Filomena Fezza

Qualifica
RICERCATORI / CONFERMATI
Fonte dei dati: Archivio della Ricerca http://art.torvergata.it
  1. Greco, L., Russo, V., Rapino, C., Germanio, C.D., Fezza, F., Bernabò, N., et al. (2020). Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response. CELLS, 9(4) [10.3390/cells9041008]. Dettagli
  2. Dainese, E., Oddi, S., Simonetti, M., Sabatucci, A., Angelucci, C.B., Ballone, A., et al. (2020). The endocannabinoid hydrolase FAAH is an allosteric enzyme. SCIENTIFIC REPORTS, 10(1) [10.1038/s41598-020-59120-1]. Dettagli
  3. Fazio, D., Criscuolo, E., Piccoli, A., Barboni, B., Fezza, F., & Maccarrone, M. (2020). Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?. EXPERT OPINION ON DRUG DISCOVERY, 1-14 [10.1080/17460441.2020.1751118]. Dettagli
  4. Grillo, A., Chemi, G., Brogi, S., Brindisi, M., Relitti, N., Fezza, F., et al. (2019). Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 183, 111674 [10.1016/j.ejmech.2019.111674]. Dettagli
  5. Oddi, S., Stepniewski, T.M., Totaro, A., Selent, J., Scipioni, L., Dufrusine, B., et al. (2017). Palmitoylation of cysteine 415 of CB1 receptor affects ligand-stimulated internalization and selective interaction with membrane cholesterol and caveolin 1. BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1862(5), 523-532. Dettagli
  6. Soethoudt, M., Grether, U., Fingerle, J., Grim, T.W., Fezza, F., De Petrocellis, L., et al. (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. NATURE COMMUNICATIONS, 8(1), 13958. Dettagli
  7. Van Esbroeck, A., Janssen, A., Cognetta, A.B., Ogasawara, D., Shpak, G., Van Der Kroeg, M., et al. (2017). Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. SCIENCE, 356(6342), 1084-1087. Dettagli
  8. Bilgin, M., Born, P., Fezza, F., Heimes, M., Mastrangelo, N., Wagner, N., et al. (2016). Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS. SCIENTIFIC REPORTS, 6, 27920. Dettagli
  9. Fezza, F., Mastrangelo, N., & Maccarrone, M. (2016). Assay of NAPE-PLD Activity. In Mauro Maccarrone (a cura di), “Endocannabinoid Signaling: Methods and Protocols” (pp. 123-130). Springer [10.1007/978-1-4939-3539-0_13]. Dettagli
  10. Madeo, G., Schirinzi, T., Maltese, M., Martella, G., Rapino, C., Fezza, F., et al. (2016). Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice. NEUROPHARMACOLOGY, 101, 460-470. Dettagli
  11. Mukhopadhyay, P., Baggelaar, M., Erdelyi, K., Cao, Z., Cinar, R., Fezza, F., et al. (2016). The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. BRITISH JOURNAL OF PHARMACOLOGY, 173(3), 446-458. Dettagli
  12. Verrotti, A., Castagnino, M., Maccarrone, M., & Fezza, F. (2016). Plant-Derived and Endogenous Cannabinoids in Epilepsy. CLINICAL DRUG INVESTIGATION, 36(5), 331-340. Dettagli
  13. Fezza, F., Bari, M., Florio, R., Talamonti, E., Feole, M., & Maccarrone, M. (2014). Endocannabinoids, related compounds and their metabolic routes. In Fatty acid (pp. 17078-17106). Derek J. McPhee [10.3390/molecules191117078]. Dettagli
  14. Chiurchiù, V., Lanuti, M., Catanzaro, G., Fezza, F., Rapino, C., & Maccarrone, M. (2014). Detailed characterization of the endocannabinoid system in human macrophages and foam cells, and anti-inflammatory role of type-2 cannabinoid receptor. ATHEROSCLEROSIS, 233(1), 55-63 [10.1016/j.atherosclerosis.2013.12.042.]. Dettagli
  15. Fezza Filomena, M.M. (2014). Endocannabinoid biochemistry: What do we know after 50 years?. In Cannabinoids. Vincenzo Di Marzo. Dettagli
  16. Fezza, F., Marrone, M.C., Avvisati, R., Di Tommaso, M., Lanuti, M., Rapino, C., et al. (2014). Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. MOLECULAR AND CELLULAR NEUROSCIENCES, Jul 24, 1-9 [10.1016/j.mcn.2014.07.003.]. Dettagli
  17. Butini, S., Gemma, S., Brindisi, M., Maramai, S., Minetti, P., Celona, D., et al. (2013). Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23(2), 492-495. Dettagli
  18. Bisicchia, E., Chiurchiù, V., Viscomi, M.T., Latini, L., Fezza, F., Battistini, L., et al. (2013). Activation of type-2 cannabinoid receptor inhibits neuroprotective and antiinflammatory actions of glucocorticoid receptor α: when one is better than two. CELLULAR AND MOLECULAR LIFE SCIENCES, 70(12), 2191-2204 [10.1007/s00018-012-1253-5]. Dettagli
  19. Butini, S., Brindisi, M., Gemma, S., Minetti, P., Cabri, W., Gallo, G., et al. (2012). Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases. JOURNAL OF MEDICINAL CHEMISTRY, 55(15), 6898-6915 [10.1021/jm300689c]. Dettagli
  20. Pucci, M., Pasquariello, N., Battista, N., Di Tommaso, M., Rapino, C., Fezza, F., et al. (2012). Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 287(19), 15466-15478. Dettagli
  21. Oddi, S., Dainese, E., Sandiford, S., Fezza, F., Lanuti, M., Chiurchiù, V., et al. (2012). Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. BRITISH JOURNAL OF PHARMACOLOGY, 165(8), 2635-2651 [10.1111/j.1476-5381.2011.01658.x]. Dettagli
  22. Di Venere, A., Dainese, E.F., Angelucci, B.C., Rosato, N., Cravatt, B.F., Finazzi-Agrò, A., et al. (2012). Rat and human fatty acid amide hydrolases: overt similarities and hidden differences. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1821(11), 1425-1433 [10.1016/j.bbalip.2012.07.021]. Dettagli
  23. Oddi, S., Dainese, E., Fezza, F., Lanuti, M., Barcaroli, D., De Laurenzi, V., et al. (2011). Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor. JOURNAL OF NEUROCHEMISTRY, 116(5), 858-865. Dettagli
  24. Amadio, D., Fezza, F., Catanzaro, G., Incani, O., van Zadelhoff, G., Finazzi Agrò, A., et al. (2010). Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system. BIOCHIMIE, 92(4), 378-387. Dettagli
  25. Gattinoni S, D.S.C. (2010). Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system. CHEMMEDCHEM, 5(3), 357-360. Dettagli
  26. Gattinoni S, S.C. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4406-4411 [10.1016/j.bmcl.2010.06.050]. Dettagli
  27. Oddi, S., Fezza, F., Catanzaro, G., De Simone, C., Pucci, M., Piomelli, D., et al. (2010). Pitfalls and solutions in assaying anandamide transport in cells. JOURNAL OF LIPID RESEARCH, 51(8), 2435-2444. Dettagli
  28. Catani, M.V., Fezza, F., Baldassarri, S., Gasperi, V., Bertoni, A., Pasquariello, N., et al. (2009). Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. JOURNAL OF MOLECULAR MEDICINE, 87(1), 65-74. Dettagli
  29. Maccarrone, M., Oddi, S., Fezza, F., & Finazzi Agro, A. (2009). Design and synthesis of biotinylated probes for n-acyl-ethanolamines. Dettagli
  30. Oddi S., F.F. (2009). Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins. CHEMISTRY & BIOLOGY, 16(6), 624-632. Dettagli
  31. Fezza F, D.S.C. (2008). Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system. In Subcell Biochem.. Ed.: Harris, Robin. Dettagli
  32. Fezza F., O.S. (2008). Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation. JOURNAL OF LIPID RESEARCH, 49(6), 1216-1223. Dettagli
  33. Maccarrone, M., Rossi, S., Bari, M., De Chiara, V., Fezza, F., Musella, A., et al. (2008). Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. NATURE NEUROSCIENCE, 11(2), 152-159. Dettagli
  34. Massi P., Valenti M., Vaccani A., Gasperi V., Perletti G., Marras E., et al. (2008). 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. JOURNAL OF NEUROCHEMISTRY, 104(4), 1091-1100 [10.1111/j.1471-4159.2007.05073.x]. Dettagli
  35. Oddi S., F.F. (2008). Evidence for the intracellular accumulation of anandamide in adiposomes. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(5), 840-850. Dettagli
  36. Centonze, D., Rossi, S., Napoli, I., Mercaldo, V., Lacoux, C., Ferrari, F., et al. (2007). The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum. THE JOURNAL OF NEUROSCIENCE, 27(33), 8885-8892 [10.1523/JNEUROSCI.0548-07.2007]. Dettagli
  37. Amantea D., S.P. (2007). Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17 beta-estradiol. THE FEBS JOURNAL, 274(17), 4464-4475. Dettagli
  38. Centonze, D., Bari, M., Rossi, S., Prosperetti, C., Furlan, R., Fezza, F., et al. (2007). The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. BRAIN, 130(Pt10), 2543-2553 [10.1093/brain/awm160]. Dettagli
  39. Gasperi, V., Fezza, F., Pasquariello, N., Bari, M., Oddi, S., Finazzi Agrò, A., et al. (2007). Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. CELLULAR AND MOLECULAR LIFE SCIENCES, 64(2), 219-229 [10.1007/s00018-006-6445-4]. Dettagli
  40. Maccarrone, M., Oddi, S., Fezza, F., & Finazzi Agrò, A. (2007). Design and synthesis of biotinylated probes for n-acyl-ethanolamines. Dettagli
  41. Marinelli S., D.M.V. (2007). N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors. NEUROPSYCHOPHARMACOLOGY, 32(2), 298-308. Dettagli
  42. (2006). Regulation of endocannabinoid system by lipid rafts along the neuroimmune axis. Dettagli
  43. Bari, M., Battista, N., Fezza, F., Gasperi, V., & Maccarrone, M. (2006). New insights into endocannabinoid degradation and its therapeutic potential. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 6(3), 257-268 [10.2174/138955706776073466]. Dettagli
  44. Bari, M., Spagnuoio, P., Fezza, F., Oddi, S., Pasquariello, N., Finazzi-Agro, A., et al. (2006). Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. JOURNAL OF IMMUNOLOGY, 177(8), 4971-4980. Dettagli
  45. Battista N, F.F. (2006). The endocannabinoid system in neurodegeneration. ITALIAN JOURNAL OF BIOCHEMISTRY, 55(3-4), 283-289. Dettagli
  46. Fezza F., B.N. (2006). Methods to assay anandamide hydrolysis and transport in synaptosomes, 123, 163-168. Dettagli
  47. Spoto B., F.F. (2006). Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. BIOCHIMIE, 88(12), 1889-1897. Dettagli
  48. Pisani, A., Fezza, F., Galati, S., Battista, N., Napolitano, S., Finazzi Agrò, A., et al. (2005). High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients. ANNALS OF NEUROLOGY, 57(5), 777-779. Dettagli
  49. Bari, M., Battista, N., Fezza, F., Finazzi-Agro, A., & Maccarrone, M. (2005). Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells: Implications for anandamide-induced apoptosis. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280(13), 12212-12220. Dettagli
  50. Battista N., Gasperi V., Fezza F., & Maccarrone M. (2005). The anandamide membrane transporter and the therapeutic implications of its inhibition. THERAPY, 2(1), 141-150 [10.1586/14750708.2.1.141]. Dettagli
  51. Cabranes A, V.K. (2005). Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. NEUROBIOLOGY OF DISEASE, 20(2), 207-217. Dettagli
  52. Fezza F., G.V. (2005). Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity. ANALYTICAL BIOCHEMISTRY, 339(1), 113-120. Dettagli
  53. Gasperi V, Fezza F, Spagnuolo P, Pasquariello N, & Maccarrone M. (2005). Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. NEUROTOXICOLOGY, 26(5), 811-817 [10.1016/j.neuro.2005.08.002]. Dettagli
  54. Maccarrone M., Barboni B., Paradisi A., Bernabo N., Gasperi V., Pistilli M.G., et al. (2005). Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. JOURNAL OF CELL SCIENCE, 118(19), 4393-4404. Dettagli
  55. Maccarrone, M., DeFelici, M., Klinger, F.G., Battista, N., Fezza, F., Dainese, E., et al. (2004). Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus. MOLECULAR HUMAN REPRODUCTION, 10(4), 215-221. Dettagli
  56. Battista N, F.F. (2004). Endocannabinoids and their involvement in the neurovascular system. CURRENT NEUROVASCULAR RESEARCH, 1(2), 129-140. Dettagli
  57. González S, V.M. (2004). Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse. BRITISH JOURNAL OF PHARMACOLOGY, 143, 455-465. Dettagli
  58. Maccarrone M, Gasperi V, Fezza F, Finazzi-Agro A, & Rossi A (2004). Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone. EUROPEAN JOURNAL OF BIOCHEMISTRY, 271(23-24), 4666-4676. Dettagli
  59. Maccarrone M., D.M. (2004). Mouse blastocyts release a lipid which activates anandamide hydrolase in intact uterus. MOLECULAR HUMAN REPRODUCTION, 10(4), 215-221. Dettagli
  60. Maccarrone M., F.F. (2004). Levels of N-Acylethanolamines in Human Tumors: In Search of Reliable Data. LIPIDS, 39(2), 193-194. Dettagli
  61. Matias I, C.J. (2004). Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 309, 745-757. Dettagli
  62. Maccarrone M., D.P.L. (2001). Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 393(2), 321-328. Dettagli