array(1) { [0]=> object(Apache_Solr_Document)#24 (3) { ["_documentBoost":protected]=> bool(false) ["_fields":protected]=> array(6) { ["content_id"]=> array(1) { [0]=> string(14) "DIRECTORY_4218" } ["content_title"]=> array(1) { [0]=> string(21) "ALESSANDRA GAMBACURTA" } ["description"]=> array(1) { [0]=> string(32144) "Inserire qui il curriculumInsert here the curriculum a:33:{i:0;a:14:{s:9:"citazione";s:302:"D'Amico, S., Krasnowska, E., Manni, I., Toietta, G., Baldari, S., Piaggio, G., et al. (2020). DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines. CELLS, 9(5), 1260.";s:4:"data";s:4:"2020";s:2:"id";s:20:"PUBBLICAZIONE_402508";s:6:"handle";s:11:"2108/258728";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:188:"DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines";s:9:"metadata6";s:169:"D'Amico, S; Krasnowska, E; Manni, I; Toietta, G; Baldari, S; Piaggio, G; Ranalli, M; Gambacurta, A; Vernieri, C; Di Giacinto, F; Bernassola, F; de Braud, F; Lucibello, M";s:9:"metadata7";s:20:"10.3390/cells9051260";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:1;a:14:{s:9:"citazione";s:275:"Scimeca, M., Bonfiglio, R., Menichini, E., Albonici, L., Urbano, N., De Caro, M.T., et al. (2019). Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20.";s:4:"data";s:7:"2019-11";s:2:"id";s:20:"PUBBLICAZIONE_359848";s:6:"handle";s:11:"2108/221731";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:36:"Settore MED/08 - Anatomia Patologica";s:9:"metadata4";N;s:9:"metadata5";s:127:"Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition.";s:9:"metadata6";s:130:"Scimeca, M; Bonfiglio, R; Menichini, E; Albonici, L; Urbano, N; De Caro, MT; Mauriello, A; Schillaci, O; Gambacurta, A; Bonanno, E";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:2;a:14:{s:9:"citazione";s:256:"Gambacurta, A., Merlini, G., Ruggiero, C., Diedenhofen, G., Battista, N., Bari, M., et al. (2019). Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis. SCIENTIFIC REPORTS [10.1038/s41598-019-44593-6].";s:4:"data";s:10:"2019-06-06";s:2:"id";s:20:"PUBBLICAZIONE_351119";s:6:"handle";s:11:"2108/214676";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:107:"Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis";s:9:"metadata6";s:147:"Gambacurta, A; Merlini, G; Ruggiero, C; Diedenhofen, G; Battista, N; Bari, M; Balsamo, M; Piccirillo, S; Valentini, G; Mascetti Mauro Maccarrone, G";s:9:"metadata7";s:26:"10.1038/s41598-019-44593-6";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:3;a:14:{s:9:"citazione";s:172:"Raschellà, G., Melino, G., & Gambacurta, A. (2019). Cell death in cancer in the era of precision medicine. GENES AND IMMUNITY, 20(7), 529-538 [10.1038/s41435-018-0048-6].";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_342360";s:6:"handle";s:11:"2108/207626";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";s:1377:"Tumors constitute a large class of diseases that affect different organs and cell lineages. The molecular characterization of cancers of a given type has revealed an extraordinary heterogeneity in terms of genetic alterations and DNA mutations; heterogeneity that is further highlighted by single-cell DNA sequencing of individual patients. To address these issues, drugs that specifically target genes or altered pathways in cancer cells are continuously developed. Indeed, the genetic fingerprint of individual tumors can direct the modern therapeutic approaches to selectively hit the tumor cells while sparing the healthy ones. In this context, the concept of precision medicine finds a vast field of application. In this review, we will briefly list some classes of target drugs (Bcl-2 family modulators, Tyrosine Kinase modulators, PARP inhibitors, and growth factors inhibitors) and discuss the application of immunotherapy in tumors (T cell-mediated immunotherapy and CAR-T cells) that in recent years has drastically changed the prognostic outlook of aggressive cancers. We will also consider how apoptosis could represent a primary end point in modern cancer therapy and how “classic” chemotherapeutic drugs that induce apoptosis are still utilized in therapeutic schedules that involve the use of target drugs or immunotherapy to optimize the antitumor response.";s:9:"metadata5";s:53:"Cell death in cancer in the era of precision medicine";s:9:"metadata6";s:40:"Raschellà, G; Melino, G; Gambacurta, A";s:9:"metadata7";s:25:"10.1038/s41435-018-0048-6";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:4;a:14:{s:9:"citazione";s:283:"Scimeca, M., Bonfiglio, R., Menichini, E., Albonici, L., Urbano, N., De Caro, M., et al. (2019). Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(22), 5633.";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_402510";s:6:"handle";s:11:"2108/258730";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:126:"Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition";s:9:"metadata6";s:129:"Scimeca, M; Bonfiglio, R; Menichini, E; Albonici, L; Urbano, N; De Caro, M; Mauriello, A; Schillaci, O; Gambacurta, A; Bonanno, E";s:9:"metadata7";s:20:"10.3390/ijms20225633";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:5;a:14:{s:9:"citazione";s:224:"Lopriore, P., Capitanio, N., Panatta, E., Di Daniele, N., Gambacurta, A., Melino, G., et al. (2018). TAp73 regulates ATP7A: possible implications for ageing-related diseases. 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Modulation of TAp73 expression influences basal expression level of ATP7A in different cellular models and chromatin immunoprecipitation confirmed a physical direct binding of TAp73 on ATP7A genomic regions. Bioinformatic analysis of expression profile datasets of human lung cancer patients suggests a possible implication of TAp73/ATP7A axis in human cancer. These data provide a novel TAp73-dependent target which might have implications in ageing-related diseases such as cancer and neurodegeneration.";s:9:"metadata5";s:72:"TAp73 regulates ATP7A: possible implications for ageing-related diseases";s:9:"metadata6";s:89:"Lopriore, P; Capitanio, N; Panatta, E; Di Daniele, N; Gambacurta, A; Melino, G; Amelio, I";s:9:"metadata7";s:21:"10.18632/aging.101669";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:6;a:14:{s:9:"citazione";s:190:"Ciuffoli, V., Lena, A.m., Gambacurta, A., Melino, G., & Candi, E. (2018). Myoblasts rely on TAp63 to control basal mitochondria respiration. AGING, 10(11), 3558-3573 [10.18632/aging.101668].";s:4:"data";s:10:"2018-11-28";s:2:"id";s:20:"PUBBLICAZIONE_342362";s:6:"handle";s:11:"2108/207628";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:56:"metabolism; mitochondria; myoblasts differentiation; p63";s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:65:"Myoblasts rely on TAp63 to control basal mitochondria respiration";s:9:"metadata6";s:57:"Ciuffoli, V; Lena, Am; Gambacurta, A; Melino, G; Candi, E";s:9:"metadata7";s:21:"10.18632/aging.101668";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:7;a:14:{s:9:"citazione";s:213:"Gambacurta, A., & Raschellà, G. (2018). Challenging tumor resistance with less toxic, more effective drug combinations: an example from neuroblastoma. CELL DEATH & DISEASE, 9(6), 686 [10.1038/s41419-018-0728-1].";s:4:"data";s:10:"2018-06-07";s:2:"id";s:20:"PUBBLICAZIONE_342358";s:6:"handle";s:11:"2108/207624";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:109:"Challenging tumor resistance with less toxic, more effective drug combinations: an example from neuroblastoma";s:9:"metadata6";s:29:"Gambacurta, A; Raschellà, G";s:9:"metadata7";s:25:"10.1038/s41419-018-0728-1";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:8;a:14:{s:9:"citazione";s:310:"Balestrieri, E., Argaw-Denboba, A., Gambacurta, A., Cipriani, C., Bei, R., Serafino, A., et al. (2018). Human Endogenous Retrovirus K in the Crosstalk Between Cancer Cells Microenvironment and Plasticity: A New Perspective for Combination Therapy. 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Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds. STEM CELLS INTERNATIONAL, 2017, 2976541 [10.1155/2017/2976541].";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_342352";s:6:"handle";s:11:"2108/207618";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:138:"Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds";s:9:"metadata6";s:102:"Carpentieri, A; Cozzoli, E; Acri, F; Ranalli, M; Diedenhofen, G; Scimeca, M; Bonanno, E; Gambacurta, A";s:9:"metadata7";s:20:"10.1155/2017/2976541";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:11;a:14:{s:9:"citazione";s:266:"Carpentieri, A., Cozzoli, E., Scimeca, M., Bonanno, E., Sardanelli, A.m., & Gambacurta, A. (2016). Erratum: Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. CELL DEATH & DISEASE, 7(4), e2202-e2202 [10.1038/cddis.2016.60].";s:4:"data";s:10:"2016-04-21";s:2:"id";s:20:"PUBBLICAZIONE_326661";s:6:"handle";s:11:"2108/194436";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:101:"Erratum: Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor";s:9:"metadata6";s:81:"Carpentieri, A; Cozzoli, E; Scimeca, M; Bonanno, E; Sardanelli, Am; Gambacurta, A";s:9:"metadata7";s:21:"10.1038/cddis.2016.60";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:12;a:14:{s:9:"citazione";s:172:"Carpentieri, A., Diedenhofen, G., & Gambacurta, A. (2016). Back on Track: New Perspectives on Cancer Cell Reprogramming. JOURNAL OF SINGLE CELL GENOMICS & PROTEOMICS, 5(3).";s:4:"data";s:4:"2016";s:2:"id";s:20:"PUBBLICAZIONE_342367";s:6:"handle";s:11:"2108/207632";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";s:853:"The possibility to obtain induced pluripotent stem cells (iPSCs) starting from cancer cells has revealed itself to be a major step forward in the understanding of the mechanisms able to regulate stemness, differentiation and neoplastic transformation. Our work proposes a new differentiation method using rapamycin and an amorphous bone matrix to promote the commitment of neuroblastoma cells towards the osteogenic lineage, switching to a different germ layer, without an intermediate iPSCs step. We followed the process from a morphological point of view with immunofluorescence analysis, cytochemistry and electron microscopy and from a metabolic point of view with enzyme activity tests and protein expression analysis. We believe that the morphological and metabolic changes observed are the foundations for a new type of cancer cell reprogramming.";s:9:"metadata5";s:60:"Back on Track: New Perspectives on Cancer Cell Reprogramming";s:9:"metadata6";s:45:"Carpentieri, A; Diedenhofen, G; Gambacurta, A";s:9:"metadata7";s:25:"10.4172/2168-9431.1000151";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:13;a:14:{s:9:"citazione";s:253:"Carpentieri, A., Cozzoli, E., Scimeca, M., Bonanno, E., Sardanelli, A.m., & Gambacurta, A. (2015). Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. CELL DEATH & DISEASE, 6(11), e1974 [10.1038/cddis.2015.244].";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_250899";s:6:"handle";s:11:"2108/194377";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:92:"Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor";s:9:"metadata6";s:81:"Carpentieri, A; Cozzoli, E; Scimeca, M; Bonanno, E; Sardanelli, Am; Gambacurta, A";s:9:"metadata7";s:22:"10.1038/cddis.2015.244";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:14;a:14:{s:9:"citazione";s:241:"Sarra, M., Cupi, M., Bernardini, R., Ronchetti, G., Monteleone, I., Ranalli, M., et al. (2013). IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism. 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A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses. LIFE SCIENCES.";s:4:"data";s:4:"2012";s:2:"id";s:20:"PUBBLICAZIONE_162529";s:6:"handle";s:10:"2108/78149";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/11";s:9:"metadata4";N;s:9:"metadata5";s:121:"A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses";s:9:"metadata6";s:113:"Marfe G; Rotta G; De Martino L; Tafani M; Fiorito F; Di Stefano C; Polettini M; Ranalli M; Russo MA; Gambacurta A";s:9:"metadata7";s:25:"10.1016/j.lfs.2012.03.004";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:18;a:14:{s:9:"citazione";s:242:"Marfe, G., Manzi, V., Tafani, M., Pucci, B., Gambacurta, A., Russo, M.A., et al. (2012). The modulation of sirtuins and apoptotic proteins in rats after exhaustive exercise. 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