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ORPHANET JOURNAL OF RARE DISEASES, 15(1), 20 [10.1186/s13023-019-1263-6].";s:4:"data";s:4:"2020";s:2:"id";s:20:"PUBBLICAZIONE_369497";s:6:"handle";s:11:"2108/229740";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:103:"Capillaries; Complement system; Hereditary angioedema; Optical coherence tomography angiography; Retina";s:9:"metadata3";s:14:"Settore MED/16";s:9:"metadata4";s:1524:"Evidence supports that hereditary angioedema (HAE) may be considered as a paroxysmal permeability disorder with defective but self-limiting endothelial barrier dysfunction. A potential subclinical abnormal vascular permeability at retinal capillaries could induce damage resulting in retinopathy. We aimed at exploring for the first time the presence of microangiopathy at retinal level from a highly selective cohort of patients with HAE due to C1 esterase inhibitor protein (C1INH) deficiency (type I). We conducted a pilot, prospective, case-control study including 20 type I HAE patients and 20 age-/sex-matched healthy controls (HC). All participants underwent standard ophthalmological examination including visual fields. Superficial and deep capillary plexi in the retina were analyzed by using new optical coherence tomography angiography (OCT-A). A total of 40 eyes from 20 HAE patients and 20 eyes from HC were evaluated. Perimetric indices of visual field were slightly worse in HAE than in controls. OCT-angiograms documented in HAE patients a lower retinal capillary density in both superficial and deep scans and a higher retinal thickness compared to healthy eyes. Our findings firstly documented subclinical abnormalities in retinal microvascular network in type I HAE patients that might be associated with early subtle functional changes. This preliminary evidence supports the hypothesis of a recurrent endothelial barrier failure at retinal level in HAE patients potentially resulting in chronic damage.";s:9:"metadata5";s:92:"Evaluation of retinal microvascular perfusion in hereditary angioedema: A case-control study";s:9:"metadata6";s:114:"Triggianese, P; Cesareo, M; Guarino, MD; Conigliaro, P; Chimenti, MS; Cedola, F; Mazzeo, C; Nucci, C; Perricone, R";s:9:"metadata7";s:25:"10.1186/s13023-019-1263-6";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:21;a:14:{s:9:"citazione";s:299:"Conigliaro, P., Cesareo, M., Chimenti, M.S., Triggianese, P., Canofari, C., Aloe, G., et al. (2019). Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: An optical coherence tomography angiography study. ANNALS OF THE RHEUMATIC DISEASES, 78(2), 287-289.";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_366097";s:6:"handle";s:11:"2108/227002";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:29:"Settore MED/16 - Reumatologia";s:9:"metadata4";N;s:9:"metadata5";s:147:"Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: An optical coherence tomography angiography study";s:9:"metadata6";s:101:"Conigliaro, P; Cesareo, M; Chimenti, MS; Triggianese, P; Canofari, C; Aloe, G; Nucci, C; Perricone, R";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:22;a:14:{s:9:"citazione";s:252:"Conigliaro, P., Cesareo, M., Chimenti, M.S., Triggianese, P., Canofari, C., Barbato, C., et al. (2019). Take a look at the eyes in Systemic Lupus Erythematosus: A novel point of view. AUTOIMMUNITY REVIEWS, 18(3), 247-254 [10.1016/j.autrev.2018.09.011].";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_364745";s:6:"handle";s:11:"2108/225724";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:29:"Settore MED/16 - Reumatologia";s:9:"metadata4";N;s:9:"metadata5";s:78:"Take a look at the eyes in Systemic Lupus Erythematosus: A novel point of view";s:9:"metadata6";s:131:"Conigliaro, P; Cesareo, M; Chimenti, MS; Triggianese, P; Canofari, C; Barbato, C; Giannini, C; Salandri, AG; Nucci, C; Perricone, R";s:9:"metadata7";s:28:"10.1016/j.autrev.2018.09.011";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:23;a:14:{s:9:"citazione";s:203:"Mancino, R., Cesareo, M., Martucci, A., Carlo, E.D., Ciuffoletti, E., Giannini, C., et al. (2019). Neurodegenerative process linking the eye and the brain. 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IEEE.";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_372583";s:6:"handle";s:11:"2108/232554";s:9:"metadata1";s:21:"Intervento a convegno";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore FIS/07";s:9:"metadata4";N;s:9:"metadata5";s:71:"Disruption of brain network organization in primary open angle glaucoma";s:9:"metadata6";s:144:"Minosse, S; Garaci, F; Martucci, A; Lanzafame, S; Di Giuliano, F; Picchi, E; Cesareo, M; Mancino, R; Guerrisi, M; Floris, R; Nucci, C; Toschi, N";s:9:"metadata7";s:25:"10.1109/EMBC.2019.8857290";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:26;a:14:{s:9:"citazione";s:223:"Minosse, S., Garaci, F., Martucci, A., Lanzafame, S., Giuliano, F.D., Picchi, E., et al. (2019). Primary open angle glaucoma is associated with functional brain network reorganization. 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Diabetic retinopathy and age-related macular degeneration: A survey of pharmacoutilization and cost in Calabria, Italy. NEURAL REGENERATION RESEARCH, 14(8), 1445-1448.";s:4:"data";s:4:"2019";s:2:"id";s:20:"PUBBLICAZIONE_383315";s:6:"handle";s:11:"2108/241869";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore MED/30";s:9:"metadata4";N;s:9:"metadata5";s:118:"Diabetic retinopathy and age-related macular degeneration: A survey of pharmacoutilization and cost in Calabria, Italy";s:9:"metadata6";s:90:"Scuteri, D; Vero, A; Zito, M; Naturale, MD; Bagetta, G; Nucci, C; Tonin, P; Corasaniti, MT";s:9:"metadata7";s:24:"10.4103/1673-5374.253528";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:29;a:14:{s:9:"citazione";s:266:"Mancino, R., Martucci, A., Cesareo, M., Giannini, C., Corasaniti, M.T., Bagetta, G., et al. (2018). Glaucoma and alzheimer disease: One age-related neurodegenerative disease of the brain. 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Anterior segment optical coherence tomography analysis of iris morphometric changes induced by prostaglandin analogues treatment in patients with primary open angle glaucoma or ocular hypertension. 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