array(1) { [0]=> object(Apache_Solr_Document)#24 (3) { ["_documentBoost":protected]=> bool(false) ["_fields":protected]=> array(6) { ["content_id"]=> array(1) { [0]=> string(13) "DIRECTORY_924" } ["content_title"]=> array(1) { [0]=> string(14) "CHIARA CIACCIO" } ["description"]=> array(1) { [0]=> string(43789) "Inserire qui il curriculumInsert here the curriculum a:49:{i:0;a:14:{s:9:"citazione";s:188:"De Simone, G., di Masi, A., Vita, G.M., Polticelli, F., Pesce, A., Nardini, M., et al. (2020). Mycobacterial and human nitrobindins: structure and function. ANTIOXIDANTS & REDOX SIGNALING.";s:4:"data";s:10:"2020-04-16";s:2:"id";s:20:"PUBBLICAZIONE_387915";s:6:"handle";s:11:"2108/245873";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:60:"Mycobacterial and human nitrobindins: structure and function";s:9:"metadata6";s:214:"De Simone, G; di Masi, A; Vita, GM; Polticelli, F; Pesce, A; Nardini, M; Bolognesi, M; Ciaccio, C; Coletta, M; Turilli, ES; Fasano, M; Tognaccini, L; Smulevich, G; Abbruzzetti, S; Viappiani, C; Bruno, S; Ascenzi, P";s:9:"metadata7";s:21:"10.1089/ars.2019.7874";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:1;a:14:{s:9:"citazione";s:216:"Ascenzi, P., De Simone, G., Ciaccio, C., & Coletta, M. (2020). Ligand-dependent inequivalence of the α and β subunits of ferric human hemoglobin bound to haptoglobin. JOURNAL OF INORGANIC BIOCHEMISTRY, 202, 110814.";s:4:"data";s:4:"2020";s:2:"id";s:20:"PUBBLICAZIONE_387891";s:6:"handle";s:11:"2108/245849";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:104:"Ligand-dependent inequivalence of the α and β subunits of ferric human hemoglobin bound to haptoglobin";s:9:"metadata6";s:48:"Ascenzi, P; De Simone, G; Ciaccio, C; Coletta, M";s:9:"metadata7";s:31:"10.1016/j.jinorgbio.2019.110814";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:2;a:14:{s:9:"citazione";s:354:"Di Pierro, D., Ciaccio, C., Sbardella, D., Tundo, G.R., Bernardini, R., Curatolo, P., et al. (2020). Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10. MOLECULAR AND CELLULAR BIOCHEMISTRY, 463(1-2), 101-113.";s:4:"data";s:4:"2020";s:2:"id";s:20:"PUBBLICAZIONE_387890";s:6:"handle";s:11:"2108/245865";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:196:"Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10";s:9:"metadata6";s:123:"Di Pierro, D; Ciaccio, C; Sbardella, D; Tundo, GR; Bernardini, R; Curatolo, P; Galasso, C; Pironi, V; Coletta, M; Marini, S";s:9:"metadata7";s:26:"10.1007/s11010-019-03633-5";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:3;a:14:{s:9:"citazione";s:292:"Sbardella, D., Tundo, G.R., Cunsolo, V., Grasso, G., Cascella, R., Caputo, V., et al. (2020). Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, 1866(7), 165793.";s:4:"data";s:4:"2020";s:2:"id";s:20:"PUBBLICAZIONE_387913";s:6:"handle";s:11:"2108/245871";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:121:"Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations";s:9:"metadata6";s:315:"Sbardella, D; Tundo, GR; Cunsolo, V; Grasso, G; Cascella, R; Caputo, V; Santoro, AM; Milardi, D; Pecorelli, A; Ciaccio, C; Di Pierro, D; Leoncini, S; Campagnolo, L; Pironi, V; Oddone, F; Manni, P; Foti, S; Giardina, E; De Felice, C; Hayek, J; Curatolo, P; Galasso, C; Valacchi, G; Coletta, M; GRAZIANI, G; Marini, S";s:9:"metadata7";s:28:"10.1016/j.bbadis.2020.165793";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:4;a:14:{s:9:"citazione";s:275:"Sbardella, D., Tundo, G.r., Coletta, A., Marcoux, J., Koufogeorgou, E.i., Ciaccio, C., et al. (2018). The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S. CELLULAR AND MOLECULAR LIFE SCIENCES, 75(18), 3441-3456.";s:4:"data";s:4:"2018";s:2:"id";s:20:"PUBBLICAZIONE_351612";s:6:"handle";s:11:"2108/215080";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:451:"IDE-20S molecular docking; IDE-20S proteasome interaction; Insulin-degrading enzyme; Open-close 20S equilibrium; Allosteric Regulation; Cell Line, Tumor; Chromatography, High Pressure Liquid; HEK293 Cells; Humans; Insulysin; Kinetics; Molecular Docking Simulation; Native Polyacrylamide Gel Electrophoresis; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Tandem Mass Spectrometry; Yeasts";s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:115:"The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S";s:9:"metadata6";s:168:"Sbardella, D; Tundo, Gr; Coletta, A; Marcoux, J; Koufogeorgou, Ei; Ciaccio, C; Santoro, Am; Milardi, D; Grasso, G; Cozza, P; Bousquet-Dubouch, M-; Marini, S; Coletta, M";s:9:"metadata7";s:25:"10.1007/s00018-018-2807-y";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:5;a:14:{s:9:"citazione";s:273:"Ciaccio, C., DI PIERRO, D., Sbardella, D., Tundo, G.r., Curatolo, P., Galasso, C., et al. (2017). Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations. MOLECULAR AND CELLULAR BIOCHEMISTRY, 426, 205-213.";s:4:"data";s:7:"2017-01";s:2:"id";s:20:"PUBBLICAZIONE_299855";s:6:"handle";s:11:"2108/170844";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:43:"Settore MED/39 - Neuropsichiatria Infantile";s:9:"metadata4";N;s:9:"metadata5";s:123:"Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations";s:9:"metadata6";s:182:"Ciaccio, C; DI PIERRO, D; Sbardella, D; Tundo, Gr; Curatolo, P; Galasso, C; Santarone, M; Casasco, M; Cozza, P; Cortelazzo, A; Rossi, M; De Felice, C; Hayek, J; Coletta, M; Marini, S";s:9:"metadata7";s:25:"10.1007/s11010-016-2893-9";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:6;a:14:{s:9:"citazione";s:286:"Ascenzi, P., Ciaccio, C., Gasperi, T., Pesce, A., Caporaso, L., & Coletta, M. (2017). Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation. JBIC, 22(6), 977-986.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_368521";s:6:"handle";s:11:"2108/229009";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:177:"Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation";s:9:"metadata6";s:69:"Ascenzi, P; Ciaccio, C; Gasperi, T; Pesce, A; Caporaso, L; Coletta, M";s:9:"metadata7";s:25:"10.1007/s00775-017-1476-x";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:7;a:14:{s:9:"citazione";s:182:"Ascenzi, P., Ciaccio, C., Santucci, R., & Coletta, M. (2017). Reductive nitrosylation of ferric carboxymethylated cytochrome c. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 21(1), 1-9.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_301836";s:6:"handle";s:11:"2108/172612";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:64:"Reductive nitrosylation of ferric carboxymethylated cytochrome c";s:9:"metadata6";s:47:"Ascenzi, P; Ciaccio, C; Santucci, R; Coletta, M";s:9:"metadata7";s:25:"10.1142/S1088424616501273";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:8;a:14:{s:9:"citazione";s:314:"Ciaccio, C., Tognaccini, L., Battista, T., Cervelli, M., Howes, B., Santucci, R., et al. (2017). The Met80Ala and Tyr67His/Met80Ala mutants of human cytochrome cshed light on the reciprocal role of Met80 and Tyr67 in regulating ligand access into the heme pocket. JOURNAL OF INORGANIC BIOCHEMISTRY, 169(24), 86-96.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_301465";s:6:"handle";s:11:"2108/172290";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:166:"The Met80Ala and Tyr67His/Met80Ala mutants of human cytochrome cshed light on the reciprocal role of Met80 and Tyr67 in regulating ligand access into the heme pocket.";s:9:"metadata6";s:128:"Ciaccio, C; Tognaccini, L; Battista, T; Cervelli, M; Howes, B; Santucci, R; Coletta, M; Mariottini, P; Smulevich, G; Fiorucci, L";s:9:"metadata7";s:31:"10.1016/j.jinorgbio.2017.01.008";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:9;a:14:{s:9:"citazione";s:257:"Gioia, M., Tomao, L., Sbardella, D., Ciaccio, C., Tundo, G.r., Di Masi, A., et al. (2017). Enzyme catalysis: the case of the prostate-specific antigen. ATTI DELLA ACCADEMIA NAZIONALE DEI LINCEI. RENDICONTI LINCEI. MATEMATICA E APPLICAZIONI, 28(S1), 229-237.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_351616";s:6:"handle";s:11:"2108/215084";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:59:"Enzyme catalysis: the case of the prostate-specific antigen";s:9:"metadata6";s:129:"Gioia, M; Tomao, L; Sbardella, D; Ciaccio, C; Tundo, Gr; Di Masi, A; Fasciglione, Gf; Marini, S; Cozza, P; Ascenzi, P; Coletta, M";s:9:"metadata7";s:25:"10.1007/s12210-017-0602-6";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:10;a:14:{s:9:"citazione";s:304:"Grasso, G., Santoro, A.m., Lanza, V., Sbardella, D., Tundo, G.r., Ciaccio, C., et al. (2017). The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration. COORDINATION CHEMISTRY REVIEWS, 347, 1-22.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_351606";s:6:"handle";s:11:"2108/215074";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:166:"The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration";s:9:"metadata6";s:104:"Grasso, G; Santoro, Am; Lanza, V; Sbardella, D; Tundo, Gr; Ciaccio, C; Marini, S; Coletta, M; Milardi, D";s:9:"metadata7";s:25:"10.1016/j.ccr.2017.06.004";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:11;a:14:{s:9:"citazione";s:246:"Sbardella, D., Tundo, G.r., Campagnolo, L., Valacchi, G., Orlandi, A., Curatolo, P., et al. (2017). Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome. SCIENTIFIC REPORTS, 7(1), 12297.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_368553";s:6:"handle";s:11:"2108/229038";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:112:"Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome";s:9:"metadata6";s:206:"Sbardella, D; Tundo, Gr; Campagnolo, L; Valacchi, G; Orlandi, A; Curatolo, P; Borsellino, G; D'Esposito, M; Ciaccio, C; Di Cesare, S; Di Pierro, D; Galasso, C; Santarone, Me; Hayek, J; Coletta, M; Marini, S";s:9:"metadata7";s:26:"10.1038/s41598-017-12069-0";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:12;a:14:{s:9:"citazione";s:236:"Tundo, G.r., Sbardella, D., Ciaccio, C., Grasso, G., Gioia, M., Coletta, A., et al. (2017). Multiple functions of insulin-degrading enzyme: a metabolic crosslight?. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 52(5), 554-582.";s:4:"data";s:4:"2017";s:2:"id";s:20:"PUBBLICAZIONE_351608";s:6:"handle";s:11:"2108/215076";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:71:"Multiple functions of insulin-degrading enzyme: a metabolic crosslight?";s:9:"metadata6";s:147:"Tundo, Gr; Sbardella, D; Ciaccio, C; Grasso, G; Gioia, M; Coletta, A; Polticelli, F; Di Pierro, D; Milardi, D; Van Endert, P; Marini, S; Coletta, M";s:9:"metadata7";s:29:"10.1080/10409238.2017.1337707";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:13;a:14:{s:9:"citazione";s:223:"Tognaccini, L., Ciaccio, C., D'Oria, V., Cervelli, M., Howes, B.d., Coletta, M., et al. (2016). Structure-function relationships in human cytochrome c: The role of tyrosine 67. JOURNAL OF INORGANIC BIOCHEMISTRY, 155, 56-66.";s:4:"data";s:7:"2016-02";s:2:"id";s:20:"PUBBLICAZIONE_301478";s:6:"handle";s:11:"2108/172296";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:79:"Structure-function relationships in human cytochrome c: The role of tyrosine 67";s:9:"metadata6";s:114:"Tognaccini, L; Ciaccio, C; D'Oria, V; Cervelli, M; Howes, Bd; Coletta, M; Mariottini, P; Smulevich, G; Fiorucci, L";s:9:"metadata7";s:31:"10.1016/j.jinorgbio.2015.11.011";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:14;a:14:{s:9:"citazione";s:197:"Santoro, A.m., Cunsolo, A., D'Urso, A., Sbardella, D., Tundo, G.r., Ciaccio, C., et al. (2016). Cationic porphyrins are tunable gatekeepers of the 20S proteasome. CHEMICAL SCIENCE, 7(2), 1286-1297.";s:4:"data";s:4:"2016";s:2:"id";s:20:"PUBBLICAZIONE_368499";s:6:"handle";s:11:"2108/228988";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:65:"Cationic porphyrins are tunable gatekeepers of the 20S proteasome";s:9:"metadata6";s:172:"Santoro, Am; Cunsolo, A; D'Urso, A; Sbardella, D; Tundo, Gr; Ciaccio, C; Coletta, M; Diana, D; Fattorusso, R; Persico, M; Di Dato, A; Fattorusso, C; Milardi, D; Purrello, R";s:9:"metadata7";s:18:"10.1039/c5sc03312h";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:15;a:14:{s:9:"citazione";s:249:"Tundo, G.r., Di Muzio, E., Ciaccio, C., Sbardella, D., Di Pierro, D., Polticelli, F., et al. (2016). Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin. THE FEBS JOURNAL, 283(20), 3755-3770.";s:4:"data";s:4:"2016";s:2:"id";s:20:"PUBBLICAZIONE_351603";s:6:"handle";s:11:"2108/215072";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:109:"Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin";s:9:"metadata6";s:100:"Tundo, Gr; Di Muzio, E; Ciaccio, C; Sbardella, D; Di Pierro, D; Polticelli, F; Coletta, M; Marini, S";s:9:"metadata7";s:18:"10.1111/febs.13841";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:16;a:14:{s:9:"citazione";s:239:"Tundo, G.r., Sbardella, D., De Pascali, S., Ciaccio, C., Coletta, M., Fanizzi, F., et al. (2015). Novel Platinum(II) compounds modulate insulin‑degrading enzyme activity and induce cell death in neuroblastoma cells. JBIC, 20(1), 101-108.";s:4:"data";s:10:"2015-01-02";s:2:"id";s:20:"PUBBLICAZIONE_222123";s:6:"handle";s:11:"2108/105571";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:119:"Novel Platinum(II) compounds modulate insulin‑degrading enzyme activity and induce cell death in neuroblastoma cells.";s:9:"metadata6";s:85:"Tundo, Gr; Sbardella, D; De Pascali, S; Ciaccio, C; Coletta, M; Fanizzi, F; Marini, S";s:9:"metadata7";s:25:"10.1007/s00775-014-1217-3";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:17;a:14:{s:9:"citazione";s:233:"Ciaccio, C., Ocana-Calahorro, F., Droghetti, E., Tundo, G.r., Sanz-Luque, E., Polticelli, F., et al. (2015). Functional and spectroscopic characterization of Chlamydomonas reinhardtii truncated hemoglobins. PLOS ONE, 10(5), e0125005.";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_368480";s:6:"handle";s:11:"2108/228974";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:96:"Functional and spectroscopic characterization of Chlamydomonas reinhardtii truncated hemoglobins";s:9:"metadata6";s:133:"Ciaccio, C; Ocana-Calahorro, F; Droghetti, E; Tundo, Gr; Sanz-Luque, E; Polticelli, F; Visca, P; Smulevich, G; Ascenzi, P; Coletta, M";s:9:"metadata7";s:28:"10.1371/journal.pone.0125005";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:18;a:14:{s:9:"citazione";s:260:"Polticelli, F., Zobnina, V., Ciaccio, C., De Sanctis, G., Ascenzi, P., & Coletta, M. (2015). Enhanced heme accessibility in horse heart mini-myoglobin: Insights from molecular modelling and reactivity studies. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 585, 1-9.";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_368482";s:6:"handle";s:11:"2108/228976";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:115:"Enhanced heme accessibility in horse heart mini-myoglobin: Insights from molecular modelling and reactivity studies";s:9:"metadata6";s:76:"Polticelli, F; Zobnina, V; Ciaccio, C; De Sanctis, G; Ascenzi, P; Coletta, M";s:9:"metadata7";s:25:"10.1016/j.abb.2015.09.005";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:19;a:14:{s:9:"citazione";s:198:"Sbardella, D., Tundo, G.r., Sciandra, F., Bozzi, M., Gioia, M., Ciaccio, C., et al. (2015). Proteasome activity is affected by fluctuations in insulin-degrading enzyme distribution. PLOS ONE, 10(7).";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_236472";s:6:"handle";s:11:"2108/117556";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:22:"IDE proteasome kinetic";s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";s:921:"Insulin-Degrading-Enzyme (IDE) is a Zn2+-dependent peptidase highly conserved throughout evolution and ubiquitously distributed in mammalian tissues wherein it displays a prevalent cytosolic localization. We have recently demonstrated a novel Heat Shock Protein-like behaviour of IDE and its association with the 26S proteasome. In the present study, we examine the mechanistic and molecular features of IDE-26S proteasome interaction in a cell experimental model, extending the investigation also to the effect of IDE on the enzymatic activities of the 26S proteasome. Further, kinetic investigations indicate that the 26S proteasome activity undergoes a functional modulation by IDE through an extra-catalytic mechanism. The IDE-26S proteasome interaction was analyzed during the Heat Shock Response and we report novel findings on IDE intracellular distribution that might be of critical relevance for cell metabolism.";s:9:"metadata5";s:88:"Proteasome activity is affected by fluctuations in insulin-degrading enzyme distribution";s:9:"metadata6";s:120:"Sbardella, D; Tundo, Gr; Sciandra, F; Bozzi, M; Gioia, M; Ciaccio, C; Tarantino, U; Brancaccio, A; Coletta, M; Marini, S";s:9:"metadata7";s:28:"10.1371/journal.pone.0132455";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:20;a:14:{s:9:"citazione";s:236:"Tilleman, L., Abbruzzetti, S., Ciaccio, C., De Sanctis, G., Nardini, M., Pesce, A., et al. (2015). Structural bases for the regulation of CO binding in the archaeal protoglobin from Methanosarcina acetivorans. PLOS ONE, 10(6), e0125959.";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_368476";s:6:"handle";s:11:"2108/228970";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:292:"Archaeal Proteins; Binding Sites; Carbon Monoxide; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Ligands; Methanosarcina; Mutagenesis, Site-Directed; Photolysis; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman";s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:109:"Structural bases for the regulation of CO binding in the archaeal protoglobin from Methanosarcina acetivorans";s:9:"metadata6";s:188:"Tilleman, L; Abbruzzetti, S; Ciaccio, C; De Sanctis, G; Nardini, M; Pesce, A; Desmet, F; Moens, L; Va Doorslaer, S; Bruno, S; Bolognesi, M; Ascenzi, P; Coletta, M; Viappiani, C; Dewilde, S";s:9:"metadata7";s:28:"10.1371/journal.pone.0125959";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:21;a:14:{s:9:"citazione";s:196:"Tundo, G.r., Sbardella, D., Ciaccio, C., De Pascali, S., Campanella, V., Cozza, P., et al. (2015). Effect of cisplatin on proteasome activity. JOURNAL OF INORGANIC BIOCHEMISTRY, 153(Dec), 253-258.";s:4:"data";s:4:"2015";s:2:"id";s:20:"PUBBLICAZIONE_261198";s:6:"handle";s:11:"2108/140487";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";s:51:"Cisplatin; Lactacystin; Neuroblastoma,; Proteasome;";s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:42:"Effect of cisplatin on proteasome activity";s:9:"metadata6";s:124:"Tundo, Gr; Sbardella, D; Ciaccio, C; De Pascali, S; Campanella, V; Cozza, P; Tarantino, U; Coletta, M; Fanizzi, F; Marini, S";s:9:"metadata7";s:31:"10.1016/j.jinorgbio.2015.08.027";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:22;a:14:{s:9:"citazione";s:219:"Ascenzi, P., Leboffe, L., Pesce, A., Ciaccio, C., Sbardella, D., Bolognesi, M., et al. (2014). Nitrite-reductase and peroxynitrite isomerization activities of Methanosarcina acetivorans protoglobin. PLOS ONE, 9, e95391.";s:4:"data";s:4:"2014";s:2:"id";s:20:"PUBBLICAZIONE_187063";s:6:"handle";s:10:"2108/89871";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:103:"Nitrite-reductase and peroxynitrite isomerization activities of Methanosarcina acetivorans protoglobin.";s:9:"metadata6";s:84:"Ascenzi, P; Leboffe, L; Pesce, A; Ciaccio, C; Sbardella, D; Bolognesi, M; Coletta, M";s:9:"metadata7";s:28:"10.1371/journal.pone.0095391";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:23;a:14:{s:9:"citazione";s:170:"Ascenzi, P., Marino, M., Ciaccio, C., Santucci, R., & Coletta, M. (2014). Reductive nitrosylation of the cardiolipin-ferric cytochrome c complex. IUBMB LIFE, 66, 438-447.";s:4:"data";s:4:"2014";s:2:"id";s:20:"PUBBLICAZIONE_186924";s:6:"handle";s:10:"2108/89855";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:70:"Reductive nitrosylation of the cardiolipin-ferric cytochrome c complex";s:9:"metadata6";s:58:"Ascenzi, P; Marino, M; Ciaccio, C; Santucci, R; Coletta, M";s:9:"metadata7";s:16:"10.1002/iub.1283";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:24;a:14:{s:9:"citazione";s:214:"Tundo, G., Sbardella, D., Ciaccio, C., Bianculli, A., Orlandi, A., Desimio, M.g., et al. (2013). Insulin-degrading enzyme (IDE): a novel heat shock-like protein. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 288, 2281-2289.";s:4:"data";s:7:"2013-09";s:2:"id";s:20:"PUBBLICAZIONE_187072";s:6:"handle";s:10:"2108/89567";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:34:"Settore MED/05 - Patologia Clinica";s:9:"metadata4";N;s:9:"metadata5";s:64:"Insulin-degrading enzyme (IDE): a novel heat shock-like protein.";s:9:"metadata6";s:107:"Tundo, G; Sbardella, D; Ciaccio, C; Bianculli, A; Orlandi, A; Desimio, Mg; Arcuri, G; Coletta, M; Marini, S";s:9:"metadata7";s:23:"10.1074/jbc.M112.393108";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:25;a:14:{s:9:"citazione";s:202:"Ascenzi, P., Coletta, A., Cao, Y., Trezza, V., Leboffe, L., Fanali, G., et al. (2013). Isoniazid Inhibits the Heme-Based Reactivity of Mycobacterium tuberculosis Truncated Hemoglobin N. PLOS ONE, 8, --.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_182919";s:6:"handle";s:10:"2108/95187";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:98:"Isoniazid Inhibits the Heme-Based Reactivity of Mycobacterium tuberculosis Truncated Hemoglobin N.";s:9:"metadata6";s:120:"Ascenzi, P; Coletta, A; Cao, Y; Trezza, V; Leboffe, L; Fanali, G; Fasano, M; Pesce, A; Ciaccio, C; MARINI, S; Coletta, M";s:9:"metadata7";s:28:"10.1371/journal.pone.0069762";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:26;a:14:{s:9:"citazione";s:249:"Ascenzi, P., Pesce, A., Nardini, M., Bolognesi, M., Ciaccio, C., Coletta, M., et al. (2013). Reductive nitrosylation of Methanosarcina acetivorans protoglobin: a comparative study. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430, 1301-1305.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_187071";s:6:"handle";s:10:"2108/90331";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:87:"Reductive nitrosylation of Methanosarcina acetivorans protoglobin: a comparative study.";s:9:"metadata6";s:82:"Ascenzi, P; Pesce, A; Nardini, M; Bolognesi, M; Ciaccio, C; Coletta, M; Dewilde, S";s:9:"metadata7";s:26:"10.1016/j.bbrc.2012.11.122";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:27;a:14:{s:9:"citazione";s:225:"Bocedi, A., De Sanctis, G., Ciaccio, C., Tundo, G., Di Masi, A., Fanali, G., et al. (2013). Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin. PLOS ONE, 8(3), e58842.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_187068";s:6:"handle";s:10:"2108/90391";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:109:"Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin.";s:9:"metadata6";s:132:"Bocedi, A; De Sanctis, G; Ciaccio, C; Tundo, G; Di Masi, A; Fanali, G; Nicoletti, F; Fasano, M; Smulevich, G; Ascenzi, P; Coletta, M";s:9:"metadata7";s:28:"10.1371/journal.pone.0058842";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:28;a:14:{s:9:"citazione";s:270:"Ciaccio, C., Pesce, A., Tundo, G., Tilleman, L., Bertolacci, L., Dewilde, S., et al. (2013). Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(9), 1813-1823.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_187069";s:6:"handle";s:10:"2108/90397";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:101:"Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin";s:9:"metadata6";s:130:"Ciaccio, C; Pesce, A; Tundo, G; Tilleman, L; Bertolacci, L; Dewilde, S; Moens, L; Ascenzi, P; Bolognesi, M; Nardini, M; Coletta, M";s:9:"metadata7";s:28:"10.1016/j.bbapap.2013.02.026";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:29;a:14:{s:9:"citazione";s:197:"Pesce, A., Tilleman, L., Donné, J., Aste, E., Ascenzi, P., Ciaccio, C., et al. (2013). Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin. PLOS ONE, 8(6), e66144.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_187067";s:6:"handle";s:10:"2108/90390";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:83:"Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin";s:9:"metadata6";s:140:"Pesce, A; Tilleman, L; Donné, J; Aste, E; Ascenzi, P; Ciaccio, C; Coletta, M; Moens, L; Viappiani, C; Dewilde, S; Bolognesi, M; Nardini, M";s:9:"metadata7";s:28:"10.1371/journal.pone.0066144";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:30;a:14:{s:9:"citazione";s:215:"Tundo, G.r., Sbardella, D., Ciaccio, C., Bianculli, A., Orlandi, A., Desimio, M.g., et al. (2013). Insulin-degrading enzyme (IDE): A novel heat shock-like protein. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(4), 2281-2289.";s:4:"data";s:4:"2013";s:2:"id";s:20:"PUBBLICAZIONE_368578";s:6:"handle";s:11:"2108/229056";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:63:"Insulin-degrading enzyme (IDE): A novel heat shock-like protein";s:9:"metadata6";s:108:"Tundo, Gr; Sbardella, D; Ciaccio, C; Bianculli, A; Orlandi, A; Desimio, Mg; Arcuri, G; Coletta, M; Marini, S";s:9:"metadata7";s:23:"10.1074/jbc.M112.393108";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:31;a:14:{s:9:"citazione";s:250:"Sbardella, D., Fasciglione, G., Gioia, M., Ciaccio, C., Tundo, G., Marini, S., et al. (2012). Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes. MOLECULAR ASPECTS OF MEDICINE, 33(2), 119-208.";s:4:"data";s:7:"2012-04";s:2:"id";s:19:"PUBBLICAZIONE_84042";s:6:"handle";s:10:"2108/52091";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:108:"Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes";s:9:"metadata6";s:83:"Sbardella, D; Fasciglione, G; Gioia, M; Ciaccio, C; Tundo, G; Marini, S; Coletta, M";s:9:"metadata7";s:25:"10.1016/j.mam.2011.10.015";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:32;a:14:{s:9:"citazione";s:230:"Tundo, G.r., Ciaccio, C., Sbardella, D., Boraso, M., Viviani, B., Coletta, M., et al. (2012). Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD. PLOS ONE, 7(4).";s:4:"data";s:7:"2012-04";s:2:"id";s:20:"PUBBLICAZIONE_133010";s:6:"handle";s:10:"2108/67301";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:119:"Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD";s:9:"metadata6";s:81:"Tundo, Gr; Ciaccio, C; Sbardella, D; Boraso, M; Viviani, B; Coletta, M; Marini, S";s:9:"metadata7";s:28:"10.1371/journal.pone.0034376";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:33;a:14:{s:9:"citazione";s:274:"Abbruzzetti, S., Tilleman, L., Bruno, S., Viappiani, C., Desmet, F., Van Doorslaer, S., et al. (2012). Ligation tunes protein reactivity in an ancient haemoglobin: kinetic evidence for an allosteric mechanism in methanosarcina acetivorans protoglobin. PLOS ONE, 7(3), 33614.";s:4:"data";s:4:"2012";s:2:"id";s:20:"PUBBLICAZIONE_162608";s:6:"handle";s:10:"2108/78184";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:147:"Ligation tunes protein reactivity in an ancient haemoglobin: kinetic evidence for an allosteric mechanism in methanosarcina acetivorans protoglobin";s:9:"metadata6";s:164:"Abbruzzetti, S; Tilleman, L; Bruno, S; Viappiani, C; Desmet, F; Van Doorslaer, S; Coletta, M; Ciaccio, C; Ascenzi, P; Nardini, M; Bolognesi, M; Moens, L; Dewilde, S";s:9:"metadata7";s:28:"10.1371/journal.pone.0033614";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:34;a:14:{s:9:"citazione";s:264:"Cao, Y., Nicoletti, F., De Sanctis, G., Bocedi, A., Ciaccio, C., Gullotta, F., et al. (2012). Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding. JBIC, 17, 133-147.";s:4:"data";s:4:"2012";s:2:"id";s:20:"PUBBLICAZIONE_162568";s:6:"handle";s:10:"2108/78161";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:151:"Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding.";s:9:"metadata6";s:154:"Cao, Y; Nicoletti, F; De Sanctis, G; Bocedi, A; Ciaccio, C; Gullotta, F; Fanali, G; Tundo, Gr; Di Masi, A; Fasano, M; Smulevich, G; Ascenzi, P; Coletta, M";s:9:"metadata7";s:26:"10.1007/s00775-011-0837-0.";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:35;a:14:{s:9:"citazione";s:195:"Grasso, G., Salomone, F., Tundo, G.r., Pappalardo, G., Ciaccio, C., Spoto, G., et al. (2012). Metal ions affect insulin-degrading enzyme activity. JOURNAL OF INORGANIC BIOCHEMISTRY, 117, 351-358.";s:4:"data";s:4:"2012";s:2:"id";s:20:"PUBBLICAZIONE_162610";s:6:"handle";s:10:"2108/78207";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:51:"Metal ions affect insulin-degrading enzyme activity";s:9:"metadata6";s:113:"Grasso, G; Salomone, F; Tundo, Gr; Pappalardo, G; Ciaccio, C; Spoto, G; Pietropaolo, A; Coletta, M; Rizzarelli, E";s:9:"metadata7";s:31:"10.1016/j.jinorgbio.2012.06.010";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:36;a:14:{s:9:"citazione";s:174:"Cao, Y. (2011). Evidence for pH-dependent multiple conformesrs in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding. JBIC.";s:4:"data";s:7:"2011-09";s:2:"id";s:19:"PUBBLICAZIONE_87813";s:6:"handle";s:10:"2108/52616";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:151:"Evidence for pH-dependent multiple conformesrs in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding";s:9:"metadata6";s:170:"Cao, Y., Nicoletti, F.P., De Sanctis, G., Bocedi, A., Ciaccio, C., Gullotta, F., Fanali, G., Tundo, G.R., di Masi, A., Fasano, M., Smulevich, G., Ascenzi, P., Coletta, M.";s:9:"metadata7";N;s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:37;a:14:{s:9:"citazione";s:227:"Giordano, D., Russo, R., Ciaccio, C., Howes, B.d., Di, P., G., M., et al. (2011). Ligand- and proton-linked conformational changes of the ferrous 2/2 hemoglobin of Pseudoalteromonas haloplanktis TAC125. IUBMB LIFE, 63, 566-573.";s:4:"data";s:7:"2011-07";s:2:"id";s:19:"PUBBLICAZIONE_87803";s:6:"handle";s:10:"2108/52610";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:119:"Ligand- and proton-linked conformational changes of the ferrous 2/2 hemoglobin of Pseudoalteromonas haloplanktis TAC125";s:9:"metadata6";s:102:"Giordano, D; Russo, R; Ciaccio, C; Howes, Bd; Di, P; G., M; M., C; Huibon, H; G., S; Coletta, M; M., V";s:9:"metadata7";s:15:"10.1002/iub.492";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:38;a:14:{s:9:"citazione";s:217:"Pesce, A., Tilleman, L., Dewilde, S., Ascenzi, P., Coletta, M., Ciaccio, C., et al. (2011). Structural heterogeneity and ligand gating in ferric Methanosarcina acetivorans protoglobin mutants. IUBMB LIFE, 63, 287-294.";s:4:"data";s:7:"2011-05";s:2:"id";s:19:"PUBBLICAZIONE_87793";s:6:"handle";s:10:"2108/52606";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:99:"Structural heterogeneity and ligand gating in ferric Methanosarcina acetivorans protoglobin mutants";s:9:"metadata6";s:115:"Pesce, A; Tilleman, L; Dewilde, S; Ascenzi, P; Coletta, M; Ciaccio, C; Bruno, S; Moens, L; Bolognesi, M; Nardini, M";s:9:"metadata7";s:15:"10.1002/iub.484";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:39;a:14:{s:9:"citazione";s:309:"Grasso, G., Pietropaolo, A., Spoto, G., Pappalardo, G., Tundo, G., Ciaccio, C., et al. (2011). Copper(I) and copper(II) inhibit Abeta peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease. CHEMISTRY-A EUROPEAN JOURNAL, 17(9), 2752-2762.";s:4:"data";s:7:"2011-02";s:2:"id";s:19:"PUBBLICAZIONE_87705";s:6:"handle";s:10:"2108/52583";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:165:"Copper(I) and copper(II) inhibit Abeta peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease";s:9:"metadata6";s:99:"Grasso, G; Pietropaolo, A; Spoto, G; Pappalardo, G; Tundo, G; Ciaccio, C; Coletta, M; Rizzarelli, E";s:9:"metadata7";s:22:"10.1002/chem.201002809";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:40;a:14:{s:9:"citazione";s:216:"Howes, B.d., Giordano, D., Boechi, L., Russo, R., Mucciacciaro, S., Ciaccio, C., et al. (2011). The peculiar heme pocket of the 2/2 hemoglobin of cold-adapted Pseudoalteromonas haloplanktis TAC125. JBIC, 16, 299-311.";s:4:"data";s:7:"2011-02";s:2:"id";s:19:"PUBBLICAZIONE_87682";s:6:"handle";s:10:"2108/52574";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:100:"The peculiar heme pocket of the 2/2 hemoglobin of cold-adapted Pseudoalteromonas haloplanktis TAC125";s:9:"metadata6";s:157:"Howes, Bd; Giordano, D; Boechi, L; Russo, R; Mucciacciaro, S; Ciaccio, C; Sinibaldi, F; Fittipaldi, M; Marti, Ma; Estrin, Da; Di, P; Coletta, M; M., V; C., S";s:9:"metadata7";s:25:"10.1007/s00775-010-0726-y";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:41;a:14:{s:9:"citazione";s:238:"Ascenzi, P., Ciaccio, C., Sinibaldi, F., Santucci, R., & Coletta, M. (2011). Cardiolipin modulates allosterically peroxynitrite detoxification by horse heart cytochrome c. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 190-194.";s:4:"data";s:4:"2011";s:2:"id";s:19:"PUBBLICAZIONE_73688";s:6:"handle";s:10:"2108/51399";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:93:"Cardiolipin modulates allosterically peroxynitrite detoxification by horse heart cytochrome c";s:9:"metadata6";s:61:"Ascenzi, P; Ciaccio, C; Sinibaldi, F; Santucci, R; Coletta, M";s:9:"metadata7";s:26:"10.1016/j.bbrc.2010.11.091";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:42;a:14:{s:9:"citazione";s:262:"Ascenzi, P., Ciaccio, C., Sinibaldi, F., Santucci, R., & Coletta, M. (2011). Peroxynitrite detoxification by horse heart carboxymethylated cytochrome c is allosterically modulated by cardiolipin. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 415, 463-467.";s:4:"data";s:4:"2011";s:2:"id";s:19:"PUBBLICAZIONE_81530";s:6:"handle";s:10:"2108/51692";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:117:"Peroxynitrite detoxification by horse heart carboxymethylated cytochrome c is allosterically modulated by cardiolipin";s:9:"metadata6";s:61:"Ascenzi, P; Ciaccio, C; Sinibaldi, F; Santucci, R; Coletta, M";s:9:"metadata7";s:26:"10.1016/j.bbrc.2011.10.094";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:43;a:14:{s:9:"citazione";s:180:"Ascenzi P., D.M.E. (2009). Peroxynitrite detoxification by ferryl Mycobacterium leprae truncated hemoglobin O. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(2), 392-396.";s:4:"data";s:4:"2009";s:2:"id";s:18:"PUBBLICAZIONE_4370";s:6:"handle";s:10:"2108/41239";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:82:"Peroxynitrite detoxification by ferryl Mycobacterium leprae truncated hemoglobin O";s:9:"metadata6";s:59:"Ascenzi P., De Marinis E., Visca P., Ciaccio C., Coletta M.";s:9:"metadata7";s:26:"10.1016/j.bbrc.2009.01.088";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:44;a:14:{s:9:"citazione";s:159:"Ciaccio C., T.G. (2009). Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity. JOURNAL OF MOLECULAR BIOLOGY, 385(5), 1556-1567.";s:4:"data";s:4:"2009";s:2:"id";s:18:"PUBBLICAZIONE_9103";s:6:"handle";s:10:"2108/41237";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:84:"Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity";s:9:"metadata6";s:101:"Ciaccio C., Tundo G.R., Grasso G., Spoto G., Marasco D., Ruvo M., Gioia M., Rizzarelli E., Coletta M.";s:9:"metadata7";s:25:"10.1016/j.jmb.2008.11.025";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:45;a:14:{s:9:"citazione";s:156:"Ciaccio, C., Coletta, A., De Sanctis, G., Marini, S., & Coletta, M. (2008). Cooperativity and allostery in haemoglobin function. IUBMB LIFE, 60(2), 112-123.";s:4:"data";s:7:"2008-02";s:2:"id";s:18:"PUBBLICAZIONE_5003";s:6:"handle";s:10:"2108/41209";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:52:"Cooperativity and allostery in haemoglobin function.";s:9:"metadata6";s:60:"Ciaccio, C; Coletta, A; De Sanctis, G; Marini, S; Coletta, M";s:9:"metadata7";s:13:"10.1002/iub.6";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:46;a:14:{s:9:"citazione";s:182:"Bolli A., C.C. (2008). Ferrous Campylobacter jejuni truncated hemoglobin P displays an extremely high reactivity for cyanide - A comparative study. THE FEBS JOURNAL, 275(4), 633-645.";s:4:"data";s:4:"2008";s:2:"id";s:18:"PUBBLICAZIONE_5119";s:6:"handle";s:10:"2108/41189";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:123:"Ferrous Campylobacter jejuni truncated hemoglobin P displays an extremely high reactivity for cyanide - A comparative study";s:9:"metadata6";s:102:"Bolli A., Ciaccio C., Coletta M., Nardini M., Bolognesi M., Pesce A., Guertin M., Visca P., Ascenzi P.";s:9:"metadata7";s:32:"10.1111/j.1742-4658.2007.06223.x";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:47;a:14:{s:9:"citazione";s:218:"Ciaccio, C., De Sanctis, G., Marini, S., Sinibaldi, F., Santucci, R., Arcovito, A., et al. (2004). Proton linkage for CO binding and redox properties of bovine lactoperoxidase. BIOPHYSICAL JOURNAL, 86(1 Pt 1), 448-454.";s:4:"data";s:7:"2004-01";s:2:"id";s:19:"PUBBLICAZIONE_84044";s:6:"handle";s:10:"2108/29329";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:76:"Proton linkage for CO binding and redox properties of bovine lactoperoxidase";s:9:"metadata6";s:131:"Ciaccio, C; De Sanctis, G; Marini, S; Sinibaldi, F; Santucci, R; Arcovito, A; Bellelli, A; Ghibaudi, E; Ferrari Rosa, P; Coletta, M";s:9:"metadata7";s:29:"10.1016/S0006-3495(04)74121-1";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}i:48;a:14:{s:9:"citazione";s:255:"Ciaccio, C., Rosati, A., De Sanctis, G., Sinibaldi, F., Marini, S., Santucci, R., et al. (2003). Relationships of ligand binding, redox properties, and protonation in Coprinus cinereus peroxidase. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 278(21), 18730-18737.";s:4:"data";s:4:"2003";s:2:"id";s:18:"PUBBLICAZIONE_1294";s:6:"handle";s:10:"2108/53082";s:9:"metadata1";s:19:"Articolo su rivista";s:9:"metadata2";N;s:9:"metadata3";s:14:"Settore BIO/10";s:9:"metadata4";N;s:9:"metadata5";s:98:"Relationships of ligand binding, redox properties, and protonation in Coprinus cinereus peroxidase";s:9:"metadata6";s:112:"Ciaccio, C; Rosati, A; De Sanctis, G; Sinibaldi, F; Marini, S; Santucci, R; Ascenzi, P; Welinder, KG; Coletta, M";s:9:"metadata7";s:22:"10.1074/jbc.M212034200";s:9:"metadata8";N;s:9:"metadata9";N;s:10:"metadata10";N;}}" } ["meta_keywords"]=> array(1) { [0]=> string(1) "," } ["reserved"]=> array(1) { [0]=> string(1) "0" } ["auth_ip"]=> array(1) { [0]=> string(1) "0" } } ["_fieldBoosts":protected]=> array(6) { ["content_id"]=> bool(false) ["content_title"]=> bool(false) ["description"]=> bool(false) ["meta_keywords"]=> bool(false) ["reserved"]=> bool(false) ["auth_ip"]=> bool(false) } } }