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Curriculum Vitae et Studiorum 

e

Pubblicazioni

 

 

 

del

 

Prof. Stefano Cianfarani

 

 

 

  

 

 

 

19.6.2024

 

 

 

 

“… Noi non cerchiamo quello che Iddio poteva fare, ma quello che Egli ha fatto…poi finalmente sollevandoci all’ultimo scopo delle nostre fatiche, cioè all’amore del Divino Artefice, ci conservino la speranza di poter apprendere in Lui, fonte di luce e di verità ogni altro vero.” (Galileo Galilei)

 

 

 

Stefano Cianfarani 

 

 

 

 

 

 

 

 

 

Nome:                                                    Stefano Cianfarani

 

Indirizzo Università:                             Clinica Pediatrica-Dipartimento di Medicina dei Sistemi, Università degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133-Roma

                                                      Tel:  06-6859 3074 (Osp.)

                                               Tel: 06-7259 6178 (Lab.)

                                                    Fax: 06-6859 2508             

                        

Indirizzo casa:                           Via Città di Castello 35, 

                                                   00191 - Roma

                                                   Tel: 06- 33 30 813

 

E-Mail:                                     stefano.cianfarani@uniroma2.it

 

Codice Fiscale:                         CNFSFN57T20H501C

 

Data di nascita:                         20 Dicembre 1957

 

Luogo di nascita:                       Roma

 

Nazionalità:                               Italiana

 

Stato Civile:                                          Sposato con Teresa Maria Martino. Padre di Francesco, Eugenia, Agnese, Bernardo, Bartolomeo e Giovanni Maria

 

Scolarità:                                                 Diploma di Maturità (60/60) presso il Liceo Classico della Scuola Pontificia Scuola "Pio IX" nel 1976.

 

Facoltà di Medicina

e Chirurgia:                                         Universita' degli Studi di Roma 

                                                               "La Sapienza" 1976-1982. 

Voto di Laurea 110/110 con Lode

Scuola di 

Specializzazione:                                  Pediatria, Universita' degli Studi 

                                                               di Roma "La Sapienza" 1982-1986. 

Voto diploma di Specializzazione 70/70 con Lode.

 

Attuale posizione :                                Professore Ordinario di Pediatria Generale e Specialistica (MED/38). Dipartimento Medicina dei Sistemi, Facoltà di Medicina e Chirurgia dell’Università di Roma Tor Vergata, Roma.

 

Responsabile della Unità Operativa Complessa (U.O.C.) di “Endocrinologia e Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.

 

Dal 1/11/2012 Visiting Professor presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.

 

Attualmente: Affiliated Researcher presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.

 

Referente dell’Unità di Ricerca “Fisiopatologia della Crescita”, Ospedale Pediatrico “Bambino Gesù”, Roma.

 

Chair of Clinical Practice Committee della European Society fo Pediatric Endocrinology (ESPE), 2022-2025.

 

 

 

Posizioni Precedenti:                            Professore Associato di Pediatria Generale e Specialistica (MED/38), Facoltà di Medicina e Chirurgia, Università degli Studi di Roma Tor Vergata.

                                                            Dal 1.11.2002 al 27/2/2018 

 

Responsabile della Unità Operativa Complessa (U.O.C.) di “Diabetologia e Patologia dell’Accrescimento”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.

 

Dal 2017 al 2018 Responsabile della Struttura Semplice Dipartimentale di “Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.

                                                            

                                                            Dal 1/10/2009 al 15/5/2017 Responsabile Struttura Semplice di “Endocrinologia Molecolare” presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.

 

                                                           Dal 1/7/1988, Funzionario Tecnico, Clinica Pediatrica,                                                                          Dipartimento            di Sanità Pubblica e Biologia Cellulare,                                                                         Università degli Studi di Roma, "Tor Vergata",                                                                                     Roma. 

 

Dal 25/11/1988, Dirigente I livello (Assistente Ospedaliero) presso la Divisione di Pediatria, Ospedale S. Eugenio, Azienda USL RM-C, Roma.

 

Dal 24/3/2003 Dirigente I Livello (ex Aiuto Ospedaliero) presso la Divisione di Pediatria (U. Org. Patologi Endocrina Pediatrica), Ospedale S. Eugenio, Azienda USL RM-C, Roma.

 

                                                           Dal 1995, Responsabile del Laboratorio di                                                                                           Endocrinologia Pediatrica, Università “Tor                                                                                          Vergata”, Roma

 

Dal 24/03/2003 al 30/09/2009 Responsabile dell’Unità Organizzativa di Patologia Endocrina Pediatrica, Ospedale S.Eugenio, ASL RM-C, Roma.

 

Dal 1/1/2009 al 31/8/2009 incaricato dal Rettore dell’Università di Roma “Tor Vergata” come Direttore della Clinica Pediatrica dell’Università di Roma “Tor Vergata” con sede presso l’Ospedale S.Eugenio Roma.

 

Presidente Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) per il biennio 2017-2019.

 

Presidente European Society fo Pediatric Endocrinology (ESPE) 2022.

 

 

 

Tipologia Prestazioni

Assistenziali:                                        -Dalla data di strutturazione (1988):Assistenza diurna, notturna e festiva presso U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata, con compiti di responsabilità diretta, con turni periodici di corresponsabilità del Reparto. Consulenze diurne, notturne e festive presso la Accettazione e il Pronto Soccorso dell’Ospedale S. Eugenio, Azienda USL RM-C, Roma, con compiti di responsabilità diretta. 

 

                                                            -Delegato periodicamente dal Primario della U.O.C. di Pediatria a sostituirlo come responsabile della stessa U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata. 

 

                                                            -Attività ambulatoriale specialistica in Patologia Endocrina Pediatrica e responsabile della Unità Organizzativa di Patologia Endocrina Pediatrica-B2 su delibera del Consiglio di Facoltà del 24/10/2002 ed in conformità con quanto stabilito dalla ASL RMC in data 23/1/2002  delibera n. 42.

 

                                                            -Incaricato dal Rettore dell’Università di Roma Tor Vergata ad esercitare funzione primariale temporanea presso la U.O.C. di Pediatria-Oncoematologia Pediatrica presso l’Ospedale S. Eugenio dal decorrenza dal 1.12.2008.

                                                            

                                   

Attività Didattica Insegnamenti:          Corso di Laurea in Medicina

                                                           2002-2012 Corso Integrato di Pediatria (Scienze                                                                                                          Pediatriche)     

 

                                                           Scuola di Specializzazione in Pediatria:

                                                           1989-1991 Clinica Pediatrica

                                                           1991-1993 Pediatria Generale e Specialistica

                                                           1993-1996 Endocrinologia

                                                           1999-2000 Pediatria Generale

                                                           2001-2004 Endocrinologia Pediatrica e Malattie del                                                                             Metabolismo Infantile e Neonatale

                                                           2002-2003 Patologia Clinica

                                                           2003-2006 Endocrinologia Pediatrica

                                                           2004-2005 Pediatria Generale e Specialistica

                                                           2007-2012 Pediatria Generale e Specialistica

                                                           

                                                           Scuola di Specializzazione Scienze                                                                                                        dell’Alimentazione:

                                                           2000/2001, 2003/2004, 2005-2008 Pediatria                                                   

                                                           Scuola di Specializzazione in Neuropsichiatria                                                                                      Infantile

                                                           2005-2008 Neuropsicoendocrinologia

 

                                                           

                                                           Scuola di Specializzazione in Ortopedia e                                                                                             Traumatologia                                                                                                                                   2009 PediatrIa

 

                                                           Diploma Universitario in Dietologia e Dietetica                                                                                    Applicata

                                                           1995-1997 Patologia dell’età evolutiva

                                                                       

                                                           

                                                           Diploma Universitario in Dietista

                                                           1997-2001 Patologia dell’età evolutiva

 

                                                           

                                                           Diploma Universitario in Ostetricia

                                                           1997-1998 Cardiologia Pediatrica

 

                                                           

Diploma Universitario Tecnici in Riabilitazione Psichiatria

2010 Pediatria

 

Dottorato di Ricerca in Pediatria Molecolare, 

Università Tor Vergata, Roma. 

Docente AA.AA. 2002-2006.

 

Scuola di Alta Formazione in Pediatria, Università Tor Vergata/Ospedale Pediatrico Bambino Gesù, Roma.

2012 Comitato Scientifico

 

Master in Endocrinologia Pediatrica, Università di Parma

AA 2010 e 2012 Basse stature da alterazione periferica

 

Docente e organizzatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 10/3-9/6, 1999-2000.

 

Docente e coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 2000-2001.

 

Docente Winter School, European Society for Paediatric Endocrinology, Varna, Bulgaria, 4-11 marzo 2006.

 

 

 

Master                                                Direttore Master II livello in Endocrinologia e Diabetologia Pediatrica, Scuola di Alta Fromazione in Pediatria, Università degli Studi di Roma Tor Vergata e Ospedale Pediatrico Bambino gesù, Roma. Primo ciclo a partire dal 2014.

 

PhD courses 

(Dottorato di ricerca)                           Docente del Corso di Dottorato in Pediatria Molecolare Università degli Studi di Roma Tor Vergata (2003-2004).

 

                                                           Docente del Corso di Dottorato in Pediatria Molecolare e Biotecnologie Applicate, Università degli Studi di Roma Tor Vergata (2005).

 

                                                           Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)"Università degli Studi di Roma Tor Vergata (2012-2016).

 

                                                           Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)"Università degli Studi di Roma Tor Vergata (2012-2017).

 

 

 

                                                           Tutor and Supervisor:

 

                                                           Supervisore della Dr.ssa Caterina Geremia, PhD, with the Thesis: “Metabolic programming in intrauterine groath retardsation (IUGR). Results from clinical and laboratory investigations”. Tor Vergata University, Rome, 2007.

 

 

Supervisore della Dr.ssa Arianna Maiorana, PhD, with the Thesis: “A Method to Isolate Omental Adipose Stem cells in Pediatric Patients: Perspectives in investigating the Pathogenesis of metabolic Syndrome”. Tor Vergata University, Rome, 2008

 

 

Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, 2006.

 

 

Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit,  Karolinska Institute, Stoccolma Sweden.

 

Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.

 

Official opponent in doctoral dissertation of PhD. Candidate Carolina Smeets, Thesis Title: 

“Silver-Russell Syndrome & Small for Gestational Age 

Long-term health perspectives” Erasmus University, Rotterdam, 2017.

 

External reviewer in doctoral dissertation of PhD. Candidate Nicola Improda, Thesis title:

“New insights in childhood-onset growth hormone deficiency: from diagnosis to long-term outcomes”. Clinical and Experimental Medicine, University of Naples Federico II, Naples, 2021.

 

Official opponent in doctoral dissertation of PhD. Candidate Wesley J. Goedegebuure, Thesis Title: 

“Small for gestational age. Adult metabolic and cardiovascular health and long-term safety of growth hormone treatment”. Erasmus University, Rotterdam, 2021.

 

 

 

 

 

Società

di appartenenza:                                 Ordine dei Medici della Provincia di Roma 

                                                           N. 32942 (10/2/1983)

                                                           

British General Medical Council 

Registration N. 3417762 (13/5/1991)

 

·       Società Italiana di Pediatria

·       Società Italiana di Endocrinologia e Diabetologia Pediatrica

·       European Society for Pediatric Endocrinology (ESPE)

 

Incarichi Internazionali                         Chairman of the Clinical Practice Committee della European Society for Pediatric Endocrinology  dal 2004 al 2010.

                                                           

                                                           Comitato scientifico della Consensus Conference                                                                                internazionale sull’approccio diagnostico e terapeutic                                                                        del bambino nato piccolo per età gestazionale. Un                                                                              Simposio internazionale organizzato congiuntamente                                                                         dalla European Society for Pediatric Endocrinology                                                                             (ESPE), Lawson Wilkins Society for Pediatric                                                                                         Endocrinology (LWPES) and la Growth Hormone                                                                                  Research Society (GRS). Manchester, UK, 2006

 

                                                           Membro del Consiglio Direttivo della European

                                                           Society for Pediatric Endocrinology  2004-2010.

 

                                                            Membro del Programme Organizing Committee della European  Society for Pediatric Endocrinology  2004-2010.

 

Consulente temporaneo Organizzazione Mondiale della Sanità (OMS). 2006.

 

Membro temporaneo dell’EMA Scientific Advisory Group (SAG) for Diabetes/Endocrinology dal  2007.

 

Membro Advisory Group della ERA-NET PRIOMEDCHILD European Network for Medicines in Childhood. 2008.

 

Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.

 

Chair of the Board of Advanced Seminars in Developmental Endocrinology (2014-2016), European Society for Pediatric Endocrinology (ESPE) 

 

Dal 2015 al 2019, membro del pannello di esperti del Science Committee della European Society for Pediatric Endocrinology (ESPE).

 

Premi Internazionali                             Nomination per il Research Award della European Society for Pediatric Endocrinology (2005, 2006, 2007).

 

Comitati e Consulenze 

Scientifiche:                                        Comitato scientifico, V Congresso della Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP). Roma 18- 19 Ottobre 1985. 

 

Scientific Secretary, International Workshop on Binding Proteins for Growth Hormone and Somatomedins, Roma, November 23-24, 1990. 

     

Consulente scientifico per la R.A.I. per trasmissioni sulla crescita e la pubertà (D.S.E.) 1985 e 1986.

 

Comitato Scientifico, Corso SIEDP in Endocrinologia Pediatrica, Sabaudia 5-7 Ottobre 2000.

 

Coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università di Tor Vergata, Roma, 2002.

 

Coordinatore Gruppo di Studio su “Fisiopatologia dei processi di accrescimento” Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), 2001-2003

 

Comitato scientifico dell’Accademia Nazionale di Medicina, coordinatore per il settore Endocrinologia e Malattie del Ricambio dell’Età Evolutiva (2005-2008).

 

Responsabile commissione giovani Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) 2007-2009

 

Responsabile commissione farmaci Società Italiana di Medicina dell’Adolescenza (SIMA) 2009-2011.

 

Membro Comitato Scientifico Fondazione “Cesare Serono”, dal 2011.

 

Membro Gruppo di Lavoro Ricerca e Sviluppo, Agenzia Italiana del Farmaco (AIFA) 2011-2012.

 

Member of the Steering Committee, European Society for Pediatric Endocrinology (ESPE) Advanced Seminar in Developmental Endocrinology (From 2012).

 

 

Borse di Studio:                                    C.N.R. borsa di studio per l'estero (n.203.04.10  6/5/1986) per il progetto: "Western Blotting Technique in the study of short stature" (1986).          Department of Chemical Endocrinology, St. Bartholomew's Hospital, Londra,  Gran Bretagna

 

C.N.R.-N.A.T.O. junior fellowship (n. 215.24 18/01/90) per il progetto: "Insulin-like growth factor binding proteins in children with short stature" (1990). Division of Pediatric Endocrinology, St. Bartholomew's Hospital, Londra,  Gran Bretagna.

 

C.N.R.-N.A.T.O. senior fellowship (n. 217.28 del  29/4/1995) per il progetto: "Effetto dell’ormone della crescita e dei fattori di crescita insulino-simili (IGFs) sulla stabilità del genoma umano: studio “in vitro” e “in vivo”. University of Bristol, Bristol, Gran Bretagna.

 

 

Precedenti  Posizioni scientifiche e 

professionali all’estero:                        Visiting Paediatrician, Department of Growth and Development, (Prof. J.M. Tanner) Institute of Child Health, University of London, U.K. Settembre 1984 

 

Visiting Researcher, Laboratory of Tumor Cell   Biology, (Dr. R.C. Gallo), National Institutes of Health,   National Cancer Institute, Bethesda, Maryland, U.S.A. 

Da Agosto a Settembre 1985 

 

Research Fellow in Endocrinology (Prof. L.H. Rees), Department of Chemical Endocrinology, St. Bartholomew's Hospital, London U.K.

Da Settembre 1988 a Febbraio 1989 

 

Research Fellow in Paediatric Endocrinology, Division of Paediatric Endocrinology, Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE

                                                               Da Maggio 1991 ad Aprile 1992

 

Honorary Clinical Assistant in Paediatric Endocrinology, Department of Paediatric Endocrinology,  Dr. Martin Savage, "The Queen Elizabeth Hospital for Children", London, E2 8PS

                                                               Da Maggio 1991 ad Aprile 1992

 

                                                           Teacher of Endocrinology of Growth,                                                                                                  Serono, Auxology Course, St.                                                                                                               Bartholomew's Hospital, London EC1A                                                                                                7BE. 1991-1992

 

Honorary Research Fellow in Pediatric Endocrinology,

Royal Hospital for Sick Children, Bristol BS2 8BJ, dal 28 Ottobre 1996 per 2 anni.

                                       

                                                           Visiting Fellow in Surgery,

Bristol Royal Infirmary, University of Bristol, Bristol BS2 8BJ, U.K. dal 30 Novembre 1996 per due anni.

 

Organizzazione Conferenze

 

Internazionali:                                      Organizer and member of the Steering Committee. International Conference  Organization Workshop on Binding Proteins for Growth Hormone and Somatomedins. Rome, November 23-24, 1990. Organizer and member of the Steering Committee.

                                                            IGF-I and IGF binding protein assessment and therapeutic benefit. Serono Symposia, New Orleans, June 14-15, 2004. 

 

                                                            Organizer and member of the Steering Committee.

                                                            ESPE/GRS/LWPES Consensus Workshop on Management of the Small for Gestational Age Child.

                                                            1-4 February 2006 Manchester, UK

 

                                                            Delegate to

                                                            ESPE/GRS/LWPES Consensus Workshop on Idiopathic Short Stature.

                                                            17-20 October 2007, Los Angeles, CA, US

 

Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.

 

Editorial Board                                     1. Editor in Chief, Frontiers in Pediatric Endocrinology, Frontiers Research Foundation, Lausanne, Switzerland, fino a Gennaio 2014

                                                            2. Associate Editor of Review of Diabetic Studies, Society for Biomedical Diabetes Research. Fino a Gennaio 2014.

                                                            3. Editor in Chief (appointed from 2014), Hormone Research in Paediatrics, Karger, Basel, Switzerland.  

                                                            4. Advisory Board member of Biomedicine Hub, Karger, Basel, Switzerland. Dal 2016   

                                                            5. Editorial board: Annals of Pediatric Endocrinology and Metabolism, dal 2016.

                                                            6. Editorial board: Jornal de Pediatria, Brazil, dal 2021

 

 

Incarichi Accademici 

Internazionali                                       Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, May 27th, 2006.

 

                                                            Teacher of Evidence-Based Medicine in Paediatric Endocrinology, at the “Advanced Postgraduate Course on Methods in Growth Research – Theory and Practice”. Karolinska Institutet, Stockholm, November 22-26, 2010.

 

Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit,  Karolinska Institute, Stoccolma Sweden.

 

Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.

 

 

Reviewer per:                          

 

Direzione  Attività Formativa ECM                       Responsabile Evento Formativo  Tavola Rotonda: Prevenzione dell’Osteoporosi dell’Adulto in Età  Pediatrica. Roma 6-9.2003. Crediti ECM assegnati: n. 3

 

  Responsabile Evento Formativo  Corso di Aggiornamento: Errori in Endocrinologia Pediatrica.  Roma 18-10.2003. Crediti ECM assegnati: n. 6

 

                                               

                                                           Responsabile Evento Formativo:

Corso di Aggiornamento in Endocrinologia Pediatrica, “Terapia Endocrina nell’Età Evolutiva”.

Roma, Marzo-Giugno, 2004. Crediti ECM assegnati: n. 23

                                                           

                                                           Responsabile Evento Formativo con US CME:

“IGF-I and IGF binding protein assessment and therapeutic benefit”. New Orleans 14-15 Giugno, 2004, Serono Symposia.

 

                                                           Responsabile Evento Formativo:

Corso di Aggiornamento in Endocrinologia Pediatrica, “Endocrinologia pediatrica per problemi”.

Roma, Marzo-Giugno, 2006. Crediti ECM assegnati: n. 17

 

                                                            Responsabile evento formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Clinical Practice in Endocrinologia Pediatrica”  Roma, Marzo-Giugno, 2008. crediti ECM: 19

 

                                                            Responsabile evento formativo: Corso di aggiornamento, “SGA: cause e conseguenze del basso peso alla nascita”.  Roma, 21 Giugno, 2008. crediti ECM: 6

 

 

Attività formativa                                Coordinatore del Corso di Endocrinologia Pediatrica, 

per paesi in via di sviluppo                   per conto della Società Europea di Endocrinologia                                                                               Pediatrica (ESPE). Nairobi (Kenia) 16-20 Maggio,                                                                          2006.

 

Research Grants Gestiti                       

come Responsabile                              “The Prevention of osteoporosis by nutrional phytoestrogens (PHYTOS)”. Shared Cost RTD actions. European Commission. Anno 1999, durata 48 mesi, Proposal No. QLRT-1999-00857. Subcontractor of Contractor 1: Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione. “Deteminazione di IGF-I, IGFBP-3, IGFBP-4 e forme circolanti di IGFBP-3”. 

Importo finanziato pari a 45.000 EURO. Principal Investigator and Coordinator

                        

                                                           “Terapia sperimentale nell’adrenoleucodistrofia”.

                                                           Fondazione Baroni. Anno 2000-2001.

                                                           Importo finanziato pari a Lire 50.000.000

                                                            

                                                            “Phytohealth”. European Network for Research on Phytoestrogens. CORDIS RTD-Project #68987, EC 2003; 5000 EURO

 

                                                            “S6 Kinase activity in Human Placentas from Normal and SGA Fetuses”. MIUR 60% 2003. 2500 EURO. Principal Investigator and Coordinator

 

                                                            “Origine fetale delle malattie dell’adulto. Identificazione precoce dei fattori di rischio cardiovascolare e metabolico nei soggetti nati con ritardo di crescita ad inizio intrauterino”. MIUR COFIN-40% - 2003 . Coordinatore Nazionale del Progetto. Euro: 136.000. Responsabile Unità Operativa, Roma, Tor Vergata, EURO 63.000. Principal Investigator and Coordinator

 

                                                            “Proteolisi della IGFBP-3 nei pazienti con deficit di GH (GHD). Effetto sulla sensibilità e specificità del dosaggio della IGFBP-3 nella diagnosi di GHD.” Progetti di Ricerca di Ateneo (ex  60%). Anno 2005. EURO 4.200. Principal Investigator and Coordinator

                                                            

                                                            Riprogrammazione dell’attività S6K e IRS-1 ed espressione dei recettori per insulina e IGF-I nei bambini small for gestational age (SGA). Progetti di Ricerca di Ateneo (ex  60%). Anno 2006. EURO 2.300. Principal Investigator and Coordinator

 

                                                            “SAGhE: Safety and Appropriateness of 

                                                            Growth hormone treatments in Europe”. FP7-HEALTH-2007: Better use of medicines

                                                            Collaborative projects (Small or medium-scale focused research projects)

                                                            Coordinating person: Jean-Claude Carel

                                                            EU grant FP7-223497, 2009-2012. Euro 440000 for the local Unit (Tor Vergata, University, Rome) coordinated by Prof. Stefano Cianfarani, Principal Investigator and Coordinator of WORKPACKAGE 4.                                                              

                                                            “Protective role of IGF-I in premature babies at risk of  neurological damage  and retinopathy” Eli Lilly grant 2009. euro 70.000. Pricipal Investigator and Coordinator

 

“Metilazione del gene igf2, ritardo di crescita ad inizio intrauterino e alterazioni metaboliche. Studio clinico in bambini obesi nati piccoli per età gestazionale e con peso alla nascita appropriato per età gestazionale.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2011. 12.000 Euro. Principal Investigator and Coordinator

 

“Growth Hormone Treatment For Short Children Born Preterm And Presenting Extrauterine Growth Retardation”. Principal Investigator and Coordinator.

                                                           Pfizer grant 2011. 164.000 Euro

 

                                                           “Studio multicentrico europeo sulla identificazione dei                                                                        fattori   di rischio metabolico in bambini ed adolescenti                                                                          obesi.” Ricerca Corrente Ospedale Pediatrico                                                                                      Bambino Gesù, IRCCS, 2012. 60.000 Euro. Principal                                                                             Investigator and Coordinator

 

                                                           Deficit Subclinico di Vitamina D e Rischio Metabolico e                                                                        Cardiovascolare in Bambini Obesi. Trial Pilota                                                                                      Randomizzato Controllato con Vitamina D3. Ricerca                                                                        Corrente Ospedale Pediatrico Bambino Gesù, IRCCS,                                                                           2013. 52000 Euro. Principal Investigator and                                                                                       Coordinator.

 

                                                           miRNA – Novel markers to predict the development of                                                                        obesity‐related disorders?

                                                           Collaborative International Project. European Society                                                                          for Paediatric Endocrinology-Research Unit. Co-                                                                                           Investigator. 2013. 60000 Euro. 

 

                                                           "PERSUADED. Phthalates and bisphenol : a                                                                                          biomonitoring in Italian mother-child pairs: link                                                                                             between exposure and juvenile diseases" LIFE13                                                                                 ENV/IT/000482. Principal Investigator of “Bambino                                                                             Gesù” Children’s Hospital Unit. 

                                                           Progetto cofinanziato Comunità Europea.                                                                                           Cofinanziamento richiesto 877658 Euro

                                                           Principal Investigator of “Bambino Gesù” Children’s                                                                            Hospital Unit. 238.853 Euro. 

 

                                                           Translational approaches to disease modifying therapy of type 1                                                         diabetes - HARVESTing the fruits of INNODIA

                                                           European Commission (BRUSSELS ) 

                                                           2020-06 to 2023-06|Grant GRANT_NUMBER: 945268

 

                                                           Translational approaches to disease modifying therapy of type 1                                                         diabetes: an innovative approach towards understanding and                                                                     arresting type 1 diabetes - Sofia ref.: 11579 European                                                                         Commission (Brussels) 2015-11-01 to 2022-10-31|Gran                                                                                  GRANT_NUMBER: 11579                                                                                                                    URL:https://app.dimensions.ai/details/grant/grant.6814282

 

 

 

 

 

 

 

TESI

 

Tesi di Laurea in Medicina e Chirurgia: "Patologia pediatrica da difetti recettoriali", 1982, Relatore Prof. B. Boscherini. 

 

Tesi di Diploma per la Specializzazione in Pediatria: "Nuovi metodi di indagine della funzionalità somatotropinica", 1986, Relatore Prof. B. Boscherini.

 

 

 

PUBBLICAZIONI

 

 

 

 

ORIGINAL ARTICLES

 

 

1.         Spadoni G.L., Cianfarani S., Boscherini B. 

            Le Somatomedine. 

            Rivista Italiana di Pediatria 10, 347-351, 1984. 

 

2.         de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M.,           

            Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.         

            Hormone-modulated rRNA gene activity is visualized by           

            selective   silver staining of the NOs. 

            Cell Biology International Reports 9, 791-796, 1985

 

3.         de Capoa, Marlekaj P., Baldini A., Felli M.P., Rocchi M.,             

            Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.         

            Growth-hormone induced regulation of rRNA gene activity in   

            human cultured cells. 

            Hormone and Metabolic Research 18, 574-575, 1986. 

 

4.         Cianfarani S., Spadoni G.L., Finocchi G., Ravet P., Costa 

            F.,   Papa M., Scirè G., Manca Bitti M.L., Boscherini B.   

            Growth hormone treatment in Noonan's syndrome. 

            Minerva Pediatrica 39, 281-284, 1987.

 

5.         Cianfarani S., Spadoni G.L., Scirè G., Galasso C., Benvenuti        

            S., Manca Bitti M.L., Rezza E., Boscherini B. Pretreatment         

            growth velocity and response to GH (HGH) therapy. 

            Minerva Pediatrica 39, 757-761, 1987.

 

6.         Vaccaro F., Cioschi S., Falvo F., Bernardini S., Spadoni   

            G.L., Cianfarani S., Carrozzo A.M., Nini G., Galasso C.,    

            Manca Bitti M.L., Pasquino A.M. 

            Acanthosis Nigricans, insulino-resistenza ed  endocrinopatie: attuali vedute e  conoscenze.

            Il Progresso Medico 43, 483-489, 1987.

 

7.         Spadoni G.L., Cianfarani S., Baldini A., Ravenna L., Felli 

            M.P., Camaioni A., Manca Bitti M.L., Scirè G., Boscherini           B., de Capoa A. 

            Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. 

            Hormone and  Metabolic Research, 20, 450-452, 1988.

 

8.         Boscherini B., Cianfarani S., Spadoni G.L. 

            Growth Disorders.        

            Medicina 8, 287-292, 1988.

 

9.         Baldini A., Felli M.P., Ravenna L., Camaioni A., de Capoa           

            A., Spadoni G.L., Cianfarani S., Boscherini B. 

            Differential ribosomal gene responsiveness to human growth hormone is        

            visualized by selective silver staining. 

            Cytogenetics and Cell Genetics 47, 22-25, 1988. 

 

10.       Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F.,    

            Galasso C., Manca Bitti M.L., Costa F., Boscherini B.      

            Twelve-hour spontaneous nocturnal growth hormone secretion           

            in growth retarded patients. 

            Clinical Pediatrics 27, 473-478, 1988. 

 

11.       Holly JMP, Smith CP, Dunger DB, Howell RJS, Chard T, Perry      

            LA, Savage MO, Cianfarani S., Rees LH, Wass JAH.         

            Relationship between the pubertal fall in sex hormone-            

            binding globulin and insulin-like growth factor binding 

            protein-I. A synchronised approach to pubertal development? 

            Clinical Endocrinology 31, 277-284, 1989. 

 

12.       Bernardini S., Cianfarani S., Galasso C., Spagnoli A.,      

            Vaccaro F., Spadoni G.L. 

            Somatotropin function in Noonan's syndrome. 

            Pediatria Oggi 9, 110-112, 1989.

 

13.       Spagnoli A., Bernardini S., Galasso C., Vaccaro F., Manca            

            Bitti M.L., Scirè G., Cianfarani S., Spadoni G.L. 

            Treatment of somatotropic deficiency with biosynthetic growth hormone.       

            Medical and Surgical Pediatrics 11, 5-10, 1989. 

 

14.       Cianfarani S., Holly JMP 

            Somatomedin-binding proteins: what role do they play in the growth process? 

            European Journal of  Pediatrics 149:76-79, 1989. 

 

15.       Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F.,    

            Galasso C., Boscherini B. 

            Growth hormone treatment in children with sporadic primary microcephaly. 

American Journal of Diseases in Childhood 143, 1282-1283, 1989. 

 

16.       Boscherini B., Cianfarani S., Spadoni G.L. 

            Clinical features of growth hormone (GH) deficiency. 

            Journal of Endocrinological Investigation 12, 17-19, 1989. 

 

17.       Holly JMP, Edeb JA, Alaghband-Zadeh J, Carter GD, Jemmott     

            RC, Cianfarani S., Chard T, Wass JAH. 

            Insulin-like growth factor binding proteins in follicular fluid from normal          

            dominant and cohort follicles, polycystic and multicystic ovaries.          

            Clinical Endocrinology 33, 53-64, 1990. 

 

18.       Vaccaro F, Cianfarani S., Spadoni GL, Spagnoli A, Bernardini      

            S, Galasso C, Boscherini B. 

            Growth hormone therapy in non GH-deficient short children. 

            Rivista Italiana di Pediatria 16, 528-534, 1990. 

 

19.       Spadoni GL, Spagnoli A, Cianfarani S., Del Principe D,    

            Menichelli A, Di Giulio S, Boscherini B. 

            Enhancement of phorbol diester-stimulated respiratory burst in human           

            polymorphonuclear leukocytes by growth hormone. 

Acta Endocrinologica (ora European Journal of Endocrinology) 124, 589-594, 1991. 

 

20.       Spadoni G.L., Rossi P., Ragno W., Galli E., Cianfarani S.,

            Galasso C., Boscherini B. 

            Immune function in growth hormone deficient children treated with biosynthetic growth hormone.    

            Acta Paediatrica Scandinavica 80, 75-79, 1991. 

 

21.       Cianfarani S., Vaccaro F, Spadoni GL,  Galasso C, Bernardini      

            S, Spagnoli A, Boscherini B. 

            Abnormal growth velocity does not impair the attainment of target height in   "small-delay"    children. 

            Acta Medica Auxologica 23, 245-251, 1991.

 

22.       Bernardini S, Spadoni GL, Cianfarani S, Scalera G, Cives C,          

            Vaccaro F, Pasquino AM, Boscherini B. 

            Growth hormone response to growth hormone releasing factor in Turner's       syndrome. 

            Acta Medica Auxologica 23, 173-178, 1991.

 

23.       Bernardini S, Spadoni GL, Cianfarani S, Vaccaro F, Pasquino       

            AM, Boscherini B. 

            Growth hormone secretion in Noonan's syndrome. 

Journal of Pediatric Endocrinology (now Journal of Pediatric Endocrinology and Metabolism) 4, 217-221, 1991. 

 

24.       Cianfarani S.    

            New modulators of growth: the somatomedin-             

            binding proteins. 

            Rivista Italiana di Pediatria 18, 119-124, 1992. 

 

25.       Cianfarani S., Holly J.M.P., Pasquino A.M., Vaccaro F.,                

            Spadoni G.L., Bernardini S., Segni M., Boscherini B.       

            Insulin-like growth factor binding protein-1 (IGFBP-1)                

            levels in Turner syndrome. 

            Hormone and Metabolic Research 24, 537-540, 1992. 

 

26.       Pasquino A.M., Bernardini S., Cianfarani S., Mancuso G., Marchione S.A., Passeri F., Pucarelli I., Spadoni G.L. 

            Growth hormone assessment and three years' hGH therapy in girls with Turner            syndrome.        

            Hormone Research 38, 120-124, 1992. 

 

27.       Tedeschi B, Spadoni G.L., Sanna M.L., Vernole P., Caporossi D., Cianfarani S.,  Nicoletti B, Boscherini B. 

Increased chromosome fragility in lymphocytes of short normal children         treated with recombinant human growth hormone. 

            Human Genetics 91, 459-463, 1993 

 

28.       Cianfarani S., Nicholl R.M., Medbach S., Charlesworth  M.C., Savage M.O. 

            Idiopathic hypothalamus-pituitary dysfunction: review of five cases.     

            Hormone Research 39, 47-50, 1993. 

 

29.       Cianfarani S., Frost V.J., Savage M.O., Holly J.M.P. 

            Glucose does not influence the insulin-like growth factor (IGF) binding to carrier          proteins           (IGFBPs): analysis of rat and human serum by western ligand blotting.           

            Experientia (now Cellular and  Molecular Life Sciences) 49, 699-701, 1993. 

 

30.       Cianfarani S., Vaccaro F., Pasquino A.M., Marchione S.A., Passeri F., Spadoni G.L., Bernardini S., Spagnoli A., Boscherini B. 

            Reduced growth hormone (GH) secretion in Turner syndrome: is body weight a            key factor?       

            Hormone Research, 41, 27-32, 1994. 

31.       Bernardini S, Cianfarani S, Spagnoli A, Melino G, Annicchiarico-Petruzzelli M, Massoud R, Boscherini B, Finazzi-Agrò A, Rosenfeld RG, Federici G.          

Expression and down regulation by retinoic acid of IGF binding protein-2 and 4 in medium from human neuroblastoma cells. 

            Journal of Neuroendocrinology 6, 409-413, 1994. 

 

32.       Cianfarani S, Vaccaro F, Boscherini B. 

            What is the rationale of growth hormone therapy in Turner syndrome?           

Lancet 344, 114-115, 1994.  

 

33.       Cianfarani S., Boscherini B. 

            La sindrome di Noonan. 

            Prospettive in   Pediatria 25, 25-32, 1995.

 

34.       Bernardini S, Cianfarani S, Pianca C, Massoud R, Germani D, Melino G, Federici           G. 

Insulin-like growth factor binding protein-1 serum levels in neuroblastoma. 

Clinical Chemistry and Enzimology Communications 6, 359-363, 1995.

 

35.       Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B. 

Is the obesity-  related insulin status the cause of the blunted growth hormone secretion in Turner syndrome? 

            Metabolism 44, 1033-1037, 1995.  

 

36.       Spagnoli A., Spadoni G.L., Cianfarani S., Pasquino A.M., Troiani S., Boscherini B. 

            Predicting outcome of growth hormone therapy in children with idiopathic short         stature.

            Journal of  Pediatrics 126, 905-909, 1995. 

 

37.       Cianfarani S., Boemi S., Spagnoli A., Cappa M., Argirò G., Vaccaro F., Manca Bitti M.L., Boscherini B. 

            Is IGFBP-3 binding protein-3 assessment helpful for the diagnosis of GH            deficiency?

            Clinical Endocrinology 43, 43-47,1995.

 

38.       Municchi G., Pasquino A.M., Pucarelli I., Cianfarani S., Passeri F.           

Growth hormone treatment in Noonan syndrome: report of four cases who reached final height. 

            Hormone Research 44, 164-167,1995. 

 

39.       Cianfarani S., Vitale S., Stanhope R., Boscherini B. 

Imperforate anus, bilateral hydronephrosis, bilateral undescended testes, and pituitary hypoplasia: a variant of Hall-Pallister syndrome or a new syndrome?       

Acta Paediatrica 84, 1322-1324, 1995. 

 

 

40.       Spagnoli A., Branca F., Spadoni G.L., Cianfarani S., Pasquino A.M., Argirò G., Vitale S., Robins S.P., Boscherini B. 

Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency. Skeletal metabolism during GH treatment. 

            Journal of Clinical Endocrinology and Metabolism 81,3589-3593,1996. 

 

41.       Cianfarani S., Germani D., Rossi P., Spagnoli A., Mercanti D. 

Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells?   

European Journal of Endocrinology 135, 716-723, 1996. 

 

42.       Cianfarani S., Rossi P. 

            Neuroblastoma and Insulin-like growth factor (IGF) system. New insights and clinical perspectives. 

            European Journal of Pediatrics 156, 256-261, 1997. 

 

43.       Cianfarani S., Boscherini B. 

Il bambino con ritardo di crescita ad inizio intrauterino (IUGR, intrauterine growth retardation). Fisiopatologia dell’asse GH-IGF-I e tentativi terapeutici.     

Prospettive in Pediatria 108, 299-306, 1997.

 

44.       Cianfarani S, Tedeschi B, Germani D, Prete SP, Rossi P, Vernole P, Caporossi D, Boscherini B. 

“In vitro” effects of growth hormone (GH) and insulin-like growth        factor-I and -II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes. 

            European Journal of Clinical Investigation 28, 41-47, 1998. 

 

45.       Cianfarani S, Germani D, Rossi L, Argirò G, Boemi S, Lemon M, Holly JMP,         

            Branca F. 

            IGF-I and IGF-binding protein-1 are related to cortisol in human cord blood. 

            European Journal of Endocrinology 138, 524-529, 1998. 

 

46.       Balducci R, Toscano V, Tedeschi B, Mangiantini A, Toscano R, Galasso C, Cianfarani S, Boscherini B. 

            A new case of Ambras syndrome associated with a paracentric inversion (8)     (q12:q22). 

            Clinical Genetics 53, 466-468, 1998. 

 

47.       Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JMP, Branca F. 

Intrauterine growth retardation (IUGR): Evidence for the activation of the        IGF-related growth promoting machinery and the presence of a cation-            independent IGFBP-3 proteolytic activity by two months of life. 

            Pediatric Research 44, 374-380, 1998. 

 

48.       Cianfarani S, Germani D, Branca F.

            Low birth weight and adult insulin resistance: the catch-up growth hypothesis.

            Archives of Disease in Childhood, 81, F71-F73, 1999. 

 

49.       Cianfarani S

            Low birth weight and IGF system, Physiology and clinical implications.

Rivista di Clinica Dietologica 27, 89-92, 1999.

 

50.       Puglianiello A, Germani D, Rossi P and Cianfarani S

Insulin-like growth factor-I (IGF-I) stimulates chemotaxis of human neuroblasts. Involvement of type I IGF receptor, insulin-like growth factor binding proteins (IGFBPs), phosphatidylinositol (PI)-3 kinase pathway and plasmin system. 

            Journal of Endocrinology 165, 123-131, 2000. 

 

51.       Rossi L., Branca F. and Cianfarani S.

Collagen cross-links and early postnatal growth in newborns with intrauterine growth retardation.

Metabolism 49, 1467-1472, 2000. 

 

52.       Elias LLK, Huebner A, Metherell LA, Canas A, Warne GL, Manca Bitti ML, Cianfarani S, Clayton PE, Savage MO, Clark AJL.

            Tall stature in familial glucocorticoid deficiency.

            Clinical Endocrinology 53, 423-430, 2000. 

 

53.       Cianfarani S, Bonfanti R, Manca Bitti ML, Germani D, Boemi S, Chiumello G, Boscherini B.  

Growth and Insulin-like Growth Factors (IGFs) in Children with Insulin- Dependent Diabetes Mellitus (IDDM) at Onset of Disease. Evidence for Normal Growth, Age Dependency of  the IGF System Alterations and Presence of a Small (18 kDa) IGFBP-3 Fragment in Serum.

            Journal of Clinical Endocrinology and Metabolism 85, 4162-4167, 2000. 

 

54.       Cianfarani S, Geremia C, Germani D, Scirè G, Maiorana A, Boemi S. 

Insulin resistance and insulin-like growth factors (IGFs) in children with intrauterine growth retardation (IUGR). Is catch-up growth a risk factor?

Hormone Research 55 (Suppl.1) 7-10, 2001. 

 

55.           Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F. 

Reduced growth and skeletal changes in zinc deficient growing rats are the consequences of impaired growth plate activity and of zinc depletion-induced inanition. 

Journal of Nutrition 131, 1142-1146, 2001.

 

56                        Tadin M, Braverman E, Cianfarani S, Sobrino AJ,m Levy B, Christiano AM, Warburton D.

Complex cytogenetic rearrrangement of chromosome 8q in a case of Ambras syndrome. 

American Journal of Medical Genetics 102, 100-104, 2001. 

 

57.       Branca F, Spagnoli A, Cianfarani S, Spadoni GL, Golden MHN, Boscherini B, Valtuena S,  Robins SP.

Urinary excretion of pyridinium cross-links in short children treated with growth hormone.

Journal of Pediatric Endocrinology and Metabolism 15, 27-34, 2002. 

 

58             Cianfarani S, Geremia C, Scott CD, Germani D.

Growth, Insulin-like growth factor (IGF) system and cortisol in children with intrauterine growth retardation (IUGR). Is catch-up growth affected by reprogramming of the hypothalamic-pituitary-adrenal axis (HPAA)?

Pediatric Research 51, 94-99, 2002. 

 

59        Cianfarani S, Tondinelli T, Spadoni GL, Scirè G, Boemi S, Boscherini B.

Height Velocity and IGF-I Assessment in the Diagnosis of Childhood Onset GH Insufficiency. Do we still need a Second GH Stimulation Test?

Clinical Endocrinology 57, 161-167, 2002. 

 

60        Cianfarani S.

Foetal origin of adult diseases: just a matter of stem cell number?

Medical Hypotheses 61:401-404, 2003. 

 

61        Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood    Glucose            Concentrations are Reduced in Children Born Small for Gestational            Age (SGA) and TSH        Levels are Increased in SGA with Blunted Postnatal      Catch-  up Growth. 

Journal of Clinical Endocrinology and Metabolism 88, 2699-2705, 2003. 

 

62        Cianfarani S., Martinez C, Maiorana A, Scirè G, Spadoni G.L., Boemi S. Adiponectin Levels Are Reduced in Children Born Small for Gestational Age (SGA) and are Inversely Related to Postnatal Catch-up Growth. 

Journal of Clinical Endocrinology and Metabolism 89: 1346-1351, 2004. 

 

63        Scommegna S., Galeazzi D., Picone S., Farinelli E., Agostino R., Bozzao A.,          Boscherini B,    Cianfarani S. Neonatal Identification of Pituitary Aplasia:a Life-        Saving Diagnosis. Review of Five           Cases.

Hormone Research 62, 10-16, 2004. 

 

64        Geremia C, Cianfarani S.

            Insulin sensitivity in children born small for gestational age (SGA)

            Review of Diabetic Sciences 1, 58-65, 2004. 

 

65       Cianfarani S.

La pubertà precoce.

Medico e Bambino 23, 485-491, 2004.

 

66         Torre P, Bertoli M, Di Giovanni S, Scommegna S., Conte C, Novelli G, Cianfarani S. Endocrine and Neuropsychological Assessment in a Child with a Novel Mutation of Thyroid Hormone Receptor. Response to 12-months Triiodothyroacetic Acid (TRIAC) Therapy.

Journal of Endocrinological Investigation 28, 657-662, 2005. 

67        Cianfarani S, Liguori A, Germani D.       

IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency.

Endocrine Development 9, 66-75, 2005 

 

68       Cianfarani S. 

Il ruolo dei fattori di crescita GH-dipendenti nella diagnosi del deficit di GH.

Area Pediatrica 4, 44-48, 2005.

 

69        Cianfarani S., Puglianiello A, Germani D.

            Central reprogramming in intrauterine growth retardation.

            Minerva Pediatrica 57(Suppl.1 N3):71-73, 2005.

 

70        Cianfarani S., Liguori A., Boemi S., Maghnie M, Iughetti L.,

Wasniewska M., Street M.E., Zucchini S., Aimaretti G., 

Grmani D.

Inaccuracy of IGFBP-3 Assessment in the Diagnosis of Growth Hormone

Deficiency (GHD) from Childhood to Young Adulthood: Association to

Low GH-Dependency of IGF-II and Presence of Circulating IGFBP-3 18 kD Fragment.

Journal of Clinical Endocrinological and Metabolism, 90, 6028-6034, 2005.

 

71        Cianfarani S, Ladaki C, Geremia C.

Hormonal regulation of post-natal growth in SGA children

Hormone  Research 65 (Suppl. 3): 70-74, 2006. 

 

72        Cianfarani S, Liguori A.

      Sensibility and Specificity of Growth Factors in GH Deficiency.

      Journal of Endocrinological Investigation, 29 (Suppl.), 71-75, 2006. 

 

73.       Geremia C, Cianfarani S.

Laboratory Tests and Measurements in Children

Born  Small for Gestational Age (SGA)

Clinica Chimica Acta 364, 113-123, 2006.

74        Puglianiello A and Cianfarani S

            Central control of glucose metabolism

            The Review of Diabetic Studies 3, 54-60, 2006. 

 

75        Kelberman D, Rizzoti K, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK,   Kirk JMW,         Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson          ICAF,    Dattani MT

                  Mutations within Sox2/SOX2 are Associated with Hypopituitarism in Mouse and          Humans. 

            Journal of Clinical Investigation 116, 2442-2455, 2006. 

 

76        Scirè G, D’Anella G, Cristofori L, Mazzuca V, and Cianfarani S

             Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with            steroid therapy for congenital adrenal hyperplasia.

            Journal of Cardiovascular Medicine 8(6):465-7, 2007

 

77.       Federico G., Street M.E., Maghnie M., Caruso-Nicoletti M., Loche S., Bertelloni S., and Cianfarani S.

            Assessment of circulating levels of insulin-like growth factors in the diagnosis   diagnosis of      isolated childhood-onset isolated growth hormone deficiency. A    proposal of the Italian Society for Pediatric Endocrinology and Diabetes.

            Journal of Endocrinological Investigation 29:732-737, 2006. 

 

78.       Ghirri P, Ladaki C, Bartoli A, Scirè G, Vuerich M, Spadoni GL, Maiorana M,         Geremia C,                   Boldrini A , and Cianfarani S.

            Low Birth Weight for Gestational Age Associates with Reduced Glucose           Concentrations at Birth,           Infancy and Childhood.

            Hormone Research 67:123–131, 2007.  

 

79.       Clayton PE,  Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A

            Management of the Child Born Small for Gestational Age Child (SGA) through to           Adulthood: A    Consensus Statement of the International Societies of Paediatric Endocrinology and the Growth Hormone Research Society.

            Journal of Clinical Endocrinology and Metabolism 92, 804-810, 2007. 

 

80.       Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia         

            Tomba and Stefano Cianfarani. Changes in the Expression of Hypothalamic      Lipid Sensing    Genes in Rat Model of Intrauterine Growth Retardation (IUGR). 

            Pediatric Research 61:433-437, 2007. 

 

81.       Zucchini S, Wasniewska M,  Cisternino M, Salerno M,  Iughetti L, Maghnie M,   Street   ME,      Caruso-Nicoletti M, Cianfarani S.

            Adult height in children with short stature and idiopathic delayed puberty after           different          management.

            European Journal  of Pediatrics 167, 677-681, 2008 

 

82.       Cianfarani S.

            Endocrine-metabolic follow-up of the small for gestational age (SGA) infant.

            Minerva Pediatr 59, 545-546, 2007

 

83.       Cianfarani S, Geremia C, Puglianiello A, Mairana A, Germani D.

            Late Effects of Disturbed IGF Signaling in Congenital Diseases.

            Endocrine Development 11, 16-27, 2007. 

 

84.       Maiorana A, Del Bianco C, and Cianfarani S.

            Adipose Tissue: a Metabolic Regulator. Potential Implications for the Metabolic           Outcome of      Subjects Born Small for Gestational Age (SGA).

            The Review of Diabetic Studies, 4, 131-143, 2007. 

 

85.       Scirè G, Del Bianco C, Spadoni GL, and Cianfarani S

            Growth hormone (GH) therapy does not alter the IGF-I/IGFBP-3 molar ratio in GH        deficient children. 

            Journal of Endocrinological Investigation 31(2):153-8, 2008.

 

86.       Torre P, Ladaki C, Scirè G, Spadoni GL, and Cianfarani S. 

            Catch-up growth in body mass index (BMI) is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for       gestational age (SGA). 

            Journal of Endocrinological Investigation 31(9):760-4, 2008. 

 

87.       Germani D, Puglianiello A and Cianfarani S.

            Uteroplacental Insufficiency Down Regulates Insulin Receptor and Affects        Expression of    Key Enzymes of Long-chain Fatty Acid (LCFA) Metabolism in Skeletal Muscle at Birth.

            Cardiovascular Diabetology, 7:14, 2008. 

 

88.       Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin        Cassidy, and     Francesco Branca on behalf of the PHYTOS Investigators

            Long-term consumption of isoflavone-enriched foods does not

            affect bone mineral density, bone metabolism, or hormonal status in

            early postmenopausal women: a randomized, double-blind, placebo

            controlled study1.

            Americal Journal of Clinical Nutrition 87:761–70, 2008. 

 

89.       Katherine A. Fantauzzo, Marija Tadin-Strapps, Yun You, Sarah E. Mentzer, Friedrich A.M. Baumeister, Stefano Cianfarani, Lionel Van Maldergem, Dorothy Warburton, John P. Sundberg and Angela M. Christiano. 

A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. 

Human Molecular Genetics 17(22):3539-51, 2008  

 

90.       P Cohen, AD Rogol, CL Deal, P Saenger, EO Reiter, JL Ross, SD Chernausek, MO Savage, JM Wit on behalf of the 2007 ISS Consensus Workshop participants*Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop.

Journal of Clinical Endocrinology and Metabolism  93(11):4210-4217. 2008. 

 

91.       Liguori A, Cianfarani S

            Postnatal onset of severe growth retardation after in utero exposure to           carbamazepine and      phenobarbital: a case report

            Journal of Medical Case Reports 2009; 3:7300 doi: 10.1186/1752-1947-3-7300

 

92        Pedicelli S, Peschiaroli E, Violi E, and Cianfarani S.

            Controversies in the definition and treatment of idiopathic short stature (ISS).

            Journal of Clinical Research in Pediatric Endocrinology. 2009; 1(3):105-115

 

93.       Puglianiello A, Germani D, and Cianfarani S.

            Exposure to uteroplacental insufficiency reduces the expression of signal         transducer and activator of transcription 3 (STAT3) and proopiomelanocortin   (POMC) in the hypothalamus of            newborn rats.

            Pediatric Research 66:208-211, 2009

 

94.       Maiorana A, Fierabracci A and Cianfarani S

            Isolation and characterization of omental adipose progenitor              cells in children: a potential tool to unravel the pathogenesis of              metabolic syndrome.

            Hormone Research 2009;72:348–358 

 

95.       Maiorana A, Cianfarani S

            Impact of Growth Hormone Therapy on Adult Height of Children Born Small     for Gestational Age: A Systematic Review of Randomized Controlled Trials.

            Pediatrics, 124, E519-E531, 2009.  

 

96.       Giacomozzi C, Savage MO and Cianfarani S

Deficit primario di IGF-I. Implicazioni diagnostico-terapeutiche.

Il Pediatra,  giugno, 26-39. 2010

 

97.       Bertelloni S, Garofalo P, and Cianfarani S.

            Il ritardo dello sviluppo puberale maschile: trattamento con androgeni.

            Rivista Italiana di Medicina dell’Adolescenza  8, 5-10,2010

 

98.       Spadoni and Cianfarani S

            Bone age assessment in the work up of children with endocrine disorders

            Hormone Research in Paediatrics Vol. 73, No. 1,  pp 2 - 5 , 2010  

 

99.       Giacomozzi C, Gullotta F, Federico G, Colapietro I, Nardone, AM,  and Cianfarani          S, Premature    Ovarian Failure associated to the Absence of Pubic and Axillary         Hair in a de       novo    Translocation X;15 (q24;q26.3).

            American Journal of Medical Genetics 2010 May;152A(5):1305-9. 

 

100.     Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L, Germani D, Boldrini A, and Cianfarani S.

            Retinol-binding protein 4 in neonates born small for gestational age.

            Journal of Endocrinological Investigation 2010 Apr;33(4):218-21. 

 

101.     Nobili V, Cianfarani S, Agostoni C.

Programming, metabolic syndrome, and NAFLD: the challenge of transforming a vicious into a virtuous cycle.

            Journal of Hepatology 2010 Jun;52(6):788-90. 

 

102.     Federico G, Cianfarani S           

Usefulness of serum insulin-like growth factor-I (IGF-I) assessment in the diagnosis of childhood-onset GH deficiency.

Hormone Research in Paediatrics 74, 145-148, 2010 

 

103.     Bertelloni S, Garofalo P, and Cianfarani S.

            The role of androgen therapy in hypogonadal adolescent males

            Homone Research in Paediatrics 74, 292-296, 2010 

 

104.     Cianfarani S

            Grand Challenges in Pediatric Endocrinology

            Frontiers in Pediatric Endocrinology doi:10.3389/fendo.2010.00001

 

105.     Deodati A, Peschiaroli E, Cianfarani S.

            Conseguenze endocrine e metaboliche del bambino nato SGA.

            Rivista Italiana di Medicina dell’Adolescenza  3, Suppl. 8  1-6, ,2010

 

106.     Liguori A, Puglianiello A, Germani D, Deodati A, Peschiaroli E and Cianfarani S,

Epigenetic changes predisposing to type 2 diabetes in intrauterine growth        retardation.

            Frontiers in Pediatric Endocrinology doi: 10.3389/fendo.2010.00005

 

107.     Deodati A and Cianfarani S.

Impact of Growth Hormone Therapy on Adult Height of Children with Idiopathic Short Stature: A Systematic Review of Randomized and non-Randomized Controlled Trials.

British Medical Journal, 2011;342:c7157

 

108.     Zanni G, Barresi S,  Travaglini L,  Bernardini L, Digilio MC, Mercuri E,  Cianfarani            S, Ferraris A,     Masotti A, Novelli A, Valente EM, Dallapiccola B, Bertini ES

FGF17, a gene involved in cerebellar development is downregulated in a patient with Dandy-Walker Malformation carrying a de novo 8p deletion.

            Neurogenetics 2011;12(3):241-5

 

 

109.     Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P, Cianfarani S. 

Il deficit di GH nel periodo di transizione (GH deficiency in the transition phase).

Il Pediatra 2011, giugno, 48-54

 

110.     Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger.

Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice

Pediatric Endocrinology Reviews, 2011 Dec;9(2):554-65.

 

111.     Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger.

                        Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice

            Pediatric Endocrinology Reviews, Dec;9(2):554-65, 2011

 

112.     Deodati A, Peschiaroli E, and Cianfarani S.

            Review of Growth Hormone Randomized Controlled Trials in Children with Idiopathic Short Stature.

            Hormone Research in Paediatrics 76 (Suppl. 3):40B-42 (DOI: 10.1159/000330157), 2011

113.     Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S,

            Nobili V, Pietrobelli A, Agostoni C. Epigenetic mechanisms elicited by nutrition  in early life. 

            Nutr Res Rev. Dec;24(2):198-205, 2011

 

114.     Cianfarani S.

            Chairman's summary: Diagnostic techniques for identifying children with idiopathic short stature. 

            Horm Res Paediatr. 76 Suppl 3:16.Epub 2011 Sep 7, 2011. 

 

115.     Cohen A, Lala R, Ravaglia A, Bernasconi S, Boscherini B, Cianfarani S, Pocecco M, Maghnie M,   Panei P 

                        Modifiche della prescrizione dell’ormone della crescita. Una proposta dell’ACP. QUADERNI ACP,           vol. 18, p. 42-44, 2011

 

116.     Alisi A, Cianfarani S, Manco M, Agostoni C, Nobili V.

            Nonalcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment.

                        Annals of Medicine, Feb;44(1):29-40 2012

 

117.     S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli

            Effect of Intrauterine Growth Retardation on Liver and Long-Term Metabolic Risk.

                        International Journal of Obesity. Oct;36(10):1270-7, 2012.

 

118.     G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, and S. Cianfarani.

                        Serum insulin-like growth factor-I (igf-I) reference ranges for chemiluminescence assay in         childhood and adolescence. Data from a population of in- and out-patients. 

                        Growth Hormone and IGF Research, 22:134-138, 2012. 

 

119.     Nobili V, Bedogni G, Berni Canani R, Brambilla P, Cianfarani S, Pietrobelli A, Agostoni C

                  The Hepato-Metabolic Syndrome In Children: A Distinct Phenotype With High Metabolic Risk?

            Pediatric Obesity Dec;7(6):e75-80, 2012.                      

 

120.     Cianfarani S

                        Long-term safety of growth hormone therapy: still a controversial issue. 

                        Frontiers in endocrinology, vol. 3, p. 1-2, 2012. doi: 10.3389/fendo.2012.00115

 

121.     Cianfarani S  

                        Insulin-like growth factor-II (IGF-II): new roles for an old actor. 

                        Frontiers in endocrinology, vol.3, 1-4, 2012, doi: 10.3389/fendo. 2012.00118

 

122.     Benevento D, Bizzarri C, Patera IP, Ravà L, Schiaffini R, Ciampalini P, Cianfarani S, Cappa M. 

                        Birth weight influences the clinical phenotype and the metabolic control of patients with type 1           diabetes (T1D) . 

                        Diabetes/metabolism research and reviews Jan;29(1):60-5, 2013

 

123.     Inzaghi E and Cianfarani S

            The challenge of growth hormone deficiency (GHD) diagnosis and treatment during the           transition from puberty into adulthood.

            Frontiers in Endocrinology 4:34. doi: 10.3389/fendo.2013.00034, 2013

 

124.     Wit. JM. Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristom B,          Schoenau E, Audi L, Hokken.Koelega A, Bamg P, Junh H, Blum WF, Silverman LA, COhen P,        Cianfarani S, Deal C, Clayton PE, de Graaf L, Dahlgren J, Kleintjens J, Roelants M. 

            Personalized approach to growth hormone treatment: clinical use of growth prediction models.

            Horm Res Paediatr. 79(5):257-70, 2013

 

125.     Deodati A, Inzaghi E, Liguori A, Puglianiello A, germani D, Brufani C, Fintini D, Cappa M, Barbetti           F, Cianfarani S.

            IGF2 Methylation Is Associated with Lipid Profile in Obese Children.

            Horm Res Paediatr, Jun 14:361-367, 2013

 

126.     Bizzarri C, Benevento D, Patera IP, Bongiovanni M, Boiani A, Cianfarani S, Cappa M

                  Residual beta-cell mass influences growth of pre-pubertal children with type 1 diabetes.

            Horm Res Paediatr 80(4):287-92, 2013 

 

127.     Bizzarri C, Spadoni GL, Bottaro G, Monatanari G, Giannone G, Cappa M, Cianfarani S. 

            The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the            progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life.

            Journal of Clinical Endocrinology and Metabolism, 99(2):433-9, 2014.

 

128.     Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi,         and Stefano Cianfarani.

            Vitamin D levels and liver histological alterations in children with non-alcoholic fatty liver disease         (NAFLD).

            European Journal of Endocrinology 170(4):547-53, 2014.

 

129.     Boscherini B and Cianfarani S.

            Considerazioni sulla diagnosi di deficienza idiopatica isolata di ormone della crescita

            Quaderni ACP 21(1): 31-32, 2014.        

 

130.     Cafiero G, Fintini D, Brufani C, Fiori R, Giordano U, Turchetta A, Deodati A, Cappa M and           

            Cianfarani S

                  Cardiovascular fitness is impaired in children that are born small for their gestational age.

            Acta Paediatrica 103(5):e219-21, 2014

 

131.     Stefano Cianfarani, Elena Inzaghi, Anna Alisi, Daniela Germani, Antonella Puglianiello, V          alerio Nobili.

            Insulin-like Growth Factor–I and –II Levels are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children.

            Journal of Pediatrics 165(1):92-8, 2014.

 

132.     Annalisa Deodati, Barbara Baldini Ferroli and Stefano Cianfarani.

                  Association between Growth Hormone Therapy and Mortality, Cancer and Cardiovascular Risk: Systematic Review and Meta-Analysis.

            Growth Hormone and IGF Research 24:105-111, 2014. 

 

133.     Elena Inzaghi, Stefano Cianfarani, Valerio Nobili.

                        Insulin-Like Growth Factors (IGF-I And –II): New Actors in the Development of Non-Alcoholic    Fatty Liver Disease.

            Expert Reviews of Endocrinology and Metabolism 9:193-195, 2014. 

 

134.     S. Cianfarani

            Is High Dose Growth Hormone Treatment During Puberty Worthwhile?

            Hormone Research in Paediatrics, 82(3):143-4, 2014

 

135.     Cianfarani S

            Editorial

            Hormone Research in Paediatrics 81:1, 2014

 

136      Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M and Cianfarani S. Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus. 

Growth Hormone and IGF Research, 24(6):256-9, 2014.

 

137      Carla Bizzarri, Stefania Pedicelli, Brunetto Boscherini, Giorgio Bedogni, Marco Cappa and Stefano Cianfarani

            Early retesting by GHRH + arginine test shows normal GH response in most children with idiopathic GH deficiency.

            Journal of Endocrinological Investigation, Apr;38(4):429-36, 2015

 

138.     Stefania Pedicelli, Paola Alessio, Giuseppe Scirè, Marco Cappa, and Stefano Cianfarani.

            Routine Screening by Brain Magnetic Resonance Imaging Is not Indicated in Every Girl with Onset of Puberty Between the Ages of Six and Eight Years.

                        Journal of Clinical Endocrinology and Metabolism, 99(12):4455-61, 2014.

 

139.     V. Pampanini,  A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F.            Dini, P.Ghirri, and S. Cianfarani

            Preterm Infants with Severe Extrauterine Growth Retardation (EUGR) Are at    High Risk of Growth Impairment during Childhood.

            European Journal of Pediatrics, 174(1):33-41, 2015.

 

140.     C. Giacomozzi,  A. Deodati, M.G. Shaikh, S.F. Ahmed, and S. Cianfarani.

                        The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: a systematic   review.

                        Hormone Research in Paediatrics, 83(3):167-76, 2015.

 

141.     D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S.   Cianfarani, A. Crinò

            Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader–Willi          Syndrome (PWS).

            Pediatric Obesity 11(3):235-8, 2016

            

142      Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani           S, Clayton P, Coste        J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC.

            Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone.

                        Hormone Research in Paediatrics, 84, 172-183, 2015.

 

143.     Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, and Cianfarani S.

            Brain Magnetic Resonance Imaging as First-Line Investigation for Growth Hormone Deficiency Diagnosis in Early Childhood.

            Hormone Research in Paediatrics, 84(5):323-30, 2015.

 

144.     D B Allen, P Backeljauw, M Bidlingmaier, BMK Biller, M Boguszewski , P Burman, G Butler, K     Chihara, J Christiansen, S Cianfarani, P Clayton, D Clemmons, P Cohen, F Darendeliler, C Deal, D Dunger, E M Erfurth, J S Fuqua, A Grimberg, M Haymond, C Higham, K Ho, A R Hoffman, A        Hokken-Koelega, G Johannsson, A Juul, J Kopchick, P Lee, M Pollak, S Radovick, L Robison, R      Rosenfeld, R J Ross, L Savendahl, P Saenger, H Toft Sorensen, K Stochholm, C Strasburger, A     Swerdlow, M Thorner.

            Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults.

            Eur J Endocrinol. 174(2):P1-9, 2016. 

 

145.     Schiaffini R, Liccardo D, Alisi A, Benevento D, Cappa M, Cianfarani S, Nobili V

            Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of    Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor?

            Hormone Research in Paediatrics 85(1):29-34, 2016.

 

146.     Brambilla P, Bedogni G, Pietrobelli A, Cianfarani S , Agostoni C. 

            Predictors of blood pressure at 7-13 years: The “new Millennium Baby” study. 

            Nutrition, Metabolism and Cardiovascular Diseases. 26(8):706-12, 2016

 

147.     Deodati A, Sallemi A, Maranghi , Germani D, Puglianiello A, Baldari F, Busani L, Mancini FR,      Tassinari R, Mantovani A, Cianfarani S

            Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche.

            Hormone research in Paediatrics 86(4):233-239, 2016. 

 

148.     Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW.

            Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders.

            Hormone Research in Paediatrics 85(5):325-32, 2016

 

149.     Fischer-Posovszky P, Roos J, Kotnik P, Battelino T, Inzaghi E, Nobili V, Cianfarani S, Wabitsch M.

            Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules            with Huge Impact.

            Hormone research in Paediatrics 86(1):3-10, 2016.

 

150.     M. Cappa, L. Iughetti, S. Loche, M. Maghnie, A. Vottero. GeNeSIS National Board on behalf of the         GeNeSIS Italian Investigators.

            Efficacy and safety of growth hormone treatment in children with short stature: the Italian      cohort of the GeNeSIS clinical study.

            Journal of Endcorinological Investigation 39:667–677, 2016

 

151.     Cambiaso P, Bottaro G, Cianfarani S, Tomà P, de Vito R, Cappa M.

            An Incidental Finding of Bilateral Adrenal Lymphoma

            The American Journal of Medical Sciences 52(1):80. doi: 10.1016/j.amjms.2016.02.018., 2016.

 

152.     Bizzari C, Pedicelli S, Cappa M, Cianfarani S.

            Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling     Defects.

            Hormone Research in Paediatrics 86(3):143-153., 2016.

 

153.     Deodati A, Cianfarani S.

            Trattamento con ormone della crescita in bambini nati piccoli per l’età gestazionale

            L’Endocrinologo 17(4):183-187, 2016

 

154.     Cianfarani S, Soder O.

            Endocrine disruptors and child health. New insights.

            Hormone Research in Paediatrics Sep 16;86(4), 2016

 

155.     Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, Overi D, Mosca A, Stronati         L, Cucchiara S, Raponi M, Gaudio E, Byrne CD, Nobili V.

            Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with   Serum Vitamin D Deficiency: Results from a Single Centre Trial.

            PLoS One. 2016 Dec 15;11(12):e0168216. doi: 10.1371/journal.pone.0168216.

 

156.     Pampanini V, Germani D, Puglianiello A, Stukenborg JB, Reda A, Savchuk I, Kjartansdóttir KR,    Cianfarani S, Soder O.

            Impact of uteroplacental insufficiency on postnatal rat male gonad.

            Journal of Endocrinology Feb;232(2):247-257, 2017.

 

157.     Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste          J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega AC, Khan AJ, Kiess W, Kuehni          CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L,             Zandwijken GR.

                        Cancer risks in patients treated with growth hormone in childhood: the SAGHE European cohort          study. 

                        Journal of Clinical Endocrinology and Metabolism 102:1661–1672, 2017.

 

158.     Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano    Cianfarani

                        Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children.

                        Hormone research in Paediatrics 87:400–404, 2017.

 

159.     Francesca Santilli, Paola G. Simeone, Maria T. Guagnano, Marika Leo, Marica T. Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C. Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro and Agostino Consoli.

Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects with Prediabetes or Early Type 2 Diabetes.

Diabetes Care 2017 Nov;40(11):1556-1564

 

160      Deodati A, Cianfarani S.

            The rationale for growth hormone therapy in children with short stature.

            Journal of Clinical Research in Pediatric Endocrinology Dec 30;9(Suppl 2):23-32,            2017.

 

161      S. Brandt, J. Roos, E. Inzaghi, P. Kotnik, J. Kovac, T. Battelino, S. Cianfarani, 

            V. Nobili, M. Colajacomo, W. Kratzer, C. Denzer, P. Fischer-Posovszky and M. Wabitsch

            Circulating levels of miR-122 and nonalcoholic fatty liver disease in pre-pubertal          obese children.

            Pediatric Obesity 13(3):175-182, 2018.

 

162      Pampanini V, Inzaghi E, Germani D, Alterio A, Puglianiello A, Alisi A, Nobili V and Cianfarani S

                  Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic

            Fatty     Liver Disease.

            Nutrition, Metabolism & Cardiovascular Diseases  Jan;28(1):71-76, 2018.

 

163      Bizzarri C, Timpanaro TA, Matteoli MC, Patera IP, Cappa M, Cianfarani S.

            Growth trajectory in children with type 1 diabetes mellitus: the impact of insulin treatment and           metabolic control.

            Hormone Research in Paediatrics. 89(3):172-177, 2018

 

164      Cinzia La Rocca, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Francesca Baldi,   Giorgia Bottaro, Emma Buzzigoli, Fabrizia Carli, Stefano Cianfarani, Raffaele Conte,      Annalisa Deodati, Amalia Gastaldelli, Anna Paola Pala, Andrea Raffaelli, Chiara Saponaro,         Giuseppe Scirè, Gian Luigi Spadon, Luca Busani, the LIFE PERSUADED Project Group.

            The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases.

            Environmental Science and Pollution Research, Jul 4. doi: 10.1007/s11356-018-2660-4, 2018.

 

165      Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi,       Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón,

                        Stefano Cianfarani  

            The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.

            PLOS ONE Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490., 2018

 

166      Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati,

            Valerio Nobili, Stefano Cianfarani

            Expression of insulin-like growth factor I and its receptor in the liver of children           with     biopsy-proven NAFLD.

                        PLOS ONE Jul 31;13(7):e0201566. 2018

 

167      Marzano F, Faienza MF, Caratozzolo MF, Brunetti G, Chiara M, Horner DS, Annese A, D’erchia AM, Consiglio A Pesole G, Sbisà E, Inzaghi E, Cianfarani S, Tullo A.         

            Pilot study on circulating miRNA signature in children with obesity born small for gestational age         and appropriate for gestational age.

            Pediatric Obesity Dec;13(12):803-811. 2018

 

168      Inzaghi E, Reiter E, Cianfarani S. 

            The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy. 

            Hormone Research in Paediatrics, 92(2):71-83, 2019

 

169      Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S.

            GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice.

            Hormone Research in Paediatrics, 92(2):71-83, 2019

 

170      Cianfarani S

            Pediatric endocrinology in the time of COVID-19 pandemic

            Hormone Research in Paediatrics 92(6):345-346, 2019

 

171      Pampanini V, Jahnukainen K, Sahlin L, Germani D, Puglianiello A, Cianfarani S, Söder O

            Impact of uteroplacental insufficiency on ovarian follicular pool in the rat.

            Reproductive Biology and Endocrinology, Jan 10;17(1):10, 2019

 

172      Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ.

            Risk of Meningioma in European Patients Treated with Growth Hormone in Childhood: Results from the SAGhE Cohort.

            Journal of Clinical Endocrinology and Metabolism, Mar 1;104(3):658-664, 2019.

 

173      Spreghini N, Cianfarani S, Spreghini MR, Brufani C, Morino GS, Inzaghi E, Convertino A, Fintini D, Manco M.

            Oral glucose effectiveness and metabolic risk in obese children and adolescents

            Acta Diabetologica, Aug;56(8):955-962, 2019

 

174      Centonze C, Guzzetti C, Orlando G, Loche S; Italian ECOS Investigators.

            Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)

            Journal of Endocrinological Investigation, Oct;42(10):1241-1244, 2019.

            

175      Bizzarri C, Pedicelli S, Romanzo A, Bocchini S, Bottaro G, Cianfarani S, Cappa M.

            The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study.

            Italian Journal of Pediatrics Apr 27;45(1):52, 2019.

 

176      Cianfarani S

            Risk of cancer in patients treated with recombinant human growth hormone in childhood.

            Annals of Pediatric Endocrinology and Metabolism, Jun;24(2):92-98, 2019

 

177      Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G.

            Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease.

            Journal of Hepatology, Oct;71(4):802-810, 2019.

 

178      Inzaghi E, Kistner A, Germani D, Deodati A, Vanpee M, Legnevall L, Berinder K, Cianfarani S.

            A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood.

            PloS One, Jan 24;15(1):e0228075, 2020

 

179      Deodati A, Inzaghi E, Cianfarani S.

            Epigenetics and In Utero Acquired Predisposition to Metabolic Disease.

            Frontiers in Genetics, Jan 29;10:127, 2020.

 

180      Tassinari R, Narciso L, Tait S, Busani L, Martinelli A, Di Virgilio A, Carli F, Deodati A, La Rocca C, Maranghi F; LIFE PERSUADED Project Group.

            Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived from Italian Children Biomonitoring Study.

            Toxicological Sciences, Feb 1;173(2):387-401, 2020

 

181      Tait S, Carli F, Busani L, Buzzigoli E, Della Latta V, Deodati A, Fabbrizi E, Gaggini M, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C; LIFE PERSUADED Project Group.

            Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project.

            Environmental Research, Jun;185:109428, 2020

 

182      Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, Manco M.

            The bones of children with obesity.

            Frontiers in Endocrinology, Apr 24;11:200, 2020.

 

183      Schiaffini R, Barbetti F, Rapini N, Inzaghi E, Deodati A, Patera IP, Matteoli MC, Ciampalini P, Carducci C, Lorubbio A, Schiaffini G, Cianfarani S.

            School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology.

            Diabetes Research in Clinical Practice, Aug;166:108302, 2020.

 

184      Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken-Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ.

            Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study.

            Lancet diabetes and Endocrinology, Aug;8(8):683-692, 2020

 

185      Amodeo ME, Inzaghi E, Deodati A, Cianfarani S.

            Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.

            Mol Genet Genomic Med.May 31;e1644.  doi: 10.1002/mgg3.16, 2021.

 

186      Petrelli A, Ravà L, Mascali A, Rapini N, Massoud M, Manca Bitti ML, Cianfarani S, Manco M.

            Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D

            Diabetes Metab Res Rev. Jun 2:e3479, 2021.

 

187      Inzaghi E, Deodati A, Loddo S, Mucciolo M, Verdecchia F, Sallicandro E, Catino G, Cappa M, Novelli A,Cianfarani S.

            Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype

            J Endocrinol Invest. Jan;45(1):79-87, 2022

 

188      Cianfarani S, Pampanini V

            The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic

            Horm Res Paediatr. Jul 14:345-349, 2021 

 

189      Giglione E, Lapolla R, Cianfarani S, Faienza MF, Fintini D, Weber G, Delvecchio M, Valerio G.

            Linear growth and puberty in childhood obesity: what is new?

            Minerva Pediatr (Torino). Dec;73(6):563-571, 2021.

 

190      Carducci C, Rapini N, Deodati A, Pampanini V, Cianfarani S, Schiaffini R.

            Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic.

            Ital J Pediatr. Aug 26;47(1):176, 2021.

 

191      Tait S, Carli F, Busani L, Ciociaro D, Della Latta V, Deodati A, Fabbrizi E, Pala AP, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C, Life Persuaded Project Group.

            Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project.

            Int J Environ Res Public Health. Nov 12;18(22):11846, 2021.

 

192      Stefano Cianfarani.

            Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance

            Frontiers in Endocrinology, Dec 24;12:811846, 2021.

 

193      Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D, Matarazzo P, Baronio F, Crocco M, Giudica G, Partenope C, Nardini B, Ubertini G, Menardi R, Guzzetti C, Iughetti L, Aversa T, Di Mase R, Cassio A, Cianfarani S, Maghnie M, Tuli G, Loche S, Bruzzi P, Wasniewska M, Salerno M, Rutigliano I, Iezzi ML, Cherubini V, Grandone A, Faienza M, Tumini S, Baldoli C, Consales A, Genitori L, Marras CE, MIlanaccio C, Mortini P, Vindigni M, Zenga F, Zucchelli M; Physiopathology of Growth Processes; Puberty Study Group of the Italian Society for Pediatric Endocrinology and Diabetology.

            Management of Childhood-onset Craniopharyngioma in Italy: A           Multicenter, 7-Year Follow-up Study of 145 Patients

            J Clin Endocrinol Metab. Feb 17;107(3):e1020-e1031, 2022.

 

194      Stefania Pedicelli, Danilo Fintini, Lucilla Ravà, Elena Inzaghi, Annalisa Deodati, Maria Rita Spreghini, Carla Bizzarri, Michela Mariani, Stefano Cianfarani, Marco Cappa, Melania Manco,

            Prevalence of prediabetes in children and adolescents by class of obesity.

            Pediatr Obes. Feb 10;e12900, 2022

 

195      Giorgia Sforza, Annalisa Deodati, Romina Moavero, Laura Papetti, Ilaria Frattale,Federico Vigevano, Stefano Cianfarani, Massimiliano Valeriani. 

            Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report.

            Frontiers in Neurology, Jan 10;12:818638, 2022

 

196      Arianna Petrelli, Lucilla Ravà, Alberto Mascali, Novella Rapini, Michela Massoud, Maria Luisa Manca     Bitti, Stefano Cianfarani, Melania Manco. 

            Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D.

            Diabetes Metab Res Rev., Jan;38(1):e3479, 2022

 

197      Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G Nichols, Stefano Cianfarani.

            Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2.

            Horm Res Paediatr. Jan 7. doi: 10.1159/000521858, 2022.

 

198      Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani.

            Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe 

            Postnatal Growth Failure.

            Horm Res Paediatr, Jan 27;1-11. doi: 10.1159/000521629, 2022

 

199      Schiaffini R, Deodati A, Nicoletti MC, Carducci C, Ciampalini P, Lorubbio A, Matteoli MC, Pampanini V, Patera IP, Rapini N, Cianfarani S.

            Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study.

            Acta Diabetologica 59:959-964, 2022

 

200      Inzaghi E, Pampanini V, Deodati A and Cianfarani S

            The effects of nutrition on linear growth

            Nutrients 14(9):1752, 2022

 

201      Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N,    Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL,           Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L            Touraine P, van Santen HM, Johannsson G.

            Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.

            European Journal of Endocrinology, 186(6):P35-P52, 2022

 

202      Pampanini V, Deodati A, Inzaghi E, Cianfarani S.

            Long-acting growth hormone preparations and their use in children with growth hormone deficiency.

            Hormone Research in Paediatrics Feb 25.  doi: 10.1159/000523791, 2022

 

203      Barbetti F, Rapini N, Schiaffini R, Bizzarri C, Cianfarani S.

            The application of precision medicine in monogenic diabetes.

            Expert Rev Endocrinol Metab. Mar;17(2):111-129, 2022

 

204      Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium.

            INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

            Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z.

 

205      Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti.

            Monogenic diabetes clinic (MDC): 3‐year experience

            Acta Diabetologica Sep 30.  doi: 10.1007/s 00592-022-01972-2, 2022 

 

206      Del Chierico F, Conta G, Matteoli MC, Fierabracci A, Reddel S, Macari G, Gardini S, Guarrasi V, Levi Mortera S, Marzano V, Vernocchi P, Sciubba F, Marini F, Deodati A, Rapini N, Cianfarani S, Miccheli A, Putignani L

            Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset.

            Int J Mol Sci. Sep 6;23(18):10256, 2022

 

207      Carli F, Tait S, Busani L, Ciociaro D, Della Latta V, Pala AP, Deodati A, Raffaelli A, Pratesi F,         Conte R, Maranghi F, Tassinari R, Fabbrizi E, Toffol G, Cianfarani S, La Rocca C,       Gastaldelli A,    Life Persuaded Project Group.

            Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and          Bisphenol A      (BPA)) in Women from Different Residing Areas in Italy: Data from         the LIFE PERSUADED     Project.

            Int J Mol Sci. Dec 16;23(24):16012. 2022

 

208      Levi Mortera S, Marzano V, Vernocchi P, Matteoli MC, Guarrasi V, Gardini S, Del Chierico F,      Rapini N, Deodati A, Fierabracci A, Cianfarani S, Putignani L

            Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes       Children at the Onset: A Metaproteomic Study.

            Int J Mol Sci. 2022 Dec 15;23(24):15982. 2022

 

209      Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L.

            Pathophysiology of Type 1 Diabetes and Gut Microbiota Role

            Int J Mol Sci. Nov 24;23(23):14650. 2022

 

210      Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano          Cianfarani,Jovanna Dahlgren, Reiko Horikawa, et al. 

            International Consensus Guideline on Small for Gestational Age: Etiology and Management From         Infancy to Early Adulthood.

            Endocrine Reviews, 2023, 00, 1–27 https://doi.org/10.1210/endrev/bnad002

 

211      Pezzino G, Ruta R, Rapini N, Chiodo DC, Mucciolo M, Tomaselli L, Cianfarani S, Barbetti F.

            A rare cause of transient neonatal diabetes mellitus: Spontaneous HNF1B splice variant.

            Diabet Med. 2024 Feb;41(2):e15202. doi: 10.1111/dme.15202.

 

212      Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A. 

            Environment,   Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic          Dysfunction (MASLD).

            Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071.

 

213      Ravà L, Fintini D, Mariani M, Deodati A, Inzaghi E, Pedicelli S, Bizzarri C, Cappa M, Cianfarani S, Manco M.

            High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk.

            J Endocrinol Invest. 2023 Dec;46(12):2555-2562. doi: 10.1007/s40618-023-02111-6.

 

214      Aureli A, Recupero R, Mariani M, Manco M, Carlomagno F, Bocchini S, Nicodemo M, Marchili   MR, Cianfarani S, Cappa M, Fintini D.

            Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a   Large Population of Children, Adolescents and Young Adults, from Underweight to Severe    Obesity.

            Int J Mol Sci. 2023 Nov 22;24(23):16588. doi: 10.3390/ijms242316588

 

215      Deodati A, Bottaro G, Germani D, Carli F, Tait S, Busani L, Della Latta V, Pala AP, Maranghi F,     Tassinari R, Gastaldelli A, La Rocca C, Cianfarani S.

            Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in            children with obesity: A case-control study. LIFE PERSUADED Project Group.

            Horm Res Paediatr. 2023 Nov 16. doi: 10.1159/000535305.

 

216      Franceschi R, Fintini D, Ravà L, Mariani M, Aureli A, Inzaghi E, Pedicelli S, Deodati A, Bizzarri C, Cappa M, Cianfarani S, Manco M.

            Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease.

            Int J Mol Sci. 2023 Oct 6;24(19):14963. doi: 10.3390/ijms241914963.

 

217      Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A,           Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S,     Andreani M, Porzio O, Palma P.

            Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple        inflammatory syndrome with cardiac involvement in children.

            Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751

 

218      Troncone A, Affuso G, Cascella C, Chianese A, Zanfardino A, Iafusco D; Diabetes Study Group of Italian Society of Paediatric Endocrinology and Diabetology.

            Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study.

            J Pediatr Psychol. 2023 Sep 20;48(9):731-739. doi: 10.1093/jpepsy/jsad016

 

219      Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C,     Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium.

            Gene expression signature predicts rate of type 1 diabetes progression.

            EBioMedicine. 2023 Jun;92:104625. doi: 10.1016/j.ebiom.2023.104625

 

220      Cianfarani S, Battelino T.

            A critical review of upcoming new therapeutic options in paediatric endocrinology.

            Horm Res Paediatr. 2023 Apr 24. doi: 10.1159/000530824.

 

221      Rapini N, Delvecchio M, Mucciolo M, Ruta R, Rabbone I, Cherubini V, Zucchini S, Cianfarani S,   Prandi E, Schiaffini R, Bizzarri C, Piccini B, Maltoni G, Predieri B, Minuto N, Di Paola R, Giordano       M, Tinto N, Grasso V, Russo L, Tiberi V, Scaramuzza A, Frontino G, Maggio MC, Musolino G,       Piccinno E, Tinti D, Carrera P, Mozzillo E, Cappa M, Iafusco D, Bonfanti R, Novelli A, Barbetti F;   Diabetes Study Group of Italian Society for Pediatric Endocrinology and Diabetes (ISPED).

            The changing landscape of neonatal diabetes mellitus in Italy between 2003-2022.

            J Clin Endocrinol Metab Feb 26:dgae095. doi: 10.1210/clinem/dgae095, 2024.

 

222      Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G,         Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG,         Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study   Group.

            Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic        type 1 diabetes.

            Diabetes Metab Res Rev. Feb;40(2):e3777. doi: 10.1002/dmrr.3777, 2024.

 

223      Rapini N, Martino M, Arnaldi C, Deodati A, Anagnostopoulou L, Amodeo ME, Ciampalini P,       Pampanini V, Lorubbio A, Tosini D, Cianfarani S, Schiaffini R.

            Efficacy and safety of advanced hybrid closed loop systems in children with type 1       diabetes younger than 6 years.

            Front Endocrinol (Lausanne). May 21:15:1382920, 2024

 

224      Schiaffini R, Lumaca A, Martino M, Rapini N, Deodati A, Amodeo ME, Ciampalini P, Matteoli     MC, Pampanini V, Cianfarani S.

            Time In Tight Range in children and adolescents with type 1 diabetes: A           cross-sectional observational single centre study evaluating efficacy of             new advanced technologies.

            Diabetes Metab Res Rev. Jul;40(5):e3826. 2024.

 

 

 

 

 

 

 

            

 

Letters

 

 

1.         Cianfarani S., Spadoni G.L., Manca Bitti M.L., Boscherini B.

Growth hormone treatment and somatomedin C levels. 

Journal of Pediatrics 105, 853, 1984. 

 

2.         Scirè G., Cianfarani S., Spadoni G.L., Manca Bitti M.L., Fonte M.T., Boscherini B., Pasquino A.M., Bozzao L. 

Primary empty sella and endocrinopathies in childhood: high prevalence among children with precocious puberty. 

European  Journal of Pediatrics 147, 665, 1988. 

 

3.         Spadoni GL, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Boscherini B. How far should indications for growth hormone expand?     

Lancet 335, 1351, 1990. 

 

4.         Scirè G, Magliocca FM, Cianfarani S, Scalamandrè A, Petrozza Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency. 

Journal of Pediatric Gastroenterology and Nutrition 13, 224-227, 1991. 

 

5.         Cianfarani S.

Growth hormone therapy in Noonan syndrome.

Journal of Pediatrics 134, 385-6, 1999. 

 

6.         Cianfarani S.

Ambras syndrome or hypertrichosis universalis, does it really matter?

Clinical Genetics 57, 158, 2000. 

 

7.         Cianfarani S, Bonfanti R, Manca Bitti ML, Chiumello G, Boscherini B.

Growth and autoantibodies to IA-2 in children with type 1 diabetes. 

Lancet 356, 1521, 2000. 

 

8.         Cianfarani S.

Role of Hormones in Puberty

Lancet 358, 1459, 2001.

 

 9.       Schiaffini R, Deodati A, Rapini N, Pampanini V, Cianfarani S.

            Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic.         Figures from an Italian tertiary care center.

            Journal of Diabetes. 2022 Aug;14(8):562-563.

 

 

 

 

 

 

 

 

Testi e Monografie

 

Boscherini B., Cianfarani S., Spadoni G.L., Mancuso G. 

Il bambino con bassa statura. 

Ed: Piccin, Padova, 1990. 

 

Cianfarani S. Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita. Ed: Mediprint, Roma, 2007.

 

 

 

 

Capitoli di testi 

 

 

C1        Boscherini B., Spadoni G.L., Cianfarani S. Le anomalie della crescita: eziologia e classificazione. In: Progressi nella Diagnosi e Terapia dei Disturbi dell'Accrescimento. A cura di E.E. Muller & G. Chiumello. Pythagora Press, Milano, pp. 175-197, 1987.

                        

C2        Cianfarani S, Spadoni GL. La bassa statura (Short                       

            Stature). In: Endocrinologia Pediatrica (Paediatric                     

            Endocrinology).  Boscherini B. & Scalamandre' A. Ed.     

            Nuova Scientifica Italiana, Roma, pp. 13-47, 1991. 

 

C3        Cianfarani S. Gli ormoni: Azione degli ormoni e loro                 

            dosaggio. In: Diagnosi e Terapia in Endocrinologia. 

            GL Spadoni,      AP Taviani, V Toscano. Ed. Grasso, Bologna, 1993, pp.1-15. 

 

C4        Cianfarani S. Disturbi della Crescita (Growth Disorders). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003.

 

C5        Cianfarani S. Tumori Associati ad Endocrinopatie (Tumors associated to Endocrinopaties). 

            In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. 

            Carocci Editore, Roma, 2003.

 

C6        Giacomozzi C and Cianfarani S. Patologie dell’ipofisi anteriore. Deficit di GH. “Hypopituitarism: GH deficiency”. Capitolo 73, pp. 659-669. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.

 

C7        Giacomozzi C and Cianfarani S. Diabete insipido e sindrome da inappropriata secrezione di ormone antidiurerico “Diabetes insipidus and sindrome of inappropriate antidiuretic hormone (SIADH)”. Capitolo 74, pp. 669-679. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.

 

C8        Cianfarani S. Neuroendocrine Complications of Central Nervous System Malformations. Chapter 23. In: Maformations of the Nervous System, Handbook of Clinical neurology, 3rd Edition. Eds: H.B. Sarnat, P. Curatolo. Elsevier Ltd., pp 433- 458, 2008.

 

C9        Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2010, pp 49-64.

 

C10      Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P e Cianfarani S. Il deficit di ormone della crescita nel periodo di transizione.  Adolescentologia Aspetti Medici e Socio-Educativi, cap. 6, pp 57-62, 2010

 

C11      Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2011, pp 47-61.

 

C12      Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2012, p. 45-59.

 

C13      Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2013, P. 45-60.

 

C14      Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2014, P. 45-61.

 

C15      Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG Haymarket, Teddington, UK, 2015, P. 40-59

 

C16      Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2016, P. 49-64.

 

C17      Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2017, P. 50-67.

 

 

 

 

      ATTIVITA' EDITORIALE 

 

Boscherini B., Cianfarani S., Spadoni G.L. Eds. 

Binding proteins for growth hormone and somatomedins. 

Acta Endocrinologica, Vol. 124, Supplement 2, 1991.

 

Cianfarani S, Clemmons DR, Savage MO (eds.). IGF-I and IGF binding proteins. Basic research and clinical 

          CURRICULUM VITAE ET STUDIORUM  E PUBBLICAZIONI       DEL   PROF. STEFANO CIANFARANI                19.6.2024         “… Noi non cerchiamo quello che Iddio poteva fare, ma quello che Egli ha fatto…poi finalmente sollevandoci all’ultimo scopo delle nostre fatiche, cioè all’amore del Divino Artefice, ci conservino la speranza di poter apprendere in Lui, fonte di luce e di verità ogni altro vero.” (Galileo Galilei)         Stefano Cianfarani                    Nome:                     Stefano Cianfarani   Indirizzo Università: Clinica Pediatrica-Dipartimento di Medicina dei Sistemi, Università degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133-Roma                                           Tel:  06-6859 3074 (Osp.) Tel: 06-7259 6178 (Lab.)                         Fax: 06-6859 2508                Indirizzo casa:       Via Città di Castello 35,                            00191 - Roma                           Tel: 06- 33 30 813   E-Mail: stefano.cianfarani@uniroma2.it   Codice Fiscale: CNFSFN57T20H501C   Data di nascita:     20 Dicembre 1957   Luogo di nascita:         Roma   Nazionalità:             Italiana   Stato Civile:       Sposato con Teresa Maria Martino. Padre di Francesco, Eugenia, Agnese, Bernardo, Bartolomeo e Giovanni Maria   Scolarità:                   Diploma di Maturità (60/60) presso il Liceo Classico della Scuola Pontificia Scuola "Pio IX" nel 1976.   Facoltà di Medicina e Chirurgia: Universita' degli Studi di Roma                            "La Sapienza" 1976-1982.  Voto di Laurea 110/110 con Lode Scuola di  Specializzazione:   Pediatria, Universita' degli Studi                            di Roma "La Sapienza" 1982-1986.  Voto diploma di Specializzazione 70/70 con Lode.   Attuale posizione :     Professore Ordinario di Pediatria Generale e Specialistica (MED/38). Dipartimento Medicina dei Sistemi, Facoltà di Medicina e Chirurgia dell’Università di Roma Tor Vergata, Roma.   Responsabile della Unità Operativa Complessa (U.O.C.) di “Endocrinologia e Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.   Dal 1/11/2012 Visiting Professor presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.   Attualmente: Affiliated Researcher presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.   Referente dell’Unità di Ricerca “Fisiopatologia della Crescita”, Ospedale Pediatrico “Bambino Gesù”, Roma.   Chair of Clinical Practice Committee della European Society fo Pediatric Endocrinology (ESPE), 2022-2025.        Posizioni Precedenti: Professore Associato di Pediatria Generale e Specialistica (MED/38), Facoltà di Medicina e Chirurgia, Università degli Studi di Roma Tor Vergata. Dal 1.11.2002 al 27/2/2018    Responsabile della Unità Operativa Complessa (U.O.C.) di “Diabetologia e Patologia dell’Accrescimento”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.   Dal 2017 al 2018 Responsabile della Struttura Semplice Dipartimentale di “Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.   Dal 1/10/2009 al 15/5/2017 Responsabile Struttura Semplice di “Endocrinologia Molecolare” presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.   Dal 1/7/1988, Funzionario Tecnico, Clinica Pediatrica, Dipartimento di Sanità Pubblica e Biologia Cellulare, Università degli Studi di Roma, "Tor Vergata", Roma.    Dal 25/11/1988, Dirigente I livello (Assistente Ospedaliero) presso la Divisione di Pediatria, Ospedale S. Eugenio, Azienda USL RM-C, Roma.   Dal 24/3/2003 Dirigente I Livello (ex Aiuto Ospedaliero) presso la Divisione di Pediatria (U. Org. Patologi Endocrina Pediatrica), Ospedale S. Eugenio, Azienda USL RM-C, Roma.   Dal 1995, Responsabile del Laboratorio di Endocrinologia Pediatrica, Università “Tor Vergata”, Roma   Dal 24/03/2003 al 30/09/2009 Responsabile dell’Unità Organizzativa di Patologia Endocrina Pediatrica, Ospedale S.Eugenio, ASL RM-C, Roma.   Dal 1/1/2009 al 31/8/2009 incaricato dal Rettore dell’Università di Roma “Tor Vergata” come Direttore della Clinica Pediatrica dell’Università di Roma “Tor Vergata” con sede presso l’Ospedale S.Eugenio Roma.   Presidente Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) per il biennio 2017-2019.   Presidente European Society fo Pediatric Endocrinology (ESPE) 2022.       Tipologia Prestazioni Assistenziali: -Dalla data di strutturazione (1988):Assistenza diurna, notturna e festiva presso U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata, con compiti di responsabilità diretta, con turni periodici di corresponsabilità del Reparto. Consulenze diurne, notturne e festive presso la Accettazione e il Pronto Soccorso dell’Ospedale S. Eugenio, Azienda USL RM-C, Roma, con compiti di responsabilità diretta.    -Delegato periodicamente dal Primario della U.O.C. di Pediatria a sostituirlo come responsabile della stessa U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata.    -Attività ambulatoriale specialistica in Patologia Endocrina Pediatrica e responsabile della Unità Organizzativa di Patologia Endocrina Pediatrica-B2 su delibera del Consiglio di Facoltà del 24/10/2002 ed in conformità con quanto stabilito dalla ASL RMC in data 23/1/2002  delibera n. 42.   -Incaricato dal Rettore dell’Università di Roma Tor Vergata ad esercitare funzione primariale temporanea presso la U.O.C. di Pediatria-Oncoematologia Pediatrica presso l’Ospedale S. Eugenio dal decorrenza dal 1.12.2008.     Attività Didattica Insegnamenti: Corso di Laurea in Medicina 2002-2012 Corso Integrato di Pediatria (Scienze Pediatriche)   Scuola di Specializzazione in Pediatria: 1989-1991 Clinica Pediatrica 1991-1993 Pediatria Generale e Specialistica 1993-1996 Endocrinologia 1999-2000 Pediatria Generale 2001-2004 Endocrinologia Pediatrica e Malattie del Metabolismo Infantile e Neonatale 2002-2003 Patologia Clinica 2003-2006 Endocrinologia Pediatrica 2004-2005 Pediatria Generale e Specialistica 2007-2012 Pediatria Generale e Specialistica   Scuola di Specializzazione Scienze dell’Alimentazione: 2000/2001, 2003/2004, 2005-2008 Pediatria Scuola di Specializzazione in Neuropsichiatria Infantile 2005-2008 Neuropsicoendocrinologia     Scuola di Specializzazione in Ortopedia e Traumatologia 2009 PediatrIa   Diploma Universitario in Dietologia e Dietetica Applicata 1995-1997 Patologia dell’età evolutiva     Diploma Universitario in Dietista 1997-2001 Patologia dell’età evolutiva     Diploma Universitario in Ostetricia 1997-1998 Cardiologia Pediatrica     Diploma Universitario Tecnici in Riabilitazione Psichiatria 2010 Pediatria   Dottorato di Ricerca in Pediatria Molecolare,  Università Tor Vergata, Roma.  Docente AA.AA. 2002-2006.   Scuola di Alta Formazione in Pediatria, Università Tor Vergata/Ospedale Pediatrico Bambino Gesù, Roma. 2012 Comitato Scientifico   Master in Endocrinologia Pediatrica, Università di Parma AA 2010 e 2012 Basse stature da alterazione periferica   Docente e organizzatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 10/3-9/6, 1999-2000.   Docente e coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 2000-2001.   Docente Winter School, European Society for Paediatric Endocrinology, Varna, Bulgaria, 4-11 marzo 2006.       Master Direttore Master II livello in Endocrinologia e Diabetologia Pediatrica, Scuola di Alta Fromazione in Pediatria, Università degli Studi di Roma Tor Vergata e Ospedale Pediatrico Bambino gesù, Roma. Primo ciclo a partire dal 2014.   PhD courses  (Dottorato di ricerca) Docente del Corso di Dottorato in Pediatria Molecolare Università degli Studi di Roma Tor Vergata (2003-2004).   Docente del Corso di Dottorato in Pediatria Molecolare e Biotecnologie Applicate, Università degli Studi di Roma Tor Vergata (2005).   Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)" Università degli Studi di Roma Tor Vergata (2012-2016).   Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)" Università degli Studi di Roma Tor Vergata (2012-2017).       Tutor and Supervisor:   Supervisore della Dr.ssa Caterina Geremia, PhD, with the Thesis: “Metabolic programming in intrauterine groath retardsation (IUGR). Results from clinical and laboratory investigations”. Tor Vergata University, Rome, 2007.     Supervisore della Dr.ssa Arianna Maiorana, PhD, with the Thesis: “A Method to Isolate Omental Adipose Stem cells in Pediatric Patients: Perspectives in investigating the Pathogenesis of metabolic Syndrome”. Tor Vergata University, Rome, 2008     Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy,  University of Kuopio, Finland, 2006.     Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit,  Karolinska Institute, Stoccolma Sweden.   Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.   Official opponent in doctoral dissertation of PhD. Candidate Carolina Smeets, Thesis Title:  “Silver-Russell Syndrome & Small for Gestational Age  Long-term health perspectives” Erasmus University, Rotterdam, 2017.   External reviewer in doctoral dissertation of PhD. Candidate Nicola Improda, Thesis title: “New insights in childhood-onset growth hormone deficiency: from diagnosis to long-term outcomes”. Clinical and Experimental Medicine, University of Naples Federico II, Naples, 2021.   Official opponent in doctoral dissertation of PhD. Candidate Wesley J. Goedegebuure, Thesis Title:  “Small for gestational age. Adult metabolic and cardiovascular health and long-term safety of growth hormone treatment”. Erasmus University, Rotterdam, 2021.           Società di appartenenza: Ordine dei Medici della Provincia di Roma  N. 32942 (10/2/1983)   British General Medical Council  Registration N. 3417762 (13/5/1991)   • Società Italiana di Pediatria • Società Italiana di Endocrinologia e Diabetologia Pediatrica • European Society for Pediatric Endocrinology (ESPE)   Incarichi Internazionali Chairman of the Clinical Practice Committee della European Society for Pediatric Endocrinology  dal 2004 al 2010.   Comitato scientifico della Consensus Conference internazionale sull’approccio diagnostico e terapeutic del bambino nato piccolo per età gestazionale. Un Simposio internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Lawson Wilkins Society for Pediatric Endocrinology (LWPES) and la Growth Hormone Research Society (GRS). Manchester, UK, 2006   Membro del Consiglio Direttivo della European Society for Pediatric Endocrinology  2004-2010.   Membro del Programme Organizing Committee della European  Society for Pediatric Endocrinology  2004-2010.   Consulente temporaneo Organizzazione Mondiale della Sanità (OMS). 2006.   Membro temporaneo dell’EMA Scientific Advisory Group (SAG) for Diabetes/Endocrinology dal  2007.   Membro Advisory Group della ERA-NET PRIOMEDCHILD European Network for Medicines in Childhood. 2008.   Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.   Chair of the Board of Advanced Seminars in Developmental Endocrinology (2014-2016), European Society for Pediatric Endocrinology (ESPE)    Dal 2015 al 2019, membro del pannello di esperti del Science Committee della European Society for Pediatric Endocrinology (ESPE).   Premi Internazionali Nomination per il Research Award della European Society for Pediatric Endocrinology (2005, 2006, 2007).   Comitati e Consulenze  Scientifiche: Comitato scientifico, V Congresso della Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP). Roma 18- 19 Ottobre 1985.    Scientific Secretary, International Workshop on Binding Proteins for Growth Hormone and Somatomedins, Roma, November 23-24, 1990.        Consulente scientifico per la R.A.I. per trasmissioni sulla crescita e la pubertà (D.S.E.) 1985 e 1986.   Comitato Scientifico, Corso SIEDP in Endocrinologia Pediatrica, Sabaudia 5-7 Ottobre 2000.   Coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università di Tor Vergata, Roma, 2002.   Coordinatore Gruppo di Studio su “Fisiopatologia dei processi di accrescimento” Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), 2001-2003   Comitato scientifico dell’Accademia Nazionale di Medicina, coordinatore per il settore Endocrinologia e Malattie del Ricambio dell’Età Evolutiva (2005-2008).   Responsabile commissione giovani Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) 2007-2009   Responsabile commissione farmaci Società Italiana di Medicina dell’Adolescenza (SIMA) 2009-2011.   Membro Comitato Scientifico Fondazione “Cesare Serono”, dal 2011.   Membro Gruppo di Lavoro Ricerca e Sviluppo, Agenzia Italiana del Farmaco (AIFA) 2011-2012.   Member of the Steering Committee, European Society for Pediatric Endocrinology (ESPE) Advanced Seminar in Developmental Endocrinology (From 2012).     Borse di Studio:   C.N.R. borsa di studio per l'estero (n.203.04.10  6/5/1986) per il progetto: "Western Blotting Technique in the study of short stature" (1986). Department of Chemical Endocrinology, St. Bartholomew's Hospital, Londra,  Gran Bretagna   C.N.R.-N.A.T.O. junior fellowship (n. 215.24 18/01/90) per il progetto: "Insulin-like growth factor binding proteins in children with short stature" (1990). Division of Pediatric Endocrinology, St. Bartholomew's Hospital, Londra,  Gran Bretagna.   C.N.R.-N.A.T.O. senior fellowship (n. 217.28 del  29/4/1995) per il progetto: "Effetto dell’ormone della crescita e dei fattori di crescita insulino-simili (IGFs) sulla stabilità del genoma umano: studio “in vitro” e “in vivo”. University of Bristol, Bristol, Gran Bretagna.     Precedenti  Posizioni scientifiche e  professionali all’estero: Visiting Paediatrician, Department of Growth and Development, (Prof. J.M. Tanner) Institute of Child Health, University of London, U.K. Settembre 1984    Visiting Researcher, Laboratory of Tumor Cell   Biology, (Dr. R.C. Gallo), National Institutes of Health,   National Cancer Institute, Bethesda, Maryland, U.S.A.  Da Agosto a Settembre 1985    Research Fellow in Endocrinology (Prof. L.H. Rees), Department of Chemical Endocrinology, St. Bartholomew's Hospital, London U.K. Da Settembre 1988 a Febbraio 1989    Research Fellow in Paediatric Endocrinology, Division of Paediatric Endocrinology, Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE                           Da Maggio 1991 ad Aprile 1992   Honorary Clinical Assistant in Paediatric Endocrinology, Department of Paediatric Endocrinology,  Dr. Martin Savage, "The Queen Elizabeth Hospital for Children", London, E2 8PS                           Da Maggio 1991 ad Aprile 1992   Teacher of Endocrinology of Growth, Serono, Auxology Course, St. Bartholomew's Hospital, London EC1A 7BE. 1991-1992   Honorary Research Fellow in Pediatric Endocrinology, Royal Hospital for Sick Children, Bristol BS2 8BJ, dal 28 Ottobre 1996 per 2 anni.                         Visiting Fellow in Surgery, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8BJ, U.K. dal 30 Novembre 1996 per due anni.   Organizzazione Conferenze   Internazionali: Organizer and member of the Steering Committee. International Conference  Organization Workshop on Binding Proteins for Growth Hormone and Somatomedins. Rome, November 23-24, 1990.   Organizer and member of the Steering Committee.  IGF-I and IGF binding protein assessment and therapeutic benefit. Serono Symposia, New Orleans, June 14-15, 2004.    Organizer and member of the Steering Committee.  ESPE/GRS/LWPES Consensus Workshop on Management of the Small for Gestational Age Child. 1-4 February 2006 Manchester, UK   Delegate to ESPE/GRS/LWPES Consensus Workshop on Idiopathic Short Stature. 17-20 October 2007, Los Angeles, CA, US   Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.   Editorial Board 1. Editor in Chief, Frontiers in Pediatric Endocrinology, Frontiers Research Foundation, Lausanne, Switzerland, fino a Gennaio 2014 2. Associate Editor of Review of Diabetic Studies, Society for Biomedical Diabetes Research. Fino a Gennaio 2014. 3. Editor in Chief (appointed from 2014), Hormone Research in Paediatrics, Karger, Basel, Switzerland.   4. Advisory Board member of Biomedicine Hub, Karger, Basel, Switzerland. Dal 2016 5. Editorial board: Annals of Pediatric Endocrinology and Metabolism, dal 2016. 6. Editorial board: Jornal de Pediatria, Brazil, dal 2021     Incarichi Accademici  Internazionali Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy,  University of Kuopio, Finland, May 27th, 2006.   Teacher of Evidence-Based Medicine in Paediatric Endocrinology, at the “Advanced Postgraduate Course on Methods in Growth Research – Theory and Practice”. Karolinska Institutet, Stockholm, November 22-26, 2010.   Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit,  Karolinska Institute, Stoccolma Sweden.   Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.     Reviewer per: Acta Paediatrica • Acta Obstetrica and Gynaecologica Scandinavica • Americal Journal of Clinical Nutrition • Archives for Diseases in Childhood • BMC Medical Genetics • Clinical Endocrinology • Diabetes • Diabetologia • Dutch Diabetes Research Foundation • Endocrinology  • European Society for Pediatric Endocrinology • European Journal of Endocrinology • Frontiers in Pediatric Endocrinology • Hormone Research • International Journal of  Cancer • International Journal of Clinical Practice • International Journal of Obesity • Italian Ministry of University and Research (MIUR). National Research Programmes (PRIN). • Journal of Clinical Endocrinology and Metabolism • Journal of Endocrinological Investigation • Journal of Pediatric Endocrinology and Metabolism • Journal of Pediatrics • Lancet • Metabolism • Obesity • Pediatric Research • Pediatrics • Psychoneuroendocrinology • Review of Diabetic Studies • Swiss National Science Foundation • Trends in Endocrinology and Metabolism • European Commission – HORIZON 2020   Direzione  Attività Formativa ECM Responsabile Evento Formativo  Tavola Rotonda: Prevenzione dell’Osteoporosi dell’Adulto in Età  Pediatrica. Roma 6-9.2003. Crediti ECM assegnati: n. 3     Responsabile Evento Formativo  Corso di Aggiornamento: Errori in Endocrinologia Pediatrica.  Roma 18-10.2003. Crediti ECM assegnati: n. 6     Responsabile Evento Formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Terapia Endocrina nell’Età Evolutiva”. Roma, Marzo-Giugno, 2004. Crediti ECM assegnati: n. 23   Responsabile Evento Formativo con US CME: “IGF-I and IGF binding protein assessment and therapeutic benefit”. New Orleans 14-15 Giugno, 2004, Serono Symposia.   Responsabile Evento Formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Endocrinologia pediatrica per problemi”. Roma, Marzo-Giugno, 2006. Crediti ECM assegnati: n. 17   Responsabile evento formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Clinical Practice in Endocrinologia Pediatrica”  Roma, Marzo-Giugno, 2008. crediti ECM: 19   Responsabile evento formativo: Corso di aggiornamento, “SGA: cause e conseguenze del basso peso alla nascita”.  Roma, 21 Giugno, 2008. crediti ECM: 6     Attività formativa Coordinatore del Corso di Endocrinologia Pediatrica,  per paesi in via di sviluppo per conto della Società Europea di Endocrinologia Pediatrica (ESPE). Nairobi (Kenia) 16-20 Maggio, 2006.   Research Grants Gestiti come Responsabile “The Prevention of osteoporosis by nutrional phytoestrogens (PHYTOS)”. Shared Cost RTD actions. European Commission. Anno 1999, durata 48 mesi, Proposal No. QLRT-1999-00857. Subcontractor of Contractor 1: Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione. “Deteminazione di IGF-I, IGFBP-3, IGFBP-4 e forme circolanti di IGFBP-3”.  Importo finanziato pari a 45.000 EURO. Principal Investigator and Coordinator   “Terapia sperimentale nell’adrenoleucodistrofia”. Fondazione Baroni. Anno 2000-2001. Importo finanziato pari a Lire 50.000.000   “Phytohealth”. European Network for Research on Phytoestrogens. CORDIS RTD-Project #68987, EC 2003; 5000 EURO   “S6 Kinase activity in Human Placentas from Normal and SGA Fetuses”. MIUR 60% 2003. 2500 EURO. Principal Investigator and Coordinator   “Origine fetale delle malattie dell’adulto. Identificazione precoce dei fattori di rischio cardiovascolare e metabolico nei soggetti nati con ritardo di crescita ad inizio intrauterino”. MIUR COFIN-40% - 2003 . Coordinatore Nazionale del Progetto. Euro: 136.000. Responsabile Unità Operativa, Roma, Tor Vergata, EURO 63.000. Principal Investigator and Coordinator   “Proteolisi della IGFBP-3 nei pazienti con deficit di GH (GHD). Effetto sulla sensibilità e specificità del dosaggio della IGFBP-3 nella diagnosi di GHD.” Progetti di Ricerca di Ateneo (ex  60%). Anno 2005. EURO 4.200. Principal Investigator and Coordinator   Riprogrammazione dell’attività S6K e IRS-1 ed espressione dei recettori per insulina e IGF-I nei bambini small for gestational age (SGA). Progetti di Ricerca di Ateneo (ex  60%). Anno 2006. EURO 2.300. Principal Investigator and Coordinator   “SAGhE: Safety and Appropriateness of  Growth hormone treatments in Europe”. FP7-HEALTH-2007: Better use of medicines Collaborative projects (Small or medium-scale focused research projects) Coordinating person: Jean-Claude Carel EU grant FP7-223497, 2009-2012. Euro 440000 for the local Unit (Tor Vergata, University, Rome) coordinated by Prof. Stefano Cianfarani, Principal Investigator and Coordinator of WORKPACKAGE 4. “Protective role of IGF-I in premature babies at risk of  neurological damage  and retinopathy” Eli Lilly grant 2009. euro 70.000. Pricipal Investigator and Coordinator   “Metilazione del gene igf2, ritardo di crescita ad inizio intrauterino e alterazioni metaboliche. Studio clinico in bambini obesi nati piccoli per età gestazionale e con peso alla nascita appropriato per età gestazionale.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2011. 12.000 Euro. Principal Investigator and Coordinator   “Growth Hormone Treatment For Short Children Born Preterm And Presenting Extrauterine Growth Retardation”. Principal Investigator and Coordinator. Pfizer grant 2011. 164.000 Euro   “Studio multicentrico europeo sulla identificazione dei fattori di rischio metabolico in bambini ed adolescenti obesi.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2012. 60.000 Euro. Principal Investigator and Coordinator   Deficit Subclinico di Vitamina D e Rischio Metabolico e Cardiovascolare in Bambini Obesi. Trial Pilota Randomizzato Controllato con Vitamina D3. Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2013. 52000 Euro. Principal Investigator and Coordinator. miRNA – Novel markers to predict the development of obesity‐related disorders? Collaborative International Project. European Society for Paediatric Endocrinology-Research Unit. Co- Investigator. 2013. 60000 Euro.    "PERSUADED. Phthalates and bisphenol : a biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases" LIFE13 ENV/IT/000482. Principal Investigator of “Bambino Gesù” Children’s Hospital Unit.  Progetto cofinanziato Comunità Europea. Cofinanziamento richiesto 877658 Euro Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. 238.853 Euro.    Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA European Commission (BRUSSELS )  2020-06 to 2023-06|Grant GRANT_NUMBER: 945268   Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 11579 European Commission (Brussels) 2015-11-01 to 2022-10-31|Gran GRANT_NUMBER: 11579 URL:https://app.dimensions.ai/details/grant/grant.6814282               TESI   Tesi di Laurea in Medicina e Chirurgia: "Patologia pediatrica da difetti recettoriali", 1982, Relatore Prof. B. Boscherini.    Tesi di Diploma per la Specializzazione in Pediatria: "Nuovi metodi di indagine della funzionalità somatotropinica", 1986, Relatore Prof. B. Boscherini.       PUBBLICAZIONI         ORIGINAL ARTICLES     1. Spadoni G.L., Cianfarani S., Boscherini B.  Le Somatomedine.  Rivista Italiana di Pediatria 10, 347-351, 1984.    2. de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M.,   Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.   Hormone-modulated rRNA gene activity is visualized by selective   silver staining of the NOs.  Cell Biology International Reports 9, 791-796, 1985   3. de Capoa, Marlekaj P., Baldini A., Felli M.P., Rocchi M.,   Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.   Growth-hormone induced regulation of rRNA gene activity in   human cultured cells.  Hormone and Metabolic Research 18, 574-575, 1986.    4. Cianfarani S., Spadoni G.L., Finocchi G., Ravet P., Costa F.,   Papa M., Scirè G., Manca Bitti M.L., Boscherini B. Growth hormone treatment in Noonan's syndrome.  Minerva Pediatrica 39, 281-284, 1987.   5. Cianfarani S., Spadoni G.L., Scirè G., Galasso C., Benvenuti S., Manca Bitti M.L., Rezza E., Boscherini B. Pretreatment growth velocity and response to GH (HGH) therapy.  Minerva Pediatrica 39, 757-761, 1987.   6. Vaccaro F., Cioschi S., Falvo F., Bernardini S., Spadoni G.L., Cianfarani S., Carrozzo A.M., Nini G., Galasso C., Manca Bitti M.L., Pasquino A.M.  Acanthosis Nigricans, insulino-resistenza ed  endocrinopatie: attuali vedute e   conoscenze. Il Progresso Medico 43, 483-489, 1987.   7. Spadoni G.L., Cianfarani S., Baldini A., Ravenna L., Felli M.P., Camaioni A., Manca Bitti M.L., Scirè G., Boscherini B., de Capoa A.  Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method.  Hormone and  Metabolic Research, 20, 450-452, 1988.   8. Boscherini B., Cianfarani S., Spadoni G.L.  Growth Disorders. Medicina 8, 287-292, 1988.   9. Baldini A., Felli M.P., Ravenna L., Camaioni A., de Capoa A., Spadoni G.L., Cianfarani S., Boscherini B.  Differential ribosomal gene responsiveness to human growth hormone is visualized by selective silver staining.  Cytogenetics and Cell Genetics 47, 22-25, 1988.    10. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Manca Bitti M.L., Costa F., Boscherini B. Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients.  Clinical Pediatrics 27, 473-478, 1988.    11. Holly JMP, Smith CP, Dunger DB, Howell RJS, Chard T, Perry LA, Savage MO, Cianfarani S., Rees LH, Wass JAH. Relationship between the pubertal fall in sex hormone- binding globulin and insulin-like growth factor binding protein-I. A synchronised approach to pubertal development? Clinical Endocrinology 31, 277-284, 1989.    12. Bernardini S., Cianfarani S., Galasso C., Spagnoli A., Vaccaro F., Spadoni G.L.  Somatotropin function in Noonan's syndrome.  Pediatria Oggi 9, 110-112, 1989.   13. Spagnoli A., Bernardini S., Galasso C., Vaccaro F., Manca Bitti M.L., Scirè G., Cianfarani S., Spadoni G.L.  Treatment of somatotropic deficiency with biosynthetic growth hormone. Medical and Surgical Pediatrics 11, 5-10, 1989.    14. Cianfarani S., Holly JMP  Somatomedin-binding proteins: what role do they play in the growth process? European Journal of  Pediatrics 149:76-79, 1989.    15. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Boscherini B.  Growth hormone treatment in children with sporadic primary microcephaly.  American Journal of Diseases in Childhood 143, 1282-1283, 1989.    16. Boscherini B., Cianfarani S., Spadoni G.L.  Clinical features of growth hormone (GH) deficiency.  Journal of Endocrinological Investigation 12, 17-19, 1989.    17. Holly JMP, Edeb JA, Alaghband-Zadeh J, Carter GD, Jemmott RC, Cianfarani S., Chard T, Wass JAH.  Insulin-like growth factor binding proteins in follicular fluid from normal dominant and cohort follicles, polycystic and multicystic ovaries. Clinical Endocrinology 33, 53-64, 1990.    18. Vaccaro F, Cianfarani S., Spadoni GL, Spagnoli A, Bernardini S, Galasso C, Boscherini B.  Growth hormone therapy in non GH-deficient short children.  Rivista Italiana di Pediatria 16, 528-534, 1990.    19. Spadoni GL, Spagnoli A, Cianfarani S., Del Principe D, Menichelli A, Di Giulio S, Boscherini B. Enhancement of phorbol diester-stimulated respiratory burst in human polymorphonuclear leukocytes by growth hormone.  Acta Endocrinologica (ora European Journal of Endocrinology) 124, 589-594, 1991.    20. Spadoni G.L., Rossi P., Ragno W., Galli E., Cianfarani S., Galasso C., Boscherini B.  Immune function in growth hormone deficient children treated with biosynthetic growth hormone. Acta Paediatrica Scandinavica 80, 75-79, 1991.    21. Cianfarani S., Vaccaro F, Spadoni GL,  Galasso C, Bernardini S, Spagnoli A, Boscherini B.  Abnormal growth velocity does not impair the attainment of target height in "small-delay" children.  Acta Medica Auxologica 23, 245-251, 1991.   22. Bernardini S, Spadoni GL, Cianfarani S, Scalera G, Cives C,       Vaccaro F, Pasquino AM, Boscherini B.  Growth hormone response to growth hormone releasing factor in Turner's       syndrome.  Acta Medica Auxologica 23, 173-178, 1991.   23.   Bernardini S, Spadoni GL, Cianfarani S, Vaccaro F, Pasquino        AM, Boscherini B.  Growth hormone secretion in Noonan's syndrome.  Journal of Pediatric Endocrinology (now Journal of Pediatric Endocrinology and Metabolism) 4, 217-221, 1991.    24. Cianfarani S. New modulators of growth: the somatomedin-       binding proteins.  Rivista Italiana di Pediatria 18, 119-124, 1992.    25. Cianfarani S., Holly J.M.P., Pasquino A.M., Vaccaro F.,       Spadoni G.L., Bernardini S., Segni M., Boscherini B.       Insulin-like growth factor binding protein-1 (IGFBP-1)       levels in Turner syndrome.  Hormone and Metabolic Research 24, 537-540, 1992.    26. Pasquino A.M., Bernardini S., Cianfarani S., Mancuso G., Marchione S.A., Passeri F., Pucarelli I., Spadoni G.L.  Growth hormone assessment and three years' hGH therapy in girls with Turner syndrome. Hormone Research 38, 120-124, 1992.    27. Tedeschi B, Spadoni G.L., Sanna M.L., Vernole P., Caporossi D., Cianfarani S.,  Nicoletti B, Boscherini B.  Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone.  Human Genetics 91, 459-463, 1993    28. Cianfarani S., Nicholl R.M., Medbach S., Charlesworth  M.C., Savage M.O.  Idiopathic hypothalamus-pituitary dysfunction: review of five cases. Hormone Research 39, 47-50, 1993.    29. Cianfarani S., Frost V.J., Savage M.O., Holly J.M.P.  Glucose does not influence the insulin-like growth factor (IGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting. Experientia (now Cellular and  Molecular Life Sciences) 49, 699-701, 1993.    30. Cianfarani S., Vaccaro F., Pasquino A.M., Marchione S.A., Passeri F., Spadoni G.L., Bernardini S., Spagnoli A., Boscherini B.  Reduced growth hormone (GH) secretion in Turner syndrome: is body weight a key factor? Hormone Research, 41, 27-32, 1994.     31. Bernardini S, Cianfarani S, Spagnoli A, Melino G, Annicchiarico-Petruzzelli M, Massoud R, Boscherini B, Finazzi-Agrò A, Rosenfeld RG, Federici G. Expression and down regulation by retinoic acid of IGF binding protein-2 and 4 in medium from human neuroblastoma cells.  Journal of Neuroendocrinology 6, 409-413, 1994.    32. Cianfarani S, Vaccaro F, Boscherini B.  What is the rationale of growth hormone therapy in Turner syndrome? Lancet 344, 114-115, 1994.     33. Cianfarani S., Boscherini B.  La sindrome di Noonan.  Prospettive in Pediatria 25, 25-32, 1995.   34. Bernardini S, Cianfarani S, Pianca C, Massoud R, Germani D, Melino G, Federici G.  Insulin-like growth factor binding protein-1 serum levels in neuroblastoma.  Clinical Chemistry and Enzimology Communications 6, 359-363, 1995.   35. Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B.  Is the obesity- related insulin status the cause of the blunted growth hormone secretion in Turner syndrome?  Metabolism 44, 1033-1037, 1995.     36. Spagnoli A., Spadoni G.L., Cianfarani S., Pasquino A.M., Troiani S., Boscherini B.  Predicting outcome of growth hormone therapy in children with idiopathic short stature.  Journal of  Pediatrics 126, 905-909, 1995.    37. Cianfarani S., Boemi S., Spagnoli A., Cappa M., Argirò G., Vaccaro F., Manca Bitti M.L., Boscherini B.  Is IGFBP-3 binding protein-3 assessment helpful for the diagnosis of GH deficiency?  Clinical Endocrinology 43, 43-47,1995.    38. Municchi G., Pasquino A.M., Pucarelli I., Cianfarani S., Passeri F. Growth hormone treatment in Noonan syndrome: report of four cases who reached final height.  Hormone Research 44, 164-167,1995.    39. Cianfarani S., Vitale S., Stanhope R., Boscherini B.  Imperforate anus, bilateral hydronephrosis, bilateral undescended testes, and pituitary hypoplasia: a variant of Hall-Pallister syndrome or a new syndrome? Acta Paediatrica 84, 1322-1324, 1995.      40. Spagnoli A., Branca F., Spadoni G.L., Cianfarani S., Pasquino A.M., Argirò G., Vitale S., Robins S.P., Boscherini B.  Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency. Skeletal metabolism during GH treatment.  Journal of Clinical Endocrinology and Metabolism 81,3589-3593,1996.    41. Cianfarani S., Germani D., Rossi P., Spagnoli A., Mercanti D.  Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells? European Journal of Endocrinology 135, 716-723, 1996.    42. Cianfarani S., Rossi P.  Neuroblastoma and Insulin-like growth factor (IGF) system. New insights and clinical perspectives.  European Journal of Pediatrics 156, 256-261, 1997.    43. Cianfarani S., Boscherini B.  Il bambino con ritardo di crescita ad inizio intrauterino (IUGR, intrauterine growth retardation). Fisiopatologia dell’asse GH-IGF-I e tentativi terapeutici. Prospettive in Pediatria 108, 299-306, 1997.   44. Cianfarani S, Tedeschi B, Germani D, Prete SP, Rossi P, Vernole P, Caporossi D, Boscherini B.  “In vitro” effects of growth hormone (GH) and insulin-like growth factor-I and -II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes.  European Journal of Clinical Investigation 28, 41-47, 1998.    45. Cianfarani S, Germani D, Rossi L, Argirò G, Boemi S, Lemon M, Holly JMP, Branca F.  IGF-I and IGF-binding protein-1 are related to cortisol in human cord blood.  European Journal of Endocrinology 138, 524-529, 1998.    46. Balducci R, Toscano V, Tedeschi B, Mangiantini A, Toscano R, Galasso C, Cianfarani S, Boscherini B.  A new case of Ambras syndrome associated with a paracentric inversion (8) (q12:q22).  Clinical Genetics 53, 466-468, 1998.    47. Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JMP, Branca F.  Intrauterine growth retardation (IUGR): Evidence for the activation of the IGF-related growth promoting machinery and the presence of a cation- independent IGFBP-3 proteolytic activity by two months of life.  Pediatric Research 44, 374-380, 1998.    48. Cianfarani S, Germani D, Branca F. Low birth weight and adult insulin resistance: the catch-up growth hypothesis. Archives of Disease in Childhood, 81, F71-F73, 1999.    49.       Cianfarani S Low birth weight and IGF system, Physiology and clinical implications. Rivista di Clinica Dietologica 27, 89-92, 1999.   50. Puglianiello A, Germani D, Rossi P and Cianfarani S Insulin-like growth factor-I (IGF-I) stimulates chemotaxis of human neuroblasts. Involvement of type I IGF receptor, insulin-like growth factor binding proteins (IGFBPs), phosphatidylinositol (PI)-3 kinase pathway and plasmin system.  Journal of Endocrinology 165, 123-131, 2000.    51. Rossi L., Branca F. and Cianfarani S. Collagen cross-links and early postnatal growth in newborns with intrauterine growth retardation. Metabolism 49, 1467-1472, 2000.    52. Elias LLK, Huebner A, Metherell LA, Canas A, Warne GL, Manca Bitti ML, Cianfarani S, Clayton PE, Savage MO, Clark AJL. Tall stature in familial glucocorticoid deficiency. Clinical Endocrinology 53, 423-430, 2000.    53. Cianfarani S, Bonfanti R, Manca Bitti ML, Germani D, Boemi S, Chiumello G, Boscherini B.   Growth and Insulin-like Growth Factors (IGFs) in Children with Insulin- Dependent Diabetes Mellitus (IDDM) at Onset of Disease. Evidence for Normal Growth, Age Dependency of  the IGF System Alterations and Presence of a Small (18 kDa) IGFBP-3 Fragment in Serum. Journal of Clinical Endocrinology and Metabolism 85, 4162-4167, 2000.    54. Cianfarani S, Geremia C, Germani D, Scirè G, Maiorana A, Boemi S.  Insulin resistance and insulin-like growth factors (IGFs) in children with intrauterine growth retardation (IUGR). Is catch-up growth a risk factor? Hormone Research 55 (Suppl.1) 7-10, 2001.    55. Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F.  Reduced growth and skeletal changes in zinc deficient growing rats are the consequences of impaired growth plate activity and of zinc depletion-induced inanition.  Journal of Nutrition 131, 1142-1146, 2001.   56 Tadin M, Braverman E, Cianfarani S, Sobrino AJ,m Levy B, Christiano AM, Warburton D. Complex cytogenetic rearrrangement of chromosome 8q in a case of Ambras syndrome.  American Journal of Medical Genetics 102, 100-104, 2001.    57. Branca F, Spagnoli A, Cianfarani S, Spadoni GL, Golden MHN, Boscherini B, Valtuena S,  Robins SP. Urinary excretion of pyridinium cross-links in short children treated with growth hormone. Journal of Pediatric Endocrinology and Metabolism 15, 27-34, 2002.    58 Cianfarani S, Geremia C, Scott CD, Germani D. Growth, Insulin-like growth factor (IGF) system and cortisol in children with intrauterine growth retardation (IUGR). Is catch-up growth affected by reprogramming of the hypothalamic-pituitary-adrenal axis (HPAA)? Pediatric Research 51, 94-99, 2002.    59 Cianfarani S, Tondinelli T, Spadoni GL, Scirè G, Boemi S, Boscherini B. Height Velocity and IGF-I Assessment in the Diagnosis of Childhood Onset GH Insufficiency. Do we still need a Second GH Stimulation Test? Clinical Endocrinology 57, 161-167, 2002.    60 Cianfarani S.  Foetal origin of adult diseases: just a matter of stem cell number? Medical Hypotheses 61:401-404, 2003.    61 Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood Glucose Concentrations are Reduced in Children Born Small for Gestational Age (SGA) and TSH Levels are Increased in SGA with Blunted Postnatal Catch- up Growth.  Journal of Clinical Endocrinology and Metabolism 88, 2699-2705, 2003.    62 Cianfarani S., Martinez C, Maiorana A, Scirè G, Spadoni G.L., Boemi S. Adiponectin Levels Are Reduced in Children Born Small for Gestational Age (SGA) and are Inversely Related to Postnatal Catch-up Growth.  Journal of Clinical Endocrinology and Metabolism 89: 1346-1351, 2004.    63 Scommegna S., Galeazzi D., Picone S., Farinelli E., Agostino R., Bozzao A., Boscherini B, Cianfarani S. Neonatal Identification of Pituitary Aplasia:a Life- Saving Diagnosis. Review of Five Cases.  Hormone Research 62, 10-16, 2004.    64 Geremia C, Cianfarani S. Insulin sensitivity in children born small for gestational age (SGA) Review of Diabetic Sciences 1, 58-65, 2004.    65       Cianfarani S. La pubertà precoce. Medico e Bambino 23, 485-491, 2004.   66   Torre P, Bertoli M, Di Giovanni S, Scommegna S., Conte C, Novelli G, Cianfarani S. Endocrine and Neuropsychological Assessment in a Child with a Novel Mutation of Thyroid Hormone Receptor. Response to 12-months Triiodothyroacetic Acid (TRIAC) Therapy. Journal of Endocrinological Investigation 28, 657-662, 2005.  67 Cianfarani S, Liguori A, Germani D. IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency. Endocrine Development 9, 66-75, 2005    68 Cianfarani S.  Il ruolo dei fattori di crescita GH-dipendenti nella diagnosi del deficit di GH. Area Pediatrica 4, 44-48, 2005.   69 Cianfarani S., Puglianiello A, Germani D. Central reprogramming in intrauterine growth retardation. Minerva Pediatrica 57(Suppl.1 N3):71-73, 2005.   70 Cianfarani S., Liguori A., Boemi S., Maghnie M, Iughetti L., Wasniewska M., Street M.E., Zucchini S., Aimaretti G.,  Grmani D. Inaccuracy of IGFBP-3 Assessment in the Diagnosis of Growth Hormone Deficiency (GHD) from Childhood to Young Adulthood: Association to Low GH-Dependency of IGF-II and Presence of Circulating IGFBP-3 18 kD Fragment. Journal of Clinical Endocrinological and Metabolism, 90, 6028-6034, 2005.    71 Cianfarani S, Ladaki C, Geremia C. Hormonal regulation of post-natal growth in SGA children Hormone  Research 65 (Suppl. 3): 70-74, 2006.    72 Cianfarani S, Liguori A. Sensibility and Specificity of Growth Factors in GH Deficiency. Journal of Endocrinological Investigation, 29 (Suppl.), 71-75, 2006.    73. Geremia C, Cianfarani S. Laboratory Tests and Measurements in Children Born  Small for Gestational Age (SGA) Clinica Chimica Acta 364, 113-123, 2006. 74 Puglianiello A and Cianfarani S Central control of glucose metabolism The Review of Diabetic Studies 3, 54-60, 2006.    75 Kelberman D, Rizzoti K, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JMW, Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson   ICAF, Dattani MT  Mutations within Sox2/SOX2 are Associated with Hypopituitarism in Mouse and Humans.  Journal of Clinical Investigation 116, 2442-2455, 2006.    76 Scirè G, D’Anella G, Cristofori L, Mazzuca V, and Cianfarani S Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia. Journal of Cardiovascular Medicine 8(6):465-7, 2007   77. Federico G., Street M.E., Maghnie M., Caruso-Nicoletti M., Loche S., Bertelloni S., and Cianfarani S. Assessment of circulating levels of insulin-like growth factors in the diagnosis diagnosis of isolated childhood-onset isolated growth hormone deficiency. A proposal of the Italian Society for Pediatric Endocrinology and Diabetes. Journal of Endocrinological Investigation 29:732-737, 2006.    78. Ghirri P, Ladaki C, Bartoli A, Scirè G, Vuerich M, Spadoni GL, Maiorana M, Geremia C, Boldrini A , and Cianfarani S. Low Birth Weight for Gestational Age Associates with Reduced Glucose Concentrations at Birth, Infancy and Childhood. Hormone Research 67:123–131, 2007.     79. Clayton PE,  Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A Management of the Child Born Small for Gestational Age Child (SGA) through to Adulthood: A Consensus Statement of the International Societies of Paediatric Endocrinology and the Growth Hormone Research Society. Journal of Clinical Endocrinology and Metabolism 92, 804-810, 2007.    80. Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia Tomba and Stefano Cianfarani. Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR).  Pediatric Research 61:433-437, 2007.    81. Zucchini S, Wasniewska M,  Cisternino M, Salerno M,  Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S. Adult height in children with short stature and idiopathic delayed puberty after different management. European Journal  of Pediatrics 167, 677-681, 2008    82. Cianfarani S. Endocrine-metabolic follow-up of the small for gestational age (SGA) infant. Minerva Pediatr 59, 545-546, 2007   83. Cianfarani S, Geremia C, Puglianiello A, Mairana A, Germani D. Late Effects of Disturbed IGF Signaling in Congenital Diseases. Endocrine Development 11, 16-27, 2007.    84. Maiorana A, Del Bianco C, and Cianfarani S. Adipose Tissue: a Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA). The Review of Diabetic Studies, 4, 131-143, 2007.    85. Scirè G, Del Bianco C, Spadoni GL, and Cianfarani S Growth hormone (GH) therapy does not alter the IGF-I/IGFBP-3 molar ratio in GH deficient children.  Journal of Endocrinological Investigation 31(2):153-8, 2008.    86. Torre P, Ladaki C, Scirè G, Spadoni GL, and Cianfarani S.  Catch-up growth in body mass index (BMI) is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for gestational age (SGA).  Journal of Endocrinological Investigation 31(9):760-4, 2008.    87. Germani D, Puglianiello A and Cianfarani S. Uteroplacental Insufficiency Down Regulates Insulin Receptor and Affects Expression of Key Enzymes of Long-chain Fatty Acid (LCFA) Metabolism in Skeletal Muscle at Birth. Cardiovascular Diabetology, 7:14, 2008.    88. Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin Cassidy, and Francesco Branca on behalf of the PHYTOS Investigators Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study1. Americal Journal of Clinical Nutrition 87:761–70, 2008.    89. Katherine A. Fantauzzo, Marija Tadin-Strapps, Yun You, Sarah E. Mentzer, Friedrich A.M. Baumeister, Stefano Cianfarani, Lionel Van Maldergem, Dorothy Warburton, John P. Sundberg and Angela M. Christiano.  A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice.  Human Molecular Genetics 17(22):3539-51, 2008     90. P Cohen, AD Rogol, CL Deal, P Saenger, EO Reiter, JL Ross, SD Chernausek, MO Savage, JM Wit on behalf of the 2007 ISS Consensus Workshop participants*Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop. Journal of Clinical Endocrinology and Metabolism  93(11):4210-4217. 2008.    91. Liguori A, Cianfarani S Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report Journal of Medical Case Reports 2009; 3:7300 doi: 10.1186/1752-1947-3-7300   92 Pedicelli S, Peschiaroli E, Violi E, and Cianfarani S. Controversies in the definition and treatment of idiopathic short stature (ISS). Journal of Clinical Research in Pediatric Endocrinology. 2009; 1(3):105-115    93. Puglianiello A, Germani D, and Cianfarani S.  Exposure to uteroplacental insufficiency reduces the expression of signal transducer and activator of transcription 3 (STAT3) and proopiomelanocortin (POMC) in the hypothalamus of newborn rats. Pediatric Research 66:208-211, 2009    94. Maiorana A, Fierabracci A and Cianfarani S Isolation and characterization of omental adipose progenitor  cells in children: a potential tool to unravel the pathogenesis of  metabolic syndrome. Hormone Research 2009;72:348–358    95. Maiorana A, Cianfarani S Impact of Growth Hormone Therapy on Adult Height of Children Born Small for Gestational Age: A Systematic Review of Randomized Controlled Trials. Pediatrics, 124, E519-E531, 2009.     96.   Giacomozzi C, Savage MO and Cianfarani S Deficit primario di IGF-I. Implicazioni diagnostico-terapeutiche. Il Pediatra,  giugno, 26-39. 2010   97. Bertelloni S, Garofalo P, and Cianfarani S. Il ritardo dello sviluppo puberale maschile: trattamento con androgeni. Rivista Italiana di Medicina dell’Adolescenza  8, 5-10,2010   98. Spadoni and Cianfarani S Bone age assessment in the work up of children with endocrine disorders Hormone Research in Paediatrics Vol. 73, No. 1,  pp 2 - 5 , 2010     99. Giacomozzi C, Gullotta F, Federico G, Colapietro I, Nardone, AM,  and Cianfarani S, Premature Ovarian Failure associated to the Absence of Pubic and Axillary Hair in a de novo Translocation X;15 (q24;q26.3). American Journal of Medical Genetics 2010 May;152A(5):1305-9.    100. Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L, Germani D, Boldrini A, and Cianfarani S. Retinol-binding protein 4 in neonates born small for gestational age. Journal of Endocrinological Investigation 2010 Apr;33(4):218-21.    101. Nobili V, Cianfarani S, Agostoni C. Programming, metabolic syndrome, and NAFLD: the challenge of transforming a vicious into a virtuous cycle. Journal of Hepatology 2010 Jun;52(6):788-90.    102. Federico G, Cianfarani S Usefulness of serum insulin-like growth factor-I (IGF-I) assessment in the diagnosis of childhood-onset GH deficiency. Hormone Research in Paediatrics 74, 145-148, 2010    103. Bertelloni S, Garofalo P, and Cianfarani S. The role of androgen therapy in hypogonadal adolescent males Homone Research in Paediatrics 74, 292-296, 2010    104. Cianfarani S Grand Challenges in Pediatric Endocrinology Frontiers in Pediatric Endocrinology doi:10.3389/fendo.2010.00001   105. Deodati A, Peschiaroli E, Cianfarani S. Conseguenze endocrine e metaboliche del bambino nato SGA. Rivista Italiana di Medicina dell’Adolescenza  3, Suppl. 8  1-6, ,2010   106. Liguori A, Puglianiello A, Germani D, Deodati A, Peschiaroli E and Cianfarani S, Epigenetic changes predisposing to type 2 diabetes in intrauterine growth       retardation. Frontiers in Pediatric Endocrinology doi: 10.3389/fendo.2010.00005   107. Deodati A and Cianfarani S. Impact of Growth Hormone Therapy on Adult Height of Children with Idiopathic Short Stature: A Systematic Review of Randomized and non-Randomized Controlled Trials. British Medical Journal, 2011;342:c7157   108. Zanni G, Barresi S,  Travaglini L,  Bernardini L, Digilio MC, Mercuri E,  Cianfarani S, Ferraris A,   Masotti A, Novelli A, Valente EM, Dallapiccola B, Bertini ES FGF17, a gene involved in cerebellar development is downregulated in a patient with Dandy-Walker Malformation carrying a de novo 8p deletion. Neurogenetics 2011;12(3):241-5     109. Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P, Cianfarani S.  Il deficit di GH nel periodo di transizione (GH deficiency in the transition phase). Il Pediatra 2011, giugno, 48-54   110. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger. Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice Pediatric Endocrinology Reviews, 2011 Dec;9(2):554-65.   111. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger. Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice Pediatric Endocrinology Reviews, Dec;9(2):554-65, 2011   112. Deodati A, Peschiaroli E, and Cianfarani S.  Review of Growth Hormone Randomized Controlled Trials in Children with Idiopathic Short Stature. Hormone Research in Paediatrics 76 (Suppl. 3):40B-42 (DOI: 10.1159/000330157), 2011   113. Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S, Nobili V, Pietrobelli A, Agostoni C. Epigenetic mechanisms elicited by nutrition  in early life.  Nutr Res Rev. Dec;24(2):198-205, 2011   114. Cianfarani S.  Chairman's summary: Diagnostic techniques for identifying children with idiopathic short stature.  Horm Res Paediatr. 76 Suppl 3:16.Epub 2011 Sep 7, 2011.    115. Cohen A, Lala R, Ravaglia A, Bernasconi S, Boscherini B, Cianfarani S, Pocecco M, Maghnie M, Panei P  Modifiche della prescrizione dell’ormone della crescita. Una proposta dell’ACP. QUADERNI ACP, vol. 18, p. 42-44, 2011   116. Alisi A, Cianfarani S, Manco M, Agostoni C, Nobili V. Nonalcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment. Annals of Medicine, Feb;44(1):29-40 2012   117. S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli Effect of Intrauterine Growth Retardation on Liver and Long-Term Metabolic Risk. International Journal of Obesity. Oct;36(10):1270-7, 2012.   118. G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, and S. Cianfarani. Serum insulin-like growth factor-I (igf-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients.  Growth Hormone and IGF Research, 22:134-138, 2012.    119. Nobili V, Bedogni G, Berni Canani R, Brambilla P, Cianfarani S, Pietrobelli A, Agostoni C The Hepato-Metabolic Syndrome In Children: A Distinct Phenotype With High Metabolic Risk? Pediatric Obesity Dec;7(6):e75-80, 2012.   120. Cianfarani S  Long-term safety of growth hormone therapy: still a controversial issue.  Frontiers in endocrinology, vol. 3, p. 1-2, 2012. doi: 10.3389/fendo.2012.00115   121. Cianfarani S   Insulin-like growth factor-II (IGF-II): new roles for an old actor.  Frontiers in endocrinology, vol.3, 1-4, 2012, doi: 10.3389/fendo. 2012.00118   122. Benevento D, Bizzarri C, Patera IP, Ravà L, Schiaffini R, Ciampalini P, Cianfarani S, Cappa M.  Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D) .  Diabetes/metabolism research and reviews Jan;29(1):60-5, 2013   123. Inzaghi E and Cianfarani S  The challenge of growth hormone deficiency (GHD) diagnosis and treatment during the transition from puberty into adulthood.  Frontiers in Endocrinology 4:34. doi: 10.3389/fendo.2013.00034, 2013   124. Wit. JM. Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristom B, Schoenau E, Audi L, Hokken.Koelega A, Bamg P, Junh H, Blum WF, Silverman LA, COhen P, Cianfarani S, Deal C, Clayton PE, de Graaf L, Dahlgren J, Kleintjens J, Roelants M.  Personalized approach to growth hormone treatment: clinical use of growth prediction models. Horm Res Paediatr. 79(5):257-70, 2013   125. Deodati A, Inzaghi E, Liguori A, Puglianiello A, germani D, Brufani C, Fintini D, Cappa M, Barbetti F, Cianfarani S.  IGF2 Methylation Is Associated with Lipid Profile in Obese Children. Horm Res Paediatr, Jun 14:361-367, 2013   126. Bizzarri C, Benevento D, Patera IP, Bongiovanni M, Boiani A, Cianfarani S, Cappa M Residual beta-cell mass influences growth of pre-pubertal children with type 1 diabetes. Horm Res Paediatr 80(4):287-92, 2013    127. Bizzarri C, Spadoni GL, Bottaro G, Monatanari G, Giannone G, Cappa M, Cianfarani S.  The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life. Journal of Clinical Endocrinology and Metabolism, 99(2):433-9, 2014.   128. Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi, and Stefano Cianfarani. Vitamin D levels and liver histological alterations in children with non-alcoholic fatty liver disease (NAFLD). European Journal of Endocrinology 170(4):547-53, 2014.   129. Boscherini B and Cianfarani S. Considerazioni sulla diagnosi di deficienza idiopatica isolata di ormone della crescita Quaderni ACP 21(1): 31-32, 2014.   130. Cafiero G, Fintini D, Brufani C, Fiori R, Giordano U, Turchetta A, Deodati A, Cappa M and Cianfarani S Cardiovascular fitness is impaired in children that are born small for their gestational age. Acta Paediatrica 103(5):e219-21, 2014   131. Stefano Cianfarani, Elena Inzaghi, Anna Alisi, Daniela Germani, Antonella Puglianiello, V alerio Nobili. Insulin-like Growth Factor–I and –II Levels are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children. Journal of Pediatrics 165(1):92-8, 2014.   132. Annalisa Deodati, Barbara Baldini Ferroli and Stefano Cianfarani. Association between Growth Hormone Therapy and Mortality, Cancer and Cardiovascular Risk: Systematic Review and Meta-Analysis. Growth Hormone and IGF Research 24:105-111, 2014.    133. Elena Inzaghi, Stefano Cianfarani, Valerio Nobili. Insulin-Like Growth Factors (IGF-I And –II): New Actors in the Development of Non-Alcoholic Fatty Liver Disease. Expert Reviews of Endocrinology and Metabolism 9:193-195, 2014.    134. S. Cianfarani Is High Dose Growth Hormone Treatment During Puberty Worthwhile? Hormone Research in Paediatrics, 82(3):143-4, 2014   135. Cianfarani S Editorial Hormone Research in Paediatrics 81:1, 2014   136 Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M and Cianfarani S. Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus.  Growth Hormone and IGF Research, 24(6):256-9, 2014.   137 Carla Bizzarri, Stefania Pedicelli, Brunetto Boscherini, Giorgio Bedogni, Marco Cappa and Stefano Cianfarani Early retesting by GHRH + arginine test shows normal GH response in most children with idiopathic GH deficiency. Journal of Endocrinological Investigation, Apr;38(4):429-36, 2015   138. Stefania Pedicelli, Paola Alessio, Giuseppe Scirè, Marco Cappa, and Stefano Cianfarani. Routine Screening by Brain Magnetic Resonance Imaging Is not Indicated in Every Girl with Onset of Puberty Between the Ages of Six and Eight Years. Journal of Clinical Endocrinology and Metabolism, 99(12):4455-61, 2014.   139. V. Pampanini,  A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F. Dini, P.Ghirri, and S. Cianfarani Preterm Infants with Severe Extrauterine Growth Retardation (EUGR) Are at High Risk of Growth Impairment during Childhood. European Journal of Pediatrics, 174(1):33-41, 2015.   140. C. Giacomozzi,  A. Deodati, M.G. Shaikh, S.F. Ahmed, and S. Cianfarani. The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: a systematic review. Hormone Research in Paediatrics, 83(3):167-76, 2015.   141. D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S. Cianfarani, A. Crinò Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader–Willi Syndrome (PWS). Pediatric Obesity 11(3):235-8, 2016   142 Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC. Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone. Hormone Research in Paediatrics, 84, 172-183, 2015.   143. Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, and Cianfarani S. Brain Magnetic Resonance Imaging as First-Line Investigation for Growth Hormone Deficiency Diagnosis in Early Childhood. Hormone Research in Paediatrics, 84(5):323-30, 2015.   144. D B Allen, P Backeljauw, M Bidlingmaier, BMK Biller, M Boguszewski , P Burman, G Butler, K Chihara, J Christiansen, S Cianfarani, P Clayton, D Clemmons, P Cohen, F Darendeliler, C Deal, D Dunger, E M Erfurth, J S Fuqua, A Grimberg, M Haymond, C Higham, K Ho, A R Hoffman, A Hokken-Koelega, G Johannsson, A Juul, J Kopchick, P Lee, M Pollak, S Radovick, L Robison, R Rosenfeld, R J Ross, L Savendahl, P Saenger, H Toft Sorensen, K Stochholm, C Strasburger, A Swerdlow, M Thorner. Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults. Eur J Endocrinol. 174(2):P1-9, 2016.    145. Schiaffini R, Liccardo D, Alisi A, Benevento D, Cappa M, Cianfarani S, Nobili V Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor? Hormone Research in Paediatrics 85(1):29-34, 2016.   146. Brambilla P, Bedogni G, Pietrobelli A, Cianfarani S , Agostoni C.  Predictors of blood pressure at 7-13 years: The “new Millennium Baby” study.  Nutrition, Metabolism and Cardiovascular Diseases. 26(8):706-12, 2016   147. Deodati A, Sallemi A, Maranghi , Germani D, Puglianiello A, Baldari F, Busani L, Mancini FR, Tassinari R, Mantovani A, Cianfarani S Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche. Hormone research in Paediatrics 86(4):233-239, 2016.    148. Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW. Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders. Hormone Research in Paediatrics 85(5):325-32, 2016   149. Fischer-Posovszky P, Roos J, Kotnik P, Battelino T, Inzaghi E, Nobili V, Cianfarani S, Wabitsch M. Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact. Hormone research in Paediatrics 86(1):3-10, 2016.   150. M. Cappa, L. Iughetti, S. Loche, M. Maghnie, A. Vottero. GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study. Journal of Endcorinological Investigation 39:667–677, 2016   151. Cambiaso P, Bottaro G, Cianfarani S, Tomà P, de Vito R, Cappa M. An Incidental Finding of Bilateral Adrenal Lymphoma The American Journal of Medical Sciences 52(1):80. doi: 10.1016/j.amjms.2016.02.018., 2016.   152. Bizzari C, Pedicelli S, Cappa M, Cianfarani S. Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects. Hormone Research in Paediatrics 86(3):143-153., 2016.   153. Deodati A, Cianfarani S. Trattamento con ormone della crescita in bambini nati piccoli per l’età gestazionale L’Endocrinologo 17(4):183-187, 2016   154.   Cianfarani S, Soder O. Endocrine disruptors and child health. New insights. Hormone Research in Paediatrics Sep 16;86(4), 2016   155. Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, Overi D, Mosca A, Stronati L, Cucchiara S, Raponi M, Gaudio E, Byrne CD, Nobili V. Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial. PLoS One. 2016 Dec 15;11(12):e0168216. doi: 10.1371/journal.pone.0168216.   156. Pampanini V, Germani D, Puglianiello A, Stukenborg JB, Reda A, Savchuk I, Kjartansdóttir KR, Cianfarani S, Soder O. Impact of uteroplacental insufficiency on postnatal rat male gonad. Journal of Endocrinology Feb;232(2):247-257, 2017.   157. Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega AC, Khan AJ, Kiess W, Kuehni CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L, Zandwijken GR. Cancer risks in patients treated with growth hormone in childhood: the SAGHE European cohort study.  Journal of Clinical Endocrinology and Metabolism 102:1661–1672, 2017.   158. Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano Cianfarani Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children. Hormone research in Paediatrics 87:400–404, 2017.   159. Francesca Santilli, Paola G. Simeone, Maria T. Guagnano, Marika Leo, Marica T. Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C. Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro and Agostino Consoli. Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects with Prediabetes or Early Type 2 Diabetes. Diabetes Care 2017 Nov;40(11):1556-1564   160 Deodati A, Cianfarani S. The rationale for growth hormone therapy in children with short stature. Journal of Clinical Research in Pediatric Endocrinology Dec 30;9(Suppl 2):23-32, 2017.   161 S. Brandt, J. Roos, E. Inzaghi, P. Kotnik, J. Kovac, T. Battelino, S. Cianfarani,  V. Nobili, M. Colajacomo, W. Kratzer, C. Denzer, P. Fischer-Posovszky and M. Wabitsch Circulating levels of miR-122 and nonalcoholic fatty liver disease in pre-pubertal obese children. Pediatric Obesity 13(3):175-182, 2018.   162 Pampanini V, Inzaghi E, Germani D, Alterio A, Puglianiello A, Alisi A, Nobili V and Cianfarani S Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic  Fatty Liver Disease. Nutrition, Metabolism & Cardiovascular Diseases  Jan;28(1):71-76, 2018.   163 Bizzarri C, Timpanaro TA, Matteoli MC, Patera IP, Cappa M, Cianfarani S. Growth trajectory in children with type 1 diabetes mellitus: the impact of insulin treatment and metabolic control. Hormone Research in Paediatrics. 89(3):172-177, 2018   164 Cinzia La Rocca, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Francesca Baldi, Giorgia Bottaro, Emma Buzzigoli, Fabrizia Carli, Stefano Cianfarani, Raffaele Conte, Annalisa Deodati, Amalia Gastaldelli, Anna Paola Pala, Andrea Raffaelli, Chiara Saponaro, Giuseppe Scirè, Gian Luigi Spadon, Luca Busani, the LIFE PERSUADED Project Group. The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases. Environmental Science and Pollution Research, Jul 4. doi: 10.1007/s11356-018-2660-4, 2018.   165 Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani   The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. PLOS ONE Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490., 2018   166 Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati, Valerio Nobili, Stefano Cianfarani Expression of insulin-like growth factor I and its receptor in the liver of children   with biopsy-proven NAFLD. PLOS ONE Jul 31;13(7):e0201566. 2018   167 Marzano F, Faienza MF, Caratozzolo MF, Brunetti G, Chiara M, Horner DS, Annese A, D’erchia AM, Consiglio A Pesole G, Sbisà E, Inzaghi E, Cianfarani S, Tullo A.   Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. Pediatric Obesity Dec;13(12):803-811. 2018   168 Inzaghi E, Reiter E, Cianfarani S.  The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy.  Hormone Research in Paediatrics, 92(2):71-83, 2019   169 Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S. GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice. Hormone Research in Paediatrics, 92(2):71-83, 2019   170 Cianfarani S Pediatric endocrinology in the time of COVID-19 pandemic Hormone Research in Paediatrics 92(6):345-346, 2019   171 Pampanini V, Jahnukainen K, Sahlin L, Germani D, Puglianiello A, Cianfarani S, Söder O Impact of uteroplacental insufficiency on ovarian follicular pool in the rat. Reproductive Biology and Endocrinology, Jan 10;17(1):10, 2019   172 Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ. Risk of Meningioma in European Patients Treated with Growth Hormone in Childhood: Results from the SAGhE Cohort. Journal of Clinical Endocrinology and Metabolism, Mar 1;104(3):658-664, 2019.   173 Spreghini N, Cianfarani S, Spreghini MR, Brufani C, Morino GS, Inzaghi E, Convertino A, Fintini D, Manco M. Oral glucose effectiveness and metabolic risk in obese children and adolescents Acta Diabetologica, Aug;56(8):955-962, 2019   174 Centonze C, Guzzetti C, Orlando G, Loche S; Italian ECOS Investigators. Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) Journal of Endocrinological Investigation, Oct;42(10):1241-1244, 2019.   175 Bizzarri C, Pedicelli S, Romanzo A, Bocchini S, Bottaro G, Cianfarani S, Cappa M. The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study. Italian Journal of Pediatrics Apr 27;45(1):52, 2019.   176 Cianfarani S Risk of cancer in patients treated with recombinant human growth hormone in childhood. Annals of Pediatric Endocrinology and Metabolism, Jun;24(2):92-98, 2019   177 Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G. Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease. Journal of Hepatology, Oct;71(4):802-810, 2019.   178 Inzaghi E, Kistner A, Germani D, Deodati A, Vanpee M, Legnevall L, Berinder K, Cianfarani S. A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood. PloS One, Jan 24;15(1):e0228075, 2020   179 Deodati A, Inzaghi E, Cianfarani S. Epigenetics and In Utero Acquired Predisposition to Metabolic Disease. Frontiers in Genetics, Jan 29;10:127, 2020.   180 Tassinari R, Narciso L, Tait S, Busani L, Martinelli A, Di Virgilio A, Carli F, Deodati A, La Rocca C, Maranghi F; LIFE PERSUADED Project Group. Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived from Italian Children Biomonitoring Study. Toxicological Sciences, Feb 1;173(2):387-401, 2020   181 Tait S, Carli F, Busani L, Buzzigoli E, Della Latta V, Deodati A, Fabbrizi E, Gaggini M, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C; LIFE PERSUADED Project Group. Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project. Environmental Research, Jun;185:109428, 2020   182 Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, Manco M. The bones of children with obesity. Frontiers in Endocrinology, Apr 24;11:200, 2020.   183 Schiaffini R, Barbetti F, Rapini N, Inzaghi E, Deodati A, Patera IP, Matteoli MC, Ciampalini P, Carducci C, Lorubbio A, Schiaffini G, Cianfarani S. School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology. Diabetes Research in Clinical Practice, Aug;166:108302, 2020.   184 Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken-Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ. Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study. Lancet diabetes and Endocrinology, Aug;8(8):683-692, 2020   185 Amodeo ME, Inzaghi E, Deodati A, Cianfarani S. Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype. Mol Genet Genomic Med.May 31;e1644.  doi: 10.1002/mgg3.16, 2021.   186 Petrelli A, Ravà L, Mascali A, Rapini N, Massoud M, Manca Bitti ML, Cianfarani S, Manco M. Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D Diabetes Metab Res Rev. Jun 2:e3479, 2021.   187 Inzaghi E, Deodati A, Loddo S, Mucciolo M, Verdecchia F, Sallicandro E, Catino G, Cappa M, Novelli A, Cianfarani S. Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype J Endocrinol Invest. Jan;45(1):79-87, 2022   188 Cianfarani S, Pampanini V The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic Horm Res Paediatr. Jul 14:345-349, 2021    189 Giglione E, Lapolla R, Cianfarani S, Faienza MF, Fintini D, Weber G, Delvecchio M, Valerio G. Linear growth and puberty in childhood obesity: what is new? Minerva Pediatr (Torino). Dec;73(6):563-571, 2021.   190 Carducci C, Rapini N, Deodati A, Pampanini V, Cianfarani S, Schiaffini R. Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic. Ital J Pediatr. Aug 26;47(1):176, 2021.   191 Tait S, Carli F, Busani L, Ciociaro D, Della Latta V, Deodati A, Fabbrizi E, Pala AP, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C, Life Persuaded Project Group. Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project. Int J Environ Res Public Health. Nov 12;18(22):11846, 2021.   192 Stefano Cianfarani. Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance Frontiers in Endocrinology, Dec 24;12:811846, 2021.   193 Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D, Matarazzo P, Baronio F, Crocco M, Giudica G, Partenope C, Nardini B, Ubertini G, Menardi R, Guzzetti C, Iughetti L, Aversa T, Di Mase R, Cassio A, Cianfarani S, Maghnie M, Tuli G, Loche S, Bruzzi P, Wasniewska M, Salerno M, Rutigliano I, Iezzi ML, Cherubini V, Grandone A, Faienza M, Tumini S, Baldoli C, Consales A, Genitori L, Marras CE, MIlanaccio C, Mortini P, Vindigni M, Zenga F, Zucchelli M; Physiopathology of Growth Processes; Puberty Study Group of the Italian Society for Pediatric Endocrinology and Diabetology. Management of Childhood-onset Craniopharyngioma in Italy: A Multicenter, 7-Year Follow-up Study of 145 Patients J Clin Endocrinol Metab. Feb 17;107(3):e1020-e1031, 2022.   194 Stefania Pedicelli, Danilo Fintini, Lucilla Ravà, Elena Inzaghi, Annalisa Deodati, Maria Rita Spreghini, Carla Bizzarri, Michela Mariani, Stefano Cianfarani, Marco Cappa, Melania Manco,   Prevalence of prediabetes in children and adolescents by class of obesity. Pediatr Obes. Feb 10;e12900, 2022   195 Giorgia Sforza, Annalisa Deodati, Romina Moavero, Laura Papetti, Ilaria Frattale,Federico Vigevano, Stefano Cianfarani, Massimiliano Valeriani.  Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report. Frontiers in Neurology, Jan 10;12:818638, 2022   196 Arianna Petrelli, Lucilla Ravà, Alberto Mascali, Novella Rapini, Michela Massoud, Maria Luisa Manca Bitti, Stefano Cianfarani, Melania Manco.  Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D. Diabetes Metab Res Rev., Jan;38(1):e3479, 2022   197 Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G Nichols, Stefano Cianfarani. Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2. Horm Res Paediatr. Jan 7. doi: 10.1159/000521858, 2022.   198 Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani.  Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe  Postnatal Growth Failure. Horm Res Paediatr, Jan 27;1-11. doi: 10.1159/000521629, 2022   199 Schiaffini R, Deodati A, Nicoletti MC, Carducci C, Ciampalini P, Lorubbio A, Matteoli MC, Pampanini V, Patera IP, Rapini N, Cianfarani S. Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study. Acta Diabetologica 59:959-964, 2022   200 Inzaghi E, Pampanini V, Deodati A and Cianfarani S The effects of nutrition on linear growth Nutrients 14(9):1752, 2022   201 Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L Touraine P, van Santen HM, Johannsson G. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement. European Journal of Endocrinology, 186(6):P35-P52, 2022   202 Pampanini V, Deodati A, Inzaghi E, Cianfarani S. Long-acting growth hormone preparations and their use in children with growth hormone deficiency. Hormone Research in Paediatrics Feb 25.  doi: 10.1159/000523791, 2022   203 Barbetti F, Rapini N, Schiaffini R, Bizzarri C, Cianfarani S. The application of precision medicine in monogenic diabetes. Expert Rev Endocrinol Metab. Mar;17(2):111-129, 2022   204 Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium. INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z.   205 Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti. Monogenic diabetes clinic (MDC): 3‐year experience Acta Diabetologica Sep 30.  doi: 10.1007/s 00592-022-01972-2, 2022    206 Del Chierico F, Conta G, Matteoli MC, Fierabracci A, Reddel S, Macari G, Gardini S, Guarrasi V, Levi Mortera S, Marzano V, Vernocchi P, Sciubba F, Marini F, Deodati A, Rapini N, Cianfarani S, Miccheli A, Putignani L Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset. Int J Mol Sci. Sep 6;23(18):10256, 2022   207 Carli F, Tait S, Busani L, Ciociaro D, Della Latta V, Pala AP, Deodati A, Raffaelli A, Pratesi F, Conte R, Maranghi F, Tassinari R, Fabbrizi E, Toffol G, Cianfarani S, La Rocca C, Gastaldelli A, Life Persuaded Project Group. Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project. Int J Mol Sci. Dec 16;23(24):16012. 2022   208 Levi Mortera S, Marzano V, Vernocchi P, Matteoli MC, Guarrasi V, Gardini S, Del Chierico F, Rapini N, Deodati A, Fierabracci A, Cianfarani S, Putignani L Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study. Int J Mol Sci. 2022 Dec 15;23(24):15982. 2022   209 Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L. Pathophysiology of Type 1 Diabetes and Gut Microbiota Role Int J Mol Sci. Nov 24;23(23):14650. 2022   210 Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, et al.  International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood. Endocrine Reviews, 2023, 00, 1–27 https://doi.org/10.1210/endrev/bnad002   211 Pezzino G, Ruta R, Rapini N, Chiodo DC, Mucciolo M, Tomaselli L, Cianfarani S, Barbetti F. A rare cause of transient neonatal diabetes mellitus: Spontaneous HNF1B splice variant. Diabet Med. 2024 Feb;41(2):e15202. doi: 10.1111/dme.15202.   212 Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A.  Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071.   213 Ravà L, Fintini D, Mariani M, Deodati A, Inzaghi E, Pedicelli S, Bizzarri C, Cappa M, Cianfarani S, Manco M. High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk. J Endocrinol Invest. 2023 Dec;46(12):2555-2562. doi: 10.1007/s40618-023-02111-6.   214 Aureli A, Recupero R, Mariani M, Manco M, Carlomagno F, Bocchini S, Nicodemo M, Marchili MR, Cianfarani S, Cappa M, Fintini D. Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity. Int J Mol Sci. 2023 Nov 22;24(23):16588. doi: 10.3390/ijms242316588   215 Deodati A, Bottaro G, Germani D, Carli F, Tait S, Busani L, Della Latta V, Pala AP, Maranghi F, Tassinari R, Gastaldelli A, La Rocca C, Cianfarani S.  Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in children with obesity: A case-control study. LIFE PERSUADED Project Group. Horm Res Paediatr. 2023 Nov 16. doi: 10.1159/000535305.   216 Franceschi R, Fintini D, Ravà L, Mariani M, Aureli A, Inzaghi E, Pedicelli S, Deodati A, Bizzarri C, Cappa M, Cianfarani S, Manco M. Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease. Int J Mol Sci. 2023 Oct 6;24(19):14963. doi: 10.3390/ijms241914963.   217 Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A, Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S, Andreani M, Porzio O, Palma P. Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children. Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751   218 Troncone A, Affuso G, Cascella C, Chianese A, Zanfardino A, Iafusco D; Diabetes Study Group of Italian Society of Paediatric Endocrinology and Diabetology. Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study. J Pediatr Psychol. 2023 Sep 20;48(9):731-739. doi: 10.1093/jpepsy/jsad016   219 Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium. Gene expression signature predicts rate of type 1 diabetes progression. EBioMedicine. 2023 Jun;92:104625. doi: 10.1016/j.ebiom.2023.104625   220 Cianfarani S, Battelino T. A critical review of upcoming new therapeutic options in paediatric endocrinology. Horm Res Paediatr. 2023 Apr 24. doi: 10.1159/000530824.   221 Rapini N, Delvecchio M, Mucciolo M, Ruta R, Rabbone I, Cherubini V, Zucchini S, Cianfarani S, Prandi E, Schiaffini R, Bizzarri C, Piccini B, Maltoni G, Predieri B, Minuto N, Di Paola R, Giordano M, Tinto N, Grasso V, Russo L, Tiberi V, Scaramuzza A, Frontino G, Maggio MC, Musolino G, Piccinno E, Tinti D, Carrera P, Mozzillo E, Cappa M, Iafusco D, Bonfanti R, Novelli A, Barbetti F; Diabetes Study Group of Italian Society for Pediatric Endocrinology and Diabetes (ISPED). The changing landscape of neonatal diabetes mellitus in Italy between 2003-2022. J Clin Endocrinol Metab Feb 26:dgae095. doi: 10.1210/clinem/dgae095, 2024.   222 Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes. Diabetes Metab Res Rev. Feb;40(2):e3777. doi: 10.1002/dmrr.3777, 2024.   223 Rapini N, Martino M, Arnaldi C, Deodati A, Anagnostopoulou L, Amodeo ME, Ciampalini P, Pampanini V, Lorubbio A, Tosini D, Cianfarani S, Schiaffini R. Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years. Front Endocrinol (Lausanne). May 21:15:1382920, 2024   224 Schiaffini R, Lumaca A, Martino M, Rapini N, Deodati A, Amodeo ME, Ciampalini P, Matteoli MC, Pampanini V, Cianfarani S. Time In Tight Range in children and adolescents with type 1 diabetes: A cross-sectional observational single centre study evaluating efficacy of new advanced technologies. Diabetes Metab Res Rev. Jul;40(5):e3826. 2024.                   Letters     1. Cianfarani S., Spadoni G.L., Manca Bitti M.L., Boscherini B.  Growth hormone treatment and somatomedin C levels.  Journal of Pediatrics 105, 853, 1984.    2. Scirè G., Cianfarani S., Spadoni G.L., Manca Bitti M.L., Fonte M.T., Boscherini B., Pasquino A.M., Bozzao L.  Primary empty sella and endocrinopathies in childhood: high prevalence among children with precocious puberty.  European  Journal of Pediatrics 147, 665, 1988.    3. Spadoni GL, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Boscherini B. How far should indications for growth hormone expand? Lancet 335, 1351, 1990.    4. Scirè G, Magliocca FM, Cianfarani S, Scalamandrè A, Petrozza Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency.  Journal of Pediatric Gastroenterology and Nutrition 13, 224-227, 1991.    5. Cianfarani S. Growth hormone therapy in Noonan syndrome. Journal of Pediatrics 134, 385-6, 1999.    6. Cianfarani S. Ambras syndrome or hypertrichosis universalis, does it really matter? Clinical Genetics 57, 158, 2000.    7. Cianfarani S, Bonfanti R, Manca Bitti ML, Chiumello G, Boscherini B. Growth and autoantibodies to IA-2 in children with type 1 diabetes.  Lancet 356, 1521, 2000.    8. Cianfarani S. Role of Hormones in Puberty Lancet 358, 1459, 2001.     9. Schiaffini R, Deodati A, Rapini N, Pampanini V, Cianfarani S. Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center. Journal of Diabetes. 2022 Aug;14(8):562-563.                 Testi e Monografie   Boscherini B., Cianfarani S., Spadoni G.L., Mancuso G.  Il bambino con bassa statura.  Ed: Piccin, Padova, 1990.    Cianfarani S. Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita. Ed: Mediprint, Roma, 2007.         Capitoli di testi      C1 Boscherini B., Spadoni G.L., Cianfarani S. Le anomalie della crescita: eziologia e classificazione. In: Progressi nella Diagnosi e Terapia dei Disturbi dell'Accrescimento. A cura di E.E. Muller & G. Chiumello. Pythagora Press, Milano, pp. 175-197, 1987.   C2 Cianfarani S, Spadoni GL. La bassa statura (Short Stature). In: Endocrinologia Pediatrica (Paediatric Endocrinology).  Boscherini B. & Scalamandre' A. Ed. Nuova Scientifica Italiana, Roma, pp. 13-47, 1991.    C3 Cianfarani S. Gli ormoni: Azione degli ormoni e loro dosaggio. In: Diagnosi e Terapia in Endocrinologia.  GL Spadoni, AP Taviani, V Toscano. Ed. Grasso, Bologna, 1993, pp.1-15.    C4 Cianfarani S. Disturbi della Crescita (Growth Disorders). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003.   C5 Cianfarani S. Tumori Associati ad Endocrinopatie (Tumors associated to Endocrinopaties).  In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto.  Carocci Editore, Roma, 2003.   C6 Giacomozzi C and Cianfarani S. Patologie dell’ipofisi anteriore. Deficit di GH. “Hypopituitarism: GH deficiency”. Capitolo 73, pp. 659-669. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.   C7 Giacomozzi C and Cianfarani S. Diabete insipido e sindrome da inappropriata secrezione di ormone antidiurerico “Diabetes insipidus and sindrome of inappropriate antidiuretic hormone (SIADH)”. Capitolo 74, pp. 669-679. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.   C8 Cianfarani S. Neuroendocrine Complications of Central Nervous System Malformations. Chapter 23. In: Maformations of the Nervous System, Handbook of Clinical neurology, 3rd Edition. Eds: H.B. Sarnat, P. Curatolo. Elsevier Ltd., pp 433- 458, 2008.   C9 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2010, pp 49-64.   C10 Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P e Cianfarani S. Il deficit di ormone della crescita nel periodo di transizione.  Adolescentologia Aspetti Medici e Socio-Educativi, cap. 6, pp 57-62, 2010   C11 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2011, pp 47-61.   C12 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2012, p. 45-59.   C13 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2013, P. 45-60.   C14 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2014, P. 45-61.   C15 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG Haymarket, Teddington, UK, 2015, P. 40-59   C16 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2016, P. 49-64.   C17 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2017, P. 50-67.               ATTIVITA' EDITORIALE    Boscherini B., Cianfarani S., Spadoni G.L. Eds.  Binding proteins for growth hormone and somatomedins.  Acta Endocrinologica, Vol. 124, Supplement 2, 1991.   Cianfarani S, Clemmons DR, Savage MO (eds.). IGF-I and IGF binding proteins. Basic research and clinical management. Endocrine Development, Basel, Karger, Vol.9, 2005   Stefano Cianfarani, Yves Le Bouc, Martin Savage (eds.). The evolving biology of growth and metabolism. European Journal of Endocrinology 157: Supplement 1, 2007.   Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (eds.) Advanced therapies in pediatric Endcorinology and Diabetology. Endocrine Development, Basel, Karger, Vol.30, 2015.   Cianfarani S and Soder O (eds.) Emdocrine disruptors and child health. Hormone Research in Paediatrics, Karger, basel, Vol. 86 (4), 215-290, 2016.         

management. Endocrine Development, Basel, Karger, Vol.9, 2005

 

Stefano Cianfarani, Yves Le Bouc, Martin Savage (eds.). The evolving biology of growth and metabolism. European Journal of Endocrinology 157: Supplement 1, 2007.

 

Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (eds.) Advanced therapies in pediatric Endcorinology and Diabetology. Endocrine Development, Basel, Karger, Vol.30, 2015.

 

Cianfarani S and Soder O (eds.) Emdocrine disruptors and child health. Hormone Research in Paediatrics, Karger, basel, Vol. 86 (4), 215-290, 2016. 

 

 

 

 

                                        CURRICULUM VITAE ET STUDIORUM AND LIST OF PUBLICATIONS         Prof. STEFANO CIANFARANI                                         15.2.2024                     Name Stefano Cianfarani   Address:           Department of Systems Medicine,  Room E-178, Tor Vergata University                           Via Montpellier 1, 00133-Roma                           Tel:  +39 6 6859 3074 (Hosp.)/+39 06 7259 6178 (Lab.)                         Fax:  +39 6 6859 2508 (Hosp,)/+39 06 7259 6172 (Lab.)          Home Address:   via Città di Castello 35,                            00191 - Roma, Italy                            Tel: +39 6 33 30 813 Mob.Ph. 338-6313626   Date of Birth:     20th December 1957   Place of Birth:     Roma, Italy   Nationality:         Italian   Marital Status: Married. Six Children   School: Liceo Classico, Pontificia Scuola "Pio IX", 1971-1976. Diploma vote 60/60   Medical School:     Universita' degli Studi di Roma                            "La Sapienza" 1976-1982. Medical degree vote 110/110 cum Laude   Specialization School: Paediatrics, Universita' degli Studi                            di Roma "La Sapienza" 1982-1986. Specialization diploma vote 70/70 cum Laude.   Present Appointment: Full Professor of Pediatrics, Department of Systems Medicine, Faculty of Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133-Rome, Italy   Chief of the Endocrinology and Diabetes Unit at the “Bambino Gesù” Children’s Hospital, Rome, Italy.   Affiliated Researcher, Department of Women´s and Children´s Health, al Karolinska Institute, Stockholm, Sweden. Since 2012.   Since 2015 Head of the Research Unit “Pathophysiology of Growth”, “Bambino Gesù” Children’s Hospital, Rome, Italy.    Chair of the Clinical Practice Committee, European Society for Pedaitric Endocrinology (ESPE)     Former President of the European Society for Pedaitric Endocrinology (ESPE)     Former President of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED). 2017-2019         Academic Assignments Teacher of Pediatrics, Medical School, Tor Vergata University, Rome.    Teacher of Pediatrics and Pediatric Endocrinology, Specialization School in Pediatrics, Tor Vergata University, Rome.    Teacher of Pediatrics, Specialization School in Orthopaedics, Tor Vergata University, Rome.   Teacher of Pediatrics and Pediatric Endocrinology, Specialization School in Science of Nutrition, Tor Vergata University, Rome.    PhD courses Member of tha Faculty of the PhD Course in Molecular Pediatrics, Tor Vergata University, Rome. Tutor and Supervisor of:   Supervisor of Dr. Caterina Geremia, PhD, with the Thesis: “Metabolic programming in intrauterine groath retardsation (IUGR). Results from clinical and laboratory investigations”. Tor Vergata University, Rome, 2007.   Supervisor of Dr. Arianna maiorana, PhD, with the Thesis: “A Method to Isolate Omental Adipose Stem cells in Pediatric Patients: Perspectives in investigating the Pathogenesis of metabolic Syndrome”. Tor Vergata University, Rome, 2008   Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy,  University of Kuopio, Finland, 2006.   Member of Faculty of the PhD course in ”Molecular Pediatrics”. University of Rome Tor Vergata. 2003-2005   Member of Faculty of the PhD course in “Immunology, Molecular Medicine and Applied Biotechnology”. University of Rome Tor Vergata. 2012-2017   Supervisor Dr. Valentina Pampanini, PhD Course Department of Women and Child’s Health, Karolinska Institute, Stockholm, Sweden. 2015-2018.   Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.   Official opponent in doctoral dissertation of PhD. Candidate Carolina Smeets, Thesis Title:  “Silver-Russell Syndrome & Small for Gestational Age  Long-term health perspectives” Erasmus University, Rotterdam, 2017.   External reviewer in doctoral dissertation of PhD. Candidate Nicola Improda, Thesis title: “New insights in childhood-onset growth hormone deficiency: from diagnosis to long-term outcomes”. Clinical and Experimental Medicine, University of Naples Federico II, Naples, 2021.   Official opponent in doctoral dissertation of PhD. Candidate Wesley J. Goedegebuure, Thesis Title:  “Small for gestational age. Adult metabolic and cardiovascular health and long-term safety of growth hormone treatment”. Erasmus University, Rotterdam, 2021.     Master Chair of Master in Pediatric Endocrinology and Diabetology, School of High Education in Pediatrics, Tor Vergata University and “Bambino Gesù” Children’s Hospital, Rome, Italy.      Learned Societies: Member of:    The Italian Society of  Paediatrics       The Italian Society of Paediatric Endocrinology and  Diabetology         European Society for Paediatric Endocrinology   Italian General Medical Council  Registration N. 32942 (10/2/1983)   British General Medical Council Registration N. 3417762 (13/5/1991)     Scientific Committees: Scientific Committee, Fifth Congress of the Italian Society of Paediatric Endocrinology and Diabethology. Roma 18- 19 October 1985.    Scientific Secretary, International Workshop on Binding Proteins for Growth Hormone and Somatomedins, Roma, November 23-24, 1990.        Scientific Consultant of Italian Radio Television (R.A.I.): for broadcasts on Growth and Puberty problems. 1985 and 1986.    Coordinator of the Italian Study Group on “Pathophysiology of Growth Processes”. Italian Society of Pediatric Endocrinology and Diabetology (SIEDP, 2001-2003).   European Society for Pediatric Endocrinology (ESPE) Visiting Scholarship.   Chairman of the Clinical Practice Committee (ESPE), European Society for Pediatric Endocrinology  2004-2010.   Council member, European Society for Pediatric Endocrinology (ESPE)  2004-2010.   Member of the Programme Organizing Committee, European Society for Pediatric Endocrinology  (ESPE) 2004-2010.     Temporary World Health Organization (WHO) advisor 2006.   Temporary member of EMEA Scientific Advisory Group (SAG) for Diabetes/Endocrinology. 2007   Member Advisory Group of  ERA-NET PRIOMEDCHILD European Network for Medicines in Childhood. 2008   Member of teaching committee, Italian Society for Pediatric Endocrinology and Diabetes. 2010   Member Scientific Committee “Cesare Serono” Foundation, Rome, Italy. 2011   Member Workgroup on Research and Development Italian Drug Agency (AIFA), Italy. 2011-2012   Chair of the Board of Advanced Seminars in Developmental Endocrinology (2014-2016), European Society for Pediatric Endocrinology (ESPE)    Member of expert panel of Science Committee, European Society for Pediatric Endocrinology (ESPE) 2015-2019.     Research Grants Awarded:   Italian National Research Council  (C.N.R. 203.04.10  6/5/1986): "Western Blotting Technique in the study of short stature" (1986).    Italian National Research Council - N.A.T.O. (C.N.R.-N.A.T.O. 215.24 18/01/90): "Insulin-like growth factor binding proteins in children with short stature" (1990).                            Italian National Research Council- N.A.T.O. (C.N.R.-N.A.T.O. senior fellowship n. 217.28 del 7/6/1995) Project: “Effects of GH and IGFs on human genome stability. In vitro and in vivo study”. University of Bristol, Bristol, U.K..     Previous Appointments: Visiting Paediatrician, Department of Growth and Development, (Prof. J.M. Tanner) Institute of Child Health, University of London, U.K. September 1984    Visiting Researcher, Laboratory of Tumor Cell   Biology, (Dr. R.C. Gallo), National Institutes of Health,   National Cancer Institute, Bethesda, Maryland, U.S.A.  From August to September 1985    Research Fellow in Endocrinology (Prof. L.H. Rees), Department of Chemical Endocrinology, St. Bartholomew's Hospital, London U.K. From September 1988 to February 1989                              Research Fellow in Paediatric Endocrinology, Division of Paediatric Endocrinology, Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE                           From May 1991 to April 1992   Honorary Clinical Assistant in Paediatric Endocrinology, Department of Paediatric Endocrinology,  Dr. Martin Savage, "The Queen Elizabeth Hospital for Children", London, E2 8PS. From May 1991 to April 1992.   Teacher of Endocrinology of Growth, Serono, Auxology Course, St.Bartholomew's Hospital, London EC1A 7BE. 1991-1992   Honorary Research Fellow in Pediatric Endocrinology, Royal Hospital for Sick Children, Bristol BS2 8BJ, 1996.                         Visiting Fellow in Surgery, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8BJ, U.K. 1996.   Chief of the Division of Pediatrics, S. Eugenio Hospital, P.le Umanesimo 10, 00144-Rome, Italy (from 01.01.2009 to 31.08.2009).   Chief of the Diabetology and Growth Disorders Unit at the “Bambino Gesù” Children’s Hospital, Rome, Italy.       Conference Organization:   Organizer and member of the Steering Committee. International Conference  Organization Workshop on Binding Proteins for Growth Hormone and Somatomedins. Rome, November 23-24, 1990.   Organizer and member of the Steering Committee.  IGF-I and IGF binding protein assessment and therapeutic benefit. Serono Symposia, New Orleans, June 14-15, 2004.    Organizer and member of the Steering Committee.  ESPE/GRS/LWPES Consensus Workshop on Management of the Small for Gestational Age Child. 1-4 February 2006 Manchester, UK   Delegate to ESPE/GRS/LWPES Consensus Workshop on Idiopathic Short Stature. 17-20 October 2007, Los Angeles, CA, US   Organizer of the ESPE Advanced Seminar in Developmental Endocrinology on “Developmental Endocrinology of the IGF System”, May 30-31, 2014, Rome, Italy     Co-organizer with Prof. Olle Soder of the ESPE Advanced Seminar in Developmental Endocrinology on “Endocrine Disruptors and Child Health”, May 29-30, 2015, Rome, Italy     Organizer and member of the Steering Committee.  ESPE/GRS/PES Consensus Workshop on Growth Hormone Safety 19-22 February 2014,  Manchester, UK.   President of 60th Annual Congress of European Society for Pediatric Endocrinology, Rome 15-17 September 2022.     CME events Chairman Round Table:  Prevention of Adult Ostoporosis in Childhood. (Prevenzione dell’Osteoporosi dell’Adulto in Età Pediatrica).  Rome, September 6, 2003. CME credits: 3   Chairman Course:  Errors in Pediatric Endocrinology (Errori in Endocrinologia Pediatrica). Rome, October 18, 2003. CME credits: 6   Chairman Course: Corso di Aggiornamento in Endocrinologia Pediatrica, Endocrine Therapy in Childhood. (Terapia Endocrina nell’Età Evolutiva). Rome, March-June, 2004. CME credits: 23   Co-Chairman: Serono Symposia Workshop  IGF-I and IGF binding protein assessment and therapeutic benefit workshop. New Orleans, June 14-15, 2004    Chairman Course: Corso di Aggiornamento in Endocrinologia Pediatrica, “Problems in Pediatric Endocrinology” (“Endocrinologia pediatrica per problemi”). Rome, March-June, 2006. CME credits: 17   Chairman Course: Corso di Aggiornamento in Endocrinologia Pediatrica, “Clinical Practice in Pediatric Endocrinology”  Rome, March-June, 2008. CME credits: 19   Chairman Course: Corso di aggiornamento, “SGA: cause e conseguenze del basso peso alla nascita”.  Rome, June 21st, 2008. CME credits: 6     Initiatives for developing  countries Chairman Course in Pediatric Endocrinology, on behalf of  the European Society for Paediatric Endocrinology (ESPE), Nairobi (Kenya) 16-20 May 2006.   Current Editorial board  Positions - Editor in Chief from 2014, Hormone Research in Paediatrics. Karger, Basel. Official Journal of European Society for Paediatric Endocrinology (ESPE), Pediatric Endocrine Society (PES) and  Sociedade Latino-Americana de Endocrinologia Pediatrica (SLEP). - Advisory Board member of Biomedicine Hub, Karger, Basel, Switzerland from 2016. - Editorial board Annals of Pediatric Endocrinology and Metabolism, from 2016.  Previous Editorial board  Positions - Editor in Chief, Frontiers in Pediatric Endocrinology, Frontiers Research Foundation, Lausanne, Switzerland - Associate Editor of Review of Diabetic Studies, Society for Biomedical Diabetes Research.    Reviewer for:  Acta Paediatrica  Acta Obstetrica and Gynaecologica Scandinavica  Americal Journal of Clinical Nutrition  Archives for Diseases in Childhood  BMC Medical Genetics  Clinical Endocrinology  Diabetes  Diabetologia  Dutch Diabetes Research Foundation  Endocrinology   European Society for Pediatric Endocrinology  European Journal of Endocrinology  Hormone Research  International Journal of  Cancer  International Journal of Clinical Practice  International Journal of Obesity  Italian Ministry of University and Research (MIUR). National Research Programmes (PRIN).  Journal of Clinical Endocrinology and Metabolism  Journal of Endocrinological Investigation  Journal of Pediatric Endocrinology and Metabolism  Journal of Pediatrics  Lancet  Metabolism  Obesity  Pediatric Research  Pediatrics  PlosONE  Psychoneuroendocrinology  Swiss National Science Foundation  Trends in Endocrinology and Metabolism  European Commission-Horizon 2020   Research Funds Granted and  Managed as Responsible The Prevention of  osteoporosis by Nutritional Phytoestrogens (PHYTOS). European Commission Shared Cost Programmes. Proposal No. QLRT-1999-00857. Subcontractor of Contractor 1 National Institute for Food and Nutrition Resarch. 1999, duration 48 months. Sum granted: 50.000 EURO.   “Experimental Therapy in Adrenoleukodystrophy”. Baroni Foundation, 2000-2001, 25.000 EURO   “Phytohealth”. European Network for Research on Phytoestrogens. EU 2003; 5000 EURO   S6 Kinase activity in Human Placentas from Normal and SGA Fetuses. Italian Ministry of Scientific Research 2003. 2500 EURO. Principal Investigator and Coordinator   “Fetal origins of adult disease. Early identification of cardiovascular and metabolic risk factors in children with intrauterine growth retardation”. Multicentric study. National coordinator. Italian Ministry of Scientific Research COFIN 2003. 136.000 EURO. Principal Investigator and National Coordinator     “Placental reprogramming in intrauterine growth retaradation (IUGR)”. Funds granted by Novo Nordisk, 2005. EURO 12.000.  Principal Investigator and Coordinator     “Central reprogramming in intrauterine growth retardation”. Funds granted by Serono, 2005. EURO 10.000. Principal Investigator and Coordinator     “Hypothalamic programming in intrauterine growth retaradation (IUGR)”. Funds granted by Novo Nordisk, 2005. EURO 15.000. Principal Investigator and Coordinator   “Hypothalamic programming in intrauterine growth retaradation (IUGR)” (II). Funds granted by Novo Nordisk, 2006. EURO 15.000. Principal Investigator and Coordinator   “Hypothalamic programming in intrauterine growth retaradation (IUGR)” (III). Funds granted by Novo Nordisk, 2007. EURO 15.000. Principal Investigator and Coordinator   “SAGhE: Safety and Appropriateness of  Growth hormone treatments in Europe”. FP7-HEALTH-2007: Better use of medicines Collaborative projects (Small or medium-scale focused research projects) Coordinating person: Jean-Claude Carel EU grant FP7-223497, 2009-2012. Euro 440000 for the local Unit (Tor Vergata, University, Rome) coordinated by Prof. Stefano Cianfarani, Principal Investigator and Coordinator of WORKPACKAGE 4.   “Protective Role Of Igf-I In Premature Babies At Risk Of  Neurological Damage  And Retinopathy” Eli Lilly grant 2009. Euro 70.000. Principal Investigator and Coordinator   “Igf2 methylation, intrauterine growth retardation (IUGR) and metabolic alterations. Clinical study in obese children born small for gestational age.” Current Research Funds “Bambino Gesù” Children’s Hospital, 2011. 12.000 Euro. Principal Investigator and Coordinator.   “Growth Hormone Treatment For Short Children Born Preterm And Presenting Extrauterine Growth Retardation”. Pfizer grant 2011. 164.000 Euro. Principal Investigator and Coordinator.   “European multi center study on identification of metabolic risk factors in obese children and adolescents. Current Research Funds “Bambino Gesù” Children’s Hospital, 2012. 60.000 Euro. Principal Investigator and Coordinator.   “Subclinical vitamin D deficiency and cardiometabolic risk in obese children”. Current Research Funds “Bambino Gesù” Children’s Hospital, 2012. 52000 Euro. Principal Investigator and Coordinator.   miRNA – Novel markers to predict the development of obesity‐related disorders? Collaborative International Project. European Society for Paediatric Endocrinology-Research Unit. Co- Investigator. 2013. 60000 Euro.    "Phthalates and bisphenol: a biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases" LIFE13 ENV/IT/000482. Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. European Commission co-financed project 877658 Euro, Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. 238.853 Euro.   Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA European Commission (BRUSSELS ) 2020-06 to 2023-06|Grant GRANT_NUMBER: 945268   Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 11579 European Commission (Brussels) 2015-11-01 to 2022-10-31|GRANT_NUMBER: 11579      LIST OF PUBLICATIONS     THESES     Thesis for Medical School Degree: "Paediatric diseases due to receptorial defects", 1982 (University of Rome, "La Sapienza").    Thesis for Specialization School Diploma in Paediatrics: "New methods for investigation of somatotropinic function", 1986 (University of Rome, "La Sapienza").              ORIGINAL ARTICLES     1. Spadoni G.L., Cianfarani S., Boscherini B.  Le Somatomedine.  Rivista Italiana di Pediatria 10, 347-351, 1984.    2. de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M.,   Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.   Hormone-modulated rRNA gene activity is visualized by selective   silver staining of the NOs.  Cell Biology International Reports 9, 791-796, 1985   3. de Capoa, Marlekaj P., Baldini A., Felli M.P., Rocchi M.,   Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.   Growth-hormone induced regulation of rRNA gene activity in   human cultured cells.  Hormone and Metabolic Research 18, 574-575, 1986.    4. Cianfarani S., Spadoni G.L., Finocchi G., Ravet P., Costa F.,   Papa M., Scirè G., Manca Bitti M.L., Boscherini B. Growth hormone treatment in Noonan's syndrome.  Minerva Pediatrica 39, 281-284, 1987.   5. Cianfarani S., Spadoni G.L., Scirè G., Galasso C., Benvenuti S., Manca Bitti M.L., Rezza E., Boscherini B. Pretreatment growth velocity and response to GH (HGH) therapy.  Minerva Pediatrica 39, 757-761, 1987.   6. Vaccaro F., Cioschi S., Falvo F., Bernardini S., Spadoni G.L., Cianfarani S., Carrozzo A.M., Nini G., Galasso C., Manca Bitti M.L., Pasquino A.M.  Acanthosis Nigricans, insulino-resistenza ed  endocrinopatie: attuali vedute e   conoscenze. Il Progresso Medico 43, 483-489, 1987.   7. Spadoni G.L., Cianfarani S., Baldini A., Ravenna L., Felli M.P., Camaioni A., Manca Bitti M.L., Scirè G., Boscherini B., de Capoa A.  Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method.  Hormone and  Metabolic Research, 20, 450-452, 1988.    8. Boscherini B., Cianfarani S., Spadoni G.L.  Growth Disorders. Medicina 8, 287-292, 1988.   9. Baldini A., Felli M.P., Ravenna L., Camaioni A., de Capoa A., Spadoni G.L., Cianfarani S., Boscherini B.  Differential ribosomal gene responsiveness to human growth hormone is visualized by selective silver staining.  Cytogenetics and Cell Genetics 47, 22-25, 1988.    10. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Manca Bitti M.L., Costa F., Boscherini B. Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients.  Clinical Pediatrics 27, 473-478, 1988.    11. Holly JMP, Smith CP, Dunger DB, Howell RJS, Chard T, Perry LA, Savage MO, Cianfarani S., Rees LH, Wass JAH. Relationship between the pubertal fall in sex hormone- binding globulin and insulin-like growth factor binding protein-I. A synchronised approach to pubertal development? Clinical Endocrinology 31, 277-284, 1989.    12. Bernardini S., Cianfarani S., Galasso C., Spagnoli A., Vaccaro F., Spadoni G.L.  Somatotropin function in Noonan's syndrome.  Pediatria Oggi 9, 110-112, 1989.   13. Spagnoli A., Bernardini S., Galasso C., Vaccaro F., Manca Bitti M.L., Scirè G., Cianfarani S., Spadoni G.L.  Treatment of somatotropic deficiency with biosynthetic growth hormone.  Medical and Surgical Pediatrics 11, 5-10, 1989.    14. Cianfarani S., Holly JMP  Somatomedin-binding proteins: what role do they play in the growth process? European Journal of  Pediatrics 149:76-79, 1989.    15. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Boscherini B.  Growth hormone treatment in children with sporadic primary microcephaly.  American Journal of Diseases in Childhood 143, 1282-1283, 1989.    16. Boscherini B., Cianfarani S., Spadoni G.L.  Clinical features of growth hormone (GH) deficiency.  Journal of Endocrinological Investigation 12, 17-19, 1989.    17. Holly JMP, Edeb JA, Alaghband-Zadeh J, Carter GD, Jemmott RC, Cianfarani S., Chard T, Wass JAH.  Insulin-like growth factor binding proteins in follicular fluid from normal dominant and cohort follicles, polycystic and multicystic ovaries. Clinical Endocrinology 33, 53-64, 1990.    18. Vaccaro F, Cianfarani S., Spadoni GL, Spagnoli A, Bernardini S, Galasso C, Boscherini B.  Growth hormone therapy in non GH-deficient short children.  Rivista Italiana di Pediatria 16, 528-534, 1990.    19. Spadoni GL, Spagnoli A, Cianfarani S., Del Principe D, Menichelli A, Di Giulio S, Boscherini B. Enhancement of phorbol diester-stimulated respiratory burst in human polymorphonuclear leukocytes by growth hormone.  Acta Endocrinologica (ora European Journal of Endocrinology) 124, 589-594, 1991.    20. Spadoni G.L., Rossi P., Ragno W., Galli E., Cianfarani S., Galasso C., Boscherini B.  Immune function in growth hormone deficient children treated with biosynthetic growth hormone. Acta Paediatrica Scandinavica 80, 75-79, 1991.    21. Cianfarani S., Vaccaro F, Spadoni GL,  Galasso C, Bernardini S, Spagnoli A, Boscherini B.  Abnormal growth velocity does not impair the attainment of target height in "small- delay" children.  Acta Medica Auxologica 23, 245-251, 1991.   22. Bernardini S, Spadoni GL, Cianfarani S, Scalera G, Cives C,       Vaccaro F, Pasquino AM, Boscherini B.  Growth hormone response to growth hormone releasing factor in Turner's syndrome.  Acta Medica Auxologica 23, 173-178, 1991.   23.   Bernardini S, Spadoni GL, Cianfarani S, Vaccaro F, Pasquino        AM, Boscherini B.  Growth hormone secretion in Noonan's syndrome.  Journal of Pediatric Endocrinology (now Journal of Pediatric Endocrinology and Metabolism) 4, 217-221, 1991.    24. Cianfarani S. New modulators of growth: the somatomedin-       binding proteins.  Rivista Italiana di Pediatria 18, 119-124, 1992.    25. Cianfarani S., Holly J.M.P., Pasquino A.M., Vaccaro F.,       Spadoni G.L., Bernardini S., Segni M., Boscherini B.       Insulin-like growth factor binding protein-1 (IGFBP-1)       levels in Turner syndrome.  Hormone and Metabolic Research 24, 537-540, 1992.    26. Pasquino A.M., Bernardini S., Cianfarani S., Mancuso G., Marchione S.A., Passeri F., Pucarelli I., Spadoni G.L.  Growth hormone assessment and three years' hGH therapy in girls with Turner syndrome. Hormone Research 38, 120-124, 1992.    27. Tedeschi B, Spadoni G.L., Sanna M.L., Vernole P., Caporossi D., Cianfarani S.,  Nicoletti B, Boscherini B.  Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone.  Human Genetics 91, 459-463, 1993    28. Cianfarani S., Nicholl R.M., Medbach S., Charlesworth  M.C., Savage M.O.  Idiopathic hypothalamus-pituitary dysfunction: review of five cases. Hormone Research 39, 47-50, 1993.    29. Cianfarani S., Frost V.J., Savage M.O., Holly J.M.P.  Glucose does not influence the insulin-like growth factor (IGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting. Experientia (now Cellular and  Molecular Life Sciences) 49, 699-701, 1993.    30. Cianfarani S., Vaccaro F., Pasquino A.M., Marchione S.A., Passeri F., Spadoni G.L., Bernardini S., Spagnoli A., Boscherini B.  Reduced growth hormone (GH) secretion in Turner syndrome: is body weight a key factor? Hormone Research, 41, 27-32, 1994.    31. Bernardini S, Cianfarani S, Spagnoli A, Melino G, Annicchiarico-Petruzzelli M, Massoud R, Boscherini B, Finazzi-Agrò A, Rosenfeld RG, Federici G. Expression and down regulation by retinoic acid of IGF binding protein-2 and 4 in medium from human neuroblastoma cells.  Journal of Neuroendocrinology 6, 409-413, 1994.    32. Cianfarani S, Vaccaro F, Boscherini B.  What is the rationale of growth hormone therapy in Turner syndrome?  Lancet 344, 114-115, 1994.     33. Cianfarani S., Boscherini B.  La sindrome di Noonan.  Prospettive in Pediatria 25, 25-32, 1995.   34. Bernardini S, Cianfarani S, Pianca C, Massoud R, Germani D, Melino G, Federici G.  Insulin-like growth factor binding protein-1 serum levels in neuroblastoma.  Clinical Chemistry and Enzimology Communications 6, 359-363, 1995.   35. Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B.  Is the obesity- related insulin status the cause of the blunted growth hormone secretion in Turner syndrome?  Metabolism 44, 1033-1037, 1995.     36. Spagnoli A., Spadoni G.L., Cianfarani S., Pasquino A.M., Troiani S., Boscherini B.  Predicting outcome of growth hormone therapy in children with idiopathic short stature.  Journal of  Pediatrics 126, 905-909, 1995.    37. Cianfarani S., Boemi S., Spagnoli A., Cappa M., Argirò G., Vaccaro F., Manca Bitti M.L., Boscherini B.  Is IGFBP-3 binding protein-3 assessment helpful for the diagnosis of GH deficiency?  Clinical Endocrinology 43, 43-47,1995.    38. Municchi G., Pasquino A.M., Pucarelli I., Cianfarani S., Passeri F. Growth hormone treatment in Noonan syndrome: report of four cases who reached final height.  Hormone Research 44, 164-167,1995.    39. Cianfarani S., Vitale S., Stanhope R., Boscherini B.  Imperforate anus, bilateral hydronephrosis, bilateral undescended testes, and pituitary hypoplasia: a variant of Hall-Pallister syndrome or a new syndrome? Acta Paediatrica 84, 1322-1324, 1995.    40. Spagnoli A., Branca F., Spadoni G.L., Cianfarani S., Pasquino A.M., Argirò G., Vitale S., Robins S.P., Boscherini B.  Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency. Skeletal metabolism during GH treatment.  Journal of Clinical Endocrinology and Metabolism 81,3589-3593,1996.    41. Cianfarani S., Germani D., Rossi P., Spagnoli A., Mercanti D.  Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells? European Journal of Endocrinology 135, 716-723, 1996.    42. Cianfarani S., Rossi P.  Neuroblastoma and Insulin-like growth factor (IGF) system. New insights and clinical perspectives.  European Journal of Pediatrics 156, 256-261, 1997.    43. Cianfarani S., Boscherini B.  Il bambino con ritardo di crescita ad inizio intrauterino (IUGR, intrauterine growth retardation). Fisiopatologia dell’asse GH-IGF-I e tentativi terapeutici. Prospettive in Pediatria 108, 299-306, 1997.   44. Cianfarani S, Tedeschi B, Germani D, Prete SP, Rossi P, Vernole P, Caporossi D, Boscherini B.  “In vitro” effects of growth hormone (GH) and insulin-like growth factor-I and -II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes.  European Journal of Clinical Investigation 28, 41-47, 1998.    45. Cianfarani S, Germani D, Rossi L, Argirò G, Boemi S, Lemon M, Holly JMP, Branca F.  IGF-I and IGF-binding protein-1 are related to cortisol in human cord blood.  European Journal of Endocrinology 138, 524-529, 1998.    46. Balducci R, Toscano V, Tedeschi B, Mangiantini A, Toscano R, Galasso C, Cianfarani S, Boscherini B.  A new case of Ambras syndrome associated with a paracentric inversion (8) (q12:q22).  Clinical Genetics 53, 466-468, 1998.    47. Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JMP, Branca F.  Intrauterine growth retardation (IUGR): Evidence for the activation of the IGF-related growth promoting machinery and the presence of a cation-independent IGFBP-3 proteolytic activity by two months of life.  Pediatric Research 44, 374-380, 1998.    48. Cianfarani S, Germani D, Branca F. Low birth weight and adult insulin resistance: the catch-up growth hypothesis. Archives of Disease in Childhood, 81, F71-F73, 1999.    49.     Cianfarani S Low birth weight and IGF system, Physiology and clinical implications. Rivista di Clinica Dietologica 27, 89-92, 1999.   50. Puglianiello A, Germani D, Rossi P and Cianfarani S Insulin-like growth factor-I (IGF-I) stimulates chemotaxis of human neuroblasts. Involvement of type I IGF receptor, insulin-like growth factor binding proteins (IGFBPs), phosphatidylinositol (PI)-3 kinase pathway and plasmin system.  Journal of Endocrinology 165, 123-131, 2000.    51. Rossi L., Branca F. and Cianfarani S. Collagen cross-links and early postnatal growth in newborns with intrauterine growth retardation. Metabolism 49, 1467-1472, 2000.    52. Elias LLK, Huebner A, Metherell LA, Canas A, Warne GL, Manca Bitti ML, Cianfarani S, Clayton PE, Savage MO, Clark AJL. Tall stature in familial glucocorticoid deficiency. Clinical Endocrinology 53, 423-430, 2000.    53. Cianfarani S, Bonfanti R, Manca Bitti ML, Germani D, Boemi S, Chiumello G, Boscherini B.   Growth and Insulin-like Growth Factors (IGFs) in Children with Insulin- Dependent Diabetes Mellitus (IDDM) at Onset of Disease. Evidence for Normal Growth, Age Dependency of  the IGF System Alterations and Presence of a Small (18 kDa) IGFBP-3 Fragment in Serum. Journal of Clinical Endocrinology and Metabolism 85, 4162-4167, 2000.    54. Cianfarani S, Geremia C, Germani D, Scirè G, Maiorana A, Boemi S.  Insulin resistance and insulin-like growth factors (IGFs) in children with intrauterine growth retardation (IUGR). Is catch-up growth a risk factor? Hormone Research 55 (Suppl.1) 7-10, 2001.    55. Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F.  Reduced growth and skeletal changes in zinc deficient growing rats are the consequences of impaired growth plate activity and of zinc depletion-induced inanition.  Journal of Nutrition 131, 1142-1146, 2001.   56 Tadin M, Braverman E, Cianfarani S, Sobrino AJ,m Levy B, Christiano AM, Warburton D. Complex cytogenetic rearrrangement of chromosome 8q in a case of Ambras syndrome.  American Journal of Medical Genetics 102, 100-104, 2001.    57. Branca F, Spagnoli A, Cianfarani S, Spadoni GL, Golden MHN, Boscherini B, Valtuena S,  Robins SP. Urinary excretion of pyridinium cross-links in short children treated with growth hormone. Journal of Pediatric Endocrinology and Metabolism 15, 27-34, 2002.    58 Cianfarani S, Geremia C, Scott CD, Germani D. Growth, Insulin-like growth factor (IGF) system and cortisol in children with intrauterine growth retardation (IUGR). Is catch-up growth affected by reprogramming of the hypothalamic-pituitary-adrenal axis (HPAA)? Pediatric Research 51, 94-99, 2002.    59 Cianfarani S, Tondinelli T, Spadoni GL, Scirè G, Boemi S, Boscherini B. Height Velocity and IGF-I Assessment in the Diagnosis of Childhood Onset GH Insufficiency. Do we still need a Second GH Stimulation Test? Clinical Endocrinology 57, 161-167, 2002.    60 Cianfarani S.  Foetal origin of adult diseases: just a matter of stem cell number? Medical Hypotheses 61:401-404, 2003.    61 Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood Glucose Concentrations are Reduced in Children Born Small for Gestational Age (SGA) and TSH Levels are Increased in SGA with Blunted Postnatal Catch-up Growth.  Journal of Clinical Endocrinology and Metabolism 88, 2699-2705, 2003.    62 Cianfarani S., Martinez C, Maiorana A, Scirè G, Spadoni G.L., Boemi S. Adiponectin Levels Are Reduced in Children Born Small for Gestational Age (SGA) and are Inversely Related to Postnatal Catch-up Growth.  Journal of Clinical Endocrinology and Metabolism 89: 1346-1351, 2004.    63 Scommegna S., Galeazzi D., Picone S., Farinelli E., Agostino R., Bozzao A., Boscherini B, Cianfarani S. Neonatal Identification of Pituitary Aplasia:a Life-Saving Diagnosis. Review of Five Cases.  Hormone Research 62, 10-16, 2004.    64 Geremia C, Cianfarani S. Insulin sensitivity in children born small for gestational age (SGA) Review of Diabetic Sciences 1, 58-65, 2004.    65     Cianfarani S. La pubertà precoce. Medico e Bambino 23, 485-491, 2004.   66   Torre P, Bertoli M, Di Giovanni S, Scommegna S., Conte C, Novelli G, Cianfarani S. Endocrine and Neuropsychological Assessment in a Child with a Novel Mutation of Thyroid Hormone Receptor. Response to 12-months Triiodothyroacetic Acid (TRIAC) Therapy. Journal of Endocrinological Investigation 28, 657-662, 2005.  67 Cianfarani S, Liguori A, Germani D. IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency. Endocrine Development 9, 66-75, 2005    68 Cianfarani S.  Il ruolo dei fattori di crescita GH-dipendenti nella diagnosi del deficit di GH. Area Pediatrica 4, 44-48, 2005.   69 Cianfarani S., Puglianiello A, Germani D. Central reprogramming in intrauterine growth retardation. Minerva Pediatrica 57(Suppl.1 N3):71-73, 2005.   70 Cianfarani S., Liguori A., Boemi S., Maghnie M, Iughetti L., Wasniewska M., Street M.E., Zucchini S., Aimaretti G.,  Grmani D. Inaccuracy of IGFBP-3 Assessment in the Diagnosis of Growth Hormone Deficiency (GHD) from Childhood to Young Adulthood: Association to Low GH-Dependency of IGF-II and Presence of Circulating IGFBP-3 18 kD Fragment. Journal of Clinical Endocrinological and Metabolism, 90, 6028-6034, 2005.    71 Cianfarani S, Ladaki C, Geremia C. Hormonal regulation of post-natal growth in SGA children Hormone  Research 65 (Suppl. 3): 70-74, 2006.    72 Cianfarani S, Liguori A. Sensibility and Specificity of Growth Factors in GH Deficiency. Journal of Endocrinological Investigation, 29 (Suppl.), 71-75, 2006.    73. Geremia C, Cianfarani S. Laboratory Tests and Measurements in Children Born  Small for Gestational Age (SGA) Clinica Chimica Acta 364, 113-123, 2006.  74 Puglianiello A and Cianfarani S Central control of glucose metabolism The Review of Diabetic Studies 3, 54-60, 2006.    75 Kelberman D, Rizzoti K, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JMW, Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson  ICAF, Dattani MT  Mutations within Sox2/SOX2 are Associated with Hypopituitarism in Mouse and Humans.  Journal of Clinical Investigation 116, 2442-2455, 2006.    76 Scirè G, D’Anella G, Cristofori L, Mazzuca V, and Cianfarani S Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia. Journal of Cardiovascular Medicine 8(6):465-7, 2007   77. Federico G., Street M.E., Maghnie M., Caruso-Nicoletti M., Loche S., Bertelloni S., and Cianfarani S. Assessment of circulating levels of insulin-like growth factors in the diagnosis diagnosis of isolated childhood-onset isolated growth hormone deficiency. A proposal of the Italian Society for Pediatric Endocrinology and Diabetes. Journal of Endocrinological Investigation 29:732-737, 2006.    78. Ghirri P, Ladaki C, Bartoli A, Scirè G, Vuerich M, Spadoni GL, Maiorana M, Geremia C, Boldrini A , and Cianfarani S. Low Birth Weight for Gestational Age Associates with Reduced Glucose Concentrations at Birth, Infancy and Childhood. Hormone Research 67:123–131, 2007.     79. Clayton PE,  Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A Management of the Child Born Small for Gestational Age Child (SGA) through to Adulthood: A Consensus Statement of the International Societies of Paediatric Endocrinology and the Growth Hormone Research Society. Journal of Clinical Endocrinology and Metabolism 92, 804-810, 2007.    80. Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia Tomba and Stefano Cianfarani. Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR).  Pediatric Research 61:433-437, 2007.    81. Zucchini S, Wasniewska M,  Cisternino M, Salerno M,  Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S. Adult height in children with short stature and idiopathic delayed puberty after different management. European Journal  of Pediatrics 167, 677-681, 2008    82. Cianfarani S. Endocrine-metabolic follow-up of the small for gestational age (SGA) infant. Minerva Pediatrica 59, 545-546, 2007   83. Cianfarani S, Geremia C, Puglianiello A, Mairana A, Germani D. Late Effects of Disturbed IGF Signaling in Congenital Diseases. Endocrine Development 11, 16-27, 2007.    84. Maiorana A, Del Bianco C, and Cianfarani S. Adipose Tissue: a Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA). The Review of Diabetic Studies, 4, 131-143, 2007.    85. Scirè G, Del Bianco C, Spadoni GL, and Cianfarani S Growth hormone (GH) therapy does not alter the IGF-I/IGFBP-3 molar ratio in GH deficient children.  Journal of Endocrinological Investigation 31(2):153-8, 2008.    86. Torre P, Ladaki C, Scirè G, Spadoni GL, and Cianfarani S.  Catch-up growth in body mass index (BMI) is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for gestational age (SGA).  Journal of Endocrinological Investigation 31(9):760-4, 2008.    87. Germani D, Puglianiello A and Cianfarani S. Uteroplacental Insufficiency Down Regulates Insulin Receptor and Affects Expression of Key Enzymes of Long-chain Fatty Acid (LCFA) Metabolism in Skeletal Muscle at Birth. Cardiovascular Diabetology, 7:14, 2008.    88. Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin Cassidy, and Francesco Branca on behalf of the PHYTOS Investigators Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study1. Americal Journal of Clinical Nutrition 87:761–70, 2008.    89. Katherine A. Fantauzzo, Marija Tadin-Strapps, Yun You, Sarah E. Mentzer, Friedrich A.M. Baumeister, Stefano Cianfarani, Lionel Van Maldergem, Dorothy Warburton, John P. Sundberg and Angela M. Christiano.  A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice.  Human Molecular Genetics 17(22):3539-51, 2008     90. P Cohen, AD Rogol, CL Deal, P Saenger, EO Reiter, JL Ross, SD Chernausek, MO Savage, JM Wit on behalf of the 2007 ISS Consensus Workshop participants* Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop. Journal of Clinical Endocrinology and Metabolism  93(11):4210-4217. 2008.    91. Liguori A, Cianfarani S Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report Journal of Medical Case Reports 2009; 3:7300 doi: 10.1186/1752-1947-3-7300   92 Pedicelli S, Peschiaroli E, Violi E, and Cianfarani S. Controversies in the definition and treatment of idiopathic short stature (ISS). Journal of Clinical Research in Pediatric Endocrinology. 2009; 1(3):105-115    93. Puglianiello A, Germani D, and Cianfarani S.  Exposure to uteroplacental insufficiency reduces the expression of signal transducer and activator of transcription 3 (STAT3) and proopiomelanocortin (POMC) in the hypothalamus of newborn rats. Pediatric Research 66:208-211, 2009    94. Maiorana A, Fierabracci A and Cianfarani S Isolation and characterization of omental adipose progenitor  cells in children: a potential tool to unravel the pathogenesis of  metabolic syndrome. Hormone Research 2009;72:348–358    95. Maiorana A, Cianfarani S Impact of Growth Hormone Therapy on Adult Height of Children Born Small for Gestational Age: A Systematic Review of Randomized Controlled Trials. Pediatrics, 124, E519-E531, 2009.     96. Spadoni and Cianfarani S Bone age assessment in the work up of children with endocrine disorders Hormone Research in Paediatrics Vol. 73, No. 1,  pp 2 - 5 , 2010     97. Giacomozzi C, Gullotta F, Federico G, Colapietro I, Nardone, AM,  and Cianfarani S, Premature Ovarian Failure associated to the Absence of Pubic and Axillary Hair in a de novo Translocation X;15 (q24;q26.3). American Journal of Medical Genetics 2010 May;152A(5):1305-9.    98. Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L, Germani D, Boldrini A,  and Cianfarani S. Retinol-binding protein 4 in neonates born small for gestational age. Journal of Endocrinological Investigation 2010 Apr;33(4):218-21.    99. Nobili V, Cianfarani S, Agostoni C. Programming, metabolic syndrome, and NAFLD: the challenge of transforming a vicious into a virtuous cycle. Journal of Hepatology 2010 Jun;52(6):788-90.    100. Federico G, Cianfarani S Usefulness of serum insulin-like growth factor-I (IGF-I) assessment in the diagnosis of childhood-onset GH deficiency. Hormone Research in Paediatrics 74, 145-148, 2010    101.   Giacomozzi C, Savage MO and Cianfarani S Deficit primario di IGF-I. Implicazioni diagnostico-terapeutiche. Il Pediatra giugno, 26-39. 2010   102 Bertelloni S, Garofalo P, and Cianfarani S. Il ritardo dello sviluppo puberale maschile: trattamento con androgeni. Rivista Italiana di Medicina dell’Adolescenza 8, 5-10,2010   103. Bertelloni S, Garofalo P, and Cianfarani S. The role of androgen therapy in hypogonadal adolescent males Homone Research in Paediatrics 74, 292-296, 2010   104. Cianfarani S Grand Challenges in Pediatric Endocrinology Frontiers in Pediatric Endocrinology doi:10.3389/fendo.2010.00001    105. Deodati A, Peschiaroli E, Cianfarani S. Conseguenze endocrine e metaboliche del bambino nato SGA. Rivista Italiana di Medicina dell’Adolescenza  3, Suppl. 8  1-6, ,2010   106. Liguori A, Puglianiello A, Germani D, Deodati A, Peschiaroli E and Cianfarani S, Epigenetic changes predisposing to type 2 diabetes in intrauterine growth      retardation. Frontiers in Pediatric Endocrinology doi: 10.3389/fendo.2010.00005   107. Deodati A and Cianfarani S. Impact of Growth Hormone Therapy on Adult Height of Children with Idiopathic Short Stature: A Systematic Review of Randomized and non-Randomized Controlled Trials. British Medical Journal, 2011 Mar 11;342:c7157.    108. Zanni G, Barresi S,  Travaglini L,  Bernardini L, Digilio MC, Mercuri E,  Cianfarani S, Ferraris A,  Masotti A, Novelli A, Valente EM, Dallapiccola B, Bertini ES FGF17, a gene involved in cerebellar development is downregulated in a patient with Dandy-Walker Malformation carrying a de novo 8p deletion. Neurogenetics 2011;12(3):241-5   109. Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P, Cianfarani S.  Il deficit di GH nel periodo di transizione (GH deficiency in the transition phase). Il Pediatra 2011, giugno, 48-54   110. C. Giacomozzi, G. L. Spadoni, S. Pedicelli, G. Scirè, L. Cristofori, E. Peschiaroli, A. Deodati, P. Cambiaso, M. Cappa and S. Cianfarani. Responses to GHRH plus Arginine Test are More Concordant with IGF-I Circulating Levels than responses to Arginine and Clonidine Provocative Tests. Journal of Endocrinological Investigation, Sep;35(8):742-, 2012.    111. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger. Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice Pediatric Endocrinology Reviews, Dec;9(2):554-65, 2011   112. Deodati A, Peschiaroli E, and Cianfarani S.  Review of Growth Hormone Randomized Controlled Trials in Children with Idiopathic Short Stature. Hormone Research in Paediatrics 76 (Suppl. 3):40B-42 (DOI: 10.1159/000330157), 2011   113. Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S, Nobili V, Pietrobelli A, Agostoni C. Epigenetic mechanisms elicited by nutrition  in early life.  Nutr Res Rev. Dec;24(2):198-205, 2011   114. Cianfarani S. Chairman's summary: Diagnostic techniques for identifying children with idiopathic short stature.  Horm Res Paediatr. 76 Suppl 3:16.Epub 2011 Sep 7, 2011.    115. Cohen A, Lala R, Ravaglia A, Bernasconi S, Boscherini B, Cianfarani S, Pocecco M, Maghnie M, Panei P  Modifiche della prescrizione dell’ormone della crescita. Una proposta dell’ACP. QUADERNI ACP, vol. 18, p. 42-44, 2011   116. Alisi A, Cianfarani S, Manco M, Agostoni C, Nobili V. Nonalcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment. Annals of Medicine, Feb;44(1):29-40 2012   117. S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli Effect of Intrauterine Growth Retardation on Liver and Long-Term Metabolic Risk. International Journal of Obesity. Oct;36(10):1270-7, 2012.   118. G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, and S. Cianfarani. Serum insulin-like growth factor-I (igf-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients.  Growth Hormone and IGF Research, 22:134-138, 2012.    119. Nobili V, Bedogni G, Berni Canani R, Brambilla P, Cianfarani S, Pietrobelli A, Agostoni C The Hepato-Metabolic Syndrome In Children: A Distinct Phenotype With High Metabolic Risk? Pediatric Obesity Dec;7(6):e75-80, 2012.   120. Cianfarani S  Long-term safety of growth hormone therapy: still a controversial issue.  Frontiers in endocrinology, vol. 3, p. 1-2, 2012. doi: 10.3389/fendo.2012.00115   121. Cianfarani S   Insulin-like growth factor-II (IGF-II): new roles for an old actor.  Frontiers in endocrinology, vol.3, 1-4, 2012, doi: 10.3389/fendo. 2012.00118   122. Benevento D, Bizzarri C, Patera IP, Ravà L, Schiaffini R, Ciampalini P, Cianfarani S, Cappa M.  Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D) .  Diabetes/metabolism research and reviews Jan;29(1):60-5, 2013   123. Inzaghi E and Cianfarani S  The challenge of growth hormone deficiency (GHD) diagnosis and treatment during the transition from puberty into adulthood.  Frontiers in Endocrinology 4:34. doi: 10.3389/fendo.2013.00034, 2013   124. Wit JM, Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristrom B, Schoenau E, Audi L, Hokken-Koelega AC, Bang P, Jung H,Blum WF, Silverman LA, Cohen P, Cianfarani S, Deal C, Clayton PE, de Graaff L, Dahlgren J, Kleintjens J, Roelants M. Personalized approach to growth hormone treatment: clinical use of growth prediction models. Hormone Research in Paediatrics 79(5):257-70, 2013   125. Deodati A, Inzaghi E, Liguori A, Puglianiello A, Germani D, Brufani C, Fintini D, Cappa M, Barbetti F, Cianfarani S IGF2 Methylation Is Associated with Lipid Profile in Obese Children. Hormone Research in Paediatrics Jun 14:361-367, 2013   126. Bizzarri C, Benevento D, Patera IP, Bongiovanni M, Boiani A, Cianfarani S, Cappa M Residual beta-cell mass influences growth of pre-pubertal children with type 1 diabetes. Hormone Research in Paediatrics 80(4):287-92, 2013    127. Bizzarri C, Spadoni GL, Bottaro G, Monatanari G, Giannone G, Cappa M, Cianfarani S.  The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life. Journal of Clinical Endocrinology and Metabolism 99(2):433-9, 2014.   128. Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi, and Stefano Cianfarani. Vitamin D levels and liver histological alterations in children with non-alcoholic fatty liver disease (NAFLD). European Journal of Endocrinology 170(4):547-53, 2014.   129. Boscherini B and Cianfarani S. Considerazioni sulla diagnosi di deficienza idiopatica isolata di ormone della crescita Quaderni ACP 21(1): 31-32, 2014.   130. Cafiero G, Fintini D, Brufani C, Fiori R, Giordano U, Turchetta A, Deodati A, Cappa M and Cianfarani S Cardiovascular fitness is impaired in children that are born small for their gestational age. Acta Paediatrica 103(5):e219-21, 2014   131. Stefano Cianfarani, Elena Inzaghi, Anna Alisi, Daniela Germani, Antonella Puglianiello, V alerio Nobili. Insulin-like Growth Factor–I and –II Levels are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children. Journal of Pediatrics 165(1):92-8, 2014.   132. Annalisa Deodati, Barbara Baldini Ferroli and Stefano Cianfarani. Association between Growth Hormone Therapy and Mortality, Cancer and Cardiovascular Risk: Systematic Review and Meta-Analysis. Growth Hormone and IGF Research 24:105-111, 2014.    133. Elena Inzaghi, Stefano Cianfarani, Valerio Nobili. Insulin-Like Growth Factors (IGF-I And –II): New Actors in the Development of Non-Alcoholic Fatty Liver Disease. Expert Reviews of Endocrinology and Metabolism 9:193-195, 2014.    134. S. Cianfarani Is High Dose Growth Hormone Treatment During Puberty Worthwhile? Hormone Research in Paediatrics, 82(3):143-4, 2014   135. Cianfarani S Editorial Hormone Research in Paediatrics 81:1, 2014   136.     Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M and Cianfarani S. Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus.  Growth Hormone and IGF Research, 24(6):256-9, 2014.   137. Carla Bizzarri, Stefania Pedicelli, Brunetto Boscherini, Giorgio Bedogni, Marco Cappa and Stefano Cianfarani Early retesting by GHRH + arginine test shows normal GH response in most children with idiopathic GH deficiency. Journal of Endocrinological Investigation, Apr;38(4):429-36, 2015   138. Stefania Pedicelli, Paola Alessio, Giuseppe Scirè, Marco Cappa, and Stefano Cianfarani. Routine Screening by Brain Magnetic Resonance Imaging Is Not Indicated in Every Girl With Onset of Puberty Between the Ages of Six and Eight Years. Journal of Clinical Endocrinology and Metabolism, 99(12):4455-61, 2014.   139. V. Pampanini,  A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F. Dini, P.Ghirri, and S. Cianfarani Preterm Infants with Severe Extrauterine Growth Retardation (EUGR) Are at High Risk of Growth Impairment during Childhood. European Journal of Pediatrics, 174(1):33-41, 2015.   140. C. Giacomozzi,  A. Deodati, M.G. Shaikh, S.F. Ahmed, and S. Cianfarani. The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: a systematic review. Hormone Research in Paediatrics, 83(3):167-76, 2015.   141. D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S. Cianfarani, A. Crinò Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader–Willi Syndrome (PWS). Pediatric Obesity 11(3):235-8, 2016   142 Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC. Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone. Hormone Research in Paediatrics, 84, 172-183, 2015.   143. Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, and Cianfarani S. Brain Magnetic Resonance Imaging as First-Line Investigation for Growth Hormone Deficiency Diagnosis in Early Childhood. Hormone Research in Paediatrics, 84(5):323-30, 2015.   144. D B Allen, P Backeljauw, M Bidlingmaier, BMK Biller, M Boguszewski , P Burman, G Butler, K Chihara, J Christiansen, S Cianfarani, P Clayton, D Clemmons, P Cohen, F Darendeliler, C Deal, D Dunger, E M Erfurth, J S Fuqua, A Grimberg, M Haymond, C Higham, K Ho, A R Hoffman, A Hokken-Koelega, G Johannsson, A Juul, J Kopchick, P Lee, M Pollak, S Radovick, L Robison, R Rosenfeld, R J Ross, L Savendahl, P Saenger, H Toft Sorensen, K Stochholm, C Strasburger, A Swerdlow, M Thorner. Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults. Eur J Endocrinol. 174(2):P1-9, 2016.    145. Schiaffini R, Liccardo D, Alisi A, Benevento D, Cappa M, Cianfarani S, Nobili V Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor? Hormone Research in Paediatrics 85(1):29-34, 2016.   146. Brambilla P, Bedogni G, Pietrobelli A, Cianfarani S , Agostoni C.  Predictors of blood pressure at 7-13 years: The “new Millennium Baby” study.  Nutrition, Metabolism and Cardiovascular Diseases. 26(8):706-12, 2016   147. Deodati A, Sallemi A, Maranghi , Germani D, Puglianiello A, Baldari F, Busani L, Mancini FR, Tassinari R, Mantovani A, Cianfarani S Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche. Hormone research in Paediatrics 86(4):233-239, 2016.    148. Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW. Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders. Hormone Research in Paediatrics 85(5):325-32, 2016   149. Fischer-Posovszky P, Roos J, Kotnik P, Battelino T, Inzaghi E, Nobili V, Cianfarani S, Wabitsch M. Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact. Hormone research in Paediatrics 86(1):3-10, 2016.   150. M. Cappa, L. Iughetti, S. Loche, M. Maghnie, A. Vottero. GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study. Journal of Endcorinological Investigation 39:667–677, 2016   151. Cambiaso P, Bottaro G, Cianfarani S, Tomà P, de Vito R, Cappa M. An Incidental Finding of Bilateral Adrenal Lymphoma The American Journal of Medical Sciences 52(1):80. doi: 10.1016/j.amjms.2016.02.018., 2016.   152. Bizzari C, Pedicelli S, Cappa M, Cianfarani S. Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects. Hormone Research in Paediatrics 86(3):143-153., 2016.   153. Deodati A, Cianfarani S. Trattamento con ormone della crescita in bambini nati piccoli per l’età gestazionale L’Endocrinologo 17(4):183-187, 2016   154.   Cianfarani S, Soder O. Endocrine disruptors and child health. New insights. Hormone Research in Paediatrics Sep 16;86(4), 2016   155. Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, Overi D, Mosca A, Stronati L, Cucchiara S, Raponi M, Gaudio E, Byrne CD, Nobili V. Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial. PLoS One. 2016 Dec 15;11(12):e0168216. doi: 10.1371/journal.pone.0168216.   156. Pampanini V, Germani D, Puglianiello A, Stukenborg JB, Reda A, Savchuk I, Kjartansdóttir KR, Cianfarani S, Soder O. Impact of uteroplacental insufficiency on postnatal rat male gonad. Journal of Endocrinology Feb;232(2):247-257, 2017.   157. Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega AC, Khan AJ, Kiess W, Kuehni CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L, Zandwijken GR. Cancer risks in patients treated with growth hormone in childhood: the SAGHE European cohort study.  Journal of Clinical Endocrinology and Metabolism 102:1661–1672, 2017.   158. Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano Cianfarani Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children. Hormone research in Paediatrics 87:400–404, 2017.   159. Francesca Santilli, Paola G. Simeone, Maria T. Guagnano, Marika Leo, Marica T. Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C. Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro and Agostino Consoli. Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects with Prediabetes or Early Type 2 Diabetes. Diabetes Care 2017 Nov;40(11):1556-1564   160 Deodati A, Cianfarani S. The rationale for growth hormone therapy in children with short stature. Journal of Clinical Research in Pediatric Endocrinology Dec 30;9(Suppl 2):23-32, 2017.   161 S. Brandt, J. Roos, E. Inzaghi, P. Kotnik, J. Kovac, T. Battelino, S. Cianfarani,  V. Nobili, M. Colajacomo, W. Kratzer, C. Denzer, P. Fischer-Posovszky and M. Wabitsch Circulating levels of miR-122 and nonalcoholic fatty liver disease in pre-pubertal obese children. Pediatric Obesity 13(3):175-182, 2018.   162 Pampanini V, Inzaghi E, Germani D, Alterio A, Puglianiello A, Alisi A, Nobili V and Cianfarani S Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic  Fatty Liver Disease. Nutrition, Metabolism & Cardiovascular Diseases  Jan;28(1):71-76, 2018.   163 Bizzarri C, Timpanaro TA, Matteoli MC, Patera IP, Cappa M, Cianfarani S. Growth trajectory in children with type 1 diabetes mellitus: the impact of insulin treatment and metabolic control. Hormone Research in Paediatrics. 89(3):172-177, 2018   164 Cinzia La Rocca, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Francesca Baldi, Giorgia Bottaro, Emma Buzzigoli, Fabrizia Carli, Stefano Cianfarani, Raffaele Conte, Annalisa Deodati, Amalia Gastaldelli, Anna Paola Pala, Andrea Raffaelli, Chiara Saponaro, Giuseppe Scirè, Gian Luigi Spadon, Luca Busani, the LIFE PERSUADED Project Group. The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases. Environmental Science and Pollution Research, Jul 4. doi: 10.1007/s11356-018-2660-4, 2018.   165 Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani   The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. PLOS ONE Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490., 2018   166 Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati, Valerio Nobili, Stefano Cianfarani Expression of insulin-like growth factor I and its receptor in the liver of children   with biopsy- proven NAFLD. PLOS ONE Jul 31;13(7):e0201566. 2018   167 Marzano F, Faienza MF, Caratozzolo MF, Brunetti G, Chiara M, Horner DS, Annese A, D'Erchia AM, Consiglio A, Pesole G, Sbisà E, Inzaghi E, Cianfarani S, Tullo A. Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. Pediatric Obesity Dec;13(12):803-811. 2018   168 Inzaghi E, Reiter E, Cianfarani S.  The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy.  Hormone Research in Paediatrics, 92(2):71-83, 2019   169 Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S. GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice. Hormone Research in Paediatrics, 92(2):71-83, 2019   170 Cianfarani S Pediatric endocrinology in the time of COVID-19 pandemic Hormone Research in Paediatrics 92(6):345-346, 2019   171 Pampanini V, Jahnukainen K, Sahlin L, Germani D, Puglianiello A, Cianfarani S, Söder O Impact of uteroplacental insufficiency on ovarian follicular pool in the rat. Reproductive Biology and Endocrinology, Jan 10;17(1):10, 2019   172 Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ. Risk of Meningioma in European Patients Treated with Growth Hormone in Childhood: Results from the SAGhE Cohort. Journal of Clinical Endocrinology and Metabolism, Mar 1;104(3):658-664, 2019.   173 Spreghini N, Cianfarani S, Spreghini MR, Brufani C, Morino GS, Inzaghi E, Convertino A, Fintini D, Manco M. Oral glucose effectiveness and metabolic risk in obese children and adolescents Acta Diabetologica, Aug;56(8):955-962, 2019   174 Centonze C, Guzzetti C, Orlando G, Loche S; Italian ECOS Investigators. Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) Journal of Endocrinological Investigation, Oct;42(10):1241-1244, 2019.   175 Bizzarri C, Pedicelli S, Romanzo A, Bocchini S, Bottaro G, Cianfarani S, Cappa M. The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study. Italian Journal of Pediatrics Apr 27;45(1):52, 2019.   176 Cianfarani S Risk of cancer in patients treated with recombinant human growth hormone in childhood. Annals of Pediatric Endocrinology and Metabolism, Jun;24(2):92-98, 2019   177 Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G. Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non- alcoholic fatty liver disease. Journal of Hepatology, Oct;71(4):802-810, 2019.   178 Inzaghi E, Kistner A, Germani D, Deodati A, Vanpee M, Legnevall L, Berinder K, Cianfarani S. A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood. PloS One, Jan 24;15(1):e0228075, 2020   179 Deodati A, Inzaghi E, Cianfarani S. Epigenetics and In Utero Acquired Predisposition to Metabolic Disease. Frontiers in Genetics, Jan 29;10:127, 2020.   180 Tassinari R, Narciso L, Tait S, Busani L, Martinelli A, Di Virgilio A, Carli F, Deodati A, La Rocca C, Maranghi F; LIFE PERSUADED Project Group. Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived from Italian Children Biomonitoring Study. Toxicological Sciences, Feb 1;173(2):387-401, 2020   181 Tait S, Carli F, Busani L, Buzzigoli E, Della Latta V, Deodati A, Fabbrizi E, Gaggini M, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C; LIFE PERSUADED Project Group. Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project. Environmental Research, Jun;185:109428, 2020   182 Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, Manco M. The bones of children with obesity. Frontiers in Endocrinology, Apr 24;11:200, 2020.   183 Schiaffini R, Barbetti F, Rapini N, Inzaghi E, Deodati A, Patera IP, Matteoli MC, Ciampalini P, Carducci C, Lorubbio A, Schiaffini G, Cianfarani S. School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology. Diabetes Research in Clinical Practice, Aug;166:108302, 2020.   184 Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken- Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ. Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study. Lancet diabetes and Endocrinology, Aug;8(8):683-692, 2020   185 Amodeo ME, Inzaghi E, Deodati A, Cianfarani S. Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype. Mol Genet Genomic Med.May 31;e1644.  doi: 10.1002/mgg3.16, 2021.   186 Petrelli A, Ravà L, Mascali A, Rapini N, Massoud M, Manca Bitti ML, Cianfarani S, Manco M. Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D Diabetes Metab Res Rev. Jun 2:e3479, 2021.   187 Inzaghi E, Deodati A, Loddo S, Mucciolo M, Verdecchia F, Sallicandro E, Catino G, Cappa M, Novelli A, Cianfarani S. Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype J Endocrinol Invest. Jan;45(1):79-87, 2022   188 Cianfarani S, Pampanini V The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic Horm Res Paediatr. Jul 14:345-349, 2021    189 Giglione E, Lapolla R, Cianfarani S, Faienza MF, Fintini D, Weber G, Delvecchio M, Valerio G. Linear growth and puberty in childhood obesity: what is new? Minerva Pediatr (Torino). Dec;73(6):563-571, 2021.   190 Carducci C, Rapini N, Deodati A, Pampanini V, Cianfarani S, Schiaffini R. Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic. Ital J Pediatr. Aug 26;47(1):176, 2021.   191 Tait S, Carli F, Busani L, Ciociaro D, Della Latta V, Deodati A, Fabbrizi E, Pala AP, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C, Life Persuaded Project Group. Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project. Int J Environ Res Public Health. Nov 12;18(22):11846, 2021.   192 Stefano Cianfarani. Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance Frontiers in Endocrinology, Dec 24;12:811846, 2021.   193 Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D, Matarazzo P, Baronio F, Crocco M, Giudica G, Partenope C, Nardini B, Ubertini G, Menardi R, Guzzetti C, Iughetti L, Aversa T, Di Mase R, Cassio A, Cianfarani S, Maghnie M, Tuli G, Loche S, Bruzzi P, Wasniewska M, Salerno M, Rutigliano I, Iezzi ML, Cherubini V, Grandone A, Faienza M, Tumini S, Baldoli C, Consales A, Genitori L, Marras CE, MIlanaccio C, Mortini P, Vindigni M, Zenga F, Zucchelli M; Physiopathology of Growth Processes; Puberty Study Group of the Italian Society for Pediatric Endocrinology and Diabetology. Management of Childhood-onset Craniopharyngioma in Italy: A Multicenter, 7-Year Follow-up Study of 145 Patients J Clin Endocrinol Metab. Feb 17;107(3):e1020-e1031, 2022.   194 Stefania Pedicelli, Danilo Fintini, Lucilla Ravà, Elena Inzaghi, Annalisa Deodati, Maria Rita Spreghini, Carla Bizzarri, Michela Mariani, Stefano Cianfarani, Marco Cappa, Melania Manco,   Prevalence of prediabetes in children and adolescents by class of obesity. Pediatr Obes. Feb 10;e12900, 2022   195 Giorgia Sforza, Annalisa Deodati, Romina Moavero, Laura Papetti, Ilaria Frattale,Federico Vigevano, Stefano Cianfarani, Massimiliano Valeriani.  Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report. Frontiers in Neurology, Jan 10;12:818638, 2022   196 Arianna Petrelli, Lucilla Ravà, Alberto Mascali, Novella Rapini, Michela Massoud, Maria Luisa Manca Bitti, Stefano Cianfarani, Melania Manco.  Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D. Diabetes Metab Res Rev., Jan;38(1):e3479, 2022   197 Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G Nichols, Stefano Cianfarani. Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2. Horm Res Paediatr. Jan 7. doi: 10.1159/000521858, 2022.   198 Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani.  Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe Postnatal Growth Failure. Horm Res Paediatr, Jan 27;1-11. doi: 10.1159/000521629, 2022   199 Schiaffini R, Deodati A, Nicoletti MC, Carducci C, Ciampalini P, Lorubbio A, Matteoli MC, Pampanini V, Patera IP, Rapini N, Cianfarani S. Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study. Acta Diabetologica 59:959-964, 2022   200 Inzaghi E, Pampanini V, Deodati A and Cianfarani S The effects of nutrition on linear growth Nutrients 14(9):1752, 2022   201 Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L Touraine P, van Santen HM, Johannsson G. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement. European Journal of Endocrinology, 186(6):P35-P52, 2022   202 Pampanini V, Deodati A, Inzaghi E, Cianfarani S. Long-acting growth hormone preparations and their use in children with growth hormone deficiency. Hormone Research in Paediatrics Feb 25.  doi: 10.1159/000523791, 2022   203 Barbetti F, Rapini N, Schiaffini R, Bizzarri C, Cianfarani S. The application of precision medicine in monogenic diabetes. Expert Rev Endocrinol Metab. Mar;17(2):111-129, 2022   204 Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium. INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z.   205 Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti. Monogenic diabetes clinic (MDC): 3‐year experience Acta Diabetologica Sep 30.  doi: 10.1007/s 00592-022-01972-2, 2022    206 Del Chierico F, Conta G, Matteoli MC, Fierabracci A, Reddel S, Macari G, Gardini S, Guarrasi V, Levi Mortera S, Marzano V, Vernocchi P, Sciubba F, Marini F, Deodati A, Rapini N, Cianfarani S, Miccheli A, Putignani L Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset. Int J Mol Sci. Sep 6;23(18):10256, 2022   207 Carli F, Tait S, Busani L, Ciociaro D, Della Latta V, Pala AP, Deodati A, Raffaelli A, Pratesi F, Conte R, Maranghi F, Tassinari R, Fabbrizi E, Toffol G, Cianfarani S, La Rocca C, Gastaldelli A, Life Persuaded Project Group. Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project. Int J Mol Sci. Dec 16;23(24):16012. 2022   208 Levi Mortera S, Marzano V, Vernocchi P, Matteoli MC, Guarrasi V, Gardini S, Del Chierico F, Rapini N, Deodati A, Fierabracci A, Cianfarani S, Putignani L Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study. Int J Mol Sci. 2022 Dec 15;23(24):15982. 2022   209 Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L. Pathophysiology of Type 1 Diabetes and Gut Microbiota Role Int J Mol Sci. Nov 24;23(23):14650. 2022     210 Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, et al.  International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood. Endocrine Reviews, 2023, 00, 1–27 https://doi.org/10.1210/endrev/bnad002   211 Pezzino G, Ruta R, Rapini N, Chiodo DC, Mucciolo M, Tomaselli L, Cianfarani S, Barbetti F. A rare cause of transient neonatal diabetes mellitus: Spontaneous HNF1B splice variant. Diabet Med. 2024 Feb;41(2):e15202. doi: 10.1111/dme.15202.   212 Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A.  Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071.   213 Ravà L, Fintini D, Mariani M, Deodati A, Inzaghi E, Pedicelli S, Bizzarri C, Cappa M, Cianfarani S, Manco M. High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk. J Endocrinol Invest. 2023 Dec;46(12):2555-2562. doi: 10.1007/s40618-023-02111-6.   214 Aureli A, Recupero R, Mariani M, Manco M, Carlomagno F, Bocchini S, Nicodemo M, Marchili MR, Cianfarani S, Cappa M, Fintini D. Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity. Int J Mol Sci. 2023 Nov 22;24(23):16588. doi: 10.3390/ijms242316588   215 Deodati A, Bottaro G, Germani D, Carli F, Tait S, Busani L, Della Latta V, Pala AP, Maranghi F, Tassinari R, Gastaldelli A, La Rocca C, Cianfarani S.  Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in children with obesity: A case-control study. LIFE PERSUADED Project Group. Horm Res Paediatr. 2023 Nov 16. doi: 10.1159/000535305.   216 Franceschi R, Fintini D, Ravà L, Mariani M, Aureli A, Inzaghi E, Pedicelli S, Deodati A, Bizzarri C, Cappa M, Cianfarani S, Manco M. Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease. Int J Mol Sci. 2023 Oct 6;24(19):14963. doi: 10.3390/ijms241914963.   217 Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A, Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S, Andreani M, Porzio O, Palma P. Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children. Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751   218 Troncone A, Affuso G, Cascella C, Chianese A, Zanfardino A, Iafusco D; Diabetes Study Group of Italian Society of Paediatric Endocrinology and Diabetology. Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study. J Pediatr Psychol. 2023 Sep 20;48(9):731-739. doi: 10.1093/jpepsy/jsad016   219 Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium. Gene expression signature predicts rate of type 1 diabetes progression. EBioMedicine. 2023 Jun;92:104625. doi: 10.1016/j.ebiom.2023.104625   220 Cianfarani S, Battelino T. A critical review of upcoming new therapeutic options in paediatric endocrinology. Horm Res Paediatr. 2023 Apr 24. doi: 10.1159/000530824.   221 Rapini N, Delvecchio M, Mucciolo M, Ruta R, Rabbone I, Cherubini V, Zucchini S, Cianfarani S, Prandi E, Schiaffini R, Bizzarri C, Piccini B, Maltoni G, Predieri B, Minuto N, Di Paola R, Giordano M, Tinto N, Grasso V, Russo L, Tiberi V, Scaramuzza A, Frontino G, Maggio MC, Musolino G, Piccinno E, Tinti D, Carrera P, Mozzillo E, Cappa M, Iafusco D, Bonfanti R, Novelli A, Barbetti F; Diabetes Study Group of Italian Society for Pediatric Endocrinology and Diabetes (ISPED). The changing landscape of neonatal diabetes mellitus in Italy between 2003-2022. J Clin Endocrinol Metab Feb 26:dgae095. doi: 10.1210/clinem/dgae095, 2024.   222 Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes. Diabetes Metab Res Rev. Feb;40(2):e3777. doi: 10.1002/dmrr.3777, 2024.   223 Rapini N, Martino M, Arnaldi C, Deodati A, Anagnostopoulou L, Amodeo ME, Ciampalini P, Pampanini V, Lorubbio A, Tosini D, Cianfarani S, Schiaffini R. Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years. Front Endocrinol (Lausanne). May 21:15:1382920, 2024   224 Schiaffini R, Lumaca A, Martino M, Rapini N, Deodati A, Amodeo ME, Ciampalini P, Matteoli MC, Pampanini V, Cianfarani S. Time In Tight Range in children and adolescents with type 1 diabetes: A cross-sectional observational single centre study evaluating efficacy of new advanced technologies. Diabetes Metab Res Rev. Jul;40(5):e3826. 2024.               Letters     1. Cianfarani S., Spadoni G.L., Manca Bitti M.L., Boscherini B.  Growth hormone treatment and somatomedin C levels.  Journal of Pediatrics 105, 853, 1984   2. Scirè G., Cianfarani S., Spadoni G.L., Manca Bitti M.L., Fonte M.T., Boscherini B., Pasquino A.M., Bozzao L.  Primary empty sella and endocrinopathies in childhood: high prevalence among children with precocious puberty.  European  Journal of Pediatrics 147, 665, 1988.    3. Spadoni GL, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Boscherini B. How far should indications for growth hormone expand? Lancet 335, 1351, 1990.    4. Scirè G, Magliocca FM, Cianfarani S, Scalamandrè A, Petrozza Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency.  Journal of Pediatric Gastroenterology and Nutrition 13, 224-227, 1991.    5. Cianfarani S. Growth hormone therapy in Noonan syndrome. Journal of Pediatrics 134, 385-6, 1999.    6. Cianfarani S. Ambras syndrome or hypertrichosis universalis, does it really matter? Clinical Genetics 57, 158, 2000.    7. Cianfarani S, Bonfanti R, Manca Bitti ML, Chiumello G, Boscherini B. Growth and autoantibodies to IA-2 in children with type 1 diabetes.  Lancet 356, 1521, 2000.    8. Cianfarani S. Role of Hormones in Puberty Lancet 358, 1459, 2001.    9. Riccardo Schiaffini, Annalisa Deodati, Novella Rapini, Valentina Pampanini, Stefano Cianfarani Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center. Journal of Diabetes Aug 2.  doi: 10.1111/1753-0407.13298. 2022           Books    Boscherini B., Cianfarani S., Spadoni G.L., Mancuso G.  Il bambino con bassa statura.  Ed: Piccin, Padova, 1990.    Cianfarani S. Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita. Ed: Mediprint, Roma, 2007.       Textbook Chapters      C1 Boscherini B., Spadoni G.L., Cianfarani S. Le anomalie della crescita: eziologia e classificazione. In: Progressi nella Diagnosi e Terapia dei Disturbi dell'Accrescimento. A cura di E.E. Muller & G. Chiumello. Pythagora Press, Milano, pp. 175-197, 1987.   C2 Cianfarani S, Spadoni GL. La bassa statura (Short Stature). In: Endocrinologia Pediatrica (Paediatric Endocrinology).  Boscherini B. & Scalamandre' A. Ed. Nuova Scientifica Italiana, Roma, pp. 13-47, 1991.    C3 Cianfarani S. Gli ormoni: Azione degli ormoni e loro dosaggio. In: Diagnosi e Terapia in Endocrinologia.  GL Spadoni, AP Taviani, V Toscano. Ed. Grasso, Bologna, 1993, pp.1-15.    C4 Cianfarani S. Disturbi della Crescita (Growth Disorders). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003.   C5 Cianfarani S. Tumori Associati ad Endocrinopatie (Tumors associated to Endocrinopaties).  In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto.  Carocci Editore, Roma, 2003.   C6 Giacomozzi C and Cianfarani S. Patologie dell’ipofisi anteriore. Deficit di GH. “Hypopituitarism: GH deficiency”. Capitolo 73, pp. 659-669. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.   C7 Giacomozzi C and Cianfarani S. Diabete insipido e sindrome da inappropriata secrezione di ormone antidiurerico “Diabetes insipidus and sindrome of inappropriate antidiuretic hormone (SIADH)”. Capitolo 74, pp. 669-679. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.   C8 Cianfarani S. Neuroendocrine Complications of Central Nervous System Malformations. Chapter 23. In: Maformations of the Nervous System, Handbook of Clinical neurology, 3rd Edition. Eds: H.B. Sarnat, P. Curatolo. Elsevier Ltd., pp 433- 458, 2008.   C9 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2010, pp 49-64.   C10 Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P e Cianfarani S. Il deficit di ormone della crescita nel periodo di transizione.  Adolescentologia Aspetti Medici e Socio-Educativi, cap. 6, pp 57-62, 2010   C11 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2011, pp 47-61.   C12 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2012, p. 45-59.   C13 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2013, p. 45-60.   C14 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2014, P. 45-61.   C15. Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z., Haymarket, Teddington, UK, 2015, P. 40-59   C16 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2016, P. 49-64.   C17 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2017, P. 50-67.         Editorial Activity   Boscherini B., Cianfarani S., Spadoni G.L. Eds.  Binding proteins for growth hormone and somatomedins.  Acta Endocrinologica, Vol. 124, Supplement 2, 1991.   Cianfarani S, Clemmons DR, Savage MO (eds.). IGF-I and IGF binding proteins. Basic research and clinical management. Endocrine Development, Basel, Karger, Vol.9, 2005   Stefano Cianfarani, Yves Le Bouc, Martin Savage (eds.). The evolving biology of growth and metabolism. European Journal of Endocrinology 157:Supplement 1, 2007.   Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (eds.) Advanced therapies in pediatric Endocrinology and Diabetology. Endocrine Development, Basel, Karger, Vol.30, 2015.   Cianfarani S and Soder O (eds.) Emdocrine disruptors and child health. Hormone Research in Paediatrics, Karger, basel, Vol. 86 (4), 215-290, 2016.          a:0:{}" } ["meta_keywords"]=> array(1) { [0]=> string(1) "," } ["reserved"]=> array(1) { [0]=> string(1) "0" } ["auth_ip"]=> array(1) { [0]=> string(1) "0" } } ["_fieldBoosts":protected]=> array(6) { ["content_id"]=> bool(false) ["content_title"]=> bool(false) ["description"]=> bool(false) ["meta_keywords"]=> bool(false) ["reserved"]=> bool(false) ["auth_ip"]=> bool(false) } } }