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Maria Rosa Ciriolo

Curriculum vitae

 POSIZIONE ATTUALE

Professore Ordinario di Biochimica, Dipartimento di Biologia, Università di Roma “Tor Vergata”

Coordinatore del Dottorato in Biologia Cellulare e Molecolare

 

FORMAZIONE

1980 Università di Roma “La Sapienza” : Dottore in Biologia cum laude

1988 University of Yeshiva, New York, NY, USA: Specializzazione in Farmacologia with

Honors

 

CRONOLOGIA DI IMPIEGO

1980-1983: Borsista, Istituto di Biochimica, Università di Roma “La Sapienza”, Roma

1983-1994: Ricercatore, Università di Roma “Tor Vergata”, Roma

1986-1988: Research associate, Yeshiva University, New York, NY (USA)

1994-2002: Professore Ordinario, Università di Chieti “G. D’Annunzio”, Chieti

2002- ad oggi: Professore Ordinario, Università di Roma “Tor Vergata”, Roma

2007- ad oggi: Capo del Laboratorio “Biochimica dell’invecchiamento” IRCCS San Raffaele, Roma

2019- ad oggi: Coordinatore del Dottorato in Biologia Cellulare  e Molecolare, Università di Roma “Tor Vergata”

 

INSEGNAMENTI

Biochimica – Corso di Laurea Triennale in Scienze Biologiche

Proteine e Metabolismo – Corso di Laurea Magistrale in Biologia Cellulare e Molecolare

Biochemistry – Corso di Laurea a ciclo unico in Pharmacy

Biochimica della Nutrizione – Corso di Laurea Magistrale in Scienze della Nutrizione

Laboratorio di Biochimica – Corso di Laurea Triennale in Scienze Biologiche

 

PREMI E RICONOSCIMENTI

È tra i migliori scienziati al mondo secondo il Plos Biology Journal nel 2020 (doi.org/10.1371/journal.pbio.3000918) e tra i Top Italian Scientist in Biomedical Sciences (https://topitalianscientists.org).

1988: Performance of duties come Research Associate in Molecular Pharmacology dall’Università Albert Einstein College of  Medicine, New York, USA

2011: Attestato di apprezzamento per il contributo e servizio dedicato come revisore di ACS Journals

2018-2022: Attestato di apprezzamento per il servizio svolto come Editorial Board Member per Scientific Report

 

BREVETTI

- RM92A000930 " Uso del glutatione per preparazioni farmaceutiche ad attività antivirale”

ottenuto in data 28.12.1992.

- nº. 0.600.985-9 “Preparazione ed attività farmacologica di complessi a rame con isatina e

derivati imminici come agenti antitumorali” depositato il 20.03.2006.

 

MEMBRO DI SOCIETÀ

Società Italiana di Biochimica (SIB); Ordine Nazionale dei Biologi; Society for Free Radical

Research (SFRR); Consorzio I.N.B.B. (Istituto Nazionale Biostrutture e Biosistemi); National

Health committee on the evaluation of copper risk assessment; European Cell Death

Organization (ECDO); INCT Redoxoma; European Association for the Study of Diabetes (EASD); Society for Redox Biology and Medicine (SfRBM).

                                         

ATTIVITÀ EDITORIALE

Editor: Scientific Reports; Genes & Nutrition; Frontiers in Cancer: Molecular Targets and Therapeutics; MAP Kinase; Trends in Cell & Molecular Biology; Reactive Oxygen Species; Oxidative Medicine and Cellular Longevity; Nutrients.

Guest Editor: Antioxidants and Redox Signaling – Forum Issue on “Redox Control of Apoptosis”; Nutrients – Special issue on  “Glutathione Metabolism”; Scientific Reports – Cancer Cell Metabolism; Cells – Forum Issue on “The Role of Adipose Tissue in Metabolic Diseases and Beyond”; Frontiers in Oncology - "Hallmark of Cancer: Sustained Proliferative Signalling".

 

Attività di revisore per Riviste Scientifiche Internazionali, tra le quali: Nature Communications, Cancer Research, Nature Chemical Biology, Antioxidants & Redox Signaling, Archives of Biochemistry and Biophysics, Autophagy, Biochemical Journal, Biochimica et Biophysica Acta, Cell Death & Diseases, Cell Death and Differentiation, Cellular and Molecular Life Sciences, Current Medicinal Chemistry, European Journal of Pharmacology, Cancers, Free Radical Biology and Medicine, Cancer Communications.

 

ALTRE ATTIVITÀ

- Revisore per il Ministero dell'Università dell'Istruzione e della Ricerca;

- Revisore per VQR (Valutazione Qualità Ricerca);

- Revisore per progetti finanziati da: Regione Calabria, Università di Padova;  Università Piemonte Orientale;

  Israel Science Foundation; National Science Center of Poland; InBev-Baillet Latour Grants for Medical

  Research; Czech Science Foundation; Diabetes UK - Project Grant 2016 (16/0005484) per Università di

  Dundee; - Project grant 2022 (22/0006377) per Università di Leeds; - Project grant 2022 (22/0006453) per

  Università di Oxford. Reviewer per Postdoctoral Researcher Attraction Competition 2023, Universidad San

  Sebastian, Chile.

- Revisore per ERC starting Grant (2023) Project n.101116684.

- Membro della Task Force (Validation Team) of the Halifax Project “Getting to Know Cancer”.

- 2021- a oggi. Membro del Presidio di Qualità dell’Università di Roma “Tor Vergata”

- 2014-2020. Presidente della Commissione Paritetica Studenti Docenti del Dipartimento di Biologia, dell’Università di

  Roma “Tor Vergata”

- 2018-2019. Coordinatore pro-tempore Macroarea di Scienze MM,FF,NNdell’Università di Roma “Tor Vergata”

- 2014-2020. Componente del Comitato di coordinamento della Macroarea di Scienze MM,FF,NN dell’Università di

  Roma “Tor Vergata”

-Membro di REPRISE (albo degli esperti scientifici istituito presso il MUR) per la sezione Ricerca di base.

 

ORGANIZZAZIONE DI CONFERENZE

-  Workshop on “ Deciphering the complexity in neurodegeneration and cancer” (Rome, Italy – July 09), 2021.

-  Workshop on ”Novel technologies and therapeutics approaches to efficiently fight today’s challenging diseases” (Rome, Italy – October 07), 2022.

- Symposium entitled "Redox Regulation of biological activities" within the Annual Meeting of the Italian Society of Biochemistry (Urbino, Italy - September 14-16), 2015.

- 4th International Conference on Superoxide and Superoxide Dismutase (Rome, Italy -September 1-6), 1985.

 

PRODUTTIVITÀ E IMPATTO SCIENTIFICO

Autore di oltre 220 lavori pubblicati su riviste scientifiche “peer-reviewed”; 20 capitoli di libri e 140 abstracts a Congressi Nazionali ed Internazionali. (H-index 66, Citazioni totali >21000, fonte Scopus).

 

GRANTS (più recenti)

- HEAL ITALIA: PNRR – Missione 4 Componente 2, “Dalla ricerca all’impresa” Investimento 1.3, “Partenariati estesi alle Università, ai Centri di Ricerca, alle aziende per il finanziamento di progetti di ricerca di base”  codice identificativo MUR PE00000019 (2022-2025).

- MNESYS: PNRR – Missione 4 Componente 2, “Dalla ricerca all’impresa” Investimento 1.3, “Partenariati estesi alle università, ai centri di ricerca, alle aziende per il finanziamento di progetti di ricerca di base”  codice identificativo MUR PE00000006 (2022-2025).

- POR FESR Lazio - E85F21002340002 - ASTERIA

-Beyond Borders 2020 (University of Rome, “Tor Vergata”)

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2017, A5TXC3 (National Scientific Coordinator), “ Novel molecular players of hypoxia/Inflammation impinging in lipid homeostasis in obesity and related diseases: theranostic implications” (2019-2021).

- AIRC (Italian Association for Cancer Research) – IG – 15403 – Dissecting the Adipose triglyceride Lipase (ATGL) functions in the pathogenesis of hepatocarcinoma (2015-2018).

- CEPID - Centros de Pesquisa, Inovação e Difusão No. 2013/07937-8 Redoxome - Redox Process in Biomedicine (2013-2018).

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2009, M8FKBB (National Scientific Coordinator), “Redox regulation of pathways involved in cellular senescence and in the age-related diseases” (2011-2013).

- FAPESP - No. 11/50318-1 Desenvolvimento de Compostos com Interesse Farmacológico ou Medicinal e de Sistemas para seu Transporte, Detecção e Reconhecimento no Meio Biológico (2011-2016).

- AIRC (Italian Association for Cancer Research) – IG – 10636 – Study of the molecular players that regulate redox state, glucose fuel and autophagy in cancer cell survival (2010-2013).

- Fondazione Roma (Bank Foundation) – Intervention Program to sustain the Biomedical research “Type 2 Diabetes Mellitus: Role of Inflammation and Innate Immunity in The Pathogenesis of Endothelial Dysfunction and Atherosclerosis” (2009-2012).

- INCT de Processos Redox em Biomedicina - Redoxoma (Apoio FAPESP/CNPq/MCT) (2009-2014).

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2007, 20077S9A32 (National Scientific Coordinator) “Redox mechanisms underlying cell signaling involved in the genesis of oxidative stress-related diseases” (2008-2010).

- Projeto Bilateral, Programa Executivo Brasil-Itália, Processo CNPq 490021/2008-5. Characterization of oxidative damage caused by copper complexes: molecular bases for their antitumor action"(2008).

- Italian Ministry of Health, RF-2009-1546096 “Role of recurrent herpetic infections in neuronal damage” (2007-2009).

- FIRB - (Funding for Basic Research from Italian Ministry of University and Research) - RBIP063ANC_003 “New Neurotrophic and neuroprotective drugs for therapeutic applications in neurosciences: Alzheimer’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis” (2007-2010).

 

ATTIVITA' DI RICERCA

-Glutatione ed enzimi antiossidanti nel controllo delle specie reattive dell'ossigeno e dell'azoto e loro alterazioni nelle patologie redox-correlate (cancro, degenerazione, diabete di tipo 2, aterosclerosi);

-Metabolismo dell'ossido nitrico e regolazione dell'ossido nitrico sintasi;

-Interazione tra segnalazione redox e fosforilativa nel cancro, morte cellulare neuronale e infezioni virali;

-Vie di trasduzione del segnale redox nei processi cellulari (proliferazione, differenziamento, autofagia, apoptosi);

-Controllo della funzione mitocondriale e del turnover (biogenesi/mitofagia);

-Metabolismo deregolato (lipidi, aminoacidi, glucosio) delle cellule cancerose;

-Impatto di nutrienti e nutraceutici (polifenoli e composti organosolforati) sull'omeostasi redox, sull'epigenetica e sul metabolismo ossidativo cellulare.

Maria Rosa Ciriolo

Curriculum Vitae

 

CURRENT POSITION

Professor of Biochemistry, Department of Biology, University of Rome "Tor Vergata"

Coordinator of the Ph.D. school in Cellular and Molecular Biology, University of Rome "Tor Vergata"

 

EDUCATION

1980  University of Rome “La Sapienza”: Doctor of Biology cum laude

1988  University of  Yeshiva, New York, NY, USA: Specialization in Pharmacology with honors

 

CHRONOLOGY OF EMPLOYMENT

1980-1983: Research fellow, University of Rome “La Sapienza”, Rome, Italy

1983-1994: Researcher, University of Rome "Tor Vergata", Rome, Italy

1986-1988: Research Associate, Yeshiva University, New York, NY (USA)

1994-2002: Full Professor, University of Chieti "G. D'Annunzio", Chieti, Italy

2002- to present: Full Professor, University of Rome “Tor Vergata”, Rome, Italy

2007- to present: Head of laboratory “Biochemistry of Ageing” IRCCS San Raffaele, Rome, Italy

2019- to present: Coordinator of the PhD school in Cellular and Molecular Biology, University of Rome "Tor Vergata"

 

TEACHINGS

Biochemistry - Bachelor's Degree Course in Biological Sciences

Proteins and Metabolism - Master's Degree Course in Cellular and Molecular Biology

Biochemistry -  Degree Course in Pharmacy

Biochemistry of Nutrition - Master's Degree Course in Nutrition Sciences

Biochemistry Laboratory -  Bachelor’s Degree Course in Biological Sciences

 

AWARDS and ACKNOWLEDGMENTS

Best Scientist in the world according to the Plos Biology Journal in 2020 (doi.org/10.1371/journal.pbio.3000918) and among the Top Italian Scientists in Biomedical Sciences (https://topitalianscientists.org).

1988: Performance of duties as Research Associate in Molecular Pharmacology from Albert Einstein College of  Medicine, New York, USA

2011: Certificate of Appreciation for the contribution and dedicated service as a reviewer to ACS Journals.

2018-2022: Certificate of Appreciation as an Editorial Board Member for Scientific Report

 

PATENT

RM92A000930 entitled: " Use of glutathione for preparation of pharmaceuticals with antiviral

activity” obtained on 12.28.1992.

Patent nº. 0.600.985-9 entitled “Preparation and Pharmacological Activity of Copper complexes with Isatin and its Imine Derivatives as Antitumoral Agents” deposited on 03.20.2006.

 

SOCIETY MEMBERSHIPS

Italian Society of Biochemistry (SIB) and enlisted in National Order of Biologist; Society for Free Radical Research (SFRR); National Interuniversity Consortium  I.N.B.B. (Institute National Biostructure and Biosystems); National Health committee on the evaluation of copper risk assessment; European Cell Death Organization (ECDO); INCT Redoxoma; European Association for the Study of Diabetes (EASD); Society for Redox Biology and Medicine (SfRBM).

 

EDITORIAL ACTIVITY

Editor: Scientific Reports; Genes & Nutrition; Frontiers in Cancer: Molecular Targets and Therapeutics; MAP Kinase; Trends in Cell & Molecular Biology; Reactive Oxygen Species; Oxidative Medicine and Cellular Longevity; Nutrients.

Guest Editor: Antioxidants and Redox Signaling – Forum Issue on “Redox Control of Apoptosis”; Nutrients – Special issue on  “Glutathione Metabolism”; Scientific Reports – Cancer Cell Metabolism; Cells – Forum Issue on “The Role of Adipose Tissue in Metabolic Diseases and Beyond”; Frontiers in Oncology - "Hallmark of Cancer: Sustained Proliferative Signalling".

 

Reviewer for International Scientific Journals, such as: Nature communications, Cancer Research, Nature Chemical Biology, Antioxidants & Redox Signaling, Archives of biochemistry and Biophysics, Autophagy, Biochemical Journal, Biochimica et Biophysica Acta, Cell Death & Diseases, Cell Death and Differentiation, Cellular and Molecular Life Sciences, Current Medicinal Chemistry, European Journal of Pharmacology, Cancers, Free Radical Biology and Medicine, Cancer Communications

 

OTHER SERVICES

- Member of the National board reviewer of the Italian Ministry of Education, Universities, and Research;

- Referee for VQR (Evaluation of Research Quality);

- Grant reviewer for “Regione Calabria”, University of Padua; University of “Piemonte Orientale”; Israel Science Foundation; National Science Center of Poland; InBev-Baillet Latour Grants for Medical Research; Czech Science Foundation; Diabetes UK - Project Grant 2016 (16/0005484) for Dundee University; Project grant 2022 (22/0006377) for Leeds University; Project grant 2022 (22/0006453) for Oxford University; Reviewer for Postdoctoral Researcher Attraction Competition 2023, Universidad San Sebastian, Chile.

- Task Force Member (Validation Team) of the Halifax Project “Getting to Know Cancer”. 

- Reviewer of ERC starting Grant (2023) Project n.101116684.

-2021-to today. Member of the Presidium of Quality of the University of Rome “Tor Vergata”.

- 2014-2020. President of the “Commissione Paritetica Studenti Docenti” of the Department of Biology of the University of Rome “Tor Vergata”.

- 2018-2019. Pro-tempore Coordinator of the Macroarea of Sciences MM.FF.NN of the University of Rome “Tor Vergata”.

-2014-2020. Member of the Coordination Committee of the Macroarea of Sciences MM.FF.NN of the University of Rome “Tor Vergata”.

- Member of REPRISE (Register of Scientific Experts established at the MUR for the section Basic Research.

 

CONFERENCE ORGANIZER

-  Workshop on “ Deciphering the complexity in neurodegeneration and cancer” (Rome, Italy – July 09), 2021.

-  Workshop on ”Novel technologies and therapeutics approaches to efficiently fight today’s challenging diseases” (Rome, Italy – October 07), 2022.

- Symposium entitled "Redox Regulation of biological activities" within the Annual Meeting of the Italian Society of Biochemistry (Urbino, Italy - September 14-16), 2015.

- 4th International Conference on Superoxide and Superoxide Dismutase (Rome, Italy -September 1-6), 1985.

 

SCIENTIFIC PRODUCTIVITY AND IMPACT

Author of more than 220 papers on high-ranking journals; 20 book chapters and 140 abstracts of International and National Congresses. (H-index 66, Total citations > 21000, from Scopus).

 

GRANTS (most recent)

- HEAL ITALIA: PNRR – Missione 4 Componente 2, “Dalla ricerca all’impresa” Investimento 1.3, “Partenariati estesi alle Università, ai Centri di Ricerca, alle aziende per il finanziamento di progetti di ricerca di base”  codice identificativo MUR PE00000019 (2022-2025).

- MNESYS: PNRR – Missione 4 Componente 2, “Dalla ricerca all’impresa” Investimento 1.3, “Partenariati estesi alle università, ai centri di ricerca, alle aziende per il finanziamento di progetti di ricerca di base”  codice identificativo MUR PE00000006 (2022-2025).

- POR FESR Lazio - E85F21002340002 - ASTERIA

-Beyond Borders 2020 (University of Rome, “Tor Vergata”)

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2017, A5TXC3 (National Scientific Coordinator), “ Novel molecular players of hypoxia/Inflammation impinging in lipid homeostasis in obesity and related diseases: theranostic implications” (2019-2021).

- AIRC (Italian Association for Cancer Research) – IG – 15403 – Dissecting the Adipose triglyceride Lipase (ATGL) functions in the pathogenesis of hepatocarcinoma (2015-2018).

- CEPID - Centros de Pesquisa, Inovação e Difusão No. 2013/07937-8 Redoxome - Redox Process in Biomedicine (2013-2018).

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2009, M8FKBB (National Scientific Coordinator), “Redox regulation of pathways involved in cellular senescence and in the age-related diseases” (2011-2013).

- FAPESP - No. 11/50318-1 Desenvolvimento de Compostos com Interesse Farmacológico ou Medicinal e de Sistemas para seu Transporte, Detecção e Reconhecimento no Meio Biológico (2011-2016).

- AIRC (Italian Association for Cancer Research) – IG – 10636 – Study of the molecular players that regulate redox state, glucose fuel and autophagy in cancer cell survival (2010-2013).

- Fondazione Roma (Bank Foundation) – Intervention Program to sustain the Biomedical research “Type 2 Diabetes Mellitus: Role of Inflammation and Innate Immunity in The Pathogenesis of Endothelial Dysfunction and Atherosclerosis” (2009-2012).

- INCT de Processos Redox em Biomedicina - Redoxoma (Apoio FAPESP/CNPq/MCT) (2009-2014).

- MIUR (Italian Ministry of Education, Universities and Research) – PRIN 2007, 20077S9A32 (National Scientific Coordinator) “Redox mechanisms underlying cell signaling involved in the genesis of oxidative stress-related diseases” (2008-2010).

- Projeto Bilateral, Programa Executivo Brasil-Itália, Processo CNPq 490021/2008-5. Characterization of oxidative damage caused by copper complexes: molecular bases for their antitumor action"(2008).

- Italian Ministry of Health, RF-2009-1546096 “Role of recurrent herpetic infections in neuronal damage” (2007-2009).

- FIRB - (Funding for Basic Research from Italian Ministry of University and Research) - RBIP063ANC_003 “New Neurotrophic and neuroprotective drugs for therapeutic applications in neurosciences: Alzheimer’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis” (2007-2010).

 

RESEARCH ACTIVITY

-Glutathione and antioxidant enzymes in the control of reactive oxygen and nitrogen species and their alterations in redox-related pathologies (cancer, degeneration, Type 2 diabetes, atherosclerosis);

-Nitric oxide metabolism and regulation of nitric oxide synthases;

-Interplay between redox and phosphorylative signaling in tumor, neuronal cell death and viral infections;

-Redox signal transduction pathways in cell processes (proliferation, differentiation, autophagy, apoptosis);

-Control of mitochondrial function and turnover (biogenesis/mitophagy);

-De-regulated metabolism (lipid, amino acids, glucose) of cancerous cells;

-Impact of nutrients and nutraceuticals (polyphenols and organosulfur compounds) on redox homeostasis, epigenetics and cellular oxidative metabolism.

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