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NOME: Daniele

COGNOME: Lettieri-Barbato

E-mail: daniele.lettieri.barbato@uniroma2.it

ISTRUZIONE E FORMAZIONE

2013               PhD in Biologia Cellulare e Molecolare, Università degli Studi di Roma Tor Vergata

 

ESPERIENZE PROFESSIONALI

2024 -             Group Leader presso il laboratorio di Dinamiche Cellulari e Metabolismo, IRCCS Fondazione Bietti, Roma, Italia.

2022 -             RTDb in Fisiologia presso il Dipartimento di Biologia, Università Degli Studi di Roma Tor Vergata, Italia,

2021 -             Group Leader presso il Lab. di Fisiologia dei Sistemi Integrati e Metabolismo, Dipartimento di Biologia, Università Degli Studi di Roma Tor Vergata, Italia,

2019-2024      Principal Investigator at European Center for Brain Research (CERC), IRCCS Fondazione Santa Lucia, Roma, Italia.  

 

ATTIVITÀ DI RICERCA

La mia ricerca si concentra sullo studio dell’impatto delle perturbazioni ambientali, come l’esposizione al freddo e la modulazione dei nutrienti, sulla salute metabolica e sull’invecchiamento. In studi recenti, ho approfondito l’intricata interazione tra le risposte mitocondriali e gli adattamenti immunometabolici, in particolare nella regolazione del processo termogenico e nella cachessia indotta da cancro. Per raggiungere questi obiettivi, la mia ricerca è attualmente supportata dalla Fondazione Europea per lo Studio del Diabete (EFSD), dalla Friedreich's Ataxia Research Alliance (FARA), dal Ministero della Salute italiano (MOH), dal Dipartimento della Difesa degli Stati Uniti (DOD) e AIRC - Fondazione AIRC per la Ricerca sul Cancro.

 

MEMBRO DI SOCIETÀ SCIENTIFICHE

2024 – Membro della Società Italiana di Fisiologia

2021 - Membro della Society for Free Radical Research (SfRBM)

2015 - Membro della European Foundation for the Study of Diabetes (EFSD)  

 

PREMI E RICONOSCIMENTI

2020               Articolo scientifico selezionato da “Communications Biology” (Nature Research Journal).

2018                Premio giovani ricercatori, Ministero della Salute Italiano.

2017                Premio giovani ricercatori, European Foundation for the Study of Diabetes (EFSD).

2017                Articolo scientifico selezionato per “Special Collection on Biomarkers”, Aging-US.

2010                Premio miglior presentazione orale, Media and Metabolic Disorders, Università degli Studi di Roma La Sapienza  

 

INVITO A SEMINARI E/O CONFERENZE

2023                FARA (Friedreich’s Ataxia Research Alliance) Forum - December

2021                KEYSTONE eSYMPOSIA “Integrating Metabolism and Immunity”;

2018                26th International Conference on Clinical Diabetes, Roma, Italia;

2016                International Congress on “Amino Acids, Peptides and Proteins”, Austria;

2014                Congresso Nazionale su “Nutrition in Occupational Medicine”. Università degli Studi di Roma La Sapienza

2010                Congresso Nazionale “SIMLII - 73°”, Università degli Studi di Roma La Sapienza

2010                Congresso Nazionale su “Nutrition in Occupational Medicine”, Università degli Studi di Roma La Sapienza  

 

ATTIVITÀ DIDATTICA

2021-                          Docente di riferimento per il corso di Fisiologia Generale (SSD BIO/09), Università degli Studi di Roma Tor Vergata

2021-                          Docente di Riferimento per il Corso di Fisiologia dei Sistemi Integrati (SSD BIO/09), Università degli Studi di Roma Tor Vergata

2022 - 2023                Docente di Riferimento per il Corso di Fisiologia (SSD BIO/09), Università degli Studi di Roma Tor Vergata 

2019 - 2021                Docente di Riferimento per il Corso di Fisiologia della Nutrizione Umana (SSD BIO/09), Università degli Studi di Roma Tor Vergata  2019 - 2021                Docente di Riferimento per il Corso di Nutritional Biotechnology (SSD MED/49), Università degli Studi di Roma Tor Vergata   

 

RESPONSABILITÀ ISTITUZIONALI

2022-              Membro della Scuola di Dottorato in Evolutionary Biology and Ecology, Dipartimento di Biologia, Università degli Studi di Roma Tor Vergata

2014 –             Supervisor per gli studenti della scuola di dottorato in BEE del Corso di laurea magistrale e  triennale in Biotecnologie, Università degli Studi di Roma Tor Vergata

2014 –             Membro di commissione di esame per i corsi di  laurea triennale e magistrale in Fisiologia Generale, Fisiologia, Fisiologia dei Sistemi Integrati e Neurobiologia   

 

PROGETTI DI RICERCA FINANZIATI

2024-2029                  PI. Deciphering the Role of Adipose Tissue-derived LCN2 in Cancer-Associated Cachexia. Bando AIRC 2023. 485.000 Euro

2024-2026                  PI. Boosting resolution of inflammation to reduce neuroinflammation. Bando FISM 2023. 25.000 Euro

2023-2026                   PI. Exploring the mitochondrial transfer from adipocytes to macrophages in the control of systemic glucose metabolism. Bando PRIN 2022. 100.000 Euro

2023-2026                   PI. Adipose tissue responses in ageing. Bando PNRR-PRIN 2022. 90.000 Euro

2023-2026                   PI. MNESYS - a multiscale integrated approach to the study of nervous system in health and disease. Bando PNRR PE12 (MUR). 79.000 Euro

2023-2025                   PI. Mitochondria-Derived Extracellular Vesicles in Friedreich's Ataxia. U.S. DEPARTMENT OF DEFENSE (DOD). 230.000 USD (213.000 Euro).

2022-2024                   PI. EFSD/Boehringer Ingelheim European Research Programme on “Multi-System Challenges in Diabetes” 2021 - Deciphering the Role of Adipocyte to Macrophage Mitochondrial Transfer in Type 2 Diabetes. EUROPEAN FOUNDATION FOR THE STUDIES ON DIABETES (EFSD). 100.000 Euro.

2021-2023                   PI. General Research Grant 2021 - Testare l'efficacia del butirrato alimentare nel migliorare i sintomi atassici nei modelli murini di atassia di Friedreich – FARA (Friedreich’s Ataxia Research Alliance), USA. 254.000 USD (236.000 Euro).   2019-2023                   PI. Young Researcher Grant (Progetto N.: GR-2018-12367588). Vescicole derivate dal tessuto adiposo: immunomodulatori e biomarcatori durante la terapia antinfiammatoria nella sclerosi multipla. MINISTERO DELLA SALUTE, IT. 430.000 Euro.   2020-2021                   

2018 - 2020                 PI. Young Researcher Grant (EFSD/Lilly_2017). ProBATion: Mappatura delle proteine veicolate dai nanovescicole rilasciate dal tessuto adiposo bruno. Finanziato dalla FONDAZIONE EUROPEA PER LO STUDIO DEL DIABETE (EFSD). 50.000 Euro.  

2017 - 2019                 PI. (Progetto N.: 2016-R03). Titolo: Effetti dei miRNA derivati dalle noci sul profilo infiammatorio e metabolico delle cellule adipose (miRNUTs). Finanziato dall'INTERNATIONAL WORLD FORUM FOR NUTRITION RESEARCH, USA.  

2016 - 2018                 PI. (ProjectDOI: 10.18258/6552). Brrr…Fa Freddo! Possono i nanovescicoli del sangue incoraggiare la produzione di calore e aiutare a combattere l'obesità? Finanziato da MICRORYZA, USA.    

 

PUBBLICAZIONI SCIENTIFICHE      

[1]      Francesca Sciarretta, Fabio Zaccaria, Andrea Ninni, Veronica Ceci, Riccardo Turchi, Savina Apolloni, Martina Milani, Ilaria Della Valle, Marta Tiberi, Valerio Chiurchiù, Nadia D’Ambrosi, Silvia Pedretti, Nico Mitro, Cinzia Volontè, Susanna Amadio, Katia Aquilano, DANIELE LETTIERI-BARBATO*. Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism 1 Promoting Reactive Microglia. Life Science Alliance(2024). *Last and Corresponding Author.     

[2]      Didier F. Pisani, Daniele Lettieri-Barbato and Stoyan Ivanon. Metabolic wiring between polyamines, adipose tissues and macrophages. Trends in Endocrinology & Metabolism (2024). *Corresponding Author.    

[3]      Francesca Sciarretta, Andrea Ninni, Fabio Zaccaria, Valerio Chiurchiù, Adeline Bertola, Keaton Karlinsey, Veronica Ceci, Claudia Di Biagio, Ziyan Xu, Marta Tiberi, Jiabi Zhang, Sihem Boudina, Paolo Grumati, Beiyan Zhou, Jonathan R. Brestoff, Stoyan Ivanov, Katia Aquilano, DANIELE LETTIERI-BARBATO. Lipid-Associated Macrophages Reshape BAT Cell Identity in Obesity. Cell Reports(2024). *Lead Contact.       

[4]      Sciarretta F, Ceci V, Tiberi M, Zaccaria F, Li H, Zhou ZY, Sun Q, Konja D, Matteocci A, Bhusal A, Verri M, Fresegna D, Balletta S, Ninni A, Di Biagio C, Rosina M, Suk K, Centonze D, Wang Y, Chiurchiù V, Aquilano K, LETTIERI-BARBATO D. Lipocalin-2 promotes adipose-macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis. Mol Metab(2023). *Last & Corresponding Author      

[5]      Riccardo Turchi, Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Matteo Audano, Silvia Pedretti, Concetta Panebianco, Valentina Nesci, Valerio Pazienza, Alberto Ferri, Simone Carotti, Valerio Chiurchiù, Nico Mitro, DANIELE LETTIERI-BARBATO* and Katia Aquilano*. Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich’s ataxia mouse model. iScience(2023). *Co-Last and Corresponding Author      

[6]      Aquilano K, Zhou B, Brestoff JR, LETTIERI-BARBATO D*. Multifaceted mitochondrial quality control in brown adipose tissue. Trends in Cell Biology. (2022). *Lead Contact      

[7]      RosinaM, CeciV, TurchiR, ChuanLi, BorcherdingN, Sánchez-DíazM, KarlinseyK, FuocoC, GiwaR, FieldRL, AudanoM, SciarrettaF, ArenaS, TortoliciF, PalmaA, RiccioF, ShamsiF, RenzoneG, VerriM, CrescenziA, RizzaS, FaienzaF, ChiurchiùV, FilomeniG, KooijmanS, RufiniS, AF de VriesAntoin, ScaloniA, MitroN, TsengYH, HidalgoA, ZhouB, BrestoffJR, AquilanoK, LETTIERI-BARBATO D*. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell Metabolism. (2022). *Lead Contact      

[8]      LETTIERI-BARBATO D*, Aquilano K, Punziano C, Minopoli G, Faraonio R. MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence. Antioxidants(Basel). (2022) doi: 10.3390/antiox11030480. First Author      

[9]      Palumbo C, Mecchia A, Bocedi A, Aquilano K, LETTIERI-BARBATO D, Rosina M, Di Venere A, Rodolfo C, Caccuri AM. Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells. Int J Biochem Cell Biol. (2022). doi: 10.1016/j.biocel.2022.106193.    

[10]    La Rosa P, Petrillo S, Turchi R, Berardinelli F, Schirinzi T, Vasco G, LETTIERI-BARBATO D, Fiorenza MT, Bertini E, Aquilano K, Piemonte F. The Nrf2 induction prevents ferroptosis in Friedreich’s Ataxia. Redox Biology. (2021).    

[11]    LETTIERI-BARBATO D, Minopoli G, Caggiano R, Izzo R, Santillo M, Aquilano K, Faraonio R. Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle. Int J Mol Sci. (2020).    

[12]    Turchi R, Faraonio R, LETTIERI-BARBATO D* and Aquilano K. An Overview of The Ferroptosis Hallmarks In Friedreich’s Ataxia. Biomolecules. (2020). *Co-Last Author and *Corresponding Author    

[13]    LETTIERI-BARBATO D*, Ventura N, Faraonio R, Aquilano K. Editorial: Advances in Metabolic Mechanisms of Aging and Its Related Diseases. Front Physiol. (2020) *Corresponding Author    

[14]    Carotti S, Aquilano K, Zalfa F, Ruggiero S, Valentini F, Zingariello M, Francesconi M, Perrone G, Alletto F, Antonelli-Incalzi R, Picardi A, Morini S, LETTIERI-BARBATO D* and Vespasiani-Gentilucci U. Lipophagy Impairment Is Associated With Disease Progression in NAFLD. Front Physiol. (2020) *Co-Last Author    

[15]    LETTIERI-BARBATO D*, Aquilano K. Aging and Immunometabolic Adaptations to Thermogenesis. Ageing Res Rev. (2020) *Corresponding Author    

[16]    Aquilano K, Sciarretta F, Turchi R, Li BH and LETTIERI-BARBATO D*. Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenic response in subcutaneous adipose tissue. Redox Biology. (2020). *Last Author and *Corresponding Author    

[17]    Menduti G, Vitaliti A, Capo CR, Lettieri-Barbato D, Aquilano K, Malaspina P, Rossi L. SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult. Int J Mol Sci. (2020).    

[18]    Carotti S, Aquilano K, Valentini F, Ruggiero S, Alletto F, Morini S, Picardi A, Antonelli-Incalzi R, LETTIERI-BARBATO D* and Vespasiani-Gentilucci U. An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase. Am J Physiol Gastrointest Liver Physiol (2020). *Co-Last Author    

[19]    Turchi R, Totrtolici F, LETTIERI-BARBATO D* and Katia Aquilano. Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue. Cell Death and Disease. (2020). *Co-Last Author and *Corresponding Author    

[20]    Aquilano K, Ceci V, and LETTIERI-BARBATO D*. Adipocyte metabolism is improved by TNF receptor-targeting small RNAs identified from dried nuts. Communications Biology. (2019). *Last Author and *Corresponding Author    

[21]    La Rosa P, Russo M, D'Amico J, Petrillo S, Aquilano K, LETTIERI-BARBATO D, Turchi R, Bertini ES, Piemonte F. Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich's Ataxia Neural Stem Cells. Front Cell Neurosci. (2019).    

[22]    LETTIERI-BARBATO D. Redox control of non-shivering thermogenesis. Mol Metab. (2019).    

[23]    LETTIERI-BARBATO D, Ioannilli L, Aquilano K, Ciccarone F, Rosina M, Ciriolo MR. FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress. Metabolism. (2019).    

[24]    Sciarretta F, Fulci C, Palumbo C, Aquilano K, Pastore A, Iorio E, LETTIERI-BARBATO D, Cicconi R, Minutolo A, Parravano M, Gilardi M, Varano M, Caccuri AM. Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells. J Cell Physiol. (2019).    

[25]    LETTIERI-BARBATO D*, Aquilano K. Pushing the Limits of Cancer Therapy: The Nutrient Game. Front Oncol. (2018). *Corresponding Author    

[26]    LETTIERI-BARBATO D*, Stefano Maria Cannata, Viviana Casagrande, Maria Rosa Ciriolo and Katia Aquilano. Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle. PloS ONE. (2018).*Corresponding Author    

[27]    Tatulli G, Mitro N, Cannata SM, Audano M, Caruso D, D'Arcangelo G, LETTIERI-BARBATO D*, Aquilano K. Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice. Front Cell Neurosci. (2018). *Co-Last Author    

[28]    LETTIERI-BARBATO D*, D'Angelo F, Sciarretta F, Tatulli G, Tortolici F, Ciriolo MR, Aquilano K. Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. Oncotarget. (2017). *Corresponding Author    

[29]    LETTIERI-BARBATO D*, Giovannetti E, Aquilano K. Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human. Aging-US. (2016). *Corresponding Author    

[30]    LETTIERI BARBATO D, Aquilano K. Feast and famine: Adipose tissue adaptations for healthy aging. Ageing Res Rev. (2016). *Corresponding Author    

[31]    Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K and LETTIERI BARBATO D. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. (2016).    

[32]    LETTIERI-BARBATO D*, Tatulli G, Aquilano K, Ciriolo MR. Mitochondrial Hormesis links nutrient restriction to improved metabolism in fat cell. Aging-Us. (2015). *Corresponding Author    

[33]    LETTIERI-BARBATO D, Tatulli G, Vegliante R, Cannata SM, Bernardini S, Ciriolo MR, Aquilano K. Dietary fat overload reprograms brown fat mitochondria. Front Physiol. (2015).    

[34]    Aquilano K, LETTIERI-BARBATO D, Rosa CM. The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation. Commun Integr Biol. (2015).    

[35]    LETTIERI-BARBATO D, Tatulli G, Maria Cannata S, Bernardini S, Aquilano K, Ciriolo MR. Glutathione Decrement Drives Thermogenic Program In Adipose Cells. Sci. Rep. (2015).    

[36]    Langone F, Cannata S, Fuoco C, LETTIERI-BARBATO D, Testa S, Nardozza AP, Ciriolo MR, Castagnoli L, Gargioli C, Cesareni G. Metformin protects skeletal muscle from cardiotoxin induced degeneration. PLoS One. (2014).    

[37]    Baldelli S, LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. The role of nNOS and PGC-1?in skeletal muscle cells. J Cell Sci. (2014).    

[38]    LETTIERI-BARBATO D*, Aquilano K, Ciriolo MR. FoxO1 at the nexus between fat catabolism and longevity pathways. Biochim Biophys Acta. (2014). *Corresponding Author    

[39]    LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. Inhibition of age-related cytokines production by ATGL: a mechanism linked to the anti-inflammatory effect of resveratrol.Mediators Inflamm. (2014).    

[40]    LETTIERI-BARBATO D, Vegliante R, Desideri E, Ciriolo MR. Managing lipid metabolism in proliferating cells: new perspective for metformin usage in cancer therapy. Biochim Biophys Acta Rev on Cancer. (2014).    

[41]    LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. Cell Death Dis. (2013).    

[42]    LETTIERI-BARBATO D, Aquilano K, Baldelli S, Cannata SM, Bernardini S, Rotilio G, Ciriolo MR. Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Cell Death Diff. (2014).    

[43]    LETTIERI-BARBATO D, Tomei F, Sancini A, Morabito G, Serafini M. Effect of plant foods and beverages on plasma non-enzymatic antioxidant capacity in human subjects: a meta-analysis.Br J Nutr. (2013).    

[44]    LETTIERI-BARBATO D, Baldelli S, Pagliei B, Aquilano K, Ciriolo MR. Caloric Restriction and the Nutrient-Sensing PGC-1?in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration. Int J Cell Biol. (2012).      

[45]    LETTIERI-BARBATO D, Villaño D, Beheydt B, Guadagni F, Trogh I, Serafini M. Effect of ingestion of dark chocolates with similar lipid composition and different cocoa content on antioxidant and lipid status in healthy humans.Food Chem. (2012).    

[46]    Villaño D, LETTIERI-BARBATO D, Guadagni F, Schmid M, Serafini M. Effect of acute consumption of oolong tea on antioxidant parameters in healthy individuals. Food Chem. (2012).    

[47]    LETTIERI-BARBATO D, Sancini A, Caciari T, Rosati MV, Tomei G, Tomei F. Dietary intervention programs in the workplace: an effective prevention strategy. G Ital Med Lav Ergon. (2010).    

[48]    LETTIERI-BARBATO D, Tomei G, Tomei F, Sancini A. Traffic air pollution and oxidatively generated DNA damage: can urinary 8-oxo-7,8-dihydro-2-deoxiguanosine be considered a good biomarker? A meta-analysis. Biomarkers. (2010).  

First name: Daniele

Last name:Lettieri-Barbato

Tel: +39 3202149748

Nationality: Italian

E-mail:daniele.lettieri.barbato@uniroma2.it

ORCID ID: 0000-0002-1172-814X

Scopus Author ID: 53264259000

Websites & Social Links

https://scholar.google.it/citations?user=h6PEErIAAAAJ&hl=it

 

EDUCATION

2013                PhD in Cellular and Molecular Biology, University of Rome Tor Vergata, Rome, Italy

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE:

2024 -             Group Leader of Cell Dynamics and Metabolism Lab, IRCCS Fondazione Bietti, Rome, Italy.

2022 -             Assistant Professor in Physiology at Dept. Biology, University of Rome Tor Vergata, Italy

2021 -             Group Leader of Integrative Physiology and Metabolism Lab, Dept. Biology, University of Rome Tor Vergata, Italy;

2019-2024      Principal Investigator at European Center for Brain Research (CERC), IRCCS Fondazione Santa Lucia, Rome, Italy.

2015 -2019     Adjunct Professor at Telematic University of Rome San Raffaele, Italy

2014 - 2016    Research Associate at Dept. Biology, University of Rome Tor Vergata, Italy

2009 - 2010     Research Fellow at Dept. of Occupational Medicine, University of Rome La Sapienza, Italy

 

RESEARCH ACTIVITY

My research focuses on investigating the impact of environmental perturbations, such as cold exposure and nutrient modulation, on metabolic health and aging. In recent studies, I have delved into unraveling the intricate interplay between mitochondrial responses and immunometabolic adaptations, particularly in regulating adipose tissue thermogenesis. To achieve these goals, my research is currently supported by European Foundation for the Study of Diabetes (EFSD), Friedreich's Ataxia Research Alliance (FARA), Italian Ministry of Health (MOH), the U.S. Department of Defense (DOD) and AIRC - Fondazione AIRC per la Ricerca sul Cancro.

 

MEMBERSHIPSOFSCIENTIFICSOCIETIES

2021 - Member of Society for Free Radical Research (SfRBM)

2015 - Member of the European Foundation for the Study of Diabetes (EFSD)

 

AWARDS AND HONORS

2020                Selected paper in Communications Biology (Nature Research Journal).

2018                Young Research Award, Italian Ministry of Health.

2017                Young Research Award, European Foundation for the Study of Diabetes (EFSD).

2017                Selected paper for “Special Collection on Biomarkers”, Aging-US.

2010                Best Oral Presentation”, Media and Metabolic Disorders, AIART and University of Rome La Sapienza, Italy.

 

INVITED LECTURES AT NATIONAL AND INTERNATIONAL CONFERENCES

2023                FARA (Friedreich’s Ataxia Research Alliance) Forum - December 2023.

2021                Selected for Short Talk Presentation at KEYSTONE eSYMPOSIA “Integrating                          Metabolism and Immunity”;

2018                26th International Conference on Clinical Diabetes, Rome, Italy;

2016                International Congress on “Amino Acids, Peptides and Proteins”, Austria;

2014                           National Congress on “Nutrition in Occupational Medicine”. University of Rome La Sapienza;

2010                National Congress “SIMLII - 73°”, University of Rome La Sapienza;

2010                National Congress on “Nutrition in Occupational Medicine”, University of Rome La                  Sapienza.

 

 

TEACHING ACTIVITY

2021-                          General Physiology (SSD BIO/09), University of Rome Tor Vergata.

2021-                          Integrative and Systems Physiology (SSD BIO/09), University of Rome Tor                               Vergata.

2022 - 2023                Physiology (SSD BIO/09), University of Rome Tor Vergata.

2019 - 2021                Physiology of Human Nutrition (SSD BIO/09), University of Rome Tor Vergata.

2019 - 2021                Nutritional Biotechnology (SSD MED/49), University of Rome Tor Vergata.

2015 - 2021                 Biochemistry of Human Nutrition (SSD BIO/10), Telematic University of Rome San Raffaele.

2015 - 2019                Food Chemistry (SSD BIO/10), Telematic University of Rome San Raffaele.

2015 - 2019                Biochemistry techniques, University of Rome Tor Vergata.

2015 - 2017                 Second-level professional master’s program “management of clinical      experimentation in hematology and oncology”, University of Rome Tor Vergata

 

 

INSTITUTIONAL RESPONSIBILITIES

2022-              Member of Doctorate in Evolutionary Biology and Ecology, Dept. Biology, University of                     Rome Tor Vergata.

2014 –             Supervisor of Bachelor, Master and PhD students at University of Rome Tor Vergata

2014 –             Member of examining boards for General Physiology and Doctorate in Evolutionary Biology and Ecology at University of Rome Tor Vergata.

 

 

OTHER ACTIVITIES

-       Guest Associate Editor for Integrative Physiology “Advances in Metabolic Mechanisms of Aging and Its Related Diseases”. Frontiers in Physiology.

-       Topic Editor for Cells, Mdpi.

-       Topic Editor for Life, Mdpi.

-       Guest Associate Editor for “Adaptations to Metabolic Pressure”, Life, Mdpi.

-       Review Editor for Nature Metabolism, Cell Reports, Mol Metab, BMC Biology, Frontiers in Endocrinology, Frontiers in Genetics and Frontiers in Nutrition section on Nutrigenomics.

 

AWARDED GRANTS

2024-2029                   Role: Principal Investigator. Deciphering the Role of Adipose Tissue-derived LCN2 in Cancer-Associated Cachexia. Bando AIRC 2023. 485.000 Euro

2024-2026                   Role: Head of Research Unit:Boosting resolution of inflammation to reduce neuroinflammation. Bando FISM 2023. 25.000 Euro

2023-2026                   Role: Principal Investigator. Exploring the mitochondrial transfer from adipocytes to macrophages in the control of systemic glucose metabolism. Bando PRIN 2022. 100.000 Euro

2023-2026                   Role: Head of Research Unit: Adipose tissue responses in ageing. Bando PNRR-PRIN 2022. 90.000 Euro

2023-2026                   Role: Head of Research Unit: MNESYS - a multiscale integrated approach to the study of nervous system in health and disease. Bando PNRR PE12 (MUR). 79.000 Euro

2023-2025                   Role: Co-Principal Investigator: PR220244. Mitochondria-Derived Extracellular Vesicles in Friedreich's Ataxia. U.S. DEPARTMENT OF DEFENSE (DOD). 230.000 USD (213.000 Euro).

2022-2024                   Role: Principal Investigator. EFSD/Boehringer Ingelheim European Research Programme on “Multi-System Challenges in Diabetes” 2021 - Deciphering the Role of Adipocyte to Macrophage Mitochondrial Transfer in Type 2 Diabetes. EUROPEAN FOUNDATION FOR THE STUDIES ON DIABETES (EFSD). 100.000 Euro.

2021-2023                   Role: Principal Investigator. General Research Grant 2021 - Testing the efficacy of dietary butyrate in ameliorating ataxic symptoms in Friedreich’s ataxia mouse models – FARA (Friedreich’s Ataxia Research Alliance), US. 254.000 USD (236.000 Euro).

2019-2023                   Role: Principal Investigator. Young Researcher Grant (Project No: GR-2018-12367588). Adipose-derived vesicles: immunomodulators and biomarkers during anti-inflammatory therapy in multiple sclerosis. MINISTRY OF HEALTH, IT. 430.000 Euro.

2020-2021                   Role: Co-Principal Investigator. Testing the effectiveness of dimethyl fumarate in modulating adipokine production: an ex vivo study on subcutaneous adipose tissue of psoriasis patients. ALMIRALL, IT. 50.000 Euro

2018 - 2020                 Role: Principal Investigator. Young Researcher Grant (EFSD/Lilly_2017). ProBATion: Mapping nanovesicles-vehicled Proteins released from Brown Adipose Tissue. Funded by EUROPEAN FOUNDATION FOR THE STUDIES ON DIABETES (EFSD). 50.000 Euro

2017 - 2019                 Role: Principal Investigator.(Project No: 2016-R03). Title: Effects of nut-derived miRNAs on inflammatory and metabolic profile of fat cells (miRNUTs). Funded by INTERNATIONAL WORLD FORUM FOR NUTRITION RESEARCH, US.

2016 - 2018                 Role: Principal Investigator.(ProjectDOI: 10.18258/6552).Brrr…It’s Cold! Can Blood Nanovesicles Encourage Heat Production and Help Fight Obesity? Funded by MICRORYZA, US

2016 -                          Role: Key Personnel. Seed Money Grant - Study of the role of lipid dysmetabolism in the pathogenesis of Friedreich’s ataxia - NATIONAL ATAXIA FUNDATION (NAF), US.

2017 -                          Role: Key Personnel.General Research Grant 2016 - Studying the role of brown fat in Friedreich’s ataxia – FARA (Friedreich’s Ataxia Research Alliance), US.

2012 – 2014                Role: Key Personnel. Young Researcher Grant 2012 (GR-2011-02348047) - Dissecting the role of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1a) and adipose triglyceride lipase (ATGL) in Parkinson's disease. Funded by ITALIAN MINISTRY OF HEALTH, IT.

 

PEER-REVIEWED PUBLICATIONS

 

      [1]      Francesca Sciarretta, Fabio Zaccaria, Andrea Ninni, Veronica Ceci, Riccardo Turchi, Savina Apolloni, Martina Milani, Ilaria Della Valle, Marta Tiberi, Valerio Chiurchiù, Nadia D’Ambrosi, Silvia Pedretti, Nico Mitro, Cinzia Volontè, Susanna Amadio, Katia Aquilano, DANIELE LETTIERI-BARBATO*. Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism 1 Promoting Reactive Microglia. Life Science Alliance(2024). *Last and Corresponding Author. 

 

      [2]      Didier F. Pisani, Daniele Lettieri-Barbato and Stoyan Ivanon. Metabolic wiring between polyamines, adipose tissues and macrophages. Trends in Endocrinology & Metabolism (2024). *Corresponding Author. 

 

      [3]      Francesca Sciarretta, Andrea Ninni, Fabio Zaccaria, Valerio Chiurchiù, Adeline Bertola, Keaton Karlinsey, Veronica Ceci, Claudia Di Biagio, Ziyan Xu, Marta Tiberi, Jiabi Zhang, Sihem Boudina, Paolo Grumati, Beiyan Zhou, Jonathan R. Brestoff, Stoyan Ivanov, Katia Aquilano, DANIELE LETTIERI-BARBATO. Lipid-Associated Macrophages Reshape BAT Cell Identity in Obesity. Cell Reports(2024). *Lead Contact. 

 

      [4]      Sciarretta F, Ceci V, Tiberi M, Zaccaria F, Li H, Zhou ZY, Sun Q, Konja D, Matteocci A, Bhusal A, Verri M, Fresegna D, Balletta S, Ninni A, Di Biagio C, Rosina M, Suk K, Centonze D, Wang Y, Chiurchiù V, Aquilano K, LETTIERI-BARBATO D. Lipocalin-2 promotes adipose-macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis. Mol Metab(2023). *Last & Corresponding Author

 

      [5]      Riccardo Turchi, Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Matteo Audano, Silvia Pedretti, Concetta Panebianco, Valentina Nesci, Valerio Pazienza, Alberto Ferri, Simone Carotti, Valerio Chiurchiù, Nico Mitro, DANIELE LETTIERI-BARBATO* and Katia Aquilano*. Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich’s ataxia mouse model. iScience(2023). *Co-Last and Corresponding Author

 

      [6]      Aquilano K, Zhou B, Brestoff JR, LETTIERI-BARBATO D*. Multifaceted mitochondrial quality control in brown adipose tissue. Trends in Cell Biology. (2022). *Lead Contact

 

      [7]      RosinaM, CeciV, TurchiR, ChuanLi, BorcherdingN, Sánchez-DíazM, KarlinseyK, FuocoC, GiwaR, FieldRL, AudanoM, SciarrettaF, ArenaS, TortoliciF, PalmaA, RiccioF, ShamsiF, RenzoneG, VerriM, CrescenziA, RizzaS, FaienzaF, ChiurchiùV, FilomeniG, KooijmanS, RufiniS, AF de VriesAntoin, ScaloniA, MitroN, TsengYH, HidalgoA, ZhouB, BrestoffJR, AquilanoK, LETTIERI-BARBATO D*. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell Metabolism. (2022). *Lead Contact

 

      [8]      LETTIERI-BARBATO D*, Aquilano K, Punziano C, Minopoli G, Faraonio R. MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence. Antioxidants(Basel). (2022) doi: 10.3390/antiox11030480. First Author

 

      [9]      Palumbo C, Mecchia A, Bocedi A, Aquilano K, LETTIERI-BARBATO D, Rosina M, Di Venere A, Rodolfo C, Caccuri AM. Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells. Int J Biochem Cell Biol. (2022). doi: 10.1016/j.biocel.2022.106193.

 

    [10]    La Rosa P, Petrillo S, Turchi R, Berardinelli F, Schirinzi T, Vasco G, LETTIERI-BARBATO D, Fiorenza MT, Bertini E, Aquilano K, Piemonte F. The Nrf2 induction prevents ferroptosis in Friedreich’s Ataxia. Redox Biology. (2021).

 

    [11]    LETTIERI-BARBATO D, Minopoli G, Caggiano R, Izzo R, Santillo M, Aquilano K, Faraonio R. Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle. Int J Mol Sci. (2020).

 

    [12]    Turchi R, Faraonio R, LETTIERI-BARBATO D* and Aquilano K. An Overview of The Ferroptosis Hallmarks In Friedreich’s Ataxia. Biomolecules. (2020). *Co-Last Author and *Corresponding Author

 

    [13]    LETTIERI-BARBATO D*, Ventura N, Faraonio R, Aquilano K. Editorial: Advances in Metabolic Mechanisms of Aging and Its Related Diseases. Front Physiol. (2020) *Corresponding Author

 

    [14]    Carotti S, Aquilano K, Zalfa F, Ruggiero S, Valentini F, Zingariello M, Francesconi M, Perrone G, Alletto F, Antonelli-Incalzi R, Picardi A, Morini S, LETTIERI-BARBATO D* and Vespasiani-Gentilucci U. Lipophagy Impairment Is Associated With Disease Progression in NAFLD. Front Physiol. (2020) *Co-Last Author

 

    [15]    LETTIERI-BARBATO D*, Aquilano K. Aging and Immunometabolic Adaptations to Thermogenesis. Ageing Res Rev. (2020) *Corresponding Author

 

    [16]    Aquilano K, Sciarretta F, Turchi R, Li BH and LETTIERI-BARBATO D*. Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenic response in subcutaneous adipose tissue. Redox Biology. (2020). *Last Author and *Corresponding Author

 

    [17]    Menduti G, Vitaliti A, Capo CR, Lettieri-Barbato D, Aquilano K, Malaspina P, Rossi L. SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult. Int J Mol Sci. (2020).

 

    [18]    Carotti S, Aquilano K, Valentini F, Ruggiero S, Alletto F, Morini S, Picardi A, Antonelli-Incalzi R, LETTIERI-BARBATO D* and Vespasiani-Gentilucci U. An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase. Am J Physiol Gastrointest Liver Physiol (2020). *Co-Last Author

 

    [19]    Turchi R, Totrtolici F, LETTIERI-BARBATO D* and Katia Aquilano. Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue. Cell Death and Disease. (2020). *Co-Last Author and *Corresponding Author

 

    [20]    Aquilano K, Ceci V, and LETTIERI-BARBATO D*. Adipocyte metabolism is improved by TNF receptor-targeting small RNAs identified from dried nuts. Communications Biology. (2019). *Last Author and *Corresponding Author

 

    [21]    La Rosa P, Russo M, D'Amico J, Petrillo S, Aquilano K, LETTIERI-BARBATO D, Turchi R, Bertini ES, Piemonte F. Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich's Ataxia Neural Stem Cells. Front Cell Neurosci. (2019).

 

    [22]    LETTIERI-BARBATO D. Redox control of non-shivering thermogenesis. Mol Metab. (2019).

 

 

    [23]    LETTIERI-BARBATO D, Ioannilli L, Aquilano K, Ciccarone F, Rosina M, Ciriolo MR. FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress. Metabolism. (2019).

 

    [24]    Sciarretta F, Fulci C, Palumbo C, Aquilano K, Pastore A, Iorio E, LETTIERI-BARBATO D, Cicconi R, Minutolo A, Parravano M, Gilardi M, Varano M, Caccuri AM. Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells. J Cell Physiol. (2019).

 

    [25]    LETTIERI-BARBATO D*, Aquilano K. Pushing the Limits of Cancer Therapy: The Nutrient Game. Front Oncol. (2018). *Corresponding Author

 

    [26]    LETTIERI-BARBATO D*, Stefano Maria Cannata, Viviana Casagrande, Maria Rosa Ciriolo and Katia Aquilano. Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle. PloS ONE. (2018).*Corresponding Author

 

    [27]    Tatulli G, Mitro N, Cannata SM, Audano M, Caruso D, D'Arcangelo G, LETTIERI-BARBATO D*, Aquilano K. Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice. Front Cell Neurosci. (2018). *Co-Last Author

 

    [28]    LETTIERI-BARBATO D*, D'Angelo F, Sciarretta F, Tatulli G, Tortolici F, Ciriolo MR, Aquilano K. Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. Oncotarget. (2017). *Corresponding Author

 

    [29]    LETTIERI-BARBATO D*, Giovannetti E, Aquilano K. Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human. Aging-US. (2016). *Corresponding Author

 

    [30]    LETTIERI BARBATO D, Aquilano K. Feast and famine: Adipose tissue adaptations for healthy aging. Ageing Res Rev. (2016). *Corresponding Author

 

 

    [31]    Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K and LETTIERI BARBATO D. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. (2016).

 

    [32]    LETTIERI-BARBATO D*, Tatulli G, Aquilano K, Ciriolo MR. Mitochondrial Hormesis links nutrient restriction to improved metabolism in fat cell. Aging-Us. (2015). *Corresponding Author

 

    [33]    LETTIERI-BARBATO D, Tatulli G, Vegliante R, Cannata SM, Bernardini S, Ciriolo MR, Aquilano K. Dietary fat overload reprograms brown fat mitochondria. Front Physiol. (2015).

 

    [34]    Aquilano K, LETTIERI-BARBATO D, Rosa CM. The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation. Commun Integr Biol. (2015).

 

    [35]    LETTIERI-BARBATO D, Tatulli G, Maria Cannata S, Bernardini S, Aquilano K, Ciriolo MR. Glutathione Decrement Drives Thermogenic Program In Adipose Cells. Sci. Rep. (2015).

 

    [36]    Langone F, Cannata S, Fuoco C, LETTIERI-BARBATO D, Testa S, Nardozza AP, Ciriolo MR, Castagnoli L, Gargioli C, Cesareni G. Metformin protects skeletal muscle from cardiotoxin induced degeneration. PLoS One. (2014).

 

    [37]    Baldelli S, LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. The role of nNOS and PGC-1?in skeletal muscle cells. J Cell Sci. (2014).

 

    [38]    LETTIERI-BARBATO D*, Aquilano K, Ciriolo MR. FoxO1 at the nexus between fat catabolism and longevity pathways. Biochim Biophys Acta. (2014). *Corresponding Author

 

    [39]    LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. Inhibition of age-related cytokines production by ATGL: a mechanism linked to the anti-inflammatory effect of resveratrol.Mediators Inflamm. (2014).

 

    [40]    LETTIERI-BARBATO D, Vegliante R, Desideri E, Ciriolo MR. Managing lipid metabolism in proliferating cells: new perspective for metformin usage in cancer therapy. Biochim Biophys Acta Rev on Cancer. (2014).

 

    [41]    LETTIERI-BARBATO D, Tatulli G, Aquilano K, Ciriolo MR. FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. Cell Death Dis. (2013).

 

    [42]    LETTIERI-BARBATO D, Aquilano K, Baldelli S, Cannata SM, Bernardini S, Rotilio G, Ciriolo MR. Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Cell Death Diff. (2014).

 

    [43]    LETTIERI-BARBATO D, Tomei F, Sancini A, Morabito G, Serafini M. Effect of plant foods and beverages on plasma non-enzymatic antioxidant capacity in human subjects: a meta-analysis.Br J Nutr. (2013).

 

    [44]    LETTIERI-BARBATO D, Baldelli S, Pagliei B, Aquilano K, Ciriolo MR. Caloric Restriction and the Nutrient-Sensing PGC-1?in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration. Int J Cell Biol. (2012).

 

    [45]    LETTIERI-BARBATO D, Villaño D, Beheydt B, Guadagni F, Trogh I, Serafini M. Effect of ingestion of dark chocolates with similar lipid composition and different cocoa content on antioxidant and lipid status in healthy humans.Food Chem. (2012).

 

    [46]    Villaño D, LETTIERI-BARBATO D, Guadagni F, Schmid M, Serafini M. Effect of acute consumption of oolong tea on antioxidant parameters in healthy individuals. Food Chem. (2012).

 

    [47]    LETTIERI-BARBATO D, Sancini A, Caciari T, Rosati MV, Tomei G, Tomei F. Dietary intervention programs in the workplace: an effective prevention strategy. G Ital Med Lav Ergon. (2010).

 

    [48]    LETTIERI-BARBATO D, Tomei G, Tomei F, Sancini A. Traffic air pollution and oxidatively generated DNA damage: can urinary 8-oxo-7,8-dihydro-2-deoxiguanosine be considered a good biomarker? A meta-analysis. Biomarkers. (2010).

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