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INFORMAZIONI PERSONALI 

Nome: Luogo e data di nascita: Nazionalità: Email:

ISTRUZIONE

Claudia Fuoco Marino (RM) 22 Febbraio 1981 Italiana claudia.fuoco@uniroma2.it; c.fuoco@pec.it 

Curriculm Vitae, Claudia Fuoco

scienze MM. FF. NN., UniversitaÌ€ di Roma “Tor Vergata”. Supervisore: Prof. Francesco Cec- coni

• Marzo2006-Agosto 2006 Titolare borsa di studio erogata dalla Fondazione Telethon pro- getto N S99038CSPC, svolta presso Dipartimento di Biologia, FacoltaÌ€ di scienze MM. FF. NN., UniversitaÌ€ di Roma “Tor Vergata”. Supervisore: Prof. Francesco Cecconi

PERIODI DI CONGEDO

• Attualmente: Titolare del corso AAS “Rigenerazione e Cellule staminali”, Laurea in Biologia Cellulare e Molecolare e Scienze Biomediche LM6

QUALIFICHE

Curriculm Vitae, Claudia Fuoco

• Settembre 2018. Corso avanzato di Citofluorimetria a flusso svolto presso Miltenyi Biotech • Giugno 2021 Abilitazione Scientifica Nazionale ASN2018 settore concorsuale 05/H2

(BIO/17)

• 04/12/2019 relatrice presso il Dipartimento di Biologia UniversitaÌ€ di Roma “Tor Vergata” “Il CyTOF2: La citometria di massa a Tor Vergata”

PUBBLICAZIONI

  1. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.

    Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D.

    Cell Metab. 2022 Mar 15:S1550-4131(22)00088-2. doi: 10.1016/j.cmet.2022.02.016. PMID: 35305295

  2. Dystrophic Muscle Affects Motoneuron Axon Outgrowth and NMJ Assembly. Fornetti E, Testa S, De Paolis F, Fuoco C, Bernardini S, Pozo Devoto V, Stokin G B, Giannitelli S M, Rainer A, Bigot A, Zoccali C, Baldi J, Sandonà D, Rizzi R, Bearzi C, Forte G, Cannata S, Gargioli C. Advanced Materials Technologies. 2022. ISSN 2365709X DOI 10.1002/admt.202101216

  3. Injectable hydrogel microspheres for sustained gene delivery of antisense oligonucleotides to restore the expres- sion of dystrophin protein in duchenne muscular dystrophy Attias Cohen S, Simaan-Yameen H, Fuoco C, Gargioli C, Seliktar D. European Polymer Journal. 2022 March 5; 166(111038). ISSN 00143057 DOI 10.1016/j.eurpolymj.2022.111038

  4. Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines. Riccio F, Micarelli E, Secci R, Giuliani G, Vumbaca S, Massacci G, Castagnoli L, Fuoco C*, Cesareni G. Cell Death Discov. 2022 Jan 10;8(1):16. doi: 10.1038/s41420-021-00811-7. PMID: 35013135

  5. Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity. Orecchioni M, Fusco L, Mall R, Bordoni V, Fuoco C, Rinchai D, Guo S, Sainz R, Zoccheddu M, Gurcan C, Yil- mazer A, Zavan B, Ménard-Moyon C, Bianco A, Hendrickx W, Bedognetti D, Delogu LG.

    Nanoscale. 2022 Jan 6;14(2):333-349. doi: 10.1039/d1nr04355b. PMID: 34796889

  6. Characterization of the Skeletal Muscle Secretome Reveals a Role for Extracellular Vesicles and IL1α/IL1β in Restricting Fibro/Adipogenic Progenitor Adipogenesis. Vumbaca S, Giuliani G, Fiorentini V, Tortolici F, Cerquone Perpetuini A, Riccio F, Sennato S, Gargioli C, Fuoco C*, Castagnoli L, Cesareni G.

    Biomolecules. 2021 Aug 8;11(8):1171. doi: 10.3390/biom11081171. PMID: 34439837

  7. Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Curriculm Vitae, Claudia Fuoco

Fusco L, Orecchioni M, Reina G, Bordoni V, Fuoco C, Gurcan C, Guo S, Zoccheddu M, Collino F, Zavan B, Treossi E, Yilmazer A, Palermo V, Bianco A, Delogu L.G. NanoImpact. 2021. ISSN 24520748 DOI 10.1016/j.impact.2021.100330

  1. The War after War: Volumetric Muscle Loss Incidence, Implication, Current Therapies and Emerging Reconstruc- tive Strategies, a Comprehensive Review. Testa S, Fornetti E, Fuoco C, Sanchez-Riera C, Rizzo F, Ciccotti M, Cannata S, Sciarra T, Gargioli C. Biomedicines. 2021 May 18;9(5):564. doi: 10.3390/biomedicines9050564. PMID: 34069964

  2. A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection. Perfetto L, Micarelli E, Iannuccelli M, Lo Surdo P, Giuliani G, Latini S, Pugliese GM, Massacci G, Vumbaca S, Riccio F, Fuoco C, Paoluzi S, Castagnoli L, Cesareni G, Licata L, Sacco F. Genes (Basel). 2021 Mar 22;12(3):450. doi: 10.3390/genes12030450.PMID: 33809949

  3. Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry.

    Petrilli LL, Riccio F, Giuliani G, Palma A, Gargioli C, Vumbaca S, Faron M, Palmieri G, Pasquini L, Sacco F, Cesareni G, Castagnoli L, Fuoco C. J Clin Med. 2021 Feb 17;10(4):823. doi: 10.3390/jcm10040823. PMID: 33671425

  4. Biofabricatingmurineandhumanmyo-substitutesforrapidvolumetricmusclelossrestoration. Costantini M, Testa S, Fornetti E, Fuoco C, Sanchez Riera C, Nie M, Bernardini S, Rainer A, Baldi J, Zoccali C, Biagini R, Castagnoli L, Vitiello L, Blaauw B, Seliktar D, Święszkowski W, Garstecki P, Takeuchi S, Cesareni G, Cannata S, Gargioli C. EMBO Mol Med. 2021 Mar 5;13(3):e12778. doi: 10.15252/emmm.202012778. Epub 2021 Feb 15. PMID: 33587336

  5. SCA-1micro-heterogeneityinthefatedecisionofdystrophicfibro/adipogenicprogenitors. Giuliani G, Vumbaca S, Fuoco C, Gargioli C, Giorda E, Massacci G, Palma A, Reggio A, Riccio F, Rosina M, Vinci M, Castagnoli L, Cesareni G.Cell Death Dis. 2021 Jan 25;12(1):122. doi: 10.1038/s41419-021-03408- 1.PMID: 33495447

  6. Skeletal Muscle-Derived Human Mesenchymal Stem Cells: Influence of Different Culture Conditions on Prolifer- ative and Myogenic Capabilities. Testa S, Riera CS, Fornetti E, Riccio F, Fuoco C, Bernardini S, Baldi J, Costantini M, Foddai ML, Cannata S, Gargioli C.

    Front Physiol. 2020 Sep 16;11:553198. doi: 10.3389/fphys.2020.553198. eCollection 2020.PMID: 33041857

  7. mTORinhibitionleadstoSrc-mediatedEGFRinternalisationanddegradationingliomacells. Colella B, Colardo M, Iannone G, Contadini C, Saiz-Ladera C, Fuoco C, Barilà D, Velasco G, Segatto M, Di Bartolomeo S. Cancers 2020 Aug 13;12(8):2266. doi: 10.3390/cancers12082266. PMID: 32823532

  8. High-Dimensional Single-Cell Quantitative Profiling of Skeletal Muscle Cell Population Dynamics during Regen- eration.

    Petrilli LL, Spada F, Palma A, Reggio A, Rosina M, Gargioli C, Castagnoli L, Fuoco C*, Cesareni G.Cells. 2020 Jul 18;9(7):E1723. doi: 10.3390/cells9071723.PMID: 32708412

  9. Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis. Reggio A, Rosina M, Palma A, Cerquone Perpetuini A, Petrilli LL, Gargioli C, Fuoco C, Micarelli E, Giuliani G, Cerretani M, Bresciani A, Sacco F, Castagnoli L, Cesareni G.Cell Death Differ. 2020 May 7. doi: 10.1038/s41418- 020-0551-y. PMID: 32382110

  10. Toward High-Dimensional Single-Cell Analysis of Graphene Oxide Biological Impact: Tracking on Immune Cells by Single-Cell Mass Cytometry. Orecchioni M, Bordoni V, Fuoco C*, Reina G, Lin H, Zoccheddu M, Yilmazer A, Zavan B, Cesareni G, Bedognetti D, Bianco A, Delogu LG.Small. 2020 May;16(21):e2000123. doi: 10.1002/smll.202000123. Epub 2020 Apr 27.PMID: 32338440

  11. Metabolicreprogrammingoffibro/adipogenicprogenitorsfacilitatesmuscleregeneration. Reggio A, Rosina M, Krahmer N, Palma A, Petrilli LL, Maiolatesi G, Massacci G, Salvatori I, Valle C, Testa S, Gargioli C, Fuoco C, Castagnoli L, Cesareni G, Sacco F.Life Sci Alliance. 2020 Feb 4;3(3):e202000646. doi: 10.26508/lsa.202000660. Print 2020 Mar.PMID: 32019766

  12. Myo-REG:APortalforSignalingInteractionsinMuscleRegeneration. Palma A, Cerquone Perpetuini A, Ferrentino F, Fuoco C, Gargioli C, Giuliani G, Iannuccelli M, Licata L, Micarelli E, Paoluzi S, Perfetto L, Petrilli LL, Reggio A, Rosina M, Sacco F, Vumbaca S, Zuccotti A, Castagnoli L, Cesareni G.Front Physiol. 2019 Sep 27;10:1216. doi: 10.3389/fphys.2019.01216. eCollection 2019.PMID: 31611808

  13. MetforminDelaysSatelliteCellActivationandMaintainsQuiescence. Pavlidou T, Marinkovic M, Rosina M, Fuoco C, Vumbaca S, Gargioli C, Castagnoli L, Cesareni G. Stem Cells Int. 2019 Apr 24;2019:5980465

  1. Fibro-adipogenicprogenitorsofdystrophicmiceareinsensitivetoNOTCHregulationofadipogenesis. Marinkovic M, Fuoco C, Sacco F, Cerquone Perpetuini A, Giuliani G, Micarelli E, Pavlidou T, Petrilli LL, Reggio A, Riccio F, Spada F, Vumbaca S, Zuccotti A, Castagnoli L, Mann M, Gargioli C, Cesareni G. Life Sci Alliance. 2019 Jun 25;2(3). pii: e201900437.

  2. OsteogenicdifferentiationofskeletalmuscleprogenitorcellsisactivatedbytheDNAdamageresponse. Rosina M, Langone F, Giuliani G, Cerquone Perpetuini A, Reggio A, Calderone A, Fuoco C, Castagnoli L, Gar- gioli C, Cesareni G.Sci Rep. 2019 Apr 1;9(1):5447. doi: 10.1038/s41598-019-41926-3

  3. The immunosuppressant drug azathioprine restrains adipogenesis of muscle Fibro/Adipogenic Progenitors from dystrophic mice by affecting AKT signaling. Reggio A, Spada F, Rosina M, Massacci G, Zuccotti A, Fuoco C, Gargioli C, Castagnoli L, Cesareni G. Sci Rep. 2019 Mar 13;9(1):4360.

  4. MyoblastMyogenicDifferentiationbutNotFusionProcessIsInhibitedviaMyoDTetraplexInteraction. Testa S, D'Addabbo P, Fornetti E, Belli R, Fuoco C, Bernardini S, Cannata S, Frezza D, Gargioli C. Oxid Med Cell Longev. 2018 May 7;2018:7640272

  5. GroupIPakssupportmuscleregenerationandcounteractcancer-associatedmuscleatrophy. Cerquone Perpetuini A, Re Cecconi AD, Chiappa M, Martinelli GB, Fuoco C, Desiderio G, Castagnoli L, Gargioli C, Piccirillo R, Cesareni G. J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):727-746

  6. High-DensityZnONanowiresasaReversibleMyogenic-DifferentiationSwitch. Errico V, Arrabito G, Fornetti E, Fuoco C, Testa S, Saggio G, Rufini S, Cannata S, Desideri A, Falconi C, Gargioli C. ACS Appl Mater Interfaces. 2018 Apr 25;10(16):14097-14107.

  7. Designing a 3D printed human derived artificial myo-structure for anal sphincter defects in anorectal malfor- mations and adult secondary damage. Testa C, Fuoco C*, Costantini M, Belli R, Fascetti Leon F, Vitiello L, Rainer A, Cannata S, Gargioli C. Mat Today Comm. 2018 Mar 15; (120-123).

  8. Oxidativestresspreconditioningofmouseperivascularmyogenicprogenitorsselectsasubpopulationofcellswith a distinct survival advantage in vitro and in vivo. Gargioli C, Turturici G, Barreca MM, Spinello W, Fuoco C, Testa S, Feo S, Cannata SM, Cossu G, Sconzo G, Geraci F. Cell Death Dis. 2018 Jan 3;9(1):1.

  9. Single-cellmasscytometryandtranscriptomeprofilingrevealtheimpactofgrapheneonhumanimmunecells. Orecchioni M, Bedognetti D, Newman L, Fuoco C, Spada F, Hendrickx W, Marincola FM, Sgarrella F, Rodrigues AF, Ménard-Moyon C, Cesareni G, Kostarelos K, Bianco A, Delogu LG. Nat Commun. 2017 Oct 24;8(1):1109Cell Death Dis. 2018 Jan 3;9(1):1

  10. Regulationofmyoblastdifferentiationbymetabolicperturbationsinducedbymetformin. Pavlidou T, Rosina M, Fuoco C, Gerini G, Gargioli C, Castagnoli L, Cesareni G. PLoS One. 2017 Aug 31;12(8):e0182475.

  11. Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofi- bers in vitro and in vivo. Costantini M, Testa S, Mozetic P, Barbetta A, Fuoco C, Fornetti E, Tamiro F, Bernardini S, Jaroszewicz J, Święsz- kowski W, Trombetta M, Castagnoli L, Seliktar D, Garstecki P, Cesareni G, Cannata S, Rainer A, Gargioli C. Biomaterials. 2017 Jul;131:98-110. IF: 10.273

  12. Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia. Vono R, Fuoco C, Testa S, PirroÌ€ S, Maselli D, Ferland McCollough D, Sangalli E, Pintus G, Giordo R, Finzi G, Sessa F, Cardani R, Gotti A, Losa S, Cesareni G, Rizzi R, Bearzi C, Cannata S, Spinetti G, Gargioli C, Madeddu P. Diabetes. 2016 Dec;65(12):3691-3704.

  13. Characterizationbymasscytometryofdifferentmethodsforthepreparationofmusclemononuclearcells. Spada F, Fuoco C*, Pirrò S, Paoluzi S, Castagnoli L, Gargioli C, Cesareni G. N Biotechnol. 2016 Sep 25;33(5 Pt A):514-23. doi: 10.1016/j.nbt.2015.12.007. Epub 2016 Jan 7. PMID: 26773739

  14. Matrixscaffoldingforstemcellguidancetowardskeletalmuscletissueengineering. Fuoco C, Petrilli LL, Cannata S, Gargioli C. J Orthop Surg Res. 2016 Jul 27;11(1):86 doi: 10.1186/s13018-016- 0421-y. PMID: 27460672

  15. Couldafunctionalartificialskeletalmusclebeusefulinmusclewasting? Fuoco C, Cannata S, Gargioli C. Curr Opin Clin Nutr Metab Care. 2016 May;19(3):182-7. doi: 10.1097/MCO.0000000000000271. PMID: 26910194

Curriculm Vitae, Claudia Fuoco

  1. PIM1destabilizationactivatesap53-dependentresponsetoribosomalstressincancercells. Sagar V, Caldarola S, Aria V, Monteleone V, Fuoco C, Gargioli C, Cannata S, Loreni F. Oncotarget. 2016 Apr 26;7(17):23837-49

  2. AMBRA1linksautophagytocellproliferationandtumorigenesisbypromotingc-Mycdephosphorylationanddeg- radation.

    Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, Skobo T, Bordi M, Rohde M, Dalla Valle L, Helmer-Citterich M, Gretzmeier C, Dengjel J, Fimia GM, Piacentini M, Di Bartolomeo S, Velasco G, Cecconi F. Nat Cell Biol. 2015 May;17(5):706.

  3. Invivogenerationofamatureandfunctionalartificialskeletalmuscle. Fuoco C, Rizzi R, Biondo A, Longa E, Mascaro A, Shapira-Schweitzer K, Kossovar O, Benedetti S, Salvatori ML, Santoleri S, Testa S, Bernardini S, Bottinelli R, Bearzi C, Cannata SM, Seliktar D, Cossu G, Gargioli C. EMBO Mol Med. 2015 Apr;7(4):411-22 doi: 10.15252/emmm.201404062. PMID: 25715804

  4. Metforminprotectsskeletalmusclefromcardiotoxininduceddegeneration. Langone F, Cannata S, Fuoco C, Lettieri Barbato D, Testa S, Nardozza AP, Ciriolo MR, Castagnoli L, Gargioli C, Cesareni G. PLoS One. 2014 Dec 2;9(12):e114018.

  5. 3Dhydrogelenvironmentrejuvenatesagedpericytesforskeletalmuscletissueengineering. Fuoco C, Sangalli E, Vono R, Testa S, Sacchetti B, Latronico MV, Bernardini S, Madeddu P, Cesareni G, Seliktar D, Rizzi R, Bearzi C, Cannata SM, Spinetti G, Gargioli C. Front Physiol. 2014 May 30;5:203. doi: 10.3389/fphys.2014.00203. eCollection 2014. PMID: 24910618

  6. Injectable polyethylene glycol-fibrinogen hydrogel adjuvant improves survival and differentiation of transplanted mesoangioblasts in acute and chronic skeletal-muscle degeneration. Fuoco C, Salvatori ML, Biondo A, Shapira-Schweitzer K, Santoleri S, Antonini S, Bernardini S, Tedesco FS, Cannata S, Seliktar D, Cossu G, Gargioli C. Skelet Muscle. 2012 Nov 26;2(1):24.

  7. ThedynamicinteractionofAMBRA1withthedyneinmotorcomplexregulatesmammalianautophagy. Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M, Pagliarini V, Matteoni S, Fuoco C, Giunta L, D'Amelio M, Nardacci R, Romagnoli A, Piacentini M, Cecconi F, Fimia GM. J Cell Biol. 2010 Oct 4;191(1):155- 68.

  8. Anovelroleforautophagyinneurodevelopment. Cecconi F, Di Bartolomeo S, Nardacci R, Fuoco C, Corazzari M, Giunta L, Romagnoli A, Stoykova A, Chowdhury K, Fimia GM, Piacentini M. Autophagy. 2007 Sep-Oct;3(5):506-8.

  9. Ambra1regulatesautophagyanddevelopmentofthenervoussystem. Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F. Nature. 2007 Jun 28;447(7148):1121-5.

  10. Analysisofapoptosomedysregulationinpancreaticcancerandofitsroleinchemoresistance. Corvaro M, Fuoco C, Wagner M, Cecconi F. Cancer Biol Ther. 2007 Feb;6(2):209-17.

 

PERSONAL INFORMATION Name: Claudia Fuoco Date of birth: February 22, 1981 Birthplace: Marino (RM) Italy Nationality: Italy

Email: c.fuoco@yahoo.it/claudia.fuoco@uniroma2.it 

 

 

A. PERSONEL STATEMENT

Fixed-term researcher at the Department of Biology, “Tor Vergata” University of Rome. She published 48 articles in peer-reviewed journals (15 as first or last/corresponding author) among which several in high-impact journals likewise EMBO Mol Med, Small, and Cell Discovery. Total H index 20 (SCOPUS); i10-hindex 38 (Google Scholar). She works as a Researcher in the Laboratory of Stem Cells and Tissue Engineering directed by Prof. Cesare Gargioli. She developed great expertise in skeletal muscle tissue engineering for muscle reconstruction by manipulating biomaterials and skeletal muscle stem cells. She experienced in mass cytometry and she is currently responsible for the CyTOF2 instrument present in the Biology Department. B. EDUCATION, TRAINING AND ACADEMIC CAREER

2003: Bachelor’s Degree in Cellular and Molecular Biology, 109/110 University of Rome Tor Vergata, IT 2005: Master’s Degree in Cellular and Molecular Biology, 110/110 cum laude, University of Rome Tor Vergata, IT

2010: PhD in Cellular and Molecular Biology, University of Rome Tor Vergata, IT March 2006-November 2006: TELETHON fellowship for graduated University of Rome Tor Vergata, IT November 2006-October 2009: PhD student in Cellular and Molecular Biology, University of Rome Tor Vergata, IT November 2009-August 2010: TELETHON fellowship for PhD position, University of Rome Tor Vergata, IT September 2010-February 2012: fixed term contract for PhD position, Fondazione Centro San Raaaele del Monte Tabor (hsr) at San Raaaele Scientific Biomedical Park Foundation, Rome, IT September 2012-May 2013: Research grant for PhD, European Centre for Brain Research, Santa Lucia Foundation, IT July 2013-March 2019: Research grant for PhD position, Department of Biology, University of Rome Tor Vergata, IT April 2021 – December 2021: Scholarship for PhD position, Department of Biology, University of Rome Tor Vergata, IT December 2021-present: Fixed Term Researcher, Department of Biology, Rome University Tor Vergata, IT • PERIODS OF LEAVE March 2012-August 2012: suspension for maternity leave June 2016-November2016: suspension for maternity leave C. COMMISSIONS OF TRUST 2021-present: editorial board of “Striated Muscle Physiology” as a review editor (Frontiers in Physiology) 2021-present: guest editor of Cells for the special issue "Cell–Microenvironment Crosstalk, Models, and Molecular Mechanisms in Rhabdomyosarcoma: Current and Future Perspectives".

Curriculm Vitae, Claudia Fuoco

D. HONORS AND AWARDS 2005: Graduated with honors (110/110 cum laude) in Cellular and Molecular Biology. 2006: Awarded TELETHON fellowship project N S99038CSPC for graduated students. 2009: Awarded TELETHON fellowship project S99038TELU for PhD position 2012-19: Research Competitive 2019: Awarded Fondazione Umberto Veronesi research grant “Post-doctoral fellowship “2019” 2020: Awarded Fondazione Umberto Veronesi research grant “Post-doctoral fellowship “2019” 2021: Awarded research fellowship for PhD position with University Tor Vergata, Rome 2021-present: Fixed term Researcher competition Rome University Tor Vergata, Rome E. MAIN RESEARCH GRANTS (last 10 years) 2019-20: Fondazione Umberto Veronesi research grant “Post-doctoral fellowship “2019” 2020-21: Fondazione Umberto Veronesi research grant “Post-doctoral fellowship “2020” 2019-actual: GR2019 Project Title: Single-cell deep phenotyping of B lymphocytes to personalize immunotherapy in patients with myasthenia gravis” (Collaborator) 2021-actual: Call: HORIZON-WIDERA-2021-ACCESS-03 Project title: “Enhancing Cancer Vaccine Science for New Therapy Pathways “CANVAS” (Collaborator) 2023-actual: PRIN 2022 Project Title:” The myofascial unit: the missing point in the comprehension of muscular dystrophies” (PI of unit research) 2023-actual: Farm2Fork Horizon CL6-2023 Project title: “Fostering European cellular Agriculture for Sustainable Transition Solutions” (Team member) G. PUBBLICATIONS (last 20 publications)

1. Long-term longitudinal study on swine VML model.

De Paolis F, et al., Biology Direct, 2023, 18(1), 42

2. Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes Celikkin, N.et al. Biofabrication 2023, 15(4), 045012 3. Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation

Gupta, G. et al., ACS Nano, 2023, 17(17), pp. 17451–17467

4. A call for an ‘Asilomar’ for cultivated meat and seafood

Bottini S et al., Nature Biotechnology, 2023, 41(7), pp. 895–897

5. A 3D adipogenesis platform to study the fate of fibro/adipogenic progenitors in muscular dystrophies Reggio A et al., DMM Disease Models and Mechanisms, 2023, 16(6), dmm049915 6. A novel extrusion-based 3D bioprinting system for skeletal muscle tissue engineering

Fornetti et al., Biofabrication, 2023 15(2), 025009

7. Inter and intra-tumor heterogeneity of paediatric type diffuse high-grade gliomas revealed by single- cell mass cytometry. Petrilli LL, Fuoco C, Palma A, Pasquini L, Pericoli G, Grabovska Y, Mackay A, Rossi S, Carcaboso AM, Carai A, Mastronuzzi A, Jones C, Cesareni G, Locatelli F, Vinci M. Front Oncol. 2022 doi: 10.3389/fonc.2022.1016343. eCollection 2022.PMID: 36568177 Free PMC article.

8. Graphene nanoribbons are internalized by human primary immune cell subpopulations maintaining a safety profile: A high-dimensional pilot study by single-cell mass cytometry Fuoco C, Xiangfeng L, Fusco L, Riccio F, Giuliani G, Hazel L, Orecchioni M, Martin C, Cesareni G, Feng X, May Y, Bianco A, Delogu LG., Applaied Material Today DOI 10.1016/j.apmt.2022.101593

9. In vivo restoration of dystrophin expression in mdx mice using intra-muscular and intra-arterial injections of hydrogel microsphere carriers of exon skipping antisense oligonucleotides. Cohen SA, Bar-Am O, Fuoco C, Saar G, Gargioli C, Seliktar D. Cell Death Dis. 2022 Sep 9;13(9):779. doi: 10.1038/s41419-022-05166-0. PMID: 36085138

10. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri

Curriculm Vitae, Claudia Fuoco

M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D. Cell Metab. 2022 Apr 5;34(4):533-548.e12. doi: 10.1016/j.cmet.2022.02.016. Epub 2022 Mar 18. PMID: 35305295 11. Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines.

Riccio F, Micarelli E, Secci R, Giuliani G, Vumbaca S, Massacci G, Castagnoli L, Fuoco C, Cesareni G Cell Death Discov. 2022 Jan 10;8(1):16. doi: 10.1038/s41420-021-00811-7. PMID: 35013135 12. Dystrophic Muscle Affects Motoneuron Axon Outgrowth and NMJ Assembly Fornetti E, Testa S, De Paolis F, Fuoco C, Bernardini S, Pozo Devoto V, Stokin GB, Giannitelli SM, Rainer A, Bigot A, Zoccali C, Baldi J, Sandonà D, Rizzi R, Bearzi C, Fotte G, Cannata S, Gargioli C. Advanced Materials Technologies doi: 0.1002/admt.202101216

13. Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity Orecchioni M, Fusco L, Mall R, Bordoni V, Fuoco C, Rinchai D, Guo S, Sainz R, Zoccheddu M, Gurcan C, Yilmazer A, Zavan B, Ménard-Moyon C, Bianco A, Hendrickx W, Bedognetti D, Delogu LG.

Nanoscale. 2022 Jan 6;14(2):333-349. doi: 10.1039/d1nr04355b. PMID: 34796889

14. Characterization of the Skeletal Muscle Secretome Reveals a Role for Extracellular Vesicles and IL1α/IL1β in Restricting Fibro/Adipogenic Progenitor Adipogenesis. Vumbaca S, Giuliani G, Fiorentini V, Tortolici F, Cerquone Perpetuini A, Riccio F, Sennato S, Gargioli C, Fuoco C, Castagnoli L, Cesareni G. Biomolecules. 2021 Aug 8;11(8):1171. doi: 10.3390/biom11081171. PMID: 34439837

15. Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types Fusco L, Orecchioni M, Reina G, Bordoni V, Fuoco C, Gurcan C, Guo S, Zoccheddu M, Collino F, Zavan B, Treossi E, Yilmazer A, Palermo V, Bianco A, Delogu L.G. NanoImpact. 2021. ISSN 24520748 DOI 10.1016/j.impact.2021.100330

16. The War after War: Volumetric Muscle Loss Incidence, Implication, Current Therapies and Emerging Reconstructive Strategies, a Comprehensive Review. Testa S, Fornetti E, Fuoco C, Sanchez-Riera C, Rizzo F, Ciccotti M, Cannata S, Sciarra T, Gargioli C. Biomedicines. 2021 May 18;9(5):564. doi: 10.3390/biomedicines9050564. PMID: 34069964

17. A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection. Perfetto L, Micarelli E, Iannuccelli M, Lo Surdo P, Giuliani G, Latini S, Pugliese GM, Massacci G, Vumbaca S, Riccio F, Fuoco C, Paoluzi S, Castagnoli L, Cesareni G, Licata L, Sacco F. Genes (Basel). 2021 Mar 22;12(3):450. doi: 10.3390/genes12030450.PMID: 33809949

18. Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry. Petrilli LL, Riccio F, Giuliani G, Palma A, Gargioli C, Vumbaca S, Faron M, Palmieri G, Pasquini L, Sacco F, Cesareni G, Castagnoli L, Fuoco C. J Clin Med. 2021 Feb 17;10(4):823. doi: 10.3390/jcm10040823.PMID: 33671425

19. Biofabricating murine and human myo-substitutes for rapid volumetric muscle loss restoration. Costantini M, Testa S, Fornetti E, Fuoco C, Sanchez Riera C, Nie M, Bernardini S, Rainer A, Baldi J, Zoccali C, Biagini R, Castagnoli L, Vitiello L, Blaauw B, Seliktar D, Święszkowski W, Garstecki P, Takeuchi S, Cesareni G, Cannata S, Gargioli C. EMBO Mol Med. 2021 Mar 5;13(3):e12778. doi: 10.15252/emmm.202012778. Epub 2021 Feb 15.PMID: 33587336

20. SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors.

Giuliani G, Vumbaca S, Fuoco C, Gargioli C, Giorda E, Massacci G, Palma A, Reggio A, Riccio F, Rosina M, Vinci M, Castagnoli L, Cesareni G. Cell Death Dis. 2021 Jan 25;12(1):122. doi: 10.1038/s41419-021-03408- 1 

 

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