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ANGELO SPINEDI è nato a Roma il 12.11.1953.

Il 16.12.1977 ha conseguito, con lode, la Laurea in Scienze Biologiche presso l’Università di Roma 'La Sapienza'.

L’ 1.6.1984 ha preso servizio nel ruolo di ricercatore presso il laboratorio di Fisiologia del Dipartimento di Biologia dell'Università di Roma 'Tor Vergata'.

L’1.3.2000 è stato chiamato a ricopre il ruolo di Professore Associato di Fisiologia presso il Dipartimento di Biologia della medesima Università, ove svolge attualmente attività didattica e scientifica.

 

Soggiorni all'estero e collaborazioni con laboratori stranieri:

1978 -Institute of Pathology, Karolinska Institutionen, Huddinge Hospital, Huddinge, Svezia (Prof. A. Bergstand) per lo studio del 'turnover' delle proteine integrali di membrana.

1986 - Weitzmann Institute, Rehovot, Israele (Prof.M. Shinitzky) per studi relativi all’organizzazione delle mebrane biologiche basati sull’uso di sonde fluorescenti e della fluorescenza intrinseca delle proteine di membrana.

Dal 1986 al 1994 ha collaborato con il Prof. Ricardo N. Farias, dell' Instituto de Quìmica Biològica dell'Universidad Nacional de Tucumàn, Argentina, in una serie di studi relativi all’interazione tra molecole di interesse farmacologico e membrane biologiche.

 

L’attività di ricerca è attualmente focalizzata sullo studio della fisiologia delle membrane biologiche, con particolare attenzione al ruolo dei lipidi nella trasduzione del segnale.

 

Pubblicazioni più recenti

 

Di Bartolomeo S. & Spinedi A. (2002) Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma. Neurosi. Lett. 334, 149-152,

 

Romano, E., Cannata, S., Di Bartolomeo, S. & Spinedi, A. (2003) Caspase inhibition shifts neuroepithelioma cell response to okadaic acid from apoptosis to an apoptotic-like form of death. Biochem. Biophys. Res. Commun. 303, 469-474.

 

Di Bartolomeo, S. & Spinedi, A. (2005) Two glucosylceramide synthase inhibitors attenuate doxorubicin-induced p21Cip1/Waf1 upregulation in HepG2 cells, irrespective of their differential chemosensitizing properties. Biochem. Biophys. Res. Commun. 330, 242-246.

 

Limatola, C., Massa, V., Lauro, C., Catalano, M., Giovanetti, A., Nuccitelli, S. & Spinedi, A. (2007) Evidence for a role of glycosphingolipids in CXCR4-dependent cell migration. FEBS Lett. 581, 2641–2646.

 

Mancinetti A, Di Bartolomeo S, Spinedi A. (2009) Long-chain ceramide produced in response to N-hexanoylsphingosine does not induce apoptosis in CHP-100 cells. Lipids. 44, 1039-46.

 

Di Bartolomeo, S., Luly, P., Spinedi, A. (2010) P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin. Drug Metab. Lett. 2010 4, 39-44.

 

ANGELO SPINEDI was born in Rome on November 12th 1953.

On December 16th 1977 he took the Degree in Biological Sciences with Honour at the University of Rome 'La Sapienza'.

On June 1rst 1984 he took the position of Researcher in the laboratory of Physiology at the Department of Biology of the University of Rome 'Tor Vergata'.

On March 1rst 2000 he took the position of Associated Professor of Physiology at the Department of Biology of the same University, where he

currently carries out teaching and research activities.

 

Stays abroad and international collaborations:

1978 -Institute of Pathology, Karolinska Institutionen, Huddinge Hospital, Huddinge, Svezia (Prof. A. Bergstand) for the study of integral membrane protein turnover.

1986 - Weitzmann Institute, Rehovot, Israele (Prof.M. Shinitzky) for studies on the organization of biological membranes based on the use of fluorescent probes and of the intrinsic fluorescence of membrane proteins.

From 1986 to 1994 he has collaborated with Prof. Ricardo N. Farias, of the Instituto de Quìmica Biològica-Universidad Nacional de Tucumàn, Argentina, in studies on the interactions between molecules of pharmacological interest and biological membranes.

 

The scientific activity is currently focussed on the study of the physiology of biological membranes, with particular attention to the role of lipids in signal transduction.

 

 

More recent publications

 

Di Bartolomeo S. & Spinedi A. (2002) Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma. Neurosi. Lett. 334, 149-152,

 

Romano, E., Cannata, S., Di Bartolomeo, S. & Spinedi, A. (2003) Caspase inhibition shifts neuroepithelioma cell response to okadaic acid from apoptosis to an apoptotic-like form of death. Biochem. Biophys. Res. Commun. 303, 469-474.

 

Di Bartolomeo, S. & Spinedi, A. (2005) Two glucosylceramide synthase inhibitors attenuate doxorubicin-induced p21Cip1/Waf1 upregulation in HepG2 cells, irrespective of their differential chemosensitizing properties. Biochem. Biophys. Res. Commun. 330, 242-246.

 

Limatola, C., Massa, V., Lauro, C., Catalano, M., Giovanetti, A., Nuccitelli, S. & Spinedi, A. (2007) Evidence for a role of glycosphingolipids in CXCR4-dependent cell migration. FEBS Lett. 581, 2641–2646.

 

Mancinetti A, Di Bartolomeo S, Spinedi A. (2009) Long-chain ceramide produced in response to N-hexanoylsphingosine does not induce apoptosis in CHP-100 cells. Lipids. 44, 1039-46.

 

Di Bartolomeo, S., Luly, P., Spinedi, A. (2010) P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin. Drug Metab. Lett. 2010 4, 39-44

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