Lainez-Martinez, S.; Martinez Martinez, M., et al. Identification of COVID-19 patients at risk of hospital admission and mortality: a European multicentre retrospective analysis of mid-regional pro-adrenomedullin. Respir Res 2022, 23, 221, doi:10.1186/s12931-022-02151-1.
10. Pieri, M.; Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Tomassetti, F.; Pelagalli, M.; Minieri, M.; Terrinoni, A.; Bernardini, S. Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) rapid test for SARS-CoV-2 neutralizing antibodies. Arch Virol 2022, 167, 1285-1291, doi:10.1007/s00705-022-05422-w.
11. Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Basile, V.; Perrone, M.A.; Terrinoni, A.; Minieri, M.; Pieri, M.; Bernardini, S. Performance evaluation of the new Chemiluminescence Immunoassay CL-1200i Thyroid Panel. J. Immunoassay Immunochem. 2022, 43, 333-345, doi:10.1080/15321819.2021.2017301.
12. Minieri, M.; Di Lecce, V.N.; Lia, M.S.; Maurici, M.; Leonardis, F.; Longo, S.; Colangeli, L.; Paganelli, C.; Levantesi, S.; Terrinoni, A., et al. Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department. Diagnostics (Basel) 2022, 12, doi:10.3390/diagnostics12081971.
13. Caporali, S.; De Stefano, A.; Calabrese, C.; Giovannelli, A.; Pieri, M.; Savini, I.; Tesauro, M.; Bernardini, S.; Minieri, M.; Terrinoni, A. Anti-Inflammatory and Active Biological Properties of the Plant-Derived Bioactive Compounds Luteolin and Luteolin 7-Glucoside. Nutrients 2022, 14, doi:10.3390/nu14061155.
14. Rapanotti, M.C.; Cugini, E.; Nuccetelli, M.; Terrinoni, A.; Di Raimondo, C.; Lombardo, P.; Costanza, G.; Cosio, T.; Rossi, P.; Orlandi, A., et al. MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms222212416.
15. Pieri, M.; Pignalosa, S.; Perrone, M.A.; Russo, C.; Noce, G.; Perrone, A.; Terrinoni, A.; Massoud, R.; Bernardini, S. Evaluation of the Diesse Cube 30 touch erythrocyte sedimentation method in comparison with Alifax test 1 and the manual Westergren gold standard method. Scand. J. Clin. Lab. Invest. 2021, 81, 181-186, doi:10.1080/00365513.2021.1881996.
16. Perna, A.; Passiatore, M.; Massaro, A.; Terrinoni, A.; Bianchi, L.; Cilli, V.; D'Orio, M.; Proietti, L.; Taccardo, G.; De Vitis, R. Skin manifestations in COVID-19 patients, state of the art. A systematic review. Int. J. Dermatol. 2021, 60, 547-553, doi:10.1111/ijd.15414.
17. Nicolai, E.; Nuccetelli, M.; Sarubbi, S.; Basile, V.; Perrone, M.A.; Terrinoni, A.; Minieri, M.; Pieri, M.; Bernardini, S. Performance evaluation of the new Chemiluminescence Immunoassay CL-1200i Thyroid Panel. J. Immunoassay Immunochem. 2021, 10.1080/15321819.2021.2017301, 1-13, doi:10.1080/15321819.2021.2017301.
18. Minieri, M.; Leoni, B.D.; Bellincampi, L.; Bajo, D.; Agnoli, A.; De Angelis, A.M.; Pieri, M.; Equitani, F.; Rossi, V.; Valente, F., et al. Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation. Clin. Chim. Acta 2021, 521, 1-8, doi:10.1016/j.cca.2021.06.004.
19. De Stefano, A.; Caporali, S.; Di Daniele, N.; Rovella, V.; Cardillo, C.; Schinzari, F.; Minieri, M.; Pieri, M.; Candi, E.; Bernardini, S., et al. Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside. Int. J. Mol. Sci. 2021, 22, 1-19, doi:10.3390/ijms22031321.
20. Caporali, S.; Didona, B.; Paradisi, M.; Mauriello, A.; Campione, E.; Falconi, M.; Iacovelli, F.; Minieri, M.; Pieri, M.; Bernardini, S., et al. Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms22136901.
21. Caporali, S.; Calabrese, C.; Minieri, M.; Pieri, M.; Tarantino, U.; Marini, M.; D'Ottavio, S.; Angeletti, S.; Mauriello, A.; Cortese, C., et al. The miR-133a, TPM4 and TAp63gamma Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms22189818.
22. Campione, E.; Lanna, C.; Cosio, T.; Rosa, L.; Conte, M.P.; Iacovelli, F.; Romeo, A.; Falconi, M.; Del Vecchio, C.; Franchin, E., et al. Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence. Int. J. Environ. Res. Public Health 2021, 18, doi:10.3390/ijerph182010985.
23. Campione, E.; Lanna, C.; Cosio, T.; Rosa, L.; Conte, M.P.; Iacovelli, F.; Romeo, A.; Falconi, M.; Del Vecchio, C.; Franchin, E., et al. Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences. Front. Pharmacol. 2021, 12, 666600, doi:10.3389/fphar.2021.666600.
24. Spoto, S.; Legramante, J.M.; Minieri, M.; Fogolari, M.; Terrinoni, A.; Valeriani, E.; Sebastiano, C.; Bernardini, S.; Ciccozzi, M.; Angeletti, P.S. How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin. Biomarkers Med. 2020, 14, 549-562, doi:10.2217/bmm-2019-0414.
25. Rapanotti, M.C.; Viguria, T.M.S.; Spallone, G.; Terrinoni, A.; Rossi, P.; Costanza, G.; Campione, E.; Lombardo, P.; Pathirannehalage, C.D.; Orlandi, A., et al. Minimal Residual Disease in Melanoma:molecular characterization of in transit cutaneous metastases and Circulating Melanoma Cells recognizes an expression panel potentially related to disease progression. Cancer. Treat. Res. Commun 2020, 25, 100262, doi:10.1016/j.ctarc.2020.100262.
26. Perrone, M.A.; Viola, F.G.; Minieri, M.; Caporali, S.; Copponi, A.; Sancesario, G.; Angeletti, S.; Massoud, R.; Romeo, F.; Bernardini, S., et al. The Von Willebrand Factor Antigen Plasma Concentration: a Monitoring Marker in the Treatment of Aortic and Mitral Valve Diseases. Folia Biol. 2020, 66, 133-141.
27. Diluvio, L.; Caporali, S.; Lozzi, F.; Campione, E.; Mazzilli, S.; Lanna, C.; Bianchi, L.; Bernardini, S.; Minieri, M.; Mauriello, A., et al. Birt-Hogg-Dube syndrome, from non-invasive dermatologic assessment to gene testing, molecular and ultrastructural histologic analysis. J. Eur. Acad. Dermatol. Venereol. 2020, 34, e206-e209, doi:10.1111/jdv.16168.
28. Ciotti, M.; Ciccozzi, M.; Terrinoni, A.; Jiang, W.C.; Wang, C.B.; Bernardini, S. The COVID-19 pandemic. Crit. Rev. Clin. Lab. Sci. 2020, 57, 365-388, doi:10.1080/10408363.2020.1783198.
29. Terrinoni, A.; Palombo, R.; Pitolli, C.; Caporali, S.; De Berardinis, R.; Ciccarone, S.; Lanzillotta, A.; Mauramati, S.; Porta, G.; Minieri, M., et al. Role of the TAp63 Isoform in Recurrent Nasal Polyps. Folia Biol. 2019, 65, 170-180.
30. Terrinoni, A.; Calabrese, C.; Basso, D.; Aita, A.; Caporali, S.; Plebani, M.; Bernardini, S. The circulating miRNAs as diagnostic and prognostic markers. Clin. Chem. Lab. Med. 2019, 57, 932-953, doi:10.1515/cclm-2018-0838.
31. Spoto, S.; Fogolari, M.; De Florio, L.; Minieri, M.; Vicino, G.; Legramante, J.; Lia, M.S.; Terrinoni, A.; Caputo, D.; Costantino, S., et al. Procalcitonin and MR-proAdrenomedullin combination in the etiological diagnosis and prognosis of sepsis and septic shock. Microb. Pathog. 2019, 137, 103763, doi:10.1016/j.micpath.2019.103763.
32. Palombo, R.; Caporali, S.; Falconi, M.; Iacovelli, F.; Morozzo Della Rocca, B.; Lo Surdo, A.; Campione, E.; Candi, E.; Melino, G.; Bernardini, S., et al. Luteolin-7-O-beta-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes. Int. J. Mol. Sci. 2019, 20, doi:10.3390/ijms20112689.
33. Lozzi, F.; Lanna, C.; Mazzeo, M.; Garofalo, V.; Palumbo, V.; Mazzilli, S.; Diluvio, L.; Terrinoni, A.; Bianchi, L.; Campione, E. Investigational drugs currently in phase II clinical trials for actinic keratosis. Expert Opin. Invest. Drugs 2019, 28, 629-642, doi:10.1080/13543784.2019.1636030.
34. Terrinoni, A.; Didona, B.; Caporali, S.; Chillemi, G.; Lo Surdo, A.; Paradisi, M.; Annichiarico-Petruzzelli, M.; Candi, E.; Bernardini, S.; Melino, G. Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin. PLoS ONE 2018, 13, e0195792, doi:10.1371/journal.pone.0195792.
35. Pitolli, C.; Pietroni, V.; Marekov, L.; Terrinoni, A.; Yamanishi, K.; Mazzanti, C.; Melino, G.; Candi, E. Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis. Amino Acids 2017, 49, 635-642, doi:10.1007/s00726-016-2356-3.
36. Frezza, V.; Terrinoni, A.; Pitolli, C.; Mauriello, A.; Melino, G.; Candi, E. Transglutaminase 3 Protects against Photodamage. J. Invest. Dermatol. 2017, 137, 1590-1594, doi:10.1016/j.jid.2017.02.982.
37. Palombo, R.; Savini, I.; Avigliano, L.; Madonna, S.; Cavani, A.; Albanesi, C.; Mauriello, A.; Melino, G.; Terrinoni, A. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis. 2016, 7, e2344, doi:10.1038/cddis.2016.201.
38. Palombo, R.; Giannella, E.; Didona, B.; Annicchiarico-Petruzzelli, M.; Melino, G.; Terrinoni, A. Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease. J. Eur. Acad. Dermatol. Venereol. 2016, 30, 847-851, doi:10.1111/jdv.13153.
39. Palombo, R.; Porta, G.; Bruno, E.; Provero, P.; Serra, V.; Neduri, K.; Viziano, A.; Alessandrini, M.; Micarelli, A.; Ottaviani, F., et al. OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. Aging 2015, 7, 928-936, doi:10.18632/aging.100839.
40. Giamboi-Miraglia, A.; Cianfarani, F.; Cattani, C.; Lena, A.M.; Serra, V.; Campione, E.; Terrinoni, A.; Zambruno, G.; Odorisio, T.; Di Daniele, N., et al. The E3 ligase Itch knockout mice show hyperproliferation and wound healing alteration. FEBS J. 2015, 282, 4435-4449, doi:10.1111/febs.13514.
41. Campione, E.; Paterno, E.J.; Candi, E.; Falconi, M.; Costanza, G.; Diluvio, L.; Terrinoni, A.; Bianchi, L.; Orlandi, A. The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors. Drug Des. Dev. Ther. 2015, 9, 5843-5850, doi:10.2147/DDDT.S84849.
42. Terrinoni, A.; Giardina, E.; Pertusi, G.; Cascella, R.; Serra, V.; Bornacina, C.; Palombo, R.; Tiberio, R.; Gattoni, M.; Novelli, G., et al. Absence of filaggrin mutation in a patient affected by pachyonychia congenita and mild atopic dermatitis. Eur. J. Dermatol. 2014, 24, 703-704, doi:10.1684/ejd.2014.2446.
43. Diluvio, L.; Torti, C.; Terrinoni, A.; Candi, E.; Piancatelli, R.; Piccione, E.; Paterno, E.J.; Chimenti, S.; Orlandi, A.; Campione, E., et al. Dermoscopy as an adjuvant tool for detecting skin leiomyomas in patient with uterine fibroids and cerebral cavernomas. BMC Dermatol. 2014, 14, 7, doi:10.1186/1471-5945-14-7.
44. Campione, E.; Diluvio, L.; Terrinoni, A.; Orlandi, A.; Latino, M.P.; Torti, C.; Pietroleonardo, L.; Botti, E.; Chimenti, S.; Bianchi, L. Severe erytrodermic psoriasis in child twins: from clinical-pathological diagnosis to treatment of choice through genetic analyses: two case reports. BMC Res. Notes 2014, 7, 929, doi:10.1186/1756-0500-7-929.
45. Terrinoni, A.; Serra, V.; Bruno, E.; Strasser, A.; Valente, E.; Flores, E.R.; van Bokhoven, H.; Lu, X.; Knight, R.A.; Melino, G. Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 7300-7305, doi:10.1073/pnas.1214498110.
46. Giacobbe, A.; Bongiorno-Borbone, L.; Bernassola, F.; Terrinoni, A.; Markert, E.K.; Levine, A.J.; Feng, Z.; Agostini, M.; Zolla, L.; Agro, A.F., et al. p63 regulates glutaminase 2 expression. Cell Cycle 2013, 12, 1395-1405, doi:10.4161/cc.24478.
47. Conforti, F.; Yang, A.L.; Piro, M.C.; Mellone, M.; Terrinoni, A.; Candi, E.; Tucci, P.; Thomas, G.J.; Knight, R.A.; Melino, G., et al. PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. Oncogene 2013, 32, 4758-4765, doi:10.1038/onc.2012.497.
48. Campione, E.; Diluvio, L.; Terrinoni, A.; Di Stefani, A.; Orlandi, A.; Chimenti, S.; Bianchi, L. Progressive late-onset of cutaneous angiomatosis as possible sign of cerebral cavernous malformations. Dermatol. Online J. 2013, 19.
49. Yis, U.; Terrinoni, A. Sjogren-Larsson syndrome: report of monozygote twins and a case with a novel mutation. Turk. J. Pediatr. 2012, 54, 64-66.
50. Tucci, P.; Agostini, M.; Grespi, F.; Markert, E.K.; Terrinoni, A.; Vousden, K.H.; Muller, P.A.; Dotsch, V.; Kehrloesser, S.; Sayan, B.S., et al. Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 15312-15317, doi:10.1073/pnas.1110977109.
51. Terrinoni, A.; Serra, V.; Codispoti, A.; Talamonti, E.; Bui, L.; Palombo, R.; Sette, M.; Campione, E.; Didona, B.; Annicchiarico-Petruzzelli, M., et al. Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis. Cell Death Dis. 2012, 3, e416, doi:10.1038/cddis.2012.152.
52. Amelio, I.; Lena, A.M.; Viticchie, G.; Shalom-Feuerstein, R.; Terrinoni, A.; Dinsdale, D.; Russo, G.; Fortunato, C.; Bonanno, E.; Spagnoli, L.G., et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J. Cell Biol. 2012, 199, 347-363, doi:10.1083/jcb.201203134.
53. Vernole, P.; Muzi, A.; Volpi, A.; Terrinoni, A.; Dorio, A.S.; Tentori, L.; Shah, G.M.; Graziani, G. Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2011, 712, 40-48, doi:10.1016/j.mrfmmm.2011.03.006
10.1016/j.mrfmmm.2011.04.006.
54. Terrinoni, A.; Pagani, I.S.; Zucchi, I.; Chiaravalli, A.M.; Serra, V.; Rovera, F.; Sirchia, S.; Dionigi, G.; Miozzo, M.; Frattini, A., et al. OTX1 expression in breast cancer is regulated by p53. Oncogene 2011, 30, 3096-3103, doi:10.1038/onc.2011.31.
55. Serra, V.; Castori, M.; Paradisi, M.; Bui, L.; Melino, G.; Terrinoni, A. Functional characterization of a novel TP63 mutation in a family with overlapping features of Rapp-Hodgkin/AEC/ADULT syndromes. Am. J. Med. Genet. Part A 2011, 155A, 3104-3109, doi:10.1002/ajmg.a.34335.
56. Rufini, S.; Lena, A.M.; Cadot, B.; Mele, S.; Amelio, I.; Terrinoni, A.; Desideri, A.; Melino, G.; Candi, E. The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochem. Pharmacol. 2011, 82, 1262-1268, doi:10.1016/j.bcp.2011.07.087.
57. Browne, G.; Cipollone, R.; Lena, A.M.; Serra, V.; Zhou, H.; van Bokhoven, H.; Dotsch, V.; Merico, D.; Mantovani, R.; Terrinoni, A., et al. Differential altered stability and transcriptional activity of DeltaNp63 mutants in distinct ectodermal dysplasias. J. Cell Sci. 2011, 124, 2200-2207, doi:10.1242/jcs.079327.
58. Terrinoni, A.; Codispoti, A.; Serra, V.; Didona, B.; Bruno, E.; Nistico, R.; Giustizieri, M.; Alessandrini, M.; Campione, E.; Melino, G. Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation. Biochem. Biophys. Res. Commun. 2010, 394, 909-914, doi:10.1016/j.bbrc.2010.03.073.
59. Terrinoni, A.; Codispoti, A.; Serra, V.; Bruno, E.; Didona, B.; Paradisi, M.; Nistico, S.; Campione, E.; Napolitano, B.; Diluvio, L., et al. Connexin 26 (GJB2) mutations as a cause of the KID syndrome with hearing loss. Biochem. Biophys. Res. Commun. 2010, 395, 25-30, doi:10.1016/j.bbrc.2010.03.098.
60. Pagani, I.S.; Terrinoni, A.; Marenghi, L.; Zucchi, I.; Chiaravalli, A.M.; Serra, V.; Rovera, F.; Sirchia, S.; Dionigi, G.; Miozzo, M., et al. The mammary gland and the homeobox gene Otx1. Breast J. 2010, 16 Suppl 1, S53-56, doi:10.1111/j.1524-4741.2010.01006.x.
61. Keller, M.A.; Watschinger, K.; Golderer, G.; Maglione, M.; Sarg, B.; Lindner, H.H.; Werner-Felmayer, G.; Terrinoni, A.; Wanders, R.J.; Werner, E.R. Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal. J. Lipid Res. 2010, 51, 1554-1559, doi:10.1194/jlr.D002220.
62. Wen, Y.; Liu, Y.; Xu, Y.; Zhao, Y.; Hua, R.; Wang, K.; Sun, M.; Li, Y.; Yang, S.; Zhang, X.J., et al. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat. Genet. 2009, 41, 228-233, doi:10.1038/ng.276.
63. Vernole, P.; Muzi, A.; Volpi, A.; Dorio, A.S.; Terrinoni, A.; Shah, G.M.; Graziani, G. Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2009, 664, 39-47, doi:10.1016/j.mrfmmm.2009.02.005.
64. Menghini, R.; Casagrande, V.; Cardellini, M.; Martelli, E.; Terrinoni, A.; Amati, F.; Vasa-Nicotera, M.; Ippoliti, A.; Novelli, G.; Melino, G., et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 2009, 120, 1524-1532, doi:10.1161/CIRCULATIONAHA.109.864629.
65. Diluvio, L.; Campione, E.; Paterno, E.J.; Orlandi, A.; Terrinoni, A.; Chimenti, S. Peculiar clinical and dermoscopic remission pattern following imiquimod therapy of basal cell carcinoma in seborrhoeic areas of the face. J Dermatolog Treat 2009, 20, 124-129, doi:10.1080/09546630802441226.
66. Codispoti, A.; Colombo, E.; Zocchi, L.; Serra, V.; Pertusi, G.; Leigheb, G.; Tiberio, R.; Bornacina, G.; Zuccoli, R.; Ramponi, A., et al. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur. J. Dermatol. 2009, 19, 114-118, doi:10.1684/ejd.2008.0575.
67. Campione, E.; Diluvio, L.; Paterno, E.J.; Di Marcantonio, D.; Francesconi, A.; Terrinoni, A.; Orlandi, A.; Chimenti, S. Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia. Clin. Ther. 2009, 31, 2565-2569, doi:10.1016/j.clinthera.2009.11.018.
68. Zocchi, L.; Bourdon, J.C.; Codispoti, A.; Knight, R.; Lane, D.P.; Melino, G.; Terrinoni, A. Scotin: A new p63 target gene expressed during epidermal differentiation. Biochem. Biophys. Res. Commun. 2008, 367, 271-276, doi:10.1016/j.bbrc.2007.12.115.
69. Zocchi, L.; Terrinoni, A.; Candi, E.; Ahvazi, B.; Bagetta, G.; Corasaniti, M.T.; Lena, A.M.; Melino, G. Identification of transglutaminase 3 splicing isoforms. J. Invest. Dermatol. 2007, 127, 1791-1794, doi:10.1038/sj.jid.5700768.
70. Porzio, O.; Massa, O.; Cunsolo, V.; Colombo, C.; Malaponti, M.; Bertuzzi, F.; Hansen, T.; Johansen, A.; Pedersen, O.; Meschi, F., et al. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. Hum. Mutat. 2007, 28, 1150, doi:10.1002/humu.9511.
71. Nucci, C.; Gasperi, V.; Tartaglione, R.; Cerulli, A.; Terrinoni, A.; Bari, M.; De Simone, C.; Agro, A.F.; Morrone, L.A.; Corasaniti, M.T., et al. Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. Invest. Ophthalmol. Vis. Sci. 2007, 48, 2997-3004, doi:10.1167/iovs.06-1355.
72. Didona, B.; Codispoti, A.; Bertini, E.; Rizzo, W.B.; Carney, G.; Zambruno, G.; Dionisi-Vici, C.; Paradisi, M.; Pedicelli, C.; Melino, G., et al. Novel and recurrent ALDH3A2 mutations in Italian patients with Sjogren-Larsson syndrome. J. Hum. Genet. 2007, 52, 865-870, doi:10.1007/s10038-007-0180-z.
73. Candi, E.; Rufini, A.; Terrinoni, A.; Giamboi-Miraglia, A.; Lena, A.M.; Mantovani, R.; Knight, R.; Melino, G. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 11999-12004, doi:10.1073/pnas.0703458104.
74. Campione, E.; Terrinoni, A.; Orlandi, A.; Codispoti, A.; Melino, G.; Bianchi, L.; Mazzotta, A.; Garaci, F.G.; Ludovici, A.; Chimenti, S. Cerebral cavernomas in a family with multiple cutaneous and uterine leiomyomas associated with a new mutation in the fumarate hydratase gene. J. Invest. Dermatol. 2007, 127, 2271-2273, doi:10.1038/sj.jid.5700851.
75. Ponassi, R.; Terrinoni, A.; Chikh, A.; Rufini, A.; Lena, A.M.; Sayan, B.S.; Melino, G.; Candi, E. p63 and p73, members of the p53 gene family, transactivate PKCdelta. Biochem. Pharmacol. 2006, 72, 1417-1422, doi:10.1016/j.bcp.2006.07.031.
76. Candi, E.; Terrinoni, A.; Rufini, A.; Chikh, A.; Lena, A.M.; Suzuki, Y.; Sayan, B.S.; Knight, R.A.; Melino, G. p63 is upstream of IKK alpha in epidermal development. J. Cell Sci. 2006, 119, 4617-4622, doi:10.1242/jcs.03265.
77. Candi, E.; Rufini, A.; Terrinoni, A.; Dinsdale, D.; Ranalli, M.; Paradisi, A.; De Laurenzi, V.; Spagnoli, L.G.; Catani, M.V.; Ramadan, S., et al. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 2006, 13, 1037-1047, doi:10.1038/sj.cdd.4401926.
78. Barcaroli, D.; Bongiorno-Borbone, L.; Terrinoni, A.; Hofmann, T.G.; Rossi, M.; Knight, R.A.; Matera, A.G.; Melino, G.; De Laurenzi, V. FLASH is required for histone transcription and S-phase progression. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 14808-14812, doi:10.1073/pnas.0604227103.
79. van Steensel, M.A.; van Geel, M. Does recessive EKV exist? J. Invest. Dermatol. 2005, 124, 268-269; author reply 270-261, doi:10.1111/j.0022-202X.2004.23517.x.
80. Ramadan, S.; Terrinoni, A.; Catani, M.V.; Sayan, A.E.; Knight, R.A.; Mueller, M.; Krammer, P.H.; Melino, G.; Candi, E. p73 induces apoptosis by different mechanisms. Biochem. Biophys. Res. Commun. 2005, 331, 713-717, doi:10.1016/j.bbrc.2005.03.156.
81. Gressner, O.; Schilling, T.; Lorenz, K.; Schulze Schleithoff, E.; Koch, A.; Schulze-Bergkamen, H.; Lena, A.M.; Candi, E.; Terrinoni, A.; Catani, M.V., et al. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J. 2005, 24, 2458-2471, doi:10.1038/sj.emboj.7600708.
82. Cassidy, A.J.; van Steensel, M.A.; Steijlen, P.M.; van Geel, M.; van der Velden, J.; Morley, S.M.; Terrinoni, A.; Melino, G.; Candi, E.; McLean, W.H. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am. J. Hum. Genet. 2005, 77, 909-917, doi:10.1086/497707.
83. Terron-Kwiatkowski, A.; Terrinoni, A.; Didona, B.; Melino, G.; Atherton, D.J.; Irvine, A.D.; McLean, W.H. Atypical epidermolytic palmoplantar keratoderma presentation associated with a mutation in the keratin 1 gene. Br. J. Dermatol. 2004, 150, 1096-1103, doi:10.1111/j.1365-2133.2004.05967.x.
84. Terrinoni, A.; Ranalli, M.; Cadot, B.; Leta, A.; Bagetta, G.; Vousden, K.H.; Melino, G. p73-alpha is capable of inducing scotin and ER stress. Oncogene 2004, 23, 3721-3725, doi:10.1038/sj.onc.1207342.
85. Terrinoni, A.; Leta, A.; Pedicelli, C.; Candi, E.; Ranalli, M.; Puddu, P.; Paradis, M.; Angelo, C.; Bagetta, G.; Melino, G. A novel recessive connexin 31 (GJB3) mutation in a case of erythrokeratodermia variabilis. J. Invest. Dermatol. 2004, 122, 837-839, doi:10.1111/j.0022-202X.2004.22311.x.
86. Terrinoni, A.; Cocuroccia, B.; Gubinelli, E.; Zambruno, G.; Candi, E.; Melino, G.; Girolomoni, G. Identification of the keratin K9 R162W mutation in patients of Italian origin with epidermolytic palmoplantar keratoderma. Eur. J. Dermatol. 2004, 14, 375-378.
87. Rossi, M.; Sayan, A.E.; Terrinoni, A.; Melino, G.; Knight, R.A. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. In Annals of the New York Academy of Sciences, New York Academy of Sciences: 2004; Vol. 1028, pp 143-149.
88. Munarriz, E.; Barcaroli, D.; Stephanou, A.; Townsend, P.A.; Maisse, C.; Terrinoni, A.; Neale, M.H.; Martin, S.J.; Latchman, D.S.; Knight, R.A., et al. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol. Cell. Biol. 2004, 24, 10593-10610, doi:10.1128/MCB.24.24.10593-10610.2004.
89. Candi, E.; Paradisi, A.; Terrinoni, A.; Pietroni, V.; Oddi, S.; Cadot, B.; Jogini, V.; Meiyappan, M.; Clardy, J.; Finazzi-Agro, A., et al. Transglutaminase 5 is regulated by guanine-adenine nucleotides. Biochem. J. 2004, 381, 313-319, doi:10.1042/BJ20031474.
90. Billon, N.; Terrinoni, A.; Jolicoeur, C.; McCarthy, A.; Richardson, W.D.; Melino, G.; Raff, M. Roles for p53 and p73 during oligodendrocyte development. Development (Cambridge) 2004, 131, 1211-1220, doi:10.1242/dev.01035.
91. Marulli, G.C.; Campione, E.; Chimenti, M.S.; Terrinoni, A.; Melino, G.; Bianchi, L. Type I lamellar ichthyosis improved by tazarotene 0.1% gel. Clin. Exp. Dermatol. 2003, 28, 391-393, doi:10.1046/j.1365-2230.2003.01318.x.
92. Pucci, B.; Claudio, P.P.; Masciullo, V.; Bellincampi, L.; Terrinoni, A.; Khalili, K.; Melino, G.; Giordano, A. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 2002, 21, 5897-5905, doi:10.1038/sj.onc.1205750.
93. Candi, E.; Paradisi, A.; Terrinoni, A.; Cadot, B.; Rufini, A.; Puddu, P.; Melino, G. Role of transglutaminase 5 in epidermis. Minerva Biotecnol 2002, 14, 155-158.
94. Candi, E.; Oddi, S.; Paradisi, A.; Terrinoni, A.; Ranalli, M.; Teofoli, P.; Citro, G.; Scarpato, S.; Puddu, P.; Melino, G. Expression of transglutaminase 5 in normal and pathologic human epidermis. J. Invest. Dermatol. 2002, 119, 670-677, doi:10.1046/j.1523-1747.2002.01853.x.
95. Bernassola, F.; Federici, M.; Corazzari, M.; Terrinoni, A.; Hribal, M.L.; De Laurenzi, V.; Ranalli, M.; Massa, O.; Sesti, G.; McLean, W.H., et al. Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J. 2002, 16, 1371-1378, doi:10.1096/fj.01-0689com.
96. Terrinoni, A.; Smith, F.J.; Didona, B.; Canzona, F.; Paradisi, M.; Huber, M.; Hohl, D.; David, A.; Verloes, A.; Leigh, I.M., et al. Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. J. Invest. Dermatol. 2001, 117, 1391-1396, doi:10.1046/j.0022-202x.2001.01565.x.
97. Terrinoni, A.; Rugg, E.L.; Lane, E.B.; Melino, G.; Felix, D.H.; Munro, C.S.; McLean, W.H. A novel mutation in the keratin 13 gene causing oral white sponge nevus. J. Dent. Res. 2001, 80, 919-923, doi:10.1177/00220345010800031401.
98. Terrinoni, A.; Dell'Arciprete, R.; Fornaro, M.; Stella, M.; Alberti, S. Cyclin D1 gene contains a cryptic promoter that is functional in human cancer cells. Genes Chromosomes Cancer 2001, 31, 209-220, doi:10.1002/gcc.1137.
99. Candi, E.; Oddi, S.; Terrinoni, A.; Paradisi, A.; Ranalli, M.; Finazzi-Agro, A.; Melino, G. Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. J. Biol. Chem. 2001, 276, 35014-35023, doi:10.1074/jbc.M010157200.
100. Vernole, P.; Terrinoni, A.; Didona, B.; De Laurenzi, V.; Rossi, P.; Melino, G.; Grimaldi, P. An SRY-negative XX male with Huriez syndrome. Clin. Genet. 2000, 57, 61-66, doi:10.1034/j.1399-0004.2000.570109.x.
101. Terrinoni, A.; Puddu, P.; Didona, B.; De Laurenzi, V.; Candi, E.; Smith, F.J.; McLean, W.H.; Melino, G. A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. J. Invest. Dermatol. 2000, 114, 1136-1140, doi:10.1046/j.1523-1747.2000.00983.x.
102. Terrinoni, A.; Candi, E.; Oddi, S.; Gobello, T.; Camaione, D.B.; Mazzanti, C.; Zambruno, G.; Knight, R.; Melino, G. A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus. J. Invest. Dermatol. 2000, 114, 388-391, doi:10.1046/j.1523-1747.2000.00890.x.
103. Richard, G.; Brown, N.; Smith, L.E.; Terrinoni, A.; Melino, G.; Mackie, R.M.; Bale, S.J.; Uitto, J. The spectrum of mutations in erythrokeratodermias--novel and de novo mutations in GJB3. Hum. Genet. 2000, 106, 321-329, doi:10.1007/s004390051045.
104. De Laurenzi, V.; Rossi, A.; Terrinoni, A.; Barcaroli, D.; Levrero, M.; Costanzo, A.; Knight, R.A.; Guerrieri, P.; Melino, G. p63 and p73 transactivate differentiation gene promoters in human keratinocytes. Biochem. Biophys. Res. Commun. 2000, 273, 342-346, doi:10.1006/bbrc.2000.2932.
105. De Laurenzi, V.D.; Catani, M.V.; Terrinoni, A.; Corazzari, M.; Melino, G.; Costanzo, A.; Levrero, M.; Knight, R.A. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ. 1999, 6, 389-390, doi:10.1038/sj.cdd.4400521.
106. Melino, G.; De Laurenzi, V.; Catani, M.V.; Terrinoni, A.; Ciani, B.; Candi, E.; Marekov, L.; Steinert, P.M. The cornified envelope: a model of cell death in the skin. Results Probl Cell Differ 1998, 24, 175-212, doi:10.1007/978-3-540-69185-3_9.
107. Junakovic, N.; Terrinoni, A.; Di Franco, C.; Vieira, C.; Loevenbruck, C. Accumulation of transposable elements in the heterochromatin and on the Y chromosome of Drosophila simulans and Drosophila melanogaster. J. Mol. Evol. 1998, 46, 661-668, doi:10.1007/pl00006346.
108. De Laurenzi, V.; Costanzo, A.; Barcaroli, D.; Terrinoni, A.; Falco, M.; Annicchiarico-Petruzzelli, M.; Levrero, M.; Melino, G. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 1998, 188, 1763-1768, doi:10.1084/jem.188.9.1763.
109. Chalvet, F.; di Franco, C.; Terrinoni, A.; Pelisson, A.; Junakovic, N.; Bucheton, A. Potentially active copies of the gypsy retroelement are confined to the Y chromosome of some strains of Drosophila melanogaster possibly as the result of the female-specific effect of the flamenco gene. J. Mol. Evol. 1998, 46, 437-441, doi:10.1007/pl00006323.
110. Terrinoni, A.; Franco, C.D.; Dimitri, P.; Junakovic, N. Intragenomic distribution and stability of transposable elements in euchromatin and heterochromatin of Drosophila melanogaster: non-LTR retrotransposon. J. Mol. Evol. 1997, 45, 145-153, doi:10.1007/pl00006214.
111. Mostaccioli, S.; DeLaurenzi, V.; Terrinoni, A.; Richard, G.; Didona, B.; Cavalieri, R.; Melino, G. White sponge nevus is caused by mutations in mucosal keratins. European Journal of Dermatology 1997, 7, 405-408.
112. Junakovic, N.; Di Franco, C.; Terrinoni, A. Evidence for a host role in regulating the activity of transposable elements in Drosophila melanogaster: the case of the persistent instability of Bari 1 elements in Charolles stock. Genetica 1997, 100, 149-154, doi:10.1023/a:1018325427405.
113. Di Franco, C.; Terrinoni, A.; Dimitri, P.; Junakovic, N. Intragenomic distribution and stability of transposable elements in euchromatin and heterochromatin of Drosophila melanogaster: elements with inverted repeats Bari 1, hobo, and pogo. J. Mol. Evol. 1997, 45, 247-252, doi:10.1007/pl00006227.