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CV Prof.ssa Sonia Melino

Professore Ordinario  di Biochimica presso il Dipartimento di Medicina Sperimentale  dell'Università di Roma "Tor Vergata" via Montpellier 1 00133- Roma

melinos@uniroma2.it

studio  settore F livello 0 st. 13 via della Ricerca Scientifica

0672594410 lab 0672594449

 

Nata nel 1969 ha conseguito nel 1992 la Laurea con lode in Scienze Biologiche presso Università di Roma “La Sapienza”;

 

Attività editoriali

 

 

Attività di ricerca

La sua attività di ricerca è stata incentrata in ambito biochimico, in particolare sulla produzione e caratterizzazione strutturale e funzionale di proteine/enzimi coinvolte nei processi di detossificazione cellulare e metallopeptidi ad attività antibatterica. Gran parte della sua ricerca è stata volta allo studio della struttura e funzione delle proteine. Da alcuni anni il suo campo d’interesse si è spostato sulla messa punto di sistemi 3D a base di idrogel proteici per la crescita di cellule staminali adulte. Inoltre ha dedicato la parte della sua attività di ricerca allo studio dei composti organici naturali a lento rilascio di H2S al fine di valutarne gli effetti su particolari pathway metabolici coinvolti nei processi di crescita ed il differenziamento cellulare. Al momento è coautrice oltre 90 pubblicazioni scientifiche su riviste internazionali, tra cui quattro “invited reviews”.

Nella gran parte dei suoi lavori risulta essere primo ultimo oautore corrispondente. Ha inoltre partecipato a diversi congressi nazionali ed internazionali. H index= 38 (Scopus).

 

Finanziamenti di Progetti di Ricerca come Responsabile o Partecipante

 

 

Attività Internazionali

E’ stata la Responsabile dei seguenti Accordi Internazionali per ricerca e scambio di studenti firmati tra l’Università di Roma Tor Vergata e le seguenti Università:

1) Deakin University Melburne-Australia  siglato 2009;

2) Technion-Israel Institute of Technology of Haifa- Israel siglato nel 2011 rinnovato nel 2017 per altri 5 anni;

3) Uniwersytet Jagiellonski w Krakowie- Poland siglato 2013

 

 

Attività Didattica 

 

-2003-04 Affidamento del corso di Laboratorio di Biochimica II la laurea in Chimica Vecchio Ordinamento ed ha effettuato alcune lezioni per il corso di Biochimica II tenuto dal prof. M. Paci per la gli studenti della Laurea Specialistica in Chimica;

- 2004-2009 Affidamento il corso di Laboratorio di Biochimica II per la Laurea Specialistica in Chimica;

-2007-08 Supplenza del corso di Elementi di Biochimica per la Laurea Specialistica in Scienze e Tecnologie dei Materiali e le è stato affidato il corso di Laboratorio di Biochimica II per la Laurea Specialistica in Chimica;

-2008-09 Supplenza del corso di Elementi di Biochimica per la Laurea Specialistica in Scienze e Tecnologie dei Materiali e le è stato affidato il corso di Laboratorio di Biochimica II per la Laurea Specialistica in Chimica.

-2009-10 Supplenza per il corso di Biochimica e Laboratorio (8CFU) per la Laurea Magistrale in Chimica.

- 2009-2014 Supplenza per il corso di Macromolecole e Processi Biochimici (6CFU) per la Laurea Magistrale in Scienze e Tecnologie dei Materiali

- 2010-2014 ha effettuato il corso  di Laboratorio (2CFU) per il corso di Biochimica e Laboratorio per la Laurea Magistrale in Chimica tenuto dal prof. M. Paci.

- 2015-2017 Assegnazione del corso di Biochimica e Laboratorio per la Laurea Magistrale in Chimica (9CFU)

- 2015-2017 Assegnazione del corso di Macromolecole e Processi Biochimici (6CFU) per la Laurea Magistrale in Scienze e Tecnologie dei Materiali

- 2013-2016 ha fatto parte del PROGETTO SPERIMENTALE “Nuovi materiali” Nanotecnologie per l’energia, nanotecnologie per l’elettronica, materiali per l’ambiente”  per la formazione degli studenti di scuola secondaria superiore (modalità didattica all’interno del curricolo a.s    2013/2014)  con l’Istituto Tecnico Industriale Statale “Giovanni XXIII” di  Roma

- 2013-2014 ha partecipato al progetto di scambio Italia-Brasile “Scienza senza Frontiere/ Ci?ncias sem Fronteiras” per la formazione di studenti

- 2015 ha partecipato al progetto Erasmus come tutor di tesi sperimentali per la laurea in Chimica.

- 2016-2018 ha preso parte al Progetto Lauree Scientifiche-PLS 2016-2018 approvato dal MIUR svolgendo lezioni di Biochimica ed esperienze di laboratorio per la formazione di docenti e studenti delle scuole superiori nell’ambito;

 

Premi e riconoscimenti per l'attività scientifica

 

- 2017 Rita Levi Montalcini Award come Responsabile del Progetto “Novel 3D Hydrogel Scaffolds for Tissue Repair and Regeneration” presentato in collaborazione con il prof. Dror Seliktar del Technion-Israel Institute of Technology of Haifa- Israel

 

Trasferimento Tecnologico e terza missione

 

 

Pubblicazioni

 

  1. Di Ilio C, Angelucci S, Pennelli A, Bucciarelli T, Petruzzelli R, Tiboni GM, Melino S and Sacchetta P (1996) Purification and characterization of three Pi class glutathione transferase from monkey (Macaca fascicularis) placenta.Comp Biochem Physiol B Biochem Mol Biol114, 377-82
  2. Aceto A, Dragani B,Melino S, Allocati N, Masulli M, Di Ilio C and Petruzzelli R (1997) Identification of an N-capping box that affects the alpha 6-helix propensity in glutathione S-transferase superfamily proteins: a role for an invariant aspartic residue.Biochem J322 (Pt 1), 229-34
  3. Sacchetta P, Petruzzelli R, Melino S, Bucciarelli T, Pennelli A, Amicarelli F, Miranda M and Di Ilio C (1997) Amphibian embryo glutathione transferase: amino acid sequence and structural properties.Biochem J322 ( Pt 2), 679-680
  4. Dragani B, Stenberg G, Melino S, Petruzzelli R, Mannervik B and Aceto A (1997) The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding. Identification of a buried and conserved hydrogen bond important for protein stability.J Biol Chem 272, 25518-23
  5. Favaloro B, Melino S, Petruzzelli R, Di Ilio C and Rotilio D (1998) Purification and characterization of a novel glutathione transferase from Ochrobactrum anthropi.FEMS Microbiol Lett160, 81-86
  6. Aceto A, Dragani B, Melino S, Principato G, Saccucci F, Gualtieri G and Petruzzelli R (1998) Structural characterization of human glyoxalase II as probed by limited proteolysis.Biochem Mol Biol Int44, 761-769
  7. Melino S, Rufini S, Sette M, Morero R, Grottesi A, Paci M and Petruzzelli R (1999) Zn(2+) ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles. Identification and characterization of a zinc-binding motif present in the functional domain.Biochemistry38, 9626-9633
  8. Bucciarelli T, Sacchetta P, Pennelli A, Cornelio L, Romagnoli R, Melino S, Petruzzelli R and Di Ilio C (1999) Characterization of toad liver glutathione transferase.Biochim Biophys Acta1431, 189-198
  9. Melino S, Capo C, Dragani B, Aceto A and Petruzzelli R (1998) A zinc-binding motif conserved in glyoxalase II, beta-lactamase and arylsulfatases.Trends Biochem Sci23, 381-2
  10. Favaloro B, Tamburro A, Angelucci S, Luca AD, Melino S, di Ilio C and Rotilio D (1998) Molecular cloning, expression and site-directed mutagenesis of glutathione S-transferase from Ochrobactrum anthropi.Biochem J335 ( Pt 3), 573-579
  11. Vitali A, Botta B, Delle Monache G, Zappitelli S, Ricciardi P, Melino S, Petruzzelli R and Giardina B (1998) Purification and partial characterization of a peroxidase from plant cell cultures of Cassia didymobotrya and biotransformation studies.Biochem J331 ( Pt 2), 513-519
  12. Angelucci S, Sacchetta P, Moio P, Melino S, Petruzzelli R, Gervasi P and Di Ilio C (2000) Purification and characterization of glutathione transferases from the sea bass (Dicentrarchus labrax) liver.Arch Biochem Biophys 373, 435-441
  13. Bozzi M, Battistoni A, Sette M, Melino S, Rotilio G and Paci M (2001) Unfolding and inactivation of monomeric superoxide dismutase from E. coli by SDS.Int J Biol Macromol 29, 99-105
  14. Bucciarelli, T., Petruzzelli, R.,  Melino, S., Cornelio, L.,  Amicarelli, F.,  Di Ilio, C., Sacchetta, P.aOrgan distribution of glutathione transferase isoenzymes in common toad (Bufo bufo) Chemico-Biological Interactions (2001) 133(1-3), pp. 322-324
  15. Bucciarelli T, Sacchetta P, Amicarelli F, Petruzzelli R, Melino S, Rotilio D, Celli N and Di Ilio C Amino acid sequence of the major form of toad liver glutathione transferase.Int J Biochem Cell Biol (2002)  34, 1286-1290
  16. Fasano M, Orsale M,Melino S, Nicolai E, Forlani F, Rosato N, Cicero D, Pagani S and Paci M Surface changes and role of buried water molecules during the sulfane sulfur transfer in rhodanese from Azotobacter vinelandii: a fluorescence quenching and nuclear magnetic relaxation dispersion spectroscopic study.Biochemistry(2003) 42, 8550-7
  17. Orsale M, Melino S, Contessa GM, Torre V, Andreotti G, Motta A, Paci M, Desideri A and Cicero DO Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy.FEBS Lett(2003) 548, 11-6
  18. Melino S, Cicero DO, Orsale M, Forlani F, Pagani S and Paci M Azotobacter vinelandii rhodanese: selenium loading and ion interaction studies.Eur J Biochem (2003)270, 4208-15
  19. Cicero DO, Melino S, Orsale M, Brancato G, Amadei A, Forlani F, Pagani S and Paci M Structural rearrangements of the two domains of Azotobacter vinelandii rhodanese upon sulfane sulfur release: essential molecular dynamics, 15N NMR relaxation and deuterium exchange on the uniformly labeled protein.Int J biol Macromol (2003) 33, 193-201
  20. Trotta E, Del Grosso N, Erba M, Melino S, Cicero D and Paci M Interaction of DAPI with individual strands of trinucleotide repeats. Effects of replication in vitro of the AAT x ATT triplet.Eur J Biochem(2003)270, 4755-61
  21. Melino S*, Cicero DO, Forlani F, Pagani S and Paci M The N-terminal rhodanese domain from Azotobacter vinelandii has a stable and folded structure independently of the C-terminal domain.FEBS Lett(2004)577, 403-8
  22. Gallo M, Paludi D, Cicero DO, Chiovitti K, Millo E, Salis A, Damonte G, Corsaro A, Thellung S, Schettini G, Melino S, Florio T, Paci M and Aceto A Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation.Int J Immunopathol Pharmacol(2005) 18, 95-112
  23. Contessa GM, Orsale M, Melino S, Torre V, Paci M, Desideri A and Cicero DO Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family.J Biomol NMR (2005)31, 185-99
  24. Melino S, Pennestri M, Santoprete A, Bielli P, Paci M, Ragnini-Wilson A and Cicero DO Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae.J Biomol NMR (2005) 31, 367-8
  25. Melino S, Garlando L, Patamia M, Paci M and Petruzzelli R A metal-binding site is present in the amino terminal region of the bioactive iron regulator hepcidin-25.J Pept Res(2005)66, 65-71
  26. Fazi B1,Melino S1, Di Sano F, Cicero DO, Piacentini M and Paci M Cloning, expression, and preliminary structural characterization of RTN-1C.Biochem Biophys Res Commun(2006)342, 881-6 (1 equally contributed to this work)
  27. Melino S*, Fucito S, Campagna A, Wrubl F, Gamarnik A, Cicero DO and Paci M The active essential CFNS3d protein complex.FEBS J (2006) 273, 3650-62
  28. Gallo M, Melino S, Melis R, Paci M and Cicero DO Backbone NMR assignment of the 29.6 kDa Rhodanese protein from Azotobacter vinelandii.J Biomol NMR(2006)36 Suppl 5, 73
  29. Melino S*, Gallo M, Trotta E, Mondello F, Paci M and Petruzzelli R Metal-Binding and Nuclease Activity of an Antimicrobial Peptide Analogue of the Salivary Histatin 5.Biochemistry (2006)45, 15373-15383
  30. Pennestri M, Melino S, Contessa GM, Casavola EC, Paci M, Ragnini-Wilson A and Cicero DO Structural basis for the interaction of the myosin light chain Mlc1p with the myosin V Myo2p IQ motifs.J Biol Chem(2007)282, 667-79
  31. Cabras T, Patamia M, Melino S, Inzitari R, Messana I, Castagnola M & Petruzzelli R Pro-oxidant activity of histatin 5 related Cu(II)-model peptide probed by mass spectrometry.Biochem Biophys Res Commun (2007) 358, 277-84.
  32. Melino S*and Paci M Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach. Rev.FEBS J(2007)274, 2986-3002.
  33. Sabelli R, Iorio E, De Martino A, Podo F, Ricci A, Viticchiè G, Rotilio G, Paci M & Melino S* Rhodanese-Thioredoxin system and allyl sulfur compounds: implications in the apoptosis induction FEBS J (2008),275,3884-3899
  34. Melino S, Cicero OD, Gallo M, Sabelli R, Melis R and Paci M. New investigations on the Sulfurtransferase enzyme rhodanese by NMR and its selenium binding International Proceedings 2nd European Conference on Chemistry for Life Sciences (2008)
  35. Melino S *,Nepravishta R , Bellomaria A, Di Marco S and Paci M  Nucleic acids-binding of RTN1-C C-terminal region:towards the functional role of a reticulon protein. Biochemistry (2009)  48, 242-253
  36. Fazi B, Melino S, De Rubeis S, Bagni C, Paci M, Piacentini M, Di Sano F Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene(2009)  28:3814-3824
  37. Zhou M, Leong TS, Melino S, Cavalieri F, Kentish S, Ashokkumar M Sonochemical synthesis of liquid-encapsulated lysozyme microspheres. Ultrason Sonochem(2010) 17:333-337
  38. Nepravishta R, Bellomaria A, Polizio F, Paci M, Melino S* Reticulon RTN1-CCT peptide: a potential nuclease and inhibitor of histone deacetylase enzymes. Biochemistry(2010)49:252-258
  39. Lentini A., Tabolacci C., Melino S., Provenzano B. and Beninati S. Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity BBRC (2010) 393(3):546-50.
  40. Grenga L., Guglielmi G., Melino S., Ghelardini P., Paolozzi L.Study of E. coli FtsQ interaction mutants to detect the biological role of the division protein interaction network. New Biotechnology(2010) 27:870-881
  41. Bellomaria A, Barbato G*, Melino G, Paci M, Melino S.* Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant.Cell Cycle. (2010)Sep 8;9(18).
  42. Melino S.*, Sabelli R., Paci M. Allyl sulfur compounds and cellular detoxification system: effects and perspectives in the cancer therapy. Rev. Amino Acid (2011) 41:103-112
  43. Melino S*, Zhou M, Tortora M, Paci M, Cavalieri F*, Ashokkumar M Molecular properties of lysozyme-microbubbles: towards the protein and nucleic acid delivery. Amino Acids(2011)
  44. MELINO S*, SABELLI R, IORIO E, PACI M. Composti organici naturali contenenti zolfo estratti dall'aglio: studi sul meccanismo d'azione per la prevenzione e la terapia del cancro. ISTISAN CONGRESSI, (2011) vol. 11/19, p. 81-84, ISSN: 0393-5620
  45. MELINO S*, NEPRAVISHTA R, MONDELLO F, PETRUZZELLI M, PACI M Peptidi antimicrobici: una naturale difesa dell'organismo e una potenziale terapia. ISTISAN CONGRESSI, (2011). vol. 11, p. 101-104,ISSN: 0393-5620
  46. Nepravishta R, Sabelli R, Iorio E, Micheli L, Paci M, Melino S* Oxidative species and S-glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. Febs J (2012) 279:154-167
  47. Nepravishta R., Polizio F., Paci M., Melino S.*A metal binding site in the  RTN1-C protein: new perspectives for the physiological role of a neuronal protein. Metallomics (2012)4(5):480-7
  48. Bellomaria A., Barbato G., Melino G., Paci M. and Melino S.* Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interactionCell Cycle(2012), 11, 3638-48.
  49. Melino S*, Santone C, Di Nardo P and Sarkar B Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: Perspectives for biomedical applications. Febs J (2013),281, 657-72.
  50. R.Pallucca, S.Visconti, L.Camoni, G.Cesareni, S.Melino, S.Panni, P.Torreri and P. Aducci (2014) Specificity of ? and non-? isoforms of Arabidopsis 14-3-3 proteins towards the H+-ATPase and other targets. PLOSone (2014)9(3):e90764.
  51. Melino, S*; Bellomaria, A.; Nepravishta, R.; Paci, M.; Melino, G. p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch. Cell Cycle(2014), 13, 3207-17.
  52. Nepravishta, R.; Mandaliti, W.; Melino, S.; Eliseo, T.; Paci, M. Structure of the cyclic peptide [W8S]contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids(2014), 46, 2841-53.
  53. Landre, V.; Rotblat, B.; Melino, S.; Bernassola, F.; Melino, G. Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities. Oncotarget(2014), 5, 7988-8013.
  54. Galluzzi, L.; Bravo-San Pedro, J.M.; ….Melino, S.; …. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ(2014), 22, 58-73.
  55. Lamastra, F.R.; De Angelis, R.; Antonucci, A.; Salvatori, D.; Prosposito, P.; Casalboni, M.; Congestri, R.; Melino, S.; Nanni, F. Polymer composite random lasers based on frustules as scatterers. Rsc Advances (2014), 4, 61809-61816.
  56. Bhuiyan, A.I.; Papajani, V.T.; Paci, M.; Melino, S*. Glutathione-garlic sulfur conjugates: slow hydrogen sulfide releasing agents for therapeutic applications. Molecules(2015), 20, 1731-50.
  57. Lena AM, Duca S, Novelli F, Melino S, Annicchiarico-Petruzzelli M, Melino G, Candi E. Amino-terminal residues of ?Np63, mutated in ectodermal dysplasia, are required for its transcriptional activity. Biochem Biophys Res Commun. (2015) 467 (2), pp. 434-440
  58. Mauretti A, Neri A, Kossover O, Seliktar D, Nardo PD, Melino S.* Design of a Novel Composite H2 S-Releasing Hydrogel for Cardiac Tissue Repair. Macromol Biosci. (2016) Jun;16(6):847-58. doi: 10.1002/mabi.201500430.
  59. Ciocci M, Iorio E, Carotenuto F, Khashoggi HA, Nanni F, Melino S.* H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair. Oncotarget (2016) 20; 7(51):84338-84358. doi: 10.18632/oncotarget.12609.
  60. Klionsky, D.J,  Abdelmohsen, K.,  Abe, A. …… S. Melino et al,Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy(2016) 12(1), pp. 1-222
  61. De Angelis R1, Melino S1, Prosposito P, Casalboni M, Lamastra FR, Nanni F, Bruno L, Congestri R.The Diatom Staurosirella pinnata for Photoactive Material Production.PLoS One(2016) Nov 9;11(11):e0165571. doi: 10.1371/journal.pone.0165571 (1 equally contributed to this work)
  62. M, Ciocci, F. Mochi, F. Carotenuto, E.Di Giovanni, P. Prosposito, R. Francini, F. De Matteis, I. Reshetov, M. Casalboni1, S. Melino1, P. Di Nardo1Scaffold-in-scaffold potential to induce growth and differentiation of cardiac progenitor cells. Stem Cells and Development(2017)26(19):1438-1447. 10.1089/scd.2017.0051. (1equally contributed to this work)
  63. Prosposito P., Melino S., Ciocci M., Francini R.,  Mochi F.,  De Matteis F.,  Di Nardo, P., Schrader S., Casalboni M. Photolithography of 3D scaffolds for artificial tissue Materials Science Forum (2017) 879, pp. 1519-1523
  64. de Matteis F., Prosposito P., Francini R., de Angelis R., Mochi F.,  Melino S.,  Congestri R., Bruno L., Casalboni M. Photonic application of diatom frustules Materials Science Forum (2017) 879, pp. 419-423
  65. Mochi, F. Prosposito, P, Francini, R, De Matteis F, Melino S.ì, Ciocci, M., Di Nardo, P., Ksianzou, V., Schrader, S., Casalboni, M. Advanced biocompatible photolithographic scaffolds for tissue engineering IET Conference PublicationsVolume 2016, Issue CP704, 18th Italian National Conference on Photonic Technologies, Fotonica 2016; Rome; Italy; 6 June 2016 through 8 June 2016; Code 127361 (2016)
  66.  Bassano C, Gislao V, Bovio, E, Melino S, Tropea I, Saitto G, Pugliese M, Colella DF, Scafuri A, Ruvolo G. An unexpected risk factor for early degeneration of biological aortic valve prostheses. ANNALS OF THORACIC SURGERY - ISSN:0003-4975 (2017) 2018 Feb;105(2):521-527. doi: 10.1016/j.athoracsur.2017.07.014. Epub 2017.
  67. Giachin G, Nepravishta R, Mandaliti W, Melino S, Margon A, Scaini D, Mazzei P, Piccolo A, Legname G, Paci M, Leita L. The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein.PLoS One.2017 Nov 21;12(11):e0188308. doi: 10.1371/journal.pone.0188308
  68. Ciocci M, Cacciotti I, Seliktar D, Melino S* Injectable silk fibroin hydrogels functionalized with microspheres as adult stem cells-carrier systems. Int J Biol Macromol. (2018) Mar;108:960-971. doi: 10.1016/j.ijbiomac.2017.11.013.Select item 293624793.
  69. Galluzzi L, Vitale I, Aaronson SA,... Melino S etc. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub (2018) Jan 23. Review.
  70. Cacciotti I*, Ciocci M, Di Giovanni E, Nanni F, Melino S*. Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress. Int J Mol Sci. (2018) Aug 11;19(8). pii: E2368. doi: 10.3390/ijms19082368.
  71. Bellini E, Ciocci M, Savio S, Antonaroli S, Seliktar D, Melino S,1* Congestri R.1*Trichormus variabilis (Cyanobacteria) Biomass: From the Nutraceutical Products to Novel EPS-Cell/Protein Carrier Systems. Mar Drugs. (2018) Aug 27;16(9). pi: E298. doi: 10.3390/md16090298. (1The two authors equally contributed to this work)
  72. M. Schnabel-Lubovsky, O. Kossover, S. Melino, F. Nanni, Y. Talmon, D. Seliktar Visualizing Cell-Biomaterial Interfaces using Bimodal Confocal Microscopy and Cryogenic Scanning Electron. Microscopy Journal of Tissue Engineering and Regenerative Medicine(2019)Jan 18. doi: 10.1002/term.2813.

  73. E. Ivanir, Y. Shachaf, I. Mironi-Harpaz, D. Yeheskely-Hayon, L.Hazanov, Shlomit Harpaz-Segev, T. Birman, Limor Minai, S. Melino, D. Yelin and  D. Seliktar  A Gel-Based Model of Selective Cell Motility Involving Chemotaxis, Haptotaxis and Durotaxis: Implications for Cell Sorting, Diagnostics and Screening.  Advanced Functional Materials(2019), Article number 1807106 DOI: 10.1002/adfm.201807106

  74. Yosef, A., Kossover, O., Mironi-Harpaz, I., Mauretti A, Melino S., Mizrahi, J., Seliktar, D.Fibrinogen-Based Hydrogel Modulus and Ligand Density Effects on Cell Morphogenesis in Two-Dimensional and Three-Dimensional Cell Cultures Advanced Healthcare Materials (2019) 8(13),1801436 DOI: 10.1002/adfm.201807106

  75. Melino S.*,Leo, S., Papajani, V.T. Natural hydrogen sulfide donors from allium sp. as a nutraceutical approach in type 2 diabetes prevention and therapy Nutrients (2019) 11(7),158

  76. Di Giovanni E., Buonvino S., Amelio I., Melino S.* Glutathione–allylsulfur conjugates as mesenchymal stem cells stimulating agents for potential applications in tissue repair (2020) International Journal of Molecular Sciences 21(5),1638

  77. Sunzini F., De Stefano S., Chimenti M.S., Melino S.* Hydrogen sulfide as potential regulatory gasotransmitter in arthritic diseases International Journal of Molecular Sciences (2020) 21(4),1180

  78. Mischiati C., Feriotto G., Tabolacci C., Melino S, Borromeo I., Forni C., De Martino A., Beninati S. Polyamine oxidase is involved in spermidine reduction of transglutaminase type 2-catalyzed ?h-crystallins polymerization in calcium-induced experimental cataractInternational International Journal of Molecular Sciences (2020) 21(15),5427, pp. 1-12

  79. Verkhratsky, A., Li, Q., Melino, S., Melino, G., Shi, Y.Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases? (2020) Biology Direct, 15 (1), art. no. 28, DOI: 10.1186/s13062-020-00282-3

  80. Buonvino, S., Melino, S.*New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell–cell fusion Cell Death Discovery, (2020) 6 (1), art. no. 134. DOI: 10.1038/s41420-020-00372-1

  81. Cancelliere R., Zurlo F., Micheli L., Melino S.* Vegetable waste scaffolds for 3D-stem cell proliferating systems and low cost biosensors. (2021) Talanta 223,121671

  82. Melino, S., Seliktar, D.A hydrogel reveals an elusive cancer stem cell Cell Death and Disease,(2021)  12 (5), art. no. 415, DOI: 10.1038/s41419-021-03696-7

  83. Buonvino, S., Ciocci, M., Seliktar, D., Melino, S*. Photo-polymerization damage protection by hydrogen sulfide donors for 3D-cell culture systems optimization International Journal Molecular Sciences, (2021), 22(11), 6095 DOI: 10.3390/ijms22116095

  84. Ganini, C.Amelio, I.Bertolo, R…. Melino S…...Wang, Y., Melino, G. Global mapping of cancers: The Cancer Genome Atlas and beyond Molecular Oncology,(2021), 15(11), 2823–2840

  85. Buonvino, S., Arciero, I., Melino, S.*Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications International Journal of Molecular Sciences, (2022), 23(15), 8452

  86. Vitale, I., Pietrocola, F., Guilbaud, E., .Melino S...Kroemer, G., Galluzzi, L.Apoptotic cell death in disease—Current understanding of the NCCD 2023 Cell Death and Differentiation,(2023), 30(5), pp. 1097–1154

  87. Li, Q., Wang, Y., Sun, Q., ….Melino S.,…..Shi, Y. Immune response in COVID-19: what is next? Cell Death and Differentiation, (2022), 29(6), pp. 1107–1122

  88. Buonvino, S., Ciocci, M., Nanni, F., Cacciotti, I., Melino, S.*New vegetable-waste biomaterials by Lupin albus L. as cellular scaffolds for applications in biomedicine and food Biomaterials,(2023), 293, 121984 (Ha ricevuto un News and Views da Materialstoday (IF27)https://doi.org/10.1016/j.mattod.2023.03.012)

  89. C Nurchi, S Buonvino, I Arciero, S Melino* Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications International Journal of Molecular Sciences, (2023),24 (3), 2153

  90. S. Buonvino, G. Cinotti and S. Melino*. Sulfurtransferases Essential Enzymes for Life Chapter 6. Thiosulfate sulfurtransferase: a model of essential enzyme with potential applications in medicine and biotechnology May 1, (2023) Imprint: Academic Press Language: English No. of pages: 472 Copyright: © Academic Press 2023 Paperback ISBN: 9780443188275Editor: Noriyuki Nagahara

  91.   M. Zhu, L. Cao, S. Melino, E. Candi, Y. Wang, C.Shao, G. Melino, Yufang Shi, Xiaodong Chen. Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing.Stem cells translational medicine, (2023) 12, 9, 576 - 58715

  92.   Buonvino S., Arciero I., Martinelli E., SeliktarD. and S.Melino*. Modelling the disease: H2S-sensitivity and drug resistance of triple negative Breast cancer cells can be modulated by embedding in isotropic micro-environment. Materials Today Bio (2023), 23,100862. doi: 10.1016/j.mtbio.2023.100862

  93. Buonvino S., Di Giuseppe D., Filippi J., Martinelli D.,Seliktar D.,Melino S.* 3D Cell Migration Chip (3DCM-chip): a New Tool Toward the Modelling of 3D Cellular Complex Systems Advanced Healthcare Materials(2024)10.1002/adhm.202400040

  94. Arciero I, Buonvino S amd Melino S* Slow H2S-Releasing Donors and 3D Printable Arrays Cellular Models in Osteo-Differentiation of Mesenchymal Stem Cells for Personalized Therapies Biomolecules (2024) 14 (11), 1380    

*Corresponding author

CV of Prof.  SONIA MELINO Ph.D

 

Work Address                            Department of Sciences and

Chemical Technology, University of Rome Tor Vergata, Sogene 

F zone, level 0, room 13

via della Ricerca Scientifica 00133-Rome, Italy             

Work phone:                                      +39-06-72594449/4410

Fax:                                                    +39-06-72594328

E-mail: melinos@uniroma2.it

1992                Master Degree,summa cum laude, in “Biological Sciences”/“Biochemistry”, University of Rome "La Sapienza" Italy

1993-1995      Specialization in Biotechnology cum laude(Montedison-ENIfunded),University of Rome "Tor Vergata"

1996                Post-Graduate Fellowin an Italian  pharmaceutical company (IFI).

1997-2000      Ph.D in“Biochemistry and Molecular Genetics”

2002                 Researcher in Biochemistry (SSD 05/E1)at the Department of Sciences and Chemical Technologies,University of Rome “Tor Vergata”.

2003-2010     Member of the Centre for Biostatistics and Bioinformatics,University of Rome “Tor Vergata”.

2012/2013      National Scientific  Qualification  for Associate Professor in Biochemistry 2013-  presentMember of the Editorial Board ofMolecular & Cellular Oncology

2015                Associate Professor in Biochemistry at the of Sciences and Chemical Technologies,University of Rome “Tor Vergata”.

2024           Full Professor in Biochemistry at the Department of Experimental Medicine Univesity of Rome Tor Vergata 

2015                Member of the Spin-off Algares srl

2016 -presentMember of the CIMERFondatore and Member of the CIMER -Interdepatimental Center of Regenerative Medicine–University of Rome Tor Vergata

2017 -presentMember of “commissione paritetica” for Chemistry degree

2018                National Scientific Qualification  for Full Professor in Biochemistry           

2018- presentMember of the Editorial Board of International Journal of Molecular Science (IF-

                        3.68)

She has drawn the following INTERNATIONAL AGREEMENTS signed with the University of Rome  Tor Vergata: Deakin University Melburne- Australia  signed 2009; Technion-Israel Institute of Technology of Haifa- Israel signed  2011; Uniwersytet Jagiellonski w Krakowie- Poland signed 2013;Technion-Israel Institute of Technology of Haifa- Israel signed  2018.

RESEARCH ACTIVITY

For about 20 years she has been investigating in Biochemistry field. The Sonia Melino’s research work has been focused on the structural and functional characterization of proteins (GSTs, Glyoxalase II, Rhodanese, NS3pro DEN-2, Calmodulin-like proteins, Reticulon1-C and WW domains) and metal-peptides (histatin, hepcidin), and on the identification of the “consensus motifs” for clarifying their physiological role and mechanism of action. Her current research is focused on the study of the effects on pluripotent and cancer cells of Organ Sulfur Compounds as hydrogen sulfide releasing agents, and on the fabrication of novel hydrogel scaffolds with protein microspheres for cardiac tissue regeneration. At this moment, she is a co-author of more than 90 papers published on international peer-reviewed journals. She has been referee for several scientific journals (FEBS Letters, Biochemistry, International Journal of Nanomedicine, Amino Acid, Molecules etc) and is involved in research projects supported by national and international grants.

TEACHING ACTIVITY

Teacher of “Biochemistry and Laboratory (9CFU)”, University of Rome “Tor Vergata” (Master Degree in Chemistry); Teacher of “Macromolecules and Biochemical Processes” (6CFU), University of Rome “Tor Vergata” (Master Degree in Material Sciences and Technologies);

2010-present   Member of Teaching Council of the PhD Program in “Molecular and Cellular Biology”, University of Rome “Tor Vergata”.

 

Reviewer of Research project GrantS

2018 - for Swiss Cancer League Grant

2018 - for the executive government agency of National Science Centre (Narodowe Centrum Nauki - NCN; http://www.ncn.gov.pl)

 

GRANTS

 

PUBLICATIONS

*Corresponding author

  1. Di Ilio C, Angelucci S, Pennelli A, Bucciarelli T, Petruzzelli R, Tiboni GM, Melino S and Sacchetta P (1996) Purification and characterization of three Pi class glutathione transferase from monkey (Macaca fascicularis) placenta.Comp Biochem Physiol B Biochem Mol Biol114, 377-82
  2. Aceto A, Dragani B,Melino S, Allocati N, Masulli M, Di Ilio C and Petruzzelli R (1997) Identification of an N-capping box that affects the alpha 6-helix propensity in glutathione S-transferase superfamily proteins: a role for an invariant aspartic residue.Biochem J322 (Pt 1), 229-34
  3. Sacchetta P, Petruzzelli R, Melino S, Bucciarelli T, Pennelli A, Amicarelli F, Miranda M and Di Ilio C (1997) Amphibian embryo glutathione transferase: amino acid sequence and structural properties.Biochem J322 ( Pt 2), 679-680
  4. Dragani B, Stenberg G, Melino S, Petruzzelli R, Mannervik B and Aceto A (1997) The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding. Identification of a buried and conserved hydrogen bond important for protein stability.J Biol Chem 272, 25518-23
  5. Favaloro B, Melino S, Petruzzelli R, Di Ilio C and Rotilio D (1998) Purification and characterization of a novel glutathione transferase from Ochrobactrum anthropi.FEMS Microbiol Lett160, 81-86
  6. Aceto A, Dragani B, Melino S, Principato G, Saccucci F, Gualtieri G and Petruzzelli R (1998) Structural characterization of human glyoxalase II as probed by limited proteolysis.Biochem Mol Biol Int44, 761-769
  7. Melino S, Capo C, Dragani B, Aceto A and Petruzzelli R (1998) A zinc-binding motif conserved in glyoxalase II, beta-lactamase and arylsulfatases.Trends Biochem Sci23, 381-2
  8. Vitali A, Botta B, Delle Monache G, Zappitelli S, Ricciardi P, Melino S, Petruzzelli R and Giardina B (1998) Purification and partial characterization of a peroxidase from plant cell cultures of Cassia didymobotrya and biotransformation studies.Biochem J331 ( Pt 2), 513-519
  9. Favaloro B, Tamburro A, Angelucci S, Luca AD, Melino S, di Ilio C and Rotilio D (1998) Molecular cloning, expression and site-directed mutagenesis of glutathione S-transferase from Ochrobactrum anthropi.Biochem J335 ( Pt 3), 573-579
  10. Melino S, Rufini S, Sette M, Morero R, Grottesi A, Paci M and Petruzzelli R (1999) Zn(2+) ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles. Identification and characterization of a zinc-binding motif present in the functional domain.Biochemistry38, 9626-9633
  11. Bucciarelli T, Sacchetta P, Pennelli A, Cornelio L, Romagnoli R, Melino S, Petruzzelli R and Di Ilio C (1999) Characterization of toad liver glutathione transferase.Biochim Biophys Acta1431, 189-198
  12. Angelucci S, Sacchetta P, Moio P, Melino S, Petruzzelli R, Gervasi P and Di Ilio C (2000) Purification and characterization of glutathione transferases from the sea bass (Dicentrarchus labrax) liver.Arch Biochem Biophys 373, 435-441
  13. Bozzi M, Battistoni A, Sette M, Melino S, Rotilio G and Paci M (2001) Unfolding and inactivation of monomeric superoxide dismutase from E. coli by SDS.Int J Biol Macromol 29, 99-105
  14. Bucciarelli T, Sacchetta P, Amicarelli F, Petruzzelli R, Melino S, Rotilio D, Celli N and Di Ilio C (2002) Amino acid sequence of the major form of toad liver glutathione transferase.Int J Biochem Cell Biol 34, 1286-1290
  15. Fasano M, Orsale M,Melino S, Nicolai E, Forlani F, Rosato N, Cicero D, Pagani S and Paci M (2003) Surface changes and role of buried water molecules during the sulfane sulfur transfer in rhodanese from Azotobacter vinelandii: a fluorescence quenching and nuclear magnetic relaxation dispersion spectroscopic study.Biochemistry42, 8550-7
  16. Orsale M, Melino S, Contessa GM, Torre V, Andreotti G, Motta A, Paci M, Desideri A and Cicero DO (2003) Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy.FEBS Lett548, 11-6
  17. Melino S, Cicero DO, Orsale M, Forlani F, Pagani S and Paci M (2003) Azotobacter vinelandii rhodanese: selenium loading and ion interaction studies.Eur J Biochem 270, 4208-15
  18. Cicero DO, Melino S, Orsale M, Brancato G, Amadei A, Forlani F, Pagani S and Paci M (2003) Structural rearrangements of the two domains of Azotobacter vinelandii rhodanese upon sulfane sulfur release: essential molecular dynamics, 15N NMR relaxation and deuterium exchange on the uniformly labeled protein.Int J biol Macromol 33, 193-201
  19. Trotta E, Del Grosso N, Erba M, Melino S, Cicero D and Paci M (2003) Interaction of DAPI with individual strands of trinucleotide repeats. Effects of replication in vitro of the AAT x ATT triplet.Eur J Biochem270, 4755-61
  20. Melino S*, Cicero DO, Forlani F, Pagani S and Paci M (2004) The N-terminal rhodanese domain from Azotobacter vinelandii has a stable and folded structure independently of the C-terminal domain.FEBS Lett577, 403-8
  21. Gallo M, Paludi D, Cicero DO, Chiovitti K, Millo E, Salis A, Damonte G, Corsaro A, Thellung S, Schettini G, Melino S, Florio T, Paci M and Aceto A (2005) Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation.Int J Immunopathol Pharmacol18, 95-112
  22. Contessa GM, Orsale M, Melino S, Torre V, Paci M, Desideri A and Cicero DO (2005) Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family.J Biomol NMR 31, 185-99
  23. Melino S, Pennestri M, Santoprete A, Bielli P, Paci M, Ragnini-Wilson A and Cicero DO (2005) Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae.J Biomol NMR 31, 367-8
  24. Melino S, Garlando L, Patamia M, Paci M and Petruzzelli R (2005) A metal-binding site is present in the amino terminal region of the bioactive iron regulator hepcidin-25.J Pept Res66, 65-71
  25. Fazi B1,Melino S1, Di Sano F, Cicero DO, Piacentini M and Paci M (2006) Cloning, expression, and preliminary structural characterization of RTN-1C.Biochem Biophys Res Commun342, 881-6 (1 The first two authors equally contributed to this work)
  26. Melino S*, Fucito S, Campagna A, Wrubl F, Gamarnik A, Cicero DO and Paci M (2006) The active essential CFNS3d protein complex.FEBS J 273, 3650-62
  27. Melino S*, Gallo M, Trotta E, Mondello F, Paci M and Petruzzelli R (2006) Metal-Binding and Nuclease Activity of an Antimicrobial Peptide Analogue of the Salivary Histatin 5.Biochemistry 45, 15373-15383
  28. Gallo M, Melino S, Melis R, Paci M and Cicero DO (2006) Backbone NMR assignment of the 29.6 kDa Rhodanese protein from Azotobacter vinelandii.J Biomol NMR36 Suppl 5, 73
  29. Pennestri M, Melino S, Contessa GM, Casavola EC, Paci M, Ragnini-Wilson A and Cicero DO (2007) Structural basis for the interaction of the myosin light chain Mlc1p with the myosin V Myo2p IQ motifs.J Biol Chem282, 667-79
  30. Melino S*and Paci M (2007) Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach. Review  FEBS J 274, 2986-3002.
  31. Cabras T, Patamia M, Melino S, Inzitari R, Messana I, Castagnola M & Petruzzelli R (2007) Pro-oxidant activity of histatin 5 related Cu(II)-model peptide probed by mass spectrometry.Biochem Biophys Res Commun 358, 277-84.
  32. Sabelli R, Iorio E, De Martino A, Podo F, Ricci A, Viticchiè G, Rotilio G, Paci M and Melino S* (2008)Rhodanese-Thioredoxin system and allyl sulfur compounds: implications in the apoptosis induction FEBS J,275,3884-3899
  33. Melino S, Cicero OD, Gallo M, Sabelli R, Melis R and Paci M. New investigations on the Sulfurtransferase enzyme rhodanese by NMR and its selenium binding International (2008) Proceedings 2nd European Conference on Chemistry for Life Sciences
  34. Melino S*,Nepravishta R , Bellomaria A, Di Marco S and Paci M  (2009) Nucleic acids-binding of RTN1-C C-terminal region:towards the functional role of a reticulon protein. Biochemistry 48, 242-253
  35. Fazi B, Melino S, De Rubeis S, Bagni C, Paci M, Piacentini M, Di Sano F (2009) Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene28:3814-3824
  36. Zhou M, Leong TS, Melino S, Cavalieri F, Kentish S, Ashokkumar M Sonochemical synthesis of liquid-encapsulated lysozyme microspheres. Ultrason Sonochem (2010) 17:333-337
  37. Nepravishta R, Bellomaria A, Polizio F, Paci M, Melino S* Reticulon RTN1-CCT peptide: a potential nuclease and inhibitor of histone deacetylase enzymes. Biochemistry (2010) 49:252-258
  38. Lentini A., Tabolacci C., Melino S., Provenzano B. and Beninati S.Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity BBRC (2010) 393(3):546-50.
  39. Grenga L., Guglielmi G., Melino S., Ghelardini P., Paolozzi L.Study of E. coli FtsQ interaction mutants to detect the biological role of the division protein interaction network. New Biotechnology(2010) 27:870-881
  40. Bellomaria A, Barbato G*, Melino G, Paci M, Melino S.* Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant.Cell Cycle. (2010)Sep 8;9(18).
  41. Melino S.*, Sabelli R., Paci M. Allyl sulfur compounds and cellular detoxification system: effects and perspectives in the cancer therapy. Rev. Amino Acid (2011) 41:103-112
  42. Melino S*, Zhou M, Tortora M, Paci M, Cavalieri F*, Ashokkumar M Molecular properties of lysozyme-microbubbles: towards the protein and nucleic acid delivery. Amino Acids (2011)
  43. Melino S*, Sabelli R, Iorio E, Paci M (2011). Composti organici naturali contenenti zolfo estratti dall'aglio: studi sul meccanismo d'azione per la prevenzione e la terapia del cancro. ISTISAN CONGRESSI, vol. 11/19, p. 81-84, ISSN: 0393-5620
  44. Melino S*, Neprevishta R, Mondello F, Petruzzelli M, Paci M (2011). Peptidi antimicrobici: una naturale difesa dell'organismo e una potenziale terapia. ISTISAN CONGRESSI, vol. 11, p. 101-104, ISSN: 0393-5620
  45. Nepravishta R, Sabelli R, Iorio E, Micheli L, Paci M, Melino S* Oxidative species and S-glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. Febs J (2012) 279:154-167
  46. Nepravishta R., Polizio F., Paci M., Melino S.*A metal binding site in the  RTN1-C protein: new perspectives for the physiological role of a neuronal protein. Metallomics (2012) vol. 4 p. 480 - 487 
  47. Bellomaria A., Barbato G., Melino G., Paci M. and Melino S.* Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction Cell Cycle (2012), 11, 3638-48.
  48. Melino S*,Santone C, Di Nardo P and Sarkar B Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: Perspectives for biomedical applications. FEBS J (ePub 2013) (2014), 281, 657-72.
  49. R.Pallucca, S.Visconti, L.Camoni, G.Cesareni, S.Melino, S.Panni, P.Torreri and P. Aducci (2014) Specificity of ? and non-? isoforms of Arabidopsis 14-3-3 proteins towards the H+-ATPase and other targets. PLOSone (2014)9(3):e90764.
  50. Melino, S*., Bellomaria, A., Nepravishta, R., Paci, M., Melino, G. p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch. Cell Cycle (2014), 13, 3207-17.
  51. Nepravishta, R.; Mandaliti, W.; Melino, S.; Eliseo, T.; Paci, M. Structure of the cyclic peptide [W8S]contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids(2014), 46, 2841-53.
  52. Landre, V.; Rotblat, B.; Melino, S.; Bernassola, F.; Melino, G. Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities. Oncotarget(2014), 5, 7988-8013.
  53. Galluzzi, L.; Bravo-San Pedro, J.M.; Vitale, I.; … Melino, S.; etc Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ(2014), 22, 58-73.
  54. Lamastra, F.R.; De Angelis, R.; Antonucci, A.; Salvatori, D.; Prosposito, P.; Casalboni, M.; Congestri, R.; Melino, S.; Nanni, F. Polymer composite random lasers based on frustules as scatterers. Rsc Advances(2014), 4, 61809-61816.
  55. Bhuiyan, A.I.; Papajani, V.T.; Paci, M.; Melino, S*. Glutathione-garlic sulfur conjugates: slow hydrogen sulfide releasing agents for therapeutic applications. Molecules (2015), 20, 1731-50.
  56. Paliotta M, Rosato T, Terlizzi M, Khashoggi H, Melino S, Carbone K. Influence of apricot extracts from different agricultural management on cell proliferation of Human T-Cell Lynphoma Cell line HuT 78. Proceedings XVI Congress of Phytochemistry Italian Society –Padova (2015)
  57. Lena AM, Duca S, Novelli F, Melino S, Annicchiarico-Petruzzelli M, Melino G, Candi E. Amino-terminal residues of ?Np63, mutated in ectodermal dysplasia, are required for its transcriptional activity. Biochem Biophys Res Commun. (2015) 467 (2), pp. 434-440 
  58. Mauretti A, Neri A, Kossover O, Seliktar D, Di Nardo P, Melino S* Design of a Novel Composite H2 S-Releasing Hydrogel for Cardiac Tissue Repair. Macromol Biosci. (2016).doi: 10.1002/mabi.201500430
  59. Klionsky DJ Abdelmohsen K, Abe A, Abedin MJ, ….Melino S et al Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. (2016) Jan 2;12(1):1-222.
  60. Melino S1, De Angelis R1., Prosposito, P.,Casalboni, M.,  Lamastra, F.R., Nanni, F., Bruno, L., Congestri, R. The diatom Staurosirella pinnata for photoactive material production PLoS ONE (2016) 11 (11), e0165571 (1The first two authors equally contributed to this work)
  61. Ciocci M., Iorio E., Carotenuto, F., Khashoggi H.A., Nanni F., Melino S*. H2S-releasing nanoemulsions: A new formulation to inhibit tumor cells proliferation and improve tissue repair Oncotarget (2016) 7 (51), pp. 84338-84358
  62. Prosposito P., Melino S., Ciocci M., Francini R., Mochi F.,  De Matteis F.,  Di Nardo, P., Schrader S., Casalboni M. Photolithography of 3D scaffolds for artificial tissue Materials Science Forum (2017) 879, pp. 1519-1523
  63. de Matteis F., Prosposito P., Francini R., de Angelis R., Mochi F.,  Melino S.,  Congestri R., Bruno L., Casalboni M. Photonic application of diatom frustules Materials Science Forum (2017) 879, pp. 419-423
  64. Mochi, F. Prosposito, P, Francini, R, De Matteis F, Melino S.ì, Ciocci, M., Di Nardo, P., Ksianzou, V., Schrader, S., Casalboni, M. Advanced biocompatible photolithographic scaffolds for tissue engineering IET Conference PublicationsVolume 2016, Issue CP704, 18th Italian National Conference on Photonic Technologies, Fotonica 2016; Rome; Italy; 6 June 2016 through 8 June 2016; Code 127361 (2016)
  65. C. Bassano, Valentina G., E. Bovio, S. Melino, I Tropea, G. Saitto, M. Pugliese, D. F. Colella, A. Scafuri, and G.i Ruvolo The Mitroflow bioprosthesis Affaire: An Additional and Unexpected Risk Factor for Early Structural Deterioration Ann Thorac Surg. (2018) Feb;105(2):521-527. doi: 10.1016/j.athoracsur.2017.07.014. Epub 2017 Nov
  66. Ciocci M, Mochi F, Carotenuto F, Di Giovanni E, Prosposito P, Francini R, De Matteis F, Reshetov I, Casalboni M1, Melino S1, Di Nardo P.1 (1 equal contribution) Scaffold-in-Scaffold Potential to Induce Growth and Differentiation of Cardiac Progenitor Cells. (2017) Stem Cells Dev Jul 15. doi: 10.1089/scd.2017.0051
  67. Giachin G, Nepravishta R, Mandaliti W, Melino S, Margon A, Scaini D, Mazzei P, Piccolo A, Legname G, Paci M, Leita L. The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein.PLoS One.(2017) Nov 21;12(11):e0188308. doi: 10.1371/journal.pone.0188308. eCollection 2017.
  68. Ciocci M, Cacciotti I, Seliktar D, Melino S* Injectable silk fibroin hydrogels functionalized with microspheres as adult stem cells-carrier systems.Int J Biol Macromol.(2018) Mar;108:960-971. doi: 10.1016/j.ijbiomac.2017.11.013.Select item 293624793.
  69. Galluzzi L, Vitale I, Aaronson SA,... Melino S etc. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub (2018) Jan 23. Review.
  70. Cacciotti I*, Ciocci M, Di Giovanni E, Nanni F, Melino S*. Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress. Int J Mol Sci. (2018) Aug 11;19(8). pii: E2368. doi: 10.3390/ijms19082368.
  71. Bellini E, Ciocci M, Savio S, Antonaroli S, Seliktar D, Melino S,1* Congestri R.1*Trichormus variabilis (Cyanobacteria) Biomass: From the Nutraceutical Products to Novel EPS-Cell/Protein Carrier Systems. Mar Drugs. (2018) Aug 27;16(9). pi: E298. doi: 10.3390/md16090298. (1The two authors equally contributed to this work)
  72. M. Schnabel-Lubovsky, O. Kossover, S. Melino, F. Nanni, Y. Talmon, D. Seliktar Visualizing Cell-Biomaterial Interfaces using Bimodal Confocal Microscopy and Cryogenic Scanning Electron. Microscopy Journal of Tissue Engineering and Regenerative Medicine(2019)Jan 18. doi: 10.1002/term.2813.

  73. E. Ivanir, Y. Shachaf, I. Mironi-Harpaz, D. Yeheskely-Hayon, L.Hazanov, Shlomit Harpaz-Segev, T. Birman, Limor Minai, S. Melino, D. Yelin and  D. Seliktar  A Gel-Based Model of Selective Cell Motility Involving Chemotaxis, Haptotaxis and Durotaxis: Implications for Cell Sorting, Diagnostics and Screening.  Advanced Functional Materials(2019), Article number 1807106 DOI: 10.1002/adfm.201807106

  74. Yosef, A., Kossover, O., Mironi-Harpaz, I., Mauretti A, Melino S., Mizrahi, J., Seliktar, D.Fibrinogen-Based Hydrogel Modulus and Ligand Density Effects on Cell Morphogenesis in Two-Dimensional and Three-Dimensional Cell Cultures Advanced Healthcare Materials (2019) 8(13),1801436 DOI: 10.1002/adfm.201807106

  75. Melino S.*,Leo, S., Papajani, V.T. Natural hydrogen sulfide donors from allium sp. as a nutraceutical approach in type 2 diabetes prevention and therapy Nutrients (2019) 11(7),158

  76. Di Giovanni E., Buonvino S., Amelio I., Melino S.* Glutathione–allylsulfur conjugates as mesenchymal stem cells stimulating agents for potential applications in tissue repair (2020) International Journal of Molecular Sciences 21(5),1638

  77. Sunzini F., De Stefano S., Chimenti M.S., Melino S.* Hydrogen sulfide as potential regulatory gasotransmitter in arthritic diseases International Journal of Molecular Sciences (2020) 21(4),1180

  78. Mischiati C., Feriotto G., Tabolacci C., Melino S, Borromeo I., Forni C., De Martino A., Beninati S. Polyamine oxidase is involved in spermidine reduction of transglutaminase type 2-catalyzed ?h-crystallins polymerization in calcium-induced experimental cataractInternational International Journal of Molecular Sciences (2020) 21(15),5427, pp. 1-12

  79. Verkhratsky, A., Li, Q., Melino, S., Melino, G., Shi, Y.Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases? (2020) Biology Direct, 15 (1), art. no. 28, DOI: 10.1186/s13062-020-00282-3

  80. Buonvino, S., Melino, S.*New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell–cell fusion Cell Death Discovery, (2020) 6 (1), art. no. 134. DOI: 10.1038/s41420-020-00372-1

  81. Cancelliere R., Zurlo F., Micheli L., Melino S.* Vegetable waste scaffolds for 3D-stem cell proliferating systems and low cost biosensors. (2021) Talanta 223,121671

  82. Melino, S., Seliktar, D.A hydrogel reveals an elusive cancer stem cell Cell Death and Disease,(2021)  12 (5), art. no. 415, DOI: 10.1038/s41419-021-03696-7

  83. Buonvino, S., Ciocci, M., Seliktar, D., Melino, S*. Photo-polymerization damage protection by hydrogen sulfide donors for 3D-cell culture systems optimization International Journal Molecular Sciences, (2021), 22(11), 6095 DOI: 10.3390/ijms22116095

  84. Ganini, C.Amelio, I.Bertolo, R…. Melino S…...Wang, Y., Melino, G. Global mapping of cancers: The Cancer Genome Atlas and beyond Molecular Oncology,(2021), 15(11), 2823–2840

  85. Buonvino, S., Arciero, I., Melino, S.*Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications International Journal of Molecular Sciences, (2022), 23(15), 8452

  86. Vitale, I., Pietrocola, F., Guilbaud, E., .Melino S...Kroemer, G., Galluzzi, L.Apoptotic cell death in disease—Current understanding of the NCCD 2023 Cell Death and Differentiation,(2023), 30(5), pp. 1097–1154

  87. Li, Q., Wang, Y., Sun, Q., ….Melino S.,…..Shi, Y. Immune response in COVID-19: what is next? Cell Death and Differentiation, (2022), 29(6), pp. 1107–1122

  88. Buonvino, S., Ciocci, M., Nanni, F., Cacciotti, I., Melino, S.*New vegetable-waste biomaterials by Lupin albus L. as cellular scaffolds for applications in biomedicine and food Biomaterials,(2023), 293, 121984 (Ha ricevuto un News and Views da Materialstoday (IF27)https://doi.org/10.1016/j.mattod.2023.03.012)

  89. C Nurchi, S Buonvino, I Arciero, S Melino* Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications International Journal of Molecular Sciences, (2023),24 (3), 2153

  90. S. Buonvino, G. Cinotti and S. Melino*. Sulfurtransferases Essential Enzymes for Life Chapter 6. Thiosulfate sulfurtransferase: a model of essential enzyme with potential applications in medicine and biotechnology May 1, (2023) Imprint: Academic Press Language: English No. of pages: 472 Copyright: © Academic Press 2023 Paperback ISBN: 9780443188275Editor: Noriyuki Nagahara

  91.   M. Zhu, L. Cao, S. Melino, E. Candi, Y. Wang, C.Shao, G. Melino, Yufang Shi, Xiaodong Chen. Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing.Stem cells translational medicine, (2023) 12, 9, 576 - 58715

  92. Buonvino S., Arciero I., Martinelli E., SeliktarD. and S.Melino*. Modelling the disease: H2S-sensitivity and drug resistance of triple negative Breast cancer cells can be modulated by embedding in isotropic micro-environment. Materials Today Bio (2023), 23,100862. doi: 10.1016/j.mtbio.2023.100862

  93. Buonvino S., Di Giuseppe D., Filippi J., Martinelli D.,Seliktar D.,Melino S.* 3D Cell Migration Chip (3DCM-chip): a New Tool Toward the Modelling of 3D Cellular Complex Systems Advanced Healthcare Materials(2024)10.1002/adhm.20240004

  94. Arciero I, Buonvino S amd Melino S* Slow H2S-Releasing Donors and 3D Printable Arrays Cellular Models in Osteo-Differentiation of Mesenchymal Stem Cells for Personalized Therapies Biomolecules (2024) 14 (11), 1380  

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