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Even if chronic kidney disease remains the ''Cinderella of the cardiovascular profile'', the presence of microalbuminuria is closely related to a high risk of development of coronary artery disease. The same risk factors that impair heart function are also harmful to the kidney, and the common pathophysiological features of the two systems are at the origin of a new subspecialty, cardionephrology. A crucial task of cardiologists and nephrologists is the early identification of high risk patients with concurrent cardiovascular and kidney disease. The utilization of simple screening methods such as assessment of microalbuminuria and glomerular filtration rate by family doctors may help in establishing prevention strategies directed towards cardiovascular risk and progression of kidney disease. 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Catheter ablation of atrial fibrillation in patients with diabetes mellitus type 2: results from a randomized study comparing pulmonary vein isolation versus antiarrhythmic drug therapy. 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New insights in atherosclerosis research: LOX-1, leading actor of cardiovascular diseases [Nuovi approfondimenti nella ricerca su l'ateroslerosi: LOX-1, un primo attore nelle malattie cardiovascolari]. LA CLINICA TERAPEUTICA, 158(3), 239-248.";s:4:"data";s:4:"2007";s:2:"id";s:19:"PUBBLICAZIONE_22073";s:6:"handle";s:10:"2108/30251";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:200:"New insights in atherosclerosis research: LOX-1, leading actor of cardiovascular diseases [Nuovi approfondimenti nella ricerca su l'ateroslerosi: LOX-1, un primo attore nelle malattie cardiovascolari]";s:9:"metadata6";s:81:"Novelli, G; Mango, R; Vecchione, L; Mariotti, E; Borgiani, P; Mehta, JL; Romeo, F";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:91;a:14:{s:9:"citazione";s:227:"Vecchione, L., Gargiul, E., Borgiani, P., Predazzi, I., Mango, R., Romeo, F., et al. (2007). 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Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. 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Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. JOURNAL OF CLINICAL PSYCHIATRY, 67(11), 1760-1766.";s:4:"data";s:7:"2006-11";s:2:"id";s:20:"PUBBLICAZIONE_240037";s:6:"handle";s:11:"2108/121168";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:259:"Adult; Biological Markers; CD40 Ligand; Citalopram; Depressive Disorder, Major; Factor VIIa; Female; Humans; Inflammation; Interleukin-1beta; Male; P-Selectin; Pilot Projects; Serotonin Uptake Inhibitors; Sertraline; Tumor Necrosis Factor-alpha; Up-Regulation";s:9:"metadata3";s:33:"Settore MED/09 - Medicina Interna";s:9:"metadata4";s:526:"Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.";s:9:"metadata5";s:207:"Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy";s:9:"metadata6";s:137:"Leo, R; Di Lorenzo, G; Tesauro, M; Razzini, C; Forleo, Gb; Chiricolo, G; Cola, C; Zanasi, M; Troisi, A; Siracusano, A; Lauro, R; Romeo, F";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:94;a:14:{s:9:"citazione";s:190:"Leo, R., Di Lorenzo, G., Tesauro, M., Cola, C., Fortuna, E., Zanasi, M., et al. (2006). Decreased plasma adiponectin concentration in major depression. NEUROSCIENCE LETTERS, 407(3), 211-213.";s:4:"data";s:10:"2006-10-30";s:2:"id";s:20:"PUBBLICAZIONE_111901";s:6:"handle";s:10:"2108/57116";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:28:"Settore MED/25 - Psichiatria";s:9:"metadata4";N;s:9:"metadata5";s:62:"Decreased plasma adiponectin concentration in major depression";s:9:"metadata6";s:111:"Leo, R; Di Lorenzo, G; Tesauro, M; Cola, C; Fortuna, E; Zanasi, M; Troisi, A; Siracusano, A; Lauro, R; Romeo, F";s:9:"metadata7";s:28:"10.1016/j.neulet.2006.08.043";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:95;a:14:{s:9:"citazione";s:299:"Pizzuto, F., Voci, P., Puddu, P., Chiricolo, G., Borzi, M., & Romeo, F. (2006). Functional assessment of the collateral-dependent circulation in chronic total coronary occlusion using transthoracic Doppler ultrasound and venous adenosine infusion. 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NEUROSCIENCE LETTERS, 407(3), 211-213.";s:4:"data";s:4:"2006";s:2:"id";s:20:"PUBBLICAZIONE_240033";s:6:"handle";s:11:"2108/121164";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:95:"Adiponectin; Adult; Depressive Disorder, Major; Female; Humans; Male; Severity of Illness Index";s:9:"metadata3";s:33:"Settore MED/09 - Medicina Interna";s:9:"metadata4";s:832:"Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear. We evaluated plasma adiponectin levels in 32 first-episode drug-naïve major depression (DSM-IV-TR) patients without conventional risk factors for cardiovascular disease and 32 matched healthy subjects. Major depression patients displayed lower adiponectin plasma levels compared to controls (P<0.01). 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CLINICAL CARDIOLOGY, 29(7), 322-322.";s:4:"data";s:4:"2006";s:2:"id";s:19:"PUBBLICAZIONE_53694";s:6:"handle";s:10:"2108/14662";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:56:"Settore MED/36 - Diagnostica per Immagini e Radioterapia";s:9:"metadata4";N;s:9:"metadata5";s:169:"Thrombolysis in ST-segment elevation myocardial infarction: potential role of thin-slice computed tomography in the assessment of reperfusion and plaque characterization";s:9:"metadata6";s:132:"MARTUSCELLI,E; ROMAGNOLI,A; SARDELLA,G; TOMASSINI,M; D'ELISEO,A; CHIRICOLO,G; RAZZINI,C; SPERANDIO,M; SIMONETTI,G; MEHTA,JL; ROMEO,F";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:98;a:14:{s:9:"citazione";s:330:"Martuscelli, E., Romagnoli, A., Sardella, G., Tomassini, M., D'Eliseo, A., Chiricolo, G., et al. (2006). Images in cardiology: Thrombolysis in ST-segment elevation myocardial infarction: Potential role of thin-slice computed tomography in the assessment of reperfusion and plaque characterization. CLINICAL CARDIOLOGY, 29(7), 322.";s:4:"data";s:4:"2006";s:2:"id";s:19:"PUBBLICAZIONE_21388";s:6:"handle";s:10:"2108/57900";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:191:"Images in cardiology: Thrombolysis in ST-segment elevation myocardial infarction: Potential role of thin-slice computed tomography in the assessment of reperfusion and plaque characterization";s:9:"metadata6";s:143:"Martuscelli, E; Romagnoli, A; Sardella, G; Tomassini, M; D'Eliseo, A; Chiricolo, G; Razzini, C; Sperandio, M; Simonetti, G; Mehta, JL; Romeo, F";s:9:"metadata7";s:22:"10.1002/clc.4960290710";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:99;a:14:{s:9:"citazione";s:243:"Novelli, G., Borgiani, P., Mango, R., Romeo, F., & Mehta, J.L. (2006). OLR1 gene and coronary artery disease/acute myocardial infarction: Replication in an independently collected sample [1]. EUROPEAN JOURNAL OF HUMAN GENETICS, 14(8), 894-895.";s:4:"data";s:4:"2006";s:2:"id";s:18:"PUBBLICAZIONE_3621";s:6:"handle";s:10:"2108/30253";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:119:"OLR1 gene and coronary artery disease/acute myocardial infarction: Replication in an independently collected sample [1]";s:9:"metadata6";s:54:"Novelli, G; Borgiani, P; Mango, R; Romeo, F; Mehta, JL";s:9:"metadata7";s:23:"10.1038/sj.ejhg.5201636";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:100;a:14:{s:9:"citazione";s:257:"Mango, R., Vecchione, L., Raso, B., Borgiani, P., Brunetti, E., Mehta, J., et al. (2005). Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy. EXPERT OPINION ON PHARMACOTHERAPY, 6(15), 2565-2576.";s:4:"data";s:7:"2005-12";s:2:"id";s:19:"PUBBLICAZIONE_80949";s:6:"handle";s:10:"2108/30261";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:113:"Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy";s:9:"metadata6";s:99:"Mango, R; Vecchione, L; Raso, B; Borgiani, P; Brunetti, E; Mehta, J; Lauro, R; Romeo, F; Novelli, G";s:9:"metadata7";s:26:"10.1517/14656566.6.15.2565";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:101;a:14:{s:9:"citazione";s:252:"Tomai, F., Ribichini, F., Ghini, A.S., Ferrero, V., Andò, G., Vassanelli, C., et al. (2005). Elevated C-reactive protein levels and coronary microvascular dysfunction in patients with coronary artery disease. EUROPEAN HEART JOURNAL, 26(20), 2099-2105.";s:4:"data";s:7:"2005-10";s:2:"id";s:19:"PUBBLICAZIONE_78767";s:6:"handle";s:10:"2108/42008";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:35:"Settore MED/23 - Chirurgia Cardiaca";s:9:"metadata4";N;s:9:"metadata5";s:115:"Elevated C-reactive protein levels and coronary microvascular dysfunction in patients with coronary artery disease.";s:9:"metadata6";s:104:"Tomai, F; Ribichini, F; Ghini, AS; Ferrero, V; Andò, G; Vassanelli, C; Romeo, F; Crea, F; Chiariello, L";s:9:"metadata7";s:24:"10.1093/eurheartj/ehi356";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:102;a:14:{s:9:"citazione";s:261:"Mango, R., Biocca, S., Del Vecchio, F., Clementi, F., Sangiuolo, F., Amati, F., et al. (2005). In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction. CIRCULATION RESEARCH, 97(2), 152-158.";s:4:"data";s:10:"2005-07-22";s:2:"id";s:19:"PUBBLICAZIONE_81009";s:6:"handle";s:10:"2108/29382";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:127:"In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction";s:9:"metadata6";s:176:"Mango, R; Biocca, S; Del Vecchio, F; Clementi, F; Sangiuolo, F; Amati, F; Filareto, A; Grelli, S; Spitalieri, P; Filesi, I; Favalli, C; Lauro, R; Mehta, J; Romeo, F; Novelli, G";s:9:"metadata7";s:34:"10.1161/01.RES.0000174563.62625.8e";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:103;a:14:{s:9:"citazione";s:313:"Pizzuto, F., Voci, P., Mariano, E., Puddu, P., Aprile, A., & Romeo, F. (2005). Evaluation of flow in the left anterior descending coronary artery but not in the left internal mammary artery graft predicts significant stenosis of the arterial conduit. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 45(3), 424-432.";s:4:"data";s:10:"2005-02-01";s:2:"id";s:20:"PUBBLICAZIONE_117230";s:6:"handle";s:10:"2108/59439";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:170:"Evaluation of flow in the left anterior descending coronary artery but not in the left internal mammary artery graft predicts significant stenosis of the arterial conduit";s:9:"metadata6";s:62:"Pizzuto, F; Voci, P; Mariano, E; Puddu, P; Aprile, A; Romeo, F";s:9:"metadata7";s:26:"10.1016/j.jacc.2004.09.072";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:104;a:14:{s:9:"citazione";s:131:"Voci, P., Pizzuto, F., & Romeo, F. (2004). Coronary flow: a new asset for the echo lab?. EUROPEAN HEART JOURNAL, 25(21), 1867-1879.";s:4:"data";s:7:"2004-11";s:2:"id";s:20:"PUBBLICAZIONE_117282";s:6:"handle";s:10:"2108/59453";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:44:"Coronary flow: a new asset for the echo lab?";s:9:"metadata6";s:29:"Voci, P; Pizzuto, F; Romeo, F";s:9:"metadata7";s:25:"10.1016/j.ehj.2004.07.029";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:105;a:14:{s:9:"citazione";s:276:"Pizzuto, F., Voci, P., Mariano, E., Puddu, P., Spedicato, P., & Romeo, F. (2004). Coronary flow reserve of the angiographically normal left anterior descending coronary artery in patients with remote coronary artery disease. THE AMERICAN JOURNAL OF CARDIOLOGY, 94(5), 577-582.";s:4:"data";s:10:"2004-09-01";s:2:"id";s:20:"PUBBLICAZIONE_117278";s:6:"handle";s:10:"2108/59450";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:141:"Coronary flow reserve of the angiographically normal left anterior descending coronary artery in patients with remote coronary artery disease";s:9:"metadata6";s:65:"Pizzuto, F; Voci, P; Mariano, E; Puddu, P; Spedicato, P; Romeo, F";s:9:"metadata7";s:29:"10.1016/j.amjcard.2004.05.019";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:106;a:14:{s:9:"citazione";s:228:"Martuscelli, E., Romagnoli, A., D'Eliseo, A., Razzini, C., Tomassini, M., Sperandio, M., et al. (2004). Accuracy of thin-slice computed tomography in the detection of coronary stenoses. EUROPEAN HEART JOURNAL, 25(12), 1043-1048.";s:4:"data";s:4:"2004";s:2:"id";s:18:"PUBBLICAZIONE_2624";s:6:"handle";s:10:"2108/57898";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:80:"Accuracy of thin-slice computed tomography in the detection of coronary stenoses";s:9:"metadata6";s:105:"Martuscelli, E; Romagnoli, A; D'Eliseo, A; Razzini, C; Tomassini, M; Sperandio, M; Simonetti, G; Romeo, F";s:9:"metadata7";s:25:"10.1016/j.ehj.2004.03.024";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:107;a:14:{s:9:"citazione";s:226:"Martuscelli, E., Romagnoli, A., D'Eliseo, A., Tomassini, M., Razzini, C., Sperandio, M., et al. (2004). Evaluation of venous and arterial conduit patency by 16-slice spiral computed tomography. CIRCULATION, 110(20), 3234-3238.";s:4:"data";s:4:"2004";s:2:"id";s:19:"PUBBLICAZIONE_14779";s:6:"handle";s:10:"2108/57453";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:88:"Evaluation of venous and arterial conduit patency by 16-slice spiral computed tomography";s:9:"metadata6";s:116:"Martuscelli, E; Romagnoli, A; D'Eliseo, A; Tomassini, M; Razzini, C; Sperandio, M; Simonetti, G; Romeo, F; Mehta, JL";s:9:"metadata7";s:34:"10.1161/01.CIR.0000147277.52036.07";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:108;a:14:{s:9:"citazione";s:332:"Muscoli, C., Sacco, I., Alecce, W., Palma, E., Nistico, R., Costa, N., et al. (2004). The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: Role of the lectin-like oxidized low-density lipoprotein receptor-1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 311(1), 44-50.";s:4:"data";s:4:"2004";s:2:"id";s:20:"PUBBLICAZIONE_246100";s:6:"handle";s:11:"2108/133216";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:298:"Animals; Arteriosclerosis; Carotid Artery Injuries; Catheterization; Gene Expression; Male; Myocytes, Smooth Muscle; Organometallic Compounds; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Superoxide Dismutase";s:9:"metadata3";s:29:"Settore BIO/14 - Farmacologia";s:9:"metadata4";s:1724:"Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the principal receptor for oxidized low-density lipoprotein (ox-LDL) in vascular endothelial cells (ECs), has recently been suggested to exert a pivotal role in atherogenesis, possibly by mediating ox-LDL-evoked endothelial dysfunction. On the other hand, LOX-1 expression seems to strongly correlate with the oxidative stress occurring in the vascular wall of experimentally injured blood vessels. Here, we investigated LOX-1 expression and superoxide generation during neointima formation in a balloon injury rat carotid artery model. To test this, we used M40401 [a manganese(II) complex with a bis(cyclo-hexylpyridine-substituted) macrocyclic ligand], a synthetic superoxide dismutase mimetic that is a selective scavenger of superoxide. The injury was performed inserting the balloon catheter through the rat common carotid artery and after 14 days a histopathological analysis revealed a significant restenosis with smooth muscle cell proliferation and neointima formation that was associated with an enhanced expression of LOX-1, nitrotyrosine (the footprint of peroxynitrite) staining, and lipid peroxidation as assessed by malondialdehyde (MDA) formation. Pretreatment of rats with M40401 (0.5-10 mg/kg i.p. daily) reduced neointima formation, MDA accumulation, nitrotyrosine staining, and LOX-1 expression. Here, we show that removal of superoxide formation occurring in injured arteries reduces both neointima formation and LOX-1 expression and that this may represent a novel therapeutical approach in the treatment of vascular disorders in which proliferation of vascular smooth muscle cells and ox-LDL-related endothelial cell dysfunction occur.";s:9:"metadata5";s:175:"The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: Role of the lectin-like oxidized low-density lipoprotein receptor-1";s:9:"metadata6";s:136:"Muscoli, C; Sacco, I; Alecce, W; Palma, E; Nistico, R; Costa, N; Clementi, F; Rotiroti, D; Romeo, F; Salvemini, D; Mehta, JL; Mollace, V";s:9:"metadata7";s:23:"10.1124/jpet.104.068205";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:109;a:14:{s:9:"citazione";s:190:"Santini L., F.G. (2004). Oesophageal electrical cardioversion of atrial fibrillation [Cardioversione elettrica esofagea della fibrillazione atriale]. MINERVA CARDIOANGIOLOGICA, 52(2), 73-80.";s:4:"data";s:4:"2004";s:2:"id";s:18:"PUBBLICAZIONE_2774";s:6:"handle";s:10:"2108/57810";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:123:"Oesophageal electrical cardioversion of atrial fibrillation [Cardioversione elettrica esofagea della fibrillazione atriale]";s:9:"metadata6";s:45:"Santini L., Forleo G.B., Santini M., Romeo F.";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:110;a:14:{s:9:"citazione";s:327:"Sodani, G., Sciuto, F., Di Roma, M., Romagnoli, A., Novelli, G., Squillaci, E., et al. (2004). Cardiac MRI with SENSE technology: Study of ventricular and valvular functionality in 30 patients = Cardio-RM con tecnologia SENSE: studio della funzionalità ventricolare e valvolare in 30 pazienti. LA RADIOLOGIA MEDICA, 105, 1-10.";s:4:"data";s:4:"2004";s:2:"id";s:19:"PUBBLICAZIONE_84988";s:6:"handle";s:10:"2108/34629";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:56:"Settore MED/36 - Diagnostica per Immagini e Radioterapia";s:9:"metadata4";N;s:9:"metadata5";s:198:"Cardiac MRI with SENSE technology: Study of ventricular and valvular functionality in 30 patients = Cardio-RM con tecnologia SENSE: studio della funzionalità ventricolare e valvolare in 30 pazienti";s:9:"metadata6";s:124:"Sodani, G; Sciuto, F; Di Roma, M; Romagnoli, A; Novelli, G; Squillaci, E; Forleo, G. B; Romeo, F; Schillaci, O; Simonetti G.";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:111;a:14:{s:9:"citazione";s:276:"Mango, R., Clementi, F., Borgiani, P., Forleo, G.B., Federici, M., Contino, G., et al. (2003). Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction. JOURNAL OF MEDICAL GENETICS, 40(12), 933-936.";s:4:"data";s:4:"2003";s:2:"id";s:20:"PUBBLICAZIONE_208648";s:6:"handle";s:11:"2108/103589";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:135:"Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction.";s:9:"metadata6";s:148:"Mango, R; Clementi, F; Borgiani, P; Forleo, GB; Federici, M; Contino, G; Giardina, E; Garza, L; Fahdi, IE; Lauro, R; Mehta, JL; Novelli, G; Romeo, F";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:112;a:14:{s:9:"citazione";s:194:"Novelli, G., Borgiani, P., Giardina, E., Mango, R., Contino, G., Romeo, F., et al. (2003). Role of genetics in prevention of coronary atherosclerosis. CURRENT OPINION IN CARDIOLOGY, 18, 368-371.";s:4:"data";s:4:"2003";s:2:"id";s:20:"PUBBLICAZIONE_208647";s:6:"handle";s:11:"2108/103599";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:32:"Settore MED/03 - Genetica Medica";s:9:"metadata4";N;s:9:"metadata5";s:58:"Role of genetics in prevention of coronary atherosclerosis";s:9:"metadata6";s:79:"Novelli, G; Borgiani, P; Giardina, E; Mango, R; Contino, G; Romeo, F; Mehta, JL";s:9:"metadata7";s:32:"10.1097/00001573-200309000-00008";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:113;a:14:{s:9:"citazione";s:236:"Mollace, V., Muscoli, C., Iannone, M., Palma, E., Rotiroti, D., Romeo, F., et al. (2002). Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 39(4), 544-551.";s:4:"data";s:7:"2002-04";s:2:"id";s:20:"PUBBLICAZIONE_246418";s:6:"handle";s:11:"2108/133231";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:204:"Animals; Cattle; Cells, Cultured; Cyclic GMP; Dexamethasone; Endothelium, Vascular; Hemodynamics; Lipopolysaccharides; Male; Mice; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Rats; Vasodilation";s:9:"metadata3";s:29:"Settore BIO/14 - Farmacologia";s:9:"metadata4";s:1433:"The aim of this study was to assess the effects of dexamethasone (DEX) on the inducible bioconversion of glyceryl trinitrate (GTN) into nitric oxide in cultured smooth muscle cells, endothelial cells, and the J774 macrophage cell line as well as in vivo and ex vivo in rats either untreated or pretreated with Escherichia coli lipopolysaccharide. In vitro, an increased bioconversion of GTN to nitrite and an elevation of cyclosine guanosine 3,5;-monophosphate (cGMP) levels occurred after treatment with lipopolysaccharide (LPS) (0.5 microg/ml, 18 h). This effect was ablated by co-incubation with DEX (10 microM, 18 h). Rats treated with an intraperitoneal (IP) injection of LPS (4 mg/kg) 18 h beforehand showed enhanced hypotensive responses to GTN (1 mg/kg, intravenously [IV]) and this was prevented when DEX (4 mg/kg, IP) was given together with LPS. Progesterone (50 mg/kg, IP) had no effect on GTN-induced hypotensive response. Conversely, exposure of rat aortic strips obtained from animals pretreated with LPS produced an enhanced vasorelaxant response in LPS-treated rats. Also, this effect was inhibited by pretreatment with DEX. Thus, the induction of the pathway leading to the formation of nitric oxide from GTN is blocked by DEX both in vitro and in vivo, and this may represent a useful tool in the assessment of the enhanced bioconversion of organic nitrates into nitric oxide occurring via inflammatory mechanisms.";s:9:"metadata5";s:89:"Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide";s:9:"metadata6";s:95:"Mollace, V; Muscoli, C; Iannone, M; Palma, E; Rotiroti, D; Romeo, F; Nisticò, R; Salvemini, D";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:114;a:14:{s:9:"citazione";s:300:"Li, D.Y., Chen, H.J., Romeo, F., Sawamura, T., Saldeen, T., & Mehta, J.L. (2002). Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 302(2), 601-605.";s:4:"data";s:4:"2002";s:2:"id";s:19:"PUBBLICAZIONE_17264";s:6:"handle";s:10:"2108/57772";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:145:"Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1";s:9:"metadata6";s:62:"Li, DY; Chen, HJ; Romeo, F; Sawamura, T; Saldeen, T; Mehta, JL";s:9:"metadata7";s:23:"10.1124/jpet.102.034959";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:115;a:14:{s:9:"citazione";s:203:"Mehta, J.L., Li, D.Y., Chen, H.J., Joseph, J., & Romeo, F. (2001). Inhibition of LOX-1 by statins may relate to upregulation of eNOS. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 289(4), 857-861.";s:4:"data";s:4:"2001";s:2:"id";s:19:"PUBBLICAZIONE_17420";s:6:"handle";s:10:"2108/57774";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:55:"Settore MED/11 - Malattie dell'Apparato Cardiovascolare";s:9:"metadata4";N;s:9:"metadata5";s:65:"Inhibition of LOX-1 by statins may relate to upregulation of eNOS";s:9:"metadata6";s:48:"Mehta, JL; Li, DY; Chen, HJ; Joseph, J; Romeo, F";s:9:"metadata7";s:22:"10.1006/bbrc.2001.6070";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:116;a:14:{s:9:"citazione";s:227:"Li D., S.T. (2000). Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: The potential role of transcription factor NF-╬║B. 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