Curriculum Vitae Informazioni personali Nome/ Cognome Maria Adelaide Marini Fax 06 20902679 E-mail maride.marini@uniroma2.it Maride.marini@gmail.com Cittadinanza Italiana Data di nascita 14.01.1959 Stato Civile Coniugata con due figli Lavoro o posizione ricoperti - Professore Associato Confermato, afferente alla Cattedra di Medicina Interna (MED09) del Dipartimento di Medicina dei Sistemi, presso la Facoltà di Medicina e Chirurgia dell’Università degli Studi di Roma Tor Vergata - Responsabile del “Progetto ad Alta Valenza Scientifica” “Diabete e Genere” nell’ambito dell’Area Funzionale Aggregata di Medicina Interna presso il Policlinico di Tor Vergata Università degli Studi di Roma Tor Vergata - Coordinatore del Corso di Laurea Specialistica “Scienze e tecniche delle Attività Motorie Preventive e Adattate” presso la Facoltà di Medicina e Chirurgia di Roma Tor Vergata dall’AA 2009/20010 - Direttore della Scuola di Specializzazione in Medicina delle Emergenze e Urgenze dall’AA 2016/17 Nome e indirizzo del datore di lavoro Università degli Studi di Roma Tor Vergata- Policlinico di Tor Vergata Via Monpellier 1 00133 Roma Temi di ricerca - Meccanismi molecolari dell’insulino-resistenza; - Patogenesi molecolare del diabete di tipo 2 e dell’obesità; - Genetica del Diabete di tipo 2; - Sindrome ipoglicemica autoimmune da anticorpi anti-recettore insulinico; - Regolazione della secrezione insulinica; -Valutazione del rischio cardiovascolare in soggetti affetti da prediabete; - Terapia insulinica con infusione continua.
Capacità e competenze personali Madrelingua Italiano Altra lingua Inglese- Francese Maria Adelaide Marini é autrice o coautrice di numerose pubblicazioni scientifiche nell’ambito della fisiopatologia medica pubblicate su riviste internazionali. H Index (Scopus) 23 I10Index (Google Scholar) 38 Impact factor totale 286,44 Media IF 4,64
PUBBLICAZIONI ORIGINALI SU RIVISTE INTERNAZIONALI CON PEER REVIEW
1) Bertoli A., Caputo S., Marini M.A., Santini S.A., Ghirlanda G., Greco A.V. "Inhibition of basal insulin secretion induces insulin resistance in normal man: evidence for a tonic effect of insulin on carbohydrate metabolism". Horm. Res. 31: 238-243, 1989
2) Borboni P., Di Cola G., Sesti G., Marini M.A., Del Porto P., Gilardini Montani M., Lauro R., De Pirro R. "ß-endorphin receptors on cultured and freshly isolated lymphocytes from normal subjects". Biochem. Biophys. Res. Commun. 163: 642-648; 1989.
3) De Pirro R., Borboni P., Marini M.A., Montemurro A., Sesti G., Lauro R. "Antibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action." J. Endocrinol. Invest. 13: 951-968, 1990.
4) Sesti G., Marini M.A., Tullio A.N., Montemurro A., Borboni P., Fusco, Accili D, Lauro R. "Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients".Biochem. Biophys. Res. Commun. 181: 1419-1424, 1991.
5) Sesti G., Marini M.A., Montemurro A., Borboni P., Di Cola G., Bertoli A. Lauro R., De Pirro R. "Evidence that human and porcine insulin affect differently the human insulin receptor: studies with monoclonal anti-insulin receptor antibodies". J. Endocrinol. Invest. 14: 913-918, 1991.
6) Sesti G., Marini M.A., Montemurro A., Borboni P., Condorelli L., Haring HU., Ullrich A., Goldfine D., De Pirro R., Lauro R. "Evidence that two naturally occurring human insulin receptor a-subunit variants are immunologically distinct".Diabetes 41: 6-11, 1992.
7) Sesti G., Marini M.A., Briata P., Tullio A.N., Montemurro A., Borboni P., De Pirro R., Gherzi R., Lauro R. "Androgens increase insulin receptor gene expression and insulin responsiveness in Hep-2 larynx carcinoma cells". Mol Cell Endocrinol 86: 111-118,1992
8) Sesti G., Tullio A.N., Marini M.A., Manera E., Borboni P., Accili D., Longhi R, Fusco A., Lauro R., Montemurro A."Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies". Mol Cell Endocrinol 101:121-127, 1994
9) Sesti G., Tullio A.N., D'Alfonso R., Napolitano ML., Marini M.A., Borboni P., Longhi R., Albonici L., Fusco A., Aglianò A.M., Manzari V., Lauro R. "Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein".Acta Diabetologica 31: 59-65, 1994
10) Bertoli A.,Fusco A., Magnani A, Marini M.A., Di Daniele N., Gatti S. Lauro R. "Efficacy of low dose GnRH analogue (Buserelin) in the treatment of hirsutism" Exp.Clin.Endocrinol 103 (1995) 15-20
11) Sesti G., D'Alfonso R., Vargas Punti M.D., Tullio A.N., Liu Y.Y., Federici M., Borboni P., Marini M.A., Lauro R., Fusco A."Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured EBV-transformed lymphocytes from insulin-resistant subjects" Diabetologia 39: 289-297, 1996
12) Federici M., Porzio O., Zucaro L., Giovannone B., Borboni P., Marini M.A., Lauro D., Sesti G. “Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients” Mol. Cell. Endocrinol. 135, 41-47, 1997
13) Bertoli A., Magnaterra R., Borboni P., Marini M.A., Barini A., Fusco A., Bollea M.R. "Dose-dependent effect of octreotide on insulin secretion after OGTT in obesity." Horm Res 49(1):17-21, 1998
14) D’Alfonso R., Marini M.A., Frittitta L., Sorge R., Frontoni S., Porzio O., Mariani L.M., Lauro D., Gambardella S., Trischitta V., Federici M., Lauro R., Sesti G. “Polymorphism of the Insulin Receptor Substrate-2 in Patients with Type 2 Diabetes” J.Clin.Endocrinol.Metab. 88 (1):317-322, 2003
15) Sesti G., Cardellini M., Marini M.A., Frontoni S., D’Adamo M., Del Guerra S., Lauro D., De Nocolais P., Sbraccia P., Del Prato S., Gambardella S., Federici M., Marchetti P., Lauro R. “A common Polymorphism in the promoter UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects” Diabetes. 2003 May; 52 (5): 1280-3
16) Marini M.A., Frontoni S., Mineo D. Bracaglia D. Cardellini M., De Nicolais P., Baroni A., D’Alfonso R., Perna M., Lauro D., Federici M., Gambardella S., Lauro R., Sesti G. “ The Arg 972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients” J.Clin.Endocrinol. Matab. 2003 Jul; 88 (7): 3368-71
17) Mariani L.M., Marini M.A., Veneziani A., Bertoli A., Lauro R. “Morbid obesità: evaluation of metabolic indexes after adjustable silicone gastric banding. Acta Diabetol. 2003 Oct; Suppl 1: S263-5
18) Sesti G., Marini M.A., Cardellini M., Sciacqua A., Frontoni S., Andreozzi F., Irace C., Lauro D., Gnasso A., Federici M., Perticone F., Lauro R. “ The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to solfonylurea in patients with type 2 diabetes” Diabetes Care 2004 June; 27 (6): 1394-8
19) D’Adamo M., Perego l., Cardellini M., Marini M.A.,Frontoni S., Andreozzi F., Sciacqua A., Lauro D., Sbraccia P., Federici M., Paganelli m., Pontiroli A.E., Lauro R., Perticone F., Folli.F., Sesti G. “the-866 A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistence and icreased risk of type 2 diabetes.” Diabetes 2004 Jul;53 (7):1905-10
20) Sesti G., Sciacqua A., Cardellini M., Marini M.A., Maio R., Vatrano M., Succurro E., Lauro R., Federici M., Perticone F. “Plasma concentration of IGF-1 is indipendently associated with insulin sensitività in subjects with different degrees of glucose tolerance” Diabetes Care 2005 Jan;28(1):120-5.
21) Cardellini M., Perego L., D’Adamo M., Marini M.A., Procopio C., Hribal M.L., Andreozzi F., Frontoni S., Giacomelli M., Paganelli M., Pontiroli A.E., Lauro R., Folli F., Sesti G. C-174G Polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diabetes Care. 2005 Aug;28(8):2007-12
22) Rizza S, Tesauro M, Cardellini M, meneghini R, Bellia A, Marini MA, Lauro D, Sbraccia P, Sesti G, Lauro R, Federici M. Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):431-2.
23) Scarpelli D, Cardellini M, Andreozzi F, Laratta E, Hribal ML, Marini MA, Tassi V, Lauro R, Perticone F, Sesti G. Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. Diabetes. 2006 May;55(5):1529-33.
24) Andreozzi F, Laratta E, Cardellini M, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of italian-caucasian nondiabetic subjects. Diabetes. 2006 Jul;55(7):2021-4.
25) Cardellini M, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Perticone F, Federici M, Lauro D, Sesti G. Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E347-52. Epub 2006 Sep 12.
26) Cardellini M, Andreozzi F, Laratta E, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians. Diabetes Metab Res Rev. 2006 Sep 4
27) Cardellini M, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Perticone F, Federici M, Lauro D, Sesti G. “Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.” Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E347-52
28) Ludovico O, Pellegrini F, Di Paola R, Minenna A, Mastroianno S, Cardellini M, Marini MA, Andreozzi F, Vaccaro O, Sesti G, Trischitta V. “Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk.” Obesity (Silver Spring). 2007 May;15(5):1076-81.
29) Marini MA, Succurro E, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G.“Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women.” Diabetes Care. 2007 Aug;30(8):2145-7. Epub 2007 May 16.
30) Sesti G, Andreozzi F, Bonadonna RC, De Mattia G, Leonetti F, Luzi L, Marini MA, Natali A, Vettor R, Bonora E; Group of Italian Scientists of Insulin Resistance (GISIR). “Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database.” Diabetes Metab Res Rev. 2008 Feb;24(2):130-6.
31) Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson PA, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring HU.“A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.” Diabetes. 2008 Feb;57(2):514-7
32) Bonora E, Capaldo B, Perin PC, Del Prato S, De Mattia G, Frittitta L, Frontoni S, Leonetti F, Luzi L, Marchesini G, Marini MA, Natali A, Paolisso G, Piatti PM, Pujia A, Solini A, Vettor R, Bonadonna RC; on behalf of the Group of Italian Scientists of Insulin Resistance (GISIR).“Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database.” Nutr Metab Cardiovasc Dis. 2007 Nov 28
33) Succurro E, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G. “Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals.” Obesity (Silver Spring). 2008 Aug;16(8):1881-6.
34) Presta I, Andreozzi F, Succurro E, Marini MA, Laratta E, Lauro R, Hribal ML, Perticone F, Sesti G. “IL-18 gene polymorphism and metabolic syndrome.” Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):e5-6. Epub 2009 Jan 26.
35) Succurro E, Marini MA, Grembiale A, Lugarà M, Andreozzi F, Sciacqua A, Hribal ML, Lauro R, Perticone F, Sesti G. “Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.” Diabetes Metab Res Rev. 2009 May;25(4):351-6.PMID: 19319930
36) Succurro E, Andreozzi F, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. “Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects.” Nutr Metab Cardiovasc Dis. 2009 Apr 3
37) Succurro E, Marini MA, Arturi F, Grembiale A, Lugarà M, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G “Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis” Atherosclerosis. 2009 Apr 11.
38) Fiore AM, Marinoni GM, Piccione A, Marini MA, D'Adamo M, Lauro R, Sbraccia P. A rare cardiac finding in a morbidly obese patient with severe hypertension Intern Emerg Med. 2010 Oct 9.
39) Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium.Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B Diabetologia. 2011 Jan 14.
40) Succurro E, Marini MA, Arturi F, Grembiale A, Fiorentino TV, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G Usefulness of hemoglobin A1c as a criterion to define the metabolic syndrome in a cohort of italian nondiabetic white subjects. Am J Cardiol. 2011 Jun 1;107(11):1650-5. Epub 2011 Mar 21. 41) Morviducci L, Di Flaviani A, Lauria A, Pitocco D, Pozzilli P, Suraci C, Frontoni S; Cappa M, Patera IP, Manfrini S, Bracaglia D, Ciampittiello G, Cicconetti E, Ventura C, Bloise D, Tatti P, Leotta S, Visalli N, Caputo S, Ghirlanda G, Giaccari A, Gisella Cavallo M, Leonetti F, Lauro D, Mancabitti ML, Marini MA, Spallone V, Napoli A, Pugliese G, Nardone MR, Tubili C, Giuliano M, Fava D, Piergiovanni F, Forte E, Tuccinardi F, Chiaramonte F, Buzzetti R, Leto G. CSII Study Group Of Lazio Region, Italy Continuous subcutaneous insulin infusion (CSII) in inpatient setting: unmet needs and the proposal of a CSII unit. Diabetes Technol Ther. 2011 Oct;13(10):1071-4. doi: 10.1089/dia.2011.0056. Epub 2011 Jun 29. 42) Marini MA, Succurro E, Arturi F, Ruffo MF, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G. Comparison of A1C, fasting and 2-h post-load plasma glucose criteria to diagnose diabetes in Italian Caucasians. Nutr Metab Cardiovasc Dis. 2012 Jul;22(7):561-6. Epub 2011 Sep 23. 43) Cardellini M, Menghini R, Luzi A, Davato F, Cardolini I, D'Alfonso R, Gentileschi P, Rizza S, Marini MA, Porzio O, Lauro D, Sbraccia P, Lauro R, Federici M Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. Diabetes. 2011 Dec;60(12):3265-70. Epub 2011 Oct 7. 44) Castaldo E, Sabato D, Lauro D, Sesti G, Marini MA Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance.PLoS One. 2011;6(12):e28312. Epub 2011 Dec 2. 45) Marini MA, Succurro E, Frontoni S, Mastroianni S, Arturi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G. Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels.Diabetes Care. 2012 Apr;35(4):868-72. Epub 2012 Feb 22. 46) Marini MA, Succurro E, Castaldo E, Cufone S, Arturi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G. Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria.Diabetes Care. 2012 May;35(5):1144-9. Epub 2012 Mar 7. 47) Sciacqua A, Marini MA, Hribal ML, Perticone F, Sesti G. Association of insulin resistance indexes to carotid intima-media thickness. PLoS One. 2013;8(1):e53968. doi: 10.1371/journal.pone.0053968. Epub 2013 Jan 9. 48) Marini MA, Frontoni S, Succurro E, Arturi F, Sciacqua A, Hribal ML, Perticone F, Sesti G. Insulin sensitivity, and β-cell function in relation to hemoglobin A1C. Nutr Metab Cardiovasc Dis. 2013 Apr 16. S0939-4753(13)00031-8. 49) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Hribal ML, Perticone F, Sesti G Insulin clearance is associated with carotid artery intima-media thickness. Atherosclerosis. 2013 Aug;229(2):453-8. doi: 10.1016/j.atherosclerosis.2013.06.011. Epub 2013 Jun 22 50) Mannino GC, Greco A, De Lorenzo C, Andreozzi F, Marini MA, Perticone F, Sesti G. A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity. PLoS One. 2013 Dec 31;8(12). 51) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Hribal ML, Perticone F, Sesti G. Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels. PLoS One. 2013 Oct 23;8(10):e77440. doi: 10.1371/journal.pone.0077440. eCollection 2013. 52) Sesti G, Mannino GC, De Lorenzo C, Greco A, Sciacqua A, Marini MA, Andreozzi F, Perticone F A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.Atherosclerosis. 2013 Nov;231(1):141-4. doi: 10.1016/j.atherosclerosis.2013.08.041. Epub 2013 Sep 14. 53) Sesti G, Hribal ML, Procopio T, Fiorentino TV, Sciacqua A, Andreozzi F, Marini MA, Perticone F. Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects. Nutr Metab Cardiovasc Dis. 2014 Jul 18. pii: S0939-4753 54) Sesti G, Andreozzi F, Fiorentino TV, Mannino GC, Sciacqua A, Marini MA, Perticone F High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects.Acta Diabetol. 2014 Oct;51(5):705-13. doi: 10.1007/s00592-014-0576-0. Epub 2014 Mar 12. 55) Sesti G, Mannino GC, Andreozzi F, Greco A, Perticone M, Sciacqua A, Marini MA, Perticone F. A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation. Atherosclerosis. 2014 Jan;232(1):25-30 56) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Perticone F, Sesti G. Differences in insulin clearance between metabolically healthy and unhealthy obese subjects.Acta Diabetol. 2014 Apr;51(2):257-61. 57) Bruttomesso D, Laviola L, Lepore G, Bonfanti R, Bozzetto L, Corsi A, Di Blasi V, Girelli A, Grassi G, Iafusco D, Rabbone I, Schiaffini R; Italian Study Group on Diffusion of CSII Continuous subcutaneous insulin infusion in Italy: third national survey. Diabetes Technol Ther. 2015 Feb;17(2):96-104. 58) Fiorentino TV, Marini MA, Andreozzi F, Arturi F, Succurro E, Perticone M, Sciacqua A, Hribal ML, Perticone F, Sesti G. One-Hour Postload Hyperglycemia Is a Stronger Predictor of Type 2 Diabetes Than Impaired Fasting Glucose. J Clin Endocrinol Metab. 2015 59) Fiorentino TV, Marini MA, Andreozzi F, Arturi F, Succurro E, Perticone M, Sciacqua A, Hribal ML, Perticone F, Sesti G.Response to the Letter: Comment to the letter by Marathe CS, Rayne CK, Jones KL, Horowitz M.J Clin Endocrinol Metab. 2016 Feb;101(2):L35 60) Spiga R, Marini MA, Mancuso E, Di Fatta C, Fuoco A, Perticone F, Andreozzi F, Mannino GC, Sesti G. Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1241-1249. doi: 10.1161/ATVBAHA.117.309128. Epub 2017 Apr 13. PMID: 28408375 61) Marini MA, Mannino GC, Fiorentino TV, Andreozzi F, Perticone F, Sesti G. A polymorphism at IGF1 locus is associated with anemia. Oncotarget. 2017 May 16;8(20):32398-32406. doi: 10.18632/oncotarget.16132. PMID: 28415730 62) Marini MA, Fiorentino TV, Succurro E, Pedace E, Andreozzi F, Sciacqua A, Perticone F, Sesti G. Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals. PLoS One. 2017 Apr 20;12(4):e0175547. doi: 10.1371/journal.pone.0175547. eCollection 2017. PMID: 28426788 63) Marini MA, Fiorentino TV, Andreozzi F, Mannino GC, Succurro E, Sciacqua A, Perticone F, Sesti G Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels. Nutr Metab Cardiovasc Dis. 2017 Jul;27(7):601-608. doi: 10.1016/j.numecd.2017.04.001. Epub 2017 Apr 21. PMID: 28511905 64) Marini MA, Fiorentino TV, Andreozzi F, Mannino GC, Perticone M, Sciacqua A, Perticone F, Sesti G. Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity. Acta Diabetol. 2017 Aug;54(8):775-784. doi: 10.1007/s00592-017-1004-z. Epub 2017 Jun 2. PMID: 28577138 65) Fiorentino TV, Marini MA, Succurro E, Sciacqua A, Andreozzi F, Perticone F, Sesti G Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction. Oncotarget. 2017 Jun 19. doi: 10.18632/oncotarget.18572. [Epub ahead of print]
RASSEGNE E CAPITOLI DI LIBRI
1. Bertoli A., Caputo S., Marini M.A., "I recettori insulinici nell'uomo in: "Il Diabete mellito fisiopatologia e clinica." Greco A.V., Ghirlanda G. p 159 Verducci ed.
2. Sesti G. , Marini M.A. "Le sindromi da estrema insulino - resistenza". Metabolismo Oggi 7: 95-102, 1990.
3. Sesti G., Marini M.A.“Meccanismi molecolari dell'insulino-resistenza". Metabolismo Oggi 11: 105-115, 1994
4. Marini M.A., Sesti G. "Malattie della Tiroide" Su vol. Medicina Clinica, Ed. Grasso, Capitolo XVI: 627-668, 1996 ISBN: 8886459092
5. Marini M.A., Sesti G. "Malattie delle paratiroidi" Su vol. Medicina Clinica, Ed. Grasso, Capitolo XVII: 669-682, 1996 ISBN: 8886459092
6. Marini M, Lauro D, Lauro R (2007). Malattie internistiche di interesse sessuologico. In: Iannini E A, Lennzi A, Maggi M A. Sessuologia Medica. Trattato di psicosessuologia, medicina della sessualità e salute della coppia. p. 174-179, MILANO:Elsevier Masson, ISBN: 8821429113
Curriculum Vitae
Personal Information Name / Surname Maria Adelaide Marini Fax +39 06 20902679 E-mail maride.marini@uniroma2.it Citizenship Italian Date of birth 01/14/1959 Marital Status Married with two children Education and training She obtained a baccalaureate classical in Rome in 1977 at the Institute "Santa Maria degli Angeli";
- In the academic year 1977/78 has won the competition for admission and enrolled at the Faculty of Medicine, Catholic University of the Sacred Heart;
- In the academic years 1980/81 - 1981/82 and 1982/83 was a student inside at the Division of Gastroenterology of the Department of Special Medical Pathology at the same University;
- Earned at the same University Degree in Medicine and Surgery Day 24.10.1983 with a score of 110/110 cum laude;
- In November 1983 he became qualified to practice as a Surgeon;
- In October 1986, he obtained a Postgraduate Diploma in Endocrinology with a score of 70/70 cum laude at the 'University of Rome "Tor Vergata";
- In the academic year 1988/89, after being successful in the competition for free exams and qualifications is appointed technical officer (VIII level) relating to the Chair of Endocrinology, Department of Internal Medicine of the University of Rome "Tor Vergata";
- In the academic year 2000/2001 after the winner of the competition based on qualifications and tests, was appointed researcher relating to the Chair of Internal Medicine, Department of Internal Medicine of the University of Rome "Tor Vergata";
- In the academic year 2006/2007 after becoming the suitability assessment for Associate Professor at the Faculty of Medicine, University of Milan, scientific-disciplinary sector Med / 09 has been called to serve as Associate Professor, relating to the Chair of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Rome Tor Vergata.
Occupation or position held Project Manager with a high scientific "Diabetes and Gender" in Functional Area Aggregate of Internal Medicine at the Policlinico Tor Vergata University of Rome Tor Vergata Name and address of employer University of Rome Tor Vergata Policlinico Tor Vergata Research topics - Molecular mechanisms of insulin resistance; - Molecular pathogenesis of type 2 diabetes and obesity; - Genetics of Type 2 Diabetes; - Syndrome hypoglycemic autoimmune antibodies from anti-insulin receptor; - Regulation of insulin secretion. Mother tongue Italian Others languages English French Maria Adelaide Marini is author or co-author of numerous scientific publications in the medical pathophysiology published in international journals. The results are reported in the scientific publications in full on the following journal with "peer review": ORIGINAL PUBLICATIONS IN INTERNATIONAL JOURNALS WITH PEER REVIEW
1) Sesti G., Marini M.A., Montemurro A., Di Daniele N., Bertoli A., Cordera, Andraghetti G., De Pirro R., Lauro R., Monaco F., Roche J. "Preparation of monoclonal anti-insulin receptor antibodies labelled by 125-I". C. R. Soc. Biol. 182, 167-176; 1988.
2) Bertoli A., Caputo S., Marini M.A., Santini S.A., Ghirlanda G., Greco A.V. "Inhibition of basal insulin secretion induces insulin resistance in normal man: evidence for a tonic effect of insulin on carbohydrate metabolism". Horm. Res. 31: 238-243, 1989
3) Borboni P., Di Cola G., Sesti G., Marini M.A., Del Porto P., Gilardini Montani M., Lauro R., De Pirro R. "ß-endorphin receptors on cultured and freshly isolated lymphocytes from normal subjects". Biochem. Biophys. Res. Commun. 163: 642-648; 1989.
4) De Pirro R., Borboni P., Marini M.A., Montemurro A., Sesti G., Lauro R. "Antibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action." J. Endocrinol. Invest. 13: 951-968, 1990.
5) Sesti G., Marini M.A., Tullio A.N., Montemurro A., Borboni P., Fusco, Accili D, Lauro R. "Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients".Biochem. Biophys. Res. Commun. 181: 1419-1424, 1991.
6) Sesti G., Marini M.A., Montemurro A., Borboni P., Di Cola G., Bertoli A. Lauro R., De Pirro R. "Evidence that human and porcine insulin affect differently the human insulin receptor: studies with monoclonal anti-insulin receptor antibodies". J. Endocrinol. Invest. 14: 913-918, 1991.
7) Sesti G., Marini M.A., Montemurro A., Borboni P., Condorelli L., Haring HU., Ullrich A., Goldfine D., De Pirro R., Lauro R. "Evidence that two naturally occurring human insulin receptor a-subunit variants are immunologically distinct".Diabetes 41: 6-11, 1992.
8) Sesti G., Marini M.A., Briata P., Tullio A.N., Montemurro A., Borboni P., De Pirro R., Gherzi R., Lauro R. "Androgens increase insulin receptor gene expression and insulin responsiveness in Hep-2 larynx carcinoma cells". Mol Cell Endocrinol 86: 111-118,1992
9) Sesti G., Tullio A.N., Marini M.A., Manera E., Borboni P., Accili D., Longhi R, Fusco A., Lauro R., Montemurro A."Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies". Mol Cell Endocrinol 101:121-127, 1994
10) Sesti G., Tullio A.N., D'Alfonso R., Napolitano ML., Marini M.A., Borboni P., Longhi R., Albonici L., Fusco A., Aglianò A.M., Manzari V., Lauro R. "Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein".Acta Diabetologica 31: 59-65, 1994
11) Bertoli A.,Fusco A., Magnani A, Marini M.A., Di Daniele N., Gatti S. Lauro R. "Efficacy of low dose GnRH analogue (Buserelin) in the treatment of hirsutism" Exp.Clin.Endocrinol 103 (1995) 15-20
12) Sesti G., D'Alfonso R., Vargas Punti M.D., Tullio A.N., Liu Y.Y., Federici M., Borboni P., Marini M.A., Lauro R., Fusco A."Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured EBV-transformed lymphocytes from insulin-resistant subjects" Diabetologia 39: 289-297, 1996
13) Federici M., Porzio O., Zucaro L., Giovannone B., Borboni P., Marini M.A., Lauro D., Sesti G. “Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients” Mol. Cell. Endocrinol. 135, 41-47, 1997
14) Bertoli A., Magnaterra R., Borboni P., Marini M.A., Barini A., Fusco A., Bollea M.R. "Dose-dependent effect of octreotide on insulin secretion after OGTT in obesity." Horm Res 49(1):17-21, 1998
15) D’Alfonso R., Marini M.A., Frittitta L., Sorge R., Frontoni S., Porzio O., Mariani L.M., Lauro D., Gambardella S., Trischitta V., Federici M., Lauro R., Sesti G. “Polymorphism of the Insulin Receptor Substrate-2 in Patients with Type 2 Diabetes” J.Clin.Endocrinol.Metab. 88 (1):317-322, 2003
16) Sesti G., Cardellini M., Marini M.A., Frontoni S., D’Adamo M., Del Guerra S., Lauro D., De Nocolais P., Sbraccia P., Del Prato S., Gambardella S., Federici M., Marchetti P., Lauro R. “A common Polymorphism in the promoter UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects” Diabetes. 2003 May; 52 (5): 1280-3
17) Marini M.A., Frontoni S., Mineo D. Bracaglia D. Cardellini M., De Nicolais P., Baroni A., D’Alfonso R., Perna M., Lauro D., Federici M., Gambardella S., Lauro R., Sesti G. “ The Arg 972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients” J.Clin.Endocrinol. Matab. 2003 Jul; 88 (7): 3368-71
18) Mariani L.M., Marini M.A., Veneziani A., Bertoli A., Lauro R. “Morbid obesità: evaluation of metabolic indexes after adjustable silicone gastric banding. Acta Diabetol. 2003 Oct; Suppl 1: S263-5
19) Sesti G., Marini M.A., Cardellini M., Sciacqua A., Frontoni S., Andreozzi F., Irace C., Lauro D., Gnasso A., Federici M., Perticone F., Lauro R. “ The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to solfonylurea in patients with type 2 diabetes” Diabetes Care 2004 June; 27 (6): 1394-8
20) D’Adamo M., Perego l., Cardellini M., Marini M.A.,Frontoni S., Andreozzi F., Sciacqua A., Lauro D., Sbraccia P., Federici M., Paganelli m., Pontiroli A.E., Lauro R., Perticone F., Folli.F., Sesti G. “the-866 A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistence and icreased risk of type 2 diabetes.” Diabetes 2004 Jul;53 (7):1905-10
21) Sesti G., Sciacqua A., Cardellini M., Marini M.A., Maio R., Vatrano M., Succurro E., Lauro R., Federici M., Perticone F. “Plasma concentration of IGF-1 is indipendently associated with insulin sensitività in subjects with different degrees of glucose tolerance” Diabetes Care 2005 Jan;28(1):120-5.
22) Cardellini M., Perego L., D’Adamo M., Marini M.A., Procopio C., Hribal M.L., Andreozzi F., Frontoni S., Giacomelli M., Paganelli M., Pontiroli A.E., Lauro R., Folli F., Sesti G. C-174G Polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diabetes Care. 2005 Aug;28(8):2007-12
23) Mariani M.L., Fusco A., Turriziani M., Veneziani A., Marini M.A., De Lorenzo A., Bertoli A. Transient increase of plasma ghrelin after laparoscopic adjustable gastric banding in morbid obesity. Horm Metab Res. 2005 Apr;37(4):242-5
24) Rizza S, Tesauro M, Cardellini M, meneghini R, Bellia A, Marini MA, Lauro D, Sbraccia P, Sesti G, Lauro R, Federici M. Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):431-2. 25) Scarpelli D, Cardellini M, Andreozzi F, Laratta E, Hribal ML, Marini MA, Tassi V, Lauro R, Perticone F, Sesti G. Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. Diabetes. 2006 May;55(5):1529-33. 26) Andreozzi F, Laratta E, Cardellini M, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of italian-caucasian nondiabetic subjects. Diabetes. 2006 Jul;55(7):2021-4. Cardellini M, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Perticone F, Federici M, Lauro D, Sesti G. Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E347-52. Epub 2006 Sep 12.
28) Cardellini M, Andreozzi F, Laratta E, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians. Diabetes Metab Res Rev. 2006 Sep 4
29) Cardellini M, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Perticone F, Federici M, Lauro D, Sesti G. “Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.” Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E347-52
30) Ludovico O, Pellegrini F, Di Paola R, Minenna A, Mastroianno S, Cardellini M, Marini MA, Andreozzi F, Vaccaro O, Sesti G, Trischitta V. “Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk.” Obesity (Silver Spring). 2007 May;15(5):1076-81.
31) Marini MA, Succurro E, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G.“Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women.” Diabetes Care. 2007 Aug;30(8):2145-7. Epub 2007 May 16.
32) Sesti G, Andreozzi F, Bonadonna RC, De Mattia G, Leonetti F, Luzi L, Marini MA, Natali A, Vettor R, Bonora E; Group of Italian Scientists of Insulin Resistance (GISIR). “Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database.” Diabetes Metab Res Rev. 2008 Feb;24(2):130-6.
33) Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson PA, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring HU.“A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.” Diabetes. 2008 Feb;57(2):514-7
34) Bonora E, Capaldo B, Perin PC, Del Prato S, De Mattia G, Frittitta L, Frontoni S, Leonetti F, Luzi L, Marchesini G, Marini MA, Natali A, Paolisso G, Piatti PM, Pujia A, Solini A, Vettor R, Bonadonna RC; on behalf of the Group of Italian Scientists of Insulin Resistance (GISIR).“Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database.” Nutr Metab Cardiovasc Dis. 2007 Nov 28
35) Succurro E, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G. “Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals.” Obesity (Silver Spring). 2008 Aug;16(8):1881-6.
36) Presta I, Andreozzi F, Succurro E, Marini MA, Laratta E, Lauro R, Hribal ML, Perticone F, Sesti G. “IL-18 gene polymorphism and metabolic syndrome.” Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):e5-6. Epub 2009 Jan 26.
37) Succurro E, Marini MA, Grembiale A, Lugarà M, Andreozzi F, Sciacqua A, Hribal ML, Lauro R, Perticone F, Sesti G. “Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.” Diabetes Metab Res Rev. 2009 May;25(4):351-6.PMID: 19319930
38) Succurro E, Andreozzi F, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G. “Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects.” Nutr Metab Cardiovasc Dis. 2009 Apr 3
39) Succurro E, Marini MA, Arturi F, Grembiale A, Lugarà M, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G “Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis” Atherosclerosis. 2009 Apr 11.
40) Fiore AM, Marinoni GM, Piccione A, Marini MA, D'Adamo M, Lauro R, Sbraccia P. A rare cardiac finding in a morbidly obese patient with severe hypertension Intern Emerg Med. 2010 Oct 9. [Epub ahead of print]
41) Hribal ML, Presta I, Procopio T, Marini MA, Stan?áková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium.Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B Diabetologia. 2011 Jan 14. [Epub ahead of print]
42) Succurro E, Marini MA, Arturi F, Grembiale A, Fiorentino TV, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G Usefulness of hemoglobin A1c as a criterion to define the metabolic syndrome in a cohort of italian nondiabetic white subjects. Am J Cardiol. 2011 Jun 1;107(11):1650-5. Epub 2011 Mar 21.
43) Morviducci L, Di Flaviani A, Lauria A, Pitocco D, Pozzilli P, Suraci C, Frontoni S; Cappa M, Patera IP, Manfrini S, Bracaglia D, Ciampittiello G, Cicconetti E, Ventura C, Bloise D, Tatti P, Leotta S, Visalli N, Caputo S, Ghirlanda G, Giaccari A, Gisella Cavallo M, Leonetti F, Lauro D, Mancabitti ML, Marini MA, Spallone V, Napoli A, Pugliese G, Nardone MR, Tubili C, Giuliano M, Fava D, Piergiovanni F, Forte E, Tuccinardi F, Chiaramonte F, Buzzetti R, Leto G. CSII Study Group Of Lazio Region, Italy Continuous subcutaneous insulin infusion (CSII) in inpatient setting: unmet needs and the proposal of a CSII unit. Diabetes Technol Ther. 2011 Oct;13(10):1071-4. doi: 10.1089/dia.2011.0056. Epub 2011 Jun 29.
44) Marini MA, Succurro E, Arturi F, Ruffo MF, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G. Comparison of A1C, fasting and 2-h post-load plasma glucose criteria to diagnose diabetes in Italian Caucasians. Nutr Metab Cardiovasc Dis. 2012 Jul;22(7):561-6. Epub 2011 Sep 23.
45) Cardellini M, Menghini R, Luzi A, Davato F, Cardolini I, D'Alfonso R, Gentileschi P, Rizza S, Marini MA, Porzio O, Lauro D, Sbraccia P, Lauro R, Federici M Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. Diabetes. 2011 Dec;60(12):3265-70. Epub 2011 Oct 7.
46) Castaldo E, Sabato D, Lauro D, Sesti G, Marini MA Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance.PLoS One. 2011;6(12):e28312. Epub 2011 Dec 2.
47) Marini MA, Succurro E, Frontoni S, Mastroianni S, Arturi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G.Insulin sensitivity, ?-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels.Diabetes Care. 2012 Apr;35(4):868-72. Epub 2012 Feb 22.
48) Marini MA, Succurro E, Castaldo E, Cufone S, Arturi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G. Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria.Diabetes Care. 2012 May;35(5):1144-9. Epub 2012 Mar 7.
49) Sciacqua A, Marini MA, Hribal ML, Perticone F, Sesti G Association of insulin resistance indexes to carotid intima-media thickness. PLoS One. 2013;8(1):e53968. doi: 10.1371/journal.pone.0053968. Epub 2013 Jan 9
50) Marini MA, Frontoni S, Succurro E, Arturi F, Sciacqua A, Hribal ML, Perticone F, Sesti G. .Insulin sensitivity, and ?-cell function in relation to hemoglobin A1C. Nutr Metab Cardiovasc Dis. 2013 Apr 16
51) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Hribal ML, Perticone F, Sesti G. Insulin clearance is associated with carotid artery intima-media thickness. Atherosclerosis. 2013 Aug;229(2):453-8. doi: 10.1016/j.Atherosclerosis.2013.06.011. Epub 2013 Jun 22.
52) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Perticone F, Sesti G. Differences in insulin clearance between metabolically healthy and unhealthy obese subjects. Acta Diabetol. 2013 Aug 30
53) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Hribal ML, Perticone F, Sesti G. Decreased Insulin Clearance in Individuals with Elevated 1-h Post-Load Plasma Glucose Levels. PLoS One. 2013 Oct 23;8(10):e77440
54) Sesti G, Mannino GC, De Lorenzo C, Greco A, Sciacqua A, Marini MA, Andreozzi F, Perticone F. A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease. Atherosclerosis. 2013 Nov;231(1):141-4. doi: 10.1016/j.Atherosclerosis.2013.08.041. Epub 2013 Sep 14.
55) Sesti G, Hribal ML, Procopio T, Fiorentino TV, Sciacqua A, Andreozzi F, Marini MA, Perticone F. Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects. Nutr Metab Cardiovasc Dis. 2014 Jul 18. pii: S0939-4753
56) Sesti G, Andreozzi F, Fiorentino TV, Mannino GC, Sciacqua A, Marini MA, Perticone F High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects.Acta Diabetol. 2014 Oct;51(5):705-13. doi: 10.1007/s00592-014-0576-0. Epub 2014 Mar 12.
57) Sesti G, Mannino GC, Andreozzi F, Greco A, Perticone M, Sciacqua A, Marini MA, Perticone F. A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation. Atherosclerosis. 2014 Jan;232(1):25-30
58) Marini MA, Frontoni S, Succurro E, Arturi F, Fiorentino TV, Sciacqua A, Perticone F, Sesti G. Differences in insulin clearance between metabolically healthy and unhealthy obese subjects.Acta Diabetol. 2014 Apr;51(2):257-61.
59) Bruttomesso D, Laviola L, Lepore G, Bonfanti R, Bozzetto L, Corsi A, Di Blasi V, Girelli A, Grassi G, Iafusco D, Rabbone I, Schiaffini R; Italian Study Group on Diffusion of CSII Continuous subcutaneous insulin infusion in Italy: third national survey. Diabetes Technol Ther. 2015 Feb;17(2):96-104.
60) Fiorentino TV, Marini MA, Andreozzi F, Arturi F, Succurro E, Perticone M, Sciacqua A, Hribal ML, Perticone F, Sesti G. One-Hour Postload Hyperglycemia Is a Stronger Predictor of Type 2 Diabetes Than Impaired Fasting Glucose. J Clin Endocrinol Metab. 2015
61) Fiorentino TV, Marini MA, Andreozzi F, Arturi F, Succurro E, Perticone M, Sciacqua A, Hribal ML, Perticone F, Sesti G.Response to the Letter: Comment to the letter by Marathe CS, Rayne CK, Jones KL, Horowitz M.J Clin Endocrinol Metab. 2016 Feb;101(2):L35
62) Spiga R, Marini MA, Mancuso E, Di Fatta C, Fuoco A, Perticone F, Andreozzi F, Mannino GC, Sesti G. Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-?B Signaling Pathway in HepG2 Cells. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1241-1249. doi: 10.1161/ATVBAHA.117.309128. Epub 2017 Apr 13. PMID: 28408375
63) Marini MA, Mannino GC, Fiorentino TV, Andreozzi F, Perticone F, Sesti G. A polymorphism at IGF1 locus is associated with anemia. Oncotarget. 2017 May 16;8(20):32398-32406. doi: 10.18632/oncotarget.16132. PMID: 28415730
64) Marini MA, Fiorentino TV, Succurro E, Pedace E, Andreozzi F, Sciacqua A, Perticone F, Sesti G. Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals. PLoS One. 2017 Apr 20;12(4):e0175547. doi: 10.1371/journal.pone.0175547. eCollection 2017. PMID: 28426788 65) Marini MA, Fiorentino TV, Andreozzi F, Mannino GC, Succurro E, Sciacqua A, Perticone F, Sesti G Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels. Nutr Metab Cardiovasc Dis. 2017 Jul;27(7):601-608. doi: 10.1016/j.numecd.2017.04.001. Epub 2017 Apr 21. PMID: 28511905
66) Marini MA, Fiorentino TV, Andreozzi F, Mannino GC, Perticone M, Sciacqua A, Perticone F, Sesti G. Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity. Acta Diabetol. 2017 Aug;54(8):775-784. doi: 10.1007/s00592-017-1004-z. Epub 2017 Jun 2. PMID: 28577138
67) Fiorentino TV, Marini MA, Succurro E, Sciacqua A, Andreozzi F, Perticone F, Sesti G Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction. Oncotarget. 2017 Jun 19. doi: 10.18632/oncotarget.18572. [Epub ahead of print]
REVIEW AND BOOK CHAPTERS 1. Bertoli A., Caputo S., Marini M.A., "I, recettori insulinici nell'uomo in: "Il Diabete mellito fisiopatologia e clinica." Greco A.V., Ghirlanda G. p 159 Verducci ed.
2. Sesti G. , Marini M.A. "Le sindromi da estrema insulino - resistenza". Metabolismo Oggi 7: 95-102, 1990.
3. Sesti G., Marini M.A.“Meccanismi molecolari dell'insulino-resistenza". Metabolismo Oggi 11: 105-115, 1994
4. Marini M.A., Sesti G. "Malattie della Tiroide" Su vol. Medicina Clinica, Ed. Grasso, Capitolo XVI: 627-668, 1996
5. Marini M.A., Sesti G. "Malattie delle paratiroidi" Su vol. Medicina Clinica, Ed. Grasso, Capitolo XVII: 669-682, 1996
6. Marini M, Lauro D, Lauro R (2007). Malattie internistiche di interesse sessuologico. In: Iannini E A, Lennzi A, Maggi M A. Sessuologia Medica. Trattato di psicosessuologia, medicina della sessualità e salute della coppia. p. 174-179, MILANO:Elsevier Masson, ISBN: 8821429113