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                            DONATO  AMODIO

 

 

INFORMAZIONI PERSONALI

 

 

Nome

 

Donato Amodio

 

Indirizzo

 

Viale Isacco Newton, 62 - 00151 - Roma – Italia

 

Telefono

PEC

 

+39 3285578374

donato.amodio@pz.omceo.it

 

E-mail

 

amodio.donato@gmail.com

 

Data e luogo di nascita

 

15/07/1985, Potenza

 

Nazionalità

Codice Fiscale

 

Italiana

MDADNT85L15G942M

 

 

ESPERIENZE LAVORATIVE

 

 

 

 

 

Data e organizzazione

 

Abilitazione Scientifica Nazionle alle funzioni di professore universitario di Seconda Fascia nel Settore Concorsuale 06/G1 – Pediatria Generale, Specialistica e Neuropsichiatria Infantile nela seduta 2023/2025 (Decreto Ministeriale n. 1796/2023)

 

Data e organizzazione

 

 

 

 

Data e organizzazione

 

 

 

                  

Data e organizzazione

 

 

Da marzo 2023 ad oggi

RTDA- Ricercatore con contratto di lavoro subordinato a tempo determinato e pieno ai sensi dell’art. 24, comma 3, lettera a) – Pediatra Generale e specialistica

Dipartimento di Medicina dei Sistemi dell’Università di Roma Tor Vergata

 

Da Gennaio 2024 ad oggi

Dirigente Medico

Ospedale Pediatrico Bambino Gesù, Roma - Italia

UOC Immunologia Clinica e Vaccinologia

 

Da Agosto 2017 a Dicembre 2023

Research Fellow

Ospedale Pediatrico Bambino Gesù, Roma - Italia

Dipartimento Pediatrico Universitario Ospedaliero (DPUO). Attività di ricerca e clinica nelle unità di Immunologia Clinica e Vaccinologia ed Immunoinfettivologia. L’attività comprende turni di guardia diurni e notturni

 

 

      Data e organizzazione

 

Da Settembre 2015 a Settembre 2016

Visiting Researcher

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health – Bethesda, Maryland 20892 - USA

 

 

 

 

 

 

Data e organizzazione

 

 

 

 

Da Novembre 2011 a Giugno 2015

Investigator

Ospedale Fatebenefratelli San Pietro, Roma - Italia

Progetto trial europeo “Efficacy, pharmacokinetics and safety of Meropenem in infants below 90 days of age (inclusive) with clinical or confirmed late-onset sepsis and meningitis: a European multicenter randomised phase III trial”

 

Data e organizzazione

 

 

 

 

Da Aprile 2012 ad Agosto 2012

Subinvestigator

Ospedale Fatebenefratelli San Pietro, Roma - Italy

Progetto “PAED2/FRESH”

 

Data e organizzazione

 

Da Marzo 2010 ad Ottobre 2011

 

 

 

Internato presso Ospedale Pediatrico Bambino Gesù, Roma - Italia

Dipartmento Immunoinfettivologia (Prof. Paolo Rossi)

 

 

FORMAZIONE

 

 

 

 

 

Data e organizzazione

 

 

 

Titolo qualifica ottenuta

 

 

Data e organizzazione

 

Da Novembre 2017 ad Ottobre 2020

Corso di Dottorato di Ricerca in Immunologia, Medicina Molecolare e Biotecnologie

Titolo della tesi: The emerging role of Follicular CD4 T cells in the immune system: a comprehensive analysis in different diseases and anatomic compartment in the era of COVID19

Doctor of Philosphy - Voto Eccellente cum Laude

 

 

Da Luglio 2012 a Luglio 2017

 

 

 

Scuola di Specializzazione in Pediatria, Università degli studi di Roma Tor Vergata

Titolo della tesi: Tonsil germinal center immune dynamics after influenza vaccination in children

 

 

Titolo qualifica ottenuta

 

Specializzazione in Pediatria – Vote 50/50 cum Laude

 

 

Data e organizzazione

 

Da Ottobre 2004 a Ottobre 2010

 

 

 

Università degli studi di Roma Tor Vergata, Facoltà di Medicina e Chirurgia

Titolo della tesi: “Valutazione della funzionalità renale in bambini infetti da HIV e trattati con terapia antiretrovirale contenente Tenofovir”

 

Titolo qualifica ottenuta

 

Laurea in Medicina e Chirurgia -  Voto 110/110 cum Laude

 

 

 

Data e organizzazione

 

Da Settembre 1999 a Giugno 2004

 

 

Liceo Scientifico  “Galileo Galilei”, Potenza

Titolo qualifica ottenuta

 

 

INSEGNAMENTI

 

Data e organizzazione

 

 

Data e organizzazione

 

 

 

 

Data e organizzazione

 

 

 

 

 

“Diploma di scuola media secondaria superiore”

 

 

 

 

Dal 2023 Università catotlica Nostra Signora del Buon Consiglio – Tirana, Albania

Insegnamento di Pediatria presso la Facoltà di Medicina

 

Dal 2022

Componente collegio Dottorato di Ricerca in Immunologia, Medicina Molecolare e Biotecnologie Applicate - Codice DOT13AB9TV

Università di Roma Tor Vergata – Italia

 

22/10/2022 - Master di II livello in Allergologia ed Immunologia Pediatrica Avanzata. Modulo: Vaccini

Università di Roma Tor Vergata – Italia

GRANTS

Ospedale Pediatrico Bambino Gesù IDEAL: Immune Development in early Lifei cod. 202305_INFETT_AMODIO

Ospedale Pediatrico Bambino Gesù SOON: Sars-cOv-2 Outcome vacciNation - CONVERS: Valutazione dell’Immunogenicità del vaccino COVID-19 mRNA BNT162b2 (Comirnaty) in popolazioni vulnerabili cod. 202205_INFETT_AMODIO

Ministero della salute - Progetto GR-2019-12369979 - Definition of the role of different genetic and non-genetic factors in the variability of the clinical and immunological phenotype in patients with 22q11.2 deletion syndrome.

 

SPERIMENTAZIONI                        - Investigator in the European Observational Study Profound Combined Immunodeficiency (P-CID) dal 2015

                                                                         - Investigator in the clinical trial Kedrion intravenous human normal immunoglobulin (IVIg) 10% - KB070 PID PED study dal 2021

                                                                         – Investigator studio finanziato NIH “Immune Development in Early life – IDEAL”

 

 

RUOLO IN

SOCIETÀ SCIENTIFICHE                - Consultant in ERN-RITA The European Reference Network that aims at improving the care of patients with Rare Immunological Disorders https://ern-rita.org

                                                                         - Consultant in Virtual consultation System of AIEOP in Primary immunodeficiencies https://www.aieop.org/study/VCS/

                                                                         - Review Editor per le seguenti riviste: Frontiers in Public Health, Frontiers in Pediatrics, Frontiers in Medicine, Vaccines

 

 

PUBBLICAZIONI

 

DOCUMENTI 54

 

H INDEX 16

CITAZIONI 1515

(fonte: Scopus)

 

• Publicazioni in Extenso

* Prima authorship condivisa

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ABSTRACTS

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CAPITOLI DI LIBRI

 

 

  1. BCL11B-Related Dystonia: Further Evidence of an Emerging Cause of Childhood-Onset Generalized Dystonia. Movement Disorders Clinical Practice, 2024, 11(7), pp. 897–901.

Garone, Giacomo; Capuano, Alessandro; Amodio, Donato; Nicita, Francesco; Travaglini, Lorena; Graziola, Federica; De Benedictis, Alessandro; Frascarelli, Flaminia; Parisi, Pasquale; Pizzi, Simone; Tartaglia, Marco; Marras, Carlo Efisio; Niceta, Marcello

  1. Epstein–Barr virus-associated smooth muscle tumor in a female with ataxia telangiectasia: A case report. Pediatric Blood and Cancer, 2024, 71(7), e31019

Rivalta, Beatrice; Zangari, Paola; Pacillo, Lucia; Manno, Emma Concetta; Santilli, Veronica; Rotulo, Gioacchino Andrea; Cotugno, Nicola; Rossetti, Chiara; Vallese, Silvia; Paglietti, Maria Giovanna; Tomà, Paolo; Pardi, Valerio; Inserra, Alessandro; Francalanci, Paola; Milano, Giuseppe Maria; Alaggio, Rita; Cancrini, Caterina; Finocchi, Andrea; Palma, Paolo; Amodio, Donato

  1. Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine. JCI Insight, 2024, 9(10), e177182.

Cotugno, Nicola; Neri, Alessia; Sanna, Marco; Santilli, Veronica; Manno, Emma Concetta; Pascucci, Giuseppe Rubens; Morrocchi, Elena; Amodio, Donato; Ruggiero, Alessandra; degli Atti, Marta Luisa Ciofi; Barneschi, Irene; Grappi, Silvia; Cocchi, Ilaria; Giacomet, Vania; Trabattoni, Daria; Olivieri, Giulio; Bernardi, Stefania; O’Connor, Daniel; Montomoli, Emanuele; Pollard, Andrew J.; Palma, Paolo

  1. CMV Characterization of Natural Killer Cell Profile in a Cohort of Infected Pregnant Women and Their Babies and Its Relation to CMV Transmission. Viruses, 2024, 16(5), 780

Pighi, Chiara; Rotili, Arianna; De Luca, Maia; Chiurchiù, Sara;Calò Carducci, Francesca Ippolita; Rossetti, Chiara; Cifaldi, Loredana; Bei, Roberto; Caforio, Leonardo; Bernardi, Stefania; Palma, Paolo; Amodio, Donato

  1. The Inborn Errors of Immunity—Virtual Consultation System Platform in Service for the Italian Primary Immunodeficiency Network: Results from the Validation Phase. 2024) Journal of Clinical Immunology, 44 (2), art. no. 47. Doi:10.1007/s10875-023-01644-y.

Coppola, E., Sgrulletti, M., Cortesi, M., Romano, R., Cirillo, E., Giardino, G., Dotta, L., Cancrini, C., Bruzzese, D., Badolato, R., Moschese, V., Pignata, C., Alessandro, A., Amodio, D., Azzari, C., Canessa, C., Caorsi, R., Castagnoli, R., Cicalese, M.P., Conti, F., Consolini, R., Dellepiane, R.M., Finocchi, A., Gallo, V., Gattorno, M., Graziani, S., Lippi, F., Lougaris, V., Martire, B., Matucci, A., Marzollo, A., Milito, C., Montin, D., Ottaviano, G., Palma, P., Patuzzo, G., Pession, A., Pietrogrande, M.C., Plebani, A., Quinti, I., Ricci, S., Saettini, F., Soresina, A., Spadaro, G., Tommasini, A., Trizzino, N., Volpi, S., Vultaggio, A

  1. Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression. 2024) British Journal of Haematology, 204 (1), pp. e6-e10. DOI: 10.1111/bjh.19150

Rivalta, B., Attardi, E., Cifaldi, C., Rosti, V., Pacillo, L., Hajrullaj, H., Di Cesare, S., Amodio, D., Algeri, M., Luciani, M., Barzaghi, F., Finocchi, A., Di Matteo, G., Aiuti, A., Locatelli, F., Voso, M.T., Palumbo, G., Cancrini, C.

  1. Susceptibility of SARS-CoV2 infection in children. (2023) European Journal of Pediatrics, 182 (11), pp. 4851-4857. Doi: 0.1007/s00431-023-05184-w

Cotugno, N., Amodio, D., Buonsenso, D., Palma, P

  1. Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children. Clinical Immunology Volume 255October 2023 Article number 109751. Doi: 10.1016/j.clim.2023.109751 Amodio, D.,Pascucci, G.R., Cotugno, N., Rossetti, C., Manno, E.C., Pighi, C., Morrocchi, E., D'Alessandro, A., Perrone, M.A., Valentini, A., Franceschini, A., Chinali, M., Deodati, A., Azzari, C., Rossi, P., Cianfarani, S., Andreani, M., Porzio, O., Palma, P.
  2. Relapsing myocarditis following initial recovery of post COVID-19 vaccination in two adolescent males – Case report. Vaccine: X, 2023, 14, 100318. Doi: 10.1016/j.jvacx.2023.100318

Donato Amodio, Emma Concetta Manno, Nicola Cotugno, Veronica Santilli, Alessio Franceschini, Marco Alfonso Perrone, Marcello Chinali, Fabrizio Drago, Nicoletta Cantarutti, Davide Curione, Renata Engler, Aurelio Secinaro, Paolo Palma

  1. Tailored treatments in inborn errors of immunity associated with atopy (IEIs-A) with skin involvement. Front. Pediatr. 2023 Mar 22;11:1129249.  doi: 10.3389/fped.2023.1129249.

Carmela Giancotta, Nicole Colantoni, Lucia Pacillo, Veronica Santilli, Donato Amodio, Emma Concetta Manno, Nicola Cotugno, Gioacchino Andrea Rotulo, Beatrice Rivalta, Andrea Finocchi, Caterina Cancrini, Andrea Diociaiuti, May El Hachem, Paola Zangari

  1. How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays. Biomedicines. 2023 Mar 13;11(3):888.  doi: 10.3390/biomedicines11030888. Pascucci GR, Morrocchi E, Pighi C, Rotili A, Neri A, Medri C, Olivieri G, Sanna M, Rasi G, Persaud D, Chahroudi A, Lichterfeld M, Nastouli E, Cancrini C, Amodio D, Rossi P, Cotugno N, Palma P.
  2. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease. J Exp Med. 2023 May 1;220(5):e20221755.  doi: 10.1084/jem.20221755.

Sharma M, Leung D, Momenilandi M, Jones LCW, Pacillo L, James AE, Murrell JR, Delafontaine S, Maimaris J, Vaseghi-Shanjani M, Del Bel KL, Lu HY, Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO, Meyts I, Casanova JL, Lyons JJ, Parvaneh N, Nguyen ATV, Cancrini C, Heimall J, Ahmed H, McKinnon ML, Lau YL, Béziat V, Turvey SE.

  1. Higher Troponin Levels on Admission are associated With Persistent Cardiac Magnetic Resonance Lesions in Children Developing Myocarditis After mRNA-Based COVID-19 Vaccination. Pediatr Infect Dis J. 2023 Feb 1;42(2):166-171. doi: 10.1097/INF.0000000000003762.Epub 2022 Oct 31.

Emma Concetta Manno, Donato Amodio, Nicola Cotugno, Chiara Rossetti, Carmela Giancotta, Veronica Santilli, Paola Zangari, Gioacchino Andrea Rotulo, Alberto Villani, Emanuele Giglioni, Attilio Turchetta, Giulia Cafiero, Alessio Franceschini, Marcello Chinali, Ottavia Porzio, Aurelio Secinaro, Paolo Palma

  1. The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. J Clin invest. 2023 Jan 3;133(1):e163235. doi: 10.1172/JCI163235.

Mehdi Benamar, Qian Chen, Janet Chou, Amélie M Julé, Rafik Boudra, Paola Contini, Elena Crestani, Peggy S Lai, Muyun Wang, Jason Fong, Shira Rockwitz, Pui Lee, Tsz Man Fion Chan, Ekin Zeynep Altun, Eda Kepenekli, Elif Karakoc-Aydiner, Ahmet Ozen, Perran Boran, Fatih Aygun, Pinar Onal, Ayse Ayzit Kilinc Sakalli, Haluk Cokugras, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Yuelin Zhong, Maria Lucia Taylor, Katherine Irby, Natasha B Halasa, Elizabeth H Mack; Overcoming COVID-19 Investigators; Sara Signa, Ignazia Prigione, Marco Gattorno, Nicola Cotugno, Donato Amodio, Raif S Geha, Mary Beth Son, Jane Newburger, Pankaj B Agrawal, Stefano Volpi, Paolo Palma, Ayca Kiykim, Adrienne G Randolph, Gunnur Deniz, Safa Baris, Raffaele De Palma, Klaus Schmitz-Abe, Louis-Marie Charbonnier , Lauren A Henderson, Talal A Chatila

  1. Targeted treatment of autoimmune cytopenias in primary immunodeficiencies. Front. Immunol., 16 August 2022. https://doi.org/10.3389/fimmu.2022.911385

Lucia Pacillo, Giuliana Giardino, Donato Amodio, Carmela Giancotta, Beatrice Rivalta, Gioacchino Andrea Rotulo, Emma Concetta Manno, Cristina Cifaldi, Giuseppe Palumbo, Claudio Pignata, Paolo Palma, Paolo Rossi, Andrea Finocchi and Caterina Cancrini

  1. SARS-CoV-2 infection and treatment in a cohort of patients with inborn errors of immunity. 01 August 2022. https://doi.org/10.1111/pai.13833

Francesca Conti, Lucia Pacillo, Donato Amodio, Beatrice Rivalta, Mattia Moratti, Caterina Campoli, Daniele Zama, Ilaria Corsini, Carmela Giancotta, Stefania Bernardi, Samuele Naviglio, Maria Pia Cicalese, Marco Rabusin, Alessandro Aiuti, Caterina Cancrini, Marcello Lanari, Pierluigi Viale, Paolo Palma, Andrea Pession, Andrea Finocchi (Donato Amodio: corresponding author)

  1. Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait? Front. Immunol., 29 July 2022. https://doi.org/10.3389/fimmu.2022.919237

Maria Chiriaco*, Giorgiana Madalina Ursu*, Donato Amodio*, Nicola Cotugno*, Stefano Volpi, Francesco Berardinelli, Simone Pizzi, Cristina Cifaldi, Matteo Zoccolillo, Ignazia Prigione, Silvia Di Cesare, Carmela Giancotta, Elisa Anastasio, Beatrice Rivalta, Lucia Pacillo, Paola Zangari, Alessandro G. Fiocchi, Andrea Diociaiuti, Alessandro Bruselles, Francesca Pantaleoni, Andrea Ciolfi, Valentina D’Oria, Giuseppe Palumbo, Marco Gattorno, Maya El Hachem, Jean-Pierre de Villartay, Andrea Finocchi, Paolo Palma, Paolo Rossi, Marco Tartaglia, Alessandro Aiuti, Antonio Antoccia, Gigliola Di Matteo and Caterina Cancrini

  1. Secondary cytomegalovirus infections: How much do we still not know? Comparison of children with symptomatic congenital cytomegalovirus born to mothers with primary and secondary infection. Front. Pediatr., 19 July 2022. https://doi.org/10.3389/fped.2022.885926

Fabiola Scaramuzzino, Michela Di Pastena, Sara Chiurchiu, Lorenza Romani, Maia De Luca, Giulia Lucignani, Donato Amodio, Annalisa Seccia, Pasquale Marsella, Teresa Grimaldi Capitello, Daniela Longo, Paolo Palma, Laura Lancella, Stefania Bernardi, Paolo Rossi and Francesca Ippolita Calo Carducci

  1. Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History. Vaccines 2022, 10(7), 1136; https://doi.org/10.3390/vaccines10071136

Veronica Santilli, Emma Concetta Manno, Carmela Giancotta, Chiara Rossetti, Nicola Cotugno, Donato Amodio, Gioacchino Andrea Rotulo, Annalisa Deodati, Roberto Bianchi, Giulia Lucignani, Daniela Longo, Massimiliano Valeriani and Paolo Palma

  1. Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens. Vaccines 2022, 10(7), 1109; https://doi.org/10.3390/vaccines10071109

Nicola Cotugno, Enrica Franzese, Giulia Angelino, Donato Amodio, Erminia Francesca Romeo, Francesca Rea, Simona Faraci, Renato Tambucci, Elisa Profeti, Emma Concetta Manno, Veronica Santilli, Gioacchino Andrea Rotulo, Chiara Pighi, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Giuseppe Rubens Pascucci, Diletta Valentini, Alberto Villani, Paolo Rossi, Paola De Angelis and Paolo Palma

  1. Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment. Front. Immunol., 21 June 2022; https://doi.org/10.3389/fimmu.2022.891274

Beatrice Rivalta*, Donato Amodio*, Carmela Giancotta, Veronica Santilli, Lucia Pacillo, Paola Zangari, Nicola Cotugno, Emma Concetta Manno, Andrea Finocchi, Stefania Bernardi, Luna Colagrossi, Leonarda Gentile, Cristina Russo, Carlo Federico Perno, Paolo Rossi, Caterina Cancrini and Paolo Palma

  1. COVID-19 in children: From afterthought to unknown. Cell Reports Medicine, 2022, 3(3), 100558

Donato Amodio, Nicola Cotugno, Paolo Palma

  1. Perinatally HIV-infected adolescents and young adults demonstrate distinct BNT162b2 mRNA COVID-19 vaccine immunogenicity. Clin Infect Dis. 2022 Jun 23;ciac408. Doi: 10.1093/cid/ciac408

Elena Morrocchi, Chiara Pighi, Giuseppe Rubens Pascucci, Nicola Cotugno, Chiara Medri, Donato Amodio, Luna Colagrossi, Alessandra Ruggiero, Emma Concetta Manno, Chiara Casamento Tumeo, Stefania Bernardi, Kinga K Smolen, Carlo Federico Perno, Al Ozonoff, Paolo Rossi, Ofer Levy, Paolo Palma

  1. Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA Cells 2021, 10(10), 2541; doi: 10.3390/cells10102541

Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgi, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina, Rita Carsetti

  1. Humoral and cellular response following vaccination with BNT162b2 mRNA COVID-19 Vaccine in Patients affected by Primary Immunodeficiencies. Front. Immunol. | doi: 10.3389/fimmu.2021.727850

Donato Amodio, Alessandra Ruggiero, Mayla Sgrulletti, Chiara Pighi, Nicola Cotugno, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Cristina Russo, Salvatore Zaffina, Gigliola Di Matteo, Cristina Cifaldi, Silvia Di Cesare, Beatrice Rivalta, Lucia Pacillo, Veronica Santilli, Carmela Giancotta, Emma Concetta Manno, Marta Ciofi Degli Atti, Massimiliano Raponi, Paolo Rossi, Andrea Finocchi, Caterina Cancrini, Carlo Federico Perno, Viviana Moschese, Paolo Palma

  1. BNT162b2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed? Transplantation 2022; 106(2): e158-e160. doi: 10.1097/TP.0000000000003999

Nicola Cotugno, Chiara Pighi, Elena Morrocchi, Alessandra Ruggiero, Donato Amodio, Chiara Medri, Luna Colagrossi, Cristina Russo, Silvia Di Cesare, Veronica Santilli, Emma Concetta Manno, Paola Zangari, Carmela Giancotta, Stefania Bernardi, Luciana Nicolosi, Marta Ciofi Degli Atti, Massimiliano Raponi, Salvatore Zaffina, Sara Alfieri, Richard Kirk, Carlo Federico Perno, Paolo Rossi, Antonio Amodeo, Paolo Palma

  1. Clinical, immunological and molecular variability of RAG deficiency: a retrospective analysis of 22 RAG patients. J Clin Immunol. 2022 Jan;42(1):130-145. doi: 10.1007/s10875-021-01130-3.

Cristina Cifaldi*, Beatrice Rivalta*, Donato Amodio*, Algeri Mattia*, Lucia Pacillo, Silvia Di Cesare, Maria Chiriaco, Giorgiana Madalina Ursu, Nicola Cotugno, Carmela Giancotta, Emma C Manno, Veronica Santilli, Paola Zangari, Galaverna Federica, Giuseppe Palumbo, Pietro Merli, Paolo Palma, Paolo Rossi, Gigliola Di Matteo, Franco Locatelli, Andrea Finocchi, Caterina Cancrini

  1. TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different non-malignant disorders. Blood Adv. 2022 Jan 11;6(1):281-292. doi: 10.1182/bloodadvances.2021005628.

Pietro Merli, Daria Pagliara, Federica Galaverna, Giuseppina Li Pira, Marco Andreani, Giovanna Leone, Donato Amodio, Rita Maria Pinto, Alice Bertaina, Valentina Bertaina, Angela Mastronuzzi, Luisa Strocchio, Emilia Boccieri, Daniela Pende, Michela Falco, Matteo Di Nardo, Francesca Del Bufalo, Mattia Algeri, Franco Locatelli

  1. Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-Up. Front Pediatr. 2021 Aug 27;9:703853. doi: 10.3389/fped.2021.703853.

Beatrice Rivalta, Donato Amodio, Cinzia Milito, Maria Chiriaco, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Veronica Santilli, Lucia Pacillo, Cristina Cifaldi, Maria Giovanna Desimio, Margherita Doria, Isabella Quinti, Rita De Vito, Gigliola Di Matteo, Andrea Finocchi, Paolo Palma, Antonino Trizzino, Alberto Tommasini, Caterina Cancrini (Donato Amodio: corresponding author)

  1. Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology. Pediatr Allergy Immunol. 2021 Nov;32(8):1833-1842. doi: 10.1111/pai.13585.

Nicola Cotugno, Alessandra Ruggiero, Giuseppe Rubens Pascucci, Francesco Bonfante, Maria Raffaella Petrara, Chiara Pighi, Loredana Cifaldi, Paola Zangari, Stefania Bernardi, Laura Cursi, Veronica Santilli, Emma Concetta Manno, Donato Amodio, Giulia Linardos, Livia Piccioni, Maria Antonietta Barbieri, Daniela Perrotta, Andrea Campana, Daniele Donà, Carlo Giaquinto, CACTUS Study Team; Carlo Concato, Petter Brodin, Paolo Ross, Anita De Rossi, Paolo Palma

  1. Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome Patients. Front Immunol. 2021 Jun 1;12:669893. doi: 10.3389/fimmu.2021.669893.

Genni Enza Marcovecchio, Francesca Ferrua, Elena Fontana, Stefano Beretta, Marco Genua, Ileana Bortolomai, Anastasia Conti, Davide Montin, Maria Teresa Cascarano, Sonia Bergante, Veronica D'Oria, Alessandro Giamberti, Donato Amodio, Caterina Cancrini, Adriano Carotti, Raffaella Di Micco, Ivan Merelli, Marita Bosticardo, Anna Villa

  1. Gastric cancer, inflammatory bowel disease and polyautoimmunity in a 17-year-old boy: CTLA-4 deficiency successfully treated with Abatacept. Eur J Gastroenterol Hepatol . 2021 Dec 1;33(1S Suppl 1):e1051-e1056. doi: 10.1097/MEG.0000000000002185.

Giulia Angelino, Cristina Cifaldi, Paola Zangar, Silvia Di Cesare, Gigliola Di Matteo, Maria Chiriaco, Paola Francalanci, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Donato Amodio, Giorgiana Madalina Ursu, Arianna Bertocchini, Antonella Accinni, Alessandro Crocoli, Alessandro Inserra, Raffaele Cozza, Claudio Romano, Maria Licciardello, Martina Rinelli, Luigi Dall'Oglio, Caterina Cancrini, Paola De Angelis , Andrea Finocchi

  1. Initial Presenting Manifestations In 16,486 Patients With Inborn Erros Of Immunity Include Infectious And Noninfectious Manifestations J Allergy Clin Immunol. 2021 Nov;148(5):1332-1341.e5. doi: 10.1016/j.jaci.2021.04.015.

Julian Thalhammer, Gerhard Kindle, Alexandra Nieters, Stephan Rusch, Mikko R J Seppänen, Alain Fischer, Bodo Grimbacher, David Edgar, Matthew Buckland, Nizar Mahlaoui, Stephan Ehl, European Society for Immunodeficiencies Registry Working Party

  1. VIROLOGICAL AND IMMUNOLOGICAL FEATURES OF SARS-CoV-2 INFECTED CHILDREN DEVELOPING SPECIFIC AND NEUTRALIZING ANTIBODIES 2021 Mar 16;34(11):108852.  doi: 10.1016/j.celrep.2021.108852.

Nicola Cotugno, Alessandra Ruggiero, Francesco Bonfante, Maria Raffaella Petrara, Sonia Zicari, Giuseppe Rubens Pascucci, Paola Zangari, Maria Antonietta De Ioris, Veronica Santilli, E C Manno, Donato Amodio, Alessio Bortolami, Matteo Pagliari, Carlo Concato, Giulia Linardos, Andrea Campana, Daniele Donà, Carlo Giaquinto, CACTUS Study Team; Petter Brodin, Paolo Rossi, Anita De Rossi, Paolo Palma

  1. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19, Cell. 2020 Nov 12;183(4):968-981.e7. doi: 10.1016/j.cell.2020.09.016.

Camila Rosat Consiglio*, Nicola Cotugno*, Fabian Sardh*, Christian Pou*, Donato Amodio*, Lucie Rodriguez, Ziyang Tan, Sonia Zicari, Alessandra Ruggiero, Giuseppe Rubens Pascucci, Veronica Santilli, Tessa Campbell, Yenan Bryceson, Daniel Eriksson, Jun Wang, Alessandra Marchesi, Tadepally Lakshmikanth, Andrea Campana, Alberto Villani Paolo Rossi, CACTUS Study Team; Nils Landegren, Paolo Palma, Petter Brodin

  1. Artificial Intelligence Applied to in vitro Gene Expression Testing (IVIGET) to Predict Trivalent Inactivated Influenza Vaccine Immunogenicity in HIV Infected Children Front Immunol. 2020 Oct 5;11:559590. doi: 10.3389/fimmu.2020.559590.

Nicola Cotugno, Veronica Santilli, Giuseppe Rubens Pascucci, Emma Concetta Manno, Lesley De Armas, Suresh Pallikkuth, Annalisa Deodati, Donato Amodio, Paola Zangari, Sonia Zicari, Alessandra Ruggiero, Martina Fortin, Christina Bromley, Rajendra Pahwa, Paolo Rossi, Savita Pahwa, Paolo Palma 

  1. Consensus of the Italian Primary Immunodeficiency Network on Transition Management from Pediatric to Adult Care in Patients Affected with Childhood Onset Inborn Errors of Immunity. J Allergy Clin Immunol. 2020 Nov;146(5):967-983.  doi: 10.1016/j.jaci.2020.08.010.

Emilia Cirillo, Giuliana Giardino, Silvia Ricci, Viviana Moschese, Vassilios Lougaris, Francesca Conti, Chiara Azzari, Federica Barzaghi, Clementina Canessa, Baldassarre Martire, Raffaele Badolato, Laura Dotta, Annarosa Soresina, Caterina Cancrini, Andrea Finocchi, Davide Montin, Roberta Romano, Donato Amodio, Francesca Ferrua, Alberto Tommasini, Lucia Augusta Baselli, Rosa Maria Dellepiane, Agata Polizzi, Luciana Chessa, Antonio Marzollo, Maria Pia Cicalese, Maria Caterina Putti, Andrea Pession, Alessandro Aiuti, Franco Locatelli, Alessandro Plebani, Claudio Pignata

  1. Partial T cell defects and expanded CD56bright NK cells in an SCID patient carrying hypomorphic mutation in the IL2RG gene. Leukoc Biol. 2020 Aug;108(2):739-748. doi: 10.1002/JLB.5MA0220-239R.

Cristina Cifaldi, Nicola Cotugno, Silvia Di Cesare, Silvia Giliani, Gigliola Di Matteo, Donato Amodio, Eva Piano Mortari, Maria Chiriaco, Danilo Buonsenso, Paola Zangari, Daria Pagliara, Stefania Gaspari, Rita Carsetti, Paolo Palma, Andrea Finocchi, Franco Locatelli, Paolo Rossi, Margherita Doria, Caterina Cancrini

  1. How to dissect the plasticity of antigen-specific immune response: a tissue perspective. Amodio et al. Clin Exp Immunol. 2020 Feb;199(2):119-130. doi: 10.1111/cei.13386.

D Amodio, V Santilli, P Zangari, N Cotugno, E C Manno, S Rocca, P Rossi, C Cancrini, A Finocchi, A Chassiakos, C Petrovas, P Palma

  1. Phenotypical T Cell Differentiation Analysis: A Diagnostic and Predictive Tool in the Study of Primary Immunodeficiencies. Front Immunol. 2019 Nov 29;10:2735. doi: 10.3389/fimmu.2019.02735

Enrico Attardi, Silvia Di Cesare, Donato Amodio, Carmela Giancotta, Nicola Cotugno, Cristina Cifaldi, Maria Chiriaco, Paolo Palma, Andrea Finocchi, Gigliola Di Matteo, Paolo Rossi, Caterina Cancrini

  1. Novel Compound Heterozygous Mutations in IL-7 Receptor α Gene in a 15-Month-Old Girl Presenting With Thrombocytopenia, Normal T Cell Count and Maternal Engraftment. Front Immunol. 2019 Oct 30;10:2471. doi: 10.3389/fimmu.2019.02471

Paola Zangari, Cristina Cifaldi, Silvia Di Cesare, Gigliola Di Matteo, Maria Chiriaco, Donato Amodio, Nicola Cotugno, Maia De Luca, Cecilia Surace, Saverio Ladogana, Simone Gardini, Pietro Merli, Mattia Algeri, Paolo Rossi, Paolo Palma, Caterina Cancrini, Andrea Finocchi

  1.  Immunophenotype Anomalies Predict the Development of Autoimmune Cytopenia in 22q11.2 Deletion Syndrome. J Allergy Clin Immunol Pract. Sep-Oct 2019;7(7):2369-2376. doi: 10.1016/j.jaip.2019.03.014.

Davide Montin, Agostina Marolda, Francesco Licciardi, Francesca Robasto, Silvia Di Cesare, Emanuela Ricotti, Francesca Ferro, Giacomo Scaioli, Carmela Giancotta, Donato Amodio, Francesca Conti, Giuliana Giardino, Lucia Leonardi, Silvia Ricci, Stefano Volpi, Lucia Augusta Baselli, Chiara Azzari, Grazia Bossi, Rita Consolini, Rosa Maria Dellepiane, Marzia Duse, Marco Gattorno, Baldassarre Martire, Maria Caterina Putti, Annarosa Soresina, Alessandro Plebani, Ugo Ramenghi, Silvana Martino, Claudio Pignata, Caterina Cancrini

  1. OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines. J Immunol Res. 2019 Apr 28;2019:8732191. doi: 10.1155/2019/8732191.

Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J Pollard, Paolo Palma

  1. Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development. Front Immunol. 2019 Mar 15;10:447. doi: 10.3389/fimmu.2019.00447

Genni Enza Marcovecchio, Ileana Bortolomai, Francesca Ferrua, Elena Fontana, Luisa Imberti, Erika Conforti, Donato Amodio, Sonia Bergante, Giulia Macchiarulo, Veronica D'Oria, Francesca Conti, Silvia Di Cesare, Georgia Fousteri, Adriano Carotti, Alessandro Giamberti, Pietro Luigi Poliani, Luigi D Notarangelo, Caterina Cancrini, Anna Villa, Marita Bosticardo

  1. Distinct gut microbiota profile in ART-treated perinatally HIV-infected patients associated with cardiac and inflammatory biomarkers. AIDS. 2019 May 1;33(6):1001-1011. doi: 10.1097/QAD.0000000000002131.

Libera Sessa, Sofia Reddel, Emma Manno, Andrea Quagliariello, Nicola Cotugno, Federica Del Chierico, Donato Amodio, Claudia Capponi, Fabrizio Leone, Stefania Bernardi, Paolo Rossi, Lorenza Putignani, Paolo Palma

  1. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018 Jan 15;200(2):538-550. doi: 10.4049/jimmunol.1701312.

Donato Amodio, Nicola Cotugno, Giulia Macchiarulo, Salvatore Rocca, Yiannis Dimopoulos, Maria Rita Castrucci, Rita De Vito, Filippo M Tucci, Adrian B McDermott, Sandeep Narpala, Paolo Rossi, Richard A Koup, Paolo Palma, Constantinos Petrovas

  1. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infect Dis. 2017 Apr 24;17(1):302. doi: 10.1186/s12879-017-2396-7.

Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte, Luca Gramatica, Marco Ciabattini, Susanna Livadiotti, Paolo Rossi

  1. Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: a systematic review.” Ital J Pediatr. 2016 Apr 27;42:44. doi: 10.1186/s13052-016-0242-y.

Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Francesca Calò Carducci, Alessandro Jenkner, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Alessandra Simonetti, Elena Ferretti, Martina Della Corte, Luca Gramatica, Susanna Livadiotti, Paolo Rossi

  1. Expansion of actTreg cells inversely correlates with clinical severity in septic neonates” Journal of allergy and clinical immunology. J Allergy Clin Immunol. 2016 May;137(5):1617-1620.e6. doi: 10.1016/j.jaci.2015.10.048.

Eleonora Timperi, Laura Folgori, Donato Amodio, Maia De Luca, Sara Chiurchiù, Silvia Piconese, Silvia Di Cesare, Ilenia Pacella, Carmela Martire, Giulia Bonatti, Seila Perrone, Terenzio Boni, Genni Enza Marcovecchio, Antonino Reale, Francesco Parisi, Andrea Dotta, Vincenzo Barnaba, Paolo Rossi

  1. Pituicytoma and Cushing’s Disease in a 7-Year-Old Girl: A Mere Coincidence?” Pediatrics. 2015 Dec;136(6):e1632-6. doi: 10.1542/peds.2015-0638.

Paola Cambiaso, Donato Amodio, Emidio Procaccini, Daniela Longo, Stefania Galassi, Francesca Diomedi Camassei, Marco Cappa

  1. Serum Soluble ST2 as Diagnostic Marker of Systemic Inflammatory Reactive Syndrome of Bacterial Etiology in Children. Pediatr Infect Dis J. 2014 Feb;33(2):199-203. doi: 10.1097/INF.0000000000000030.

Francesca Ippolita Calò Carducci, Lelia Rotondi Aufiero, Laura Folgori, Anna Chiara Vittucci, Donato Amodio, Maia De Luca, Giuseppina Li Pira, Alberto Bergamini, Giuseppe Pontrelli, Andrea Finocchi, Patrizia D'Argenio

  1. Granulicatella bacteraemia in children: two cases and review of the literature. BMC Pediatr. 2013 Apr 22;13:61. doi: 10.1186/1471-2431-13-61.

Maia De Luca, Donato Amodio, Sara Chiurchiù, Maria Assunta Castelluzzo, Gabriele Rinelli, Paola Bernaschi, Francesca Ippolita Calò Carducci, Patrizia D'Argenio

  1. Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors. BMC Infect Dis. 2012 Jan 23;12:18. doi: 10.1186/1471-2334-12-18.

Giuseppe Pontrelli, Nicola Cotugno, Donato Amodio, Paola Zangari, Hyppolite K Tchidjou, Stefania Baldassari, Paolo Palma, Stefania Bernardi

  1. Fulminant Fusobacterium necrophorum meningitis in an immunocompetent adolescent. Pediatr Emerg Care. 2012 Jul;28(7):703-4. doi: 10.1097/PEC.0b013e31825d23fb.

Giulia Angelino, Nicoletta Cantarutti, Sara Chiurchiù, Donato Amodio, Maia De Luca, Laura Lancella, Luana Coltella, Cristina Russo, Andrea Finocchi

 

 

The European Society of immunodeficiencies ESID 2021 Online Symposium

 

Sindrome da delezione 22q11.2 – Sindrome di Digeorge - Sindrome velo-cardio-facciale

PRESENTAZIONI A CONGRESSI NAZIONALI ED INTERNAIZIONALI

 

 

 CAPACITA’ PERSONALI E COMPETENZE

 

 

“Pediatric Advanced Life Support” provider

Competenze informatiche e software utilizzati: Office, Pubmed, GraphPad, Imaris, EpiInfo, Illustrator, FlowJo, NIS, Leica suites, NPX Manager.

Competenze di biologia cellulare e molecolare: attivazione e stimolazione cellulare, PCR, Elisa, Citofluorimetria multiparametrica, Microscopia in campo aperto, Microscopia confocale, Histocytometry, Analisi di Proteomica

 

madre lingua

altre lingue

 

 

Italiano

Inglese

Effective Operational Proficiency

C1 - Effective Operational Proficiency

 

Si dichiara che quanto riportato corrisponde a verità, ai sensi degli articoli 46 e 47 del D.P.R. 445 del 2000

Autorizzo il trattamento dei dati personali contenuti nel mio curriculum vitae in base all’art. 13 GDPR (RU 2016/679).                        

Donato Amodio

                             DONATO  AMODIO

 

 

PERSONAL INFORMATION

 

 

Name

 

Donato Amodio

 

Address

 

Viale Isacco Newton, 62 - 00151 - Rome – Italy

 

Telephone

PEC

 

+39 3285578374

donato.amodio@pz.omceo.it

 

E-mail

 

amodio.donato@gmail.com

 

Date and place of birth

 

15/07/1985, Potenza

 

Nationality

CF/Tax Code

 

Italian

MDADNT85L15G942M

 

 

WORK EXPERIENCE

 

 

 

 

 

 

Date and Organisation

 

National Scientific qualificationas associate professor in the higher education system, in the call 2023/2025 (Ministerial Decree n. 1796/2023) for the disciplinary field of 06/G1 – Paediatrics and child neuropsychiatry.

 

Date and organisation

 

 

 

Date and organisation

 

 

 

 

Date and Organisation

 

From March 2023 to date

Assistant Professor (RTDA) in Pediatrics

Departments of Systems Medicine,  University of Rome Tor Vergata, Rome – Italy

 

From January 2024 up to date

Staff physician

Bambino Gesù Children’s Hospital, Rome – Italy

Research Unit of Clinical Immunology and Vaccinology

 

From August 2017  to December 2023

Research Fellow

Bambino Gesù Children’s Hospital, Rome - Italy

University Hospital Pediatric Department (DPUO). Pediatric patient management at Immunology and infectivology Unit. Night shifts ad DPUO

 

    

Date and organisation

 

 

From September 2015 to September 2016

Visiting Researcher

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health – Bethesda, Maryland 20892  - USA

 

 

 

 

 

Date and organisation

 

 

 

 

From November 2011 to June 2015

Investigator

Hospital Fatebenefratelli San Pietro, Rome - Italy

European project “Efficacy, pharmacokinetics and safety of Meropenem in infants below 90 days of age (inclusive) with clinical or confirmed late-onset sepsis and meningitis: a European multicenter randomised phase III trial”

 

Date and organisation

 

 

 

 

From April 2012 up August 2012

SubInvestigator

Hospital Fatebenefratelli, San Pietro, Rome - Italy 

Project “PAED2/FRESH”

 

Date and organisation

 

From March 2010 to October 2011

 

 

 

Internship - Bambino Gesù Children’s Hospital, Rome - Italy

Immunoinfectivology Department (Prof. Paolo Rossi)

 

 

Education and training

 

 

 

 

 

Date and organisation

 

 

 

Title of qualification awarded

 

 

Date and organisation

 

From November 2017 to October 2020

PhD course in Molecular Medicine Immunology and Applied Biotechnology

Title of thesis: The emerging role of Follicular CD4 T cells in the immune system: a comprehensive analysis in different diseases and anatomic compartment in the era of COVID19

Doctor of Philosphy - Vote Excellent cum Laude

 

 

From July 2012 to July 2017

 

 

 

Post Graduate School in Paediatrics, University of Rome Tor Vergata

Title of thesis “Tonsil germinal center immune dynamics after influenza vaccination in children”

 

 

Title of qualification awarded

 

Residency in Paediatrics – Vote 50/50 cum Laude

 

 

Date and organisation

 

From October 2004 to October 2010

 

 

 

University of Rome Tor Vergata, School of Medicine

Title of thesis “Valutazione della funzionalità renale in bambini infetti da HIV e trattati con terapia antiretrovirale contenente Tenofovir”

 

Title of qualification awarded

 

Degree in Medicine – Vote 110/110 cum Laude

 

 

Date and organisation

 

From Semptember 1999 to June 2004 Liceo Scientifico  “Galileo Galilei”, Potenza – Italy

 

Title of qualification awarded

 

“Diploma di scuola media secondaria superiore”

 

 

 

TEACHING EXPERIENCE

 

 

 

 

Date and organisation

 

From 2023 – Catholic University Our Lady of Good Counsel – Tirana, Albania

Faculty of Medicine, Teaching of Pediatrics

 

Date and organisation

 

From 2022

University of Rome Tor Vergata - Italy

Board member of PhD course in Molecular Medicine Immunology and Applied Biotechnology

Code DOT13AB9TV

 

Date and organisation

 

 

- Master di II livello in Allergologia ed Immunologia Pediatrica Avanzata. Modulo: Vaccini University of Rome Tor Vergata – Italy 22/10/202

 

 

 

GRANTS

Ospedale Pediatrico Bambino Gesù IDEAL: Immune Development in early Lifei cod. 202305_INFETT_AMODIO

Ospedale Pediatrico Bambino Gesù SOON: Sars-cOv-2 Outcome vacciNation - CONVERS: Valutazione dell’Immunogenicità del vaccino COVID-19 mRNA BNT162b2 (Comirnaty) in popolazioni vulnerabili cod. 202205_INFETT_AMODIO

 Progetto GR-2019-12369979 Definition of the role of different genetic and non-genetic factors in the variability of the clinical and immunological phenotype in patients with 22q11.2 deletion syndrome.

 

CLINICAL STUDIES                        - Investigator in the European Observational Study Profound Combined Immunodeficiency (P-CID)

                                                                         - Investigator in the clinical trial Kedrion intravenous human normal immunoglobulin (IVIg) 10% - KB070 PID PED study

 

 

ROLE IN SCIENTIFIC SOCIETIES    - Consultant in ERN-RITA The European Reference Network that aims at improving the care of patients with Rare Immunological Disorders https://ern-rita.org

                                                                         - Consultant in Virtual consultation System of AIEOP in Primary immunodeficiencies

                                                                         - Review Editor for the following journal: Frontiers in Public Health, Frontiers in Pediatrics, Frontiers in Medicine, Vaccines

 

 

 

Publications

DOCUMENTS 54

 

H INDEX 16

Citations 1515

(Source: Scopus Author ID)

 

• Publications in Extenso

* shared first authorship

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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BOOK CHAPTER

 

 

 

 

 

  1.  BCL11B-Related Dystonia: Further Evidence of an Emerging Cause of Childhood-Onset Generalized Dystonia. Movement Disorders Clinical Practice, 2024, 11(7), pp. 897–901.

Garone, Giacomo; Capuano, Alessandro; Amodio, Donato; Nicita, Francesco; Travaglini, Lorena; Graziola, Federica; De Benedictis, Alessandro; Frascarelli, Flaminia; Parisi, Pasquale; Pizzi, Simone; Tartaglia, Marco; Marras, Carlo Efisio;Niceta, Marcello

  1.  Epstein–Barr virus-associated smooth muscle tumor in a female with ataxia telangiectasia: A case report. Pediatric Blood and Cancer, 2024, 71(7), e31019.

Rivalta, Beatrice; Zangari, Paola; Pacillo, Lucia; Manno, Emma Concetta; Santilli, Veronica; Rotulo, Gioacchino Andrea; Cotugno, Nicola; Rossetti, Chiara; Vallese, Silvia; Paglietti, Maria Giovanna; Tomà, Paolo; Pardi, Valerio; Inserra, Alessandro; Francalanci, Paola; Milano, Giuseppe Maria; Alaggio, Rita; Cancrini, Caterina; Finocchi, Andrea; Palma, Paolo; Amodio, Donato

  1. Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine. JCI Insight, 2024, 9(10), e177182.

Cotugno, Nicola; Neri, Alessia; Sanna, Marco; Santilli, Veronica; Manno, Emma Concetta; Pascucci, Giuseppe Rubens; Morrocchi, Elena; Amodio, Donato; Ruggiero, Alessandra; degli Atti, Marta Luisa Ciofi; Barneschi, Irene; Grappi, Silvia; Cocchi, Ilaria; Giacomet, Vania; Trabattoni, Daria; Olivieri, Giulio; Bernardi, Stefania; O’Connor, Daniel; Montomoli, Emanuele; Pollard, Andrew J.; Palma, Paolo

  1. CMV Characterization of Natural Killer Cell Profile in a Cohort of Infected Pregnant Women and Their Babies and Its Relation to CMV Transmission. Viruses, 2024, 16(5), 780

Pighi, Chiara; Rotili, Arianna; De Luca, Maia; Chiurchiù, Sara;Calò Carducci, Francesca Ippolita; Rossetti, Chiara; Cifaldi, Loredana; Bei, Roberto; Caforio, Leonardo; Bernardi, Stefania; Palma, Paolo; Amodio, Donato

  1. The Inborn Errors of Immunity—Virtual Consultation System Platform in Service for the Italian Primary Immunodeficiency Network: Results from the Validation Phase. 2024) Journal of Clinical Immunology, 44 (2), art. no. 47. Doi:10.1007/s10875-023-01644-y.

Coppola, E., Sgrulletti, M., Cortesi, M., Romano, R., Cirillo, E., Giardino, G., Dotta, L., Cancrini, C., Bruzzese, D., Badolato, R., Moschese, V., Pignata, C., Alessandro, A., Amodio, D., Azzari, C., Canessa, C., Caorsi, R., Castagnoli, R., Cicalese, M.P., Conti, F., Consolini, R., Dellepiane, R.M., Finocchi, A., Gallo, V., Gattorno, M., Graziani, S., Lippi, F., Lougaris, V., Martire, B., Matucci, A., Marzollo, A., Milito, C., Montin, D., Ottaviano, G., Palma, P., Patuzzo, G., Pession, A., Pietrogrande, M.C., Plebani, A., Quinti, I., Ricci, S., Saettini, F., Soresina, A., Spadaro, G., Tommasini, A., Trizzino, N., Volpi, S., Vultaggio, A

  1. Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression. 2024) British Journal of Haematology, 204 (1), pp. e6-e10. DOI: 10.1111/bjh.19150

Rivalta, B., Attardi, E., Cifaldi, C., Rosti, V., Pacillo, L., Hajrullaj, H., Di Cesare, S., Amodio, D., Algeri, M., Luciani, M., Barzaghi, F., Finocchi, A., Di Matteo, G., Aiuti, A., Locatelli, F., Voso, M.T., Palumbo, G., Cancrini, C.

  1. Susceptibility of SARS-CoV2 infection in children. (2023) European Journal of Pediatrics, 182 (11), pp. 4851-4857. Doi: 0.1007/s00431-023-05184-w

Cotugno, N., Amodio, D., Buonsenso, D., Palma, P

  1. Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children. Clinical Immunology Volume 255October 2023 Article number 109751. Doi: 10.1016/j.clim.2023.109751 Amodio, D.,Pascucci, G.R., Cotugno, N., Rossetti, C., Manno, E.C., Pighi, C., Morrocchi, E., D'Alessandro, A., Perrone, M.A., Valentini, A., Franceschini, A., Chinali, M., Deodati, A., Azzari, C., Rossi, P., Cianfarani, S., Andreani, M., Porzio, O., Palma, P
  2. Relapsing myocarditis following initial recovery of post COVID-19 vaccination in two adolescent males – Case report

Donato Amodio, Emma Concetta Manno, Nicola Cotugno, Veronica Santilli, Alessio Franceschini, Marco Alfonso Perrone, Marcello Chinali, Fabrizio Drago, Nicoletta Cantarutti, Davide Curione, Renata Engler, Aurelio Secinaro, Paolo Palma

  1. Tailored treatments in inborn errors of immunity associated with atopy (IEIs-A) with skin involvement. Front. Pediatr. 2023 Mar 22;11:1129249.  doi: 10.3389/fped.2023.1129249.

Carmela Giancotta, Nicole Colantoni, Lucia Pacillo, Veronica Santilli, Donato Amodio, Emma Concetta Manno, Nicola Cotugno, Gioacchino Andrea Rotulo, Beatrice Rivalta, Andrea Finocchi, Caterina Cancrini, Andrea Diociaiuti, May El Hachem, Paola Zangari

  1. How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays. Biomedicines. 2023 Mar 13;11(3):888.  doi: 10.3390/biomedicines11030888. Pascucci GR, Morrocchi E, Pighi C, Rotili A, Neri A, Medri C, Olivieri G, Sanna M, Rasi G, Persaud D, Chahroudi A, Lichterfeld M, Nastouli E, Cancrini C, Amodio D, Rossi P, Cotugno N, Palma P.
  2. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease. J Exp Med. 2023 May 1;220(5):e20221755.  doi: 10.1084/jem.20221755.

Sharma M, Leung D, Momenilandi M, Jones LCW, Pacillo L, James AE, Murrell JR, Delafontaine S, Maimaris J, Vaseghi-Shanjani M, Del Bel KL, Lu HY, Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO, Meyts I, Casanova JL, Lyons JJ, Parvaneh N, Nguyen ATV, Cancrini C, Heimall J, Ahmed H, McKinnon ML, Lau YL, Béziat V, Turvey SE.

  1. Higher Troponin Levels on Admission are associated With Persistent Cardiac Magnetic Resonance Lesions in Children Developing Myocarditis After mRNA-Based COVID-19 Vaccination. Pediatr Infect Dis J. 2023 Feb 1;42(2):166-171. doi: 10.1097/INF.0000000000003762.Epub 2022 Oct 31.

Emma Concetta Manno, Donato Amodio, Nicola Cotugno, Chiara Rossetti, Carmela Giancotta, Veronica Santilli, Paola Zangari, Gioacchino Andrea Rotulo, Alberto Villani, Emanuele Giglioni, Attilio Turchetta, Giulia Cafiero, Alessio Franceschini, Marcello Chinali, Ottavia Porzio, Aurelio Secinaro, Paolo Palma

  1. The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. J Clin invest. 2023 Jan 3;133(1):e163235. doi: 10.1172/JCI163235.

Mehdi Benamar, Qian Chen, Janet Chou, Amélie M Julé, Rafik Boudra, Paola Contini, Elena Crestani, Peggy S Lai, Muyun Wang, Jason Fong, Shira Rockwitz, Pui Lee, Tsz Man Fion Chan, Ekin Zeynep Altun, Eda Kepenekli, Elif Karakoc-Aydiner, Ahmet Ozen, Perran Boran, Fatih Aygun, Pinar Onal, Ayse Ayzit Kilinc Sakalli, Haluk Cokugras, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Yuelin Zhong, Maria Lucia Taylor, Katherine Irby, Natasha B Halasa, Elizabeth H Mack; Overcoming COVID-19 Investigators; Sara Signa, Ignazia Prigione, Marco Gattorno, Nicola Cotugno, Donato Amodio, Raif S Geha, Mary Beth Son, Jane Newburger, Pankaj B Agrawal, Stefano Volpi, Paolo Palma, Ayca Kiykim, Adrienne G Randolph, Gunnur Deniz, Safa Baris, Raffaele De Palma, Klaus Schmitz-Abe, Louis-Marie Charbonnier , Lauren A Henderson, Talal A Chatila

  1. Targeted treatment of autoimmune cytopenias in primary immunodeficiencies. Front. Immunol., 16 August 2022. https://doi.org/10.3389/fimmu.2022.911385

Lucia Pacillo, Giuliana Giardino, Donato Amodio, Carmela Giancotta, Beatrice Rivalta, Gioacchino Andrea Rotulo, Emma Concetta Manno, Cristina Cifaldi, Giuseppe Palumbo, Claudio Pignata, Paolo Palma, Paolo Rossi, Andrea Finocchi and Caterina Cancrini

  1. SARS-CoV-2 infection and treatment in a cohort of patients with inborn errors of immunity. 01 August 2022. https://doi.org/10.1111/pai.13833

Francesca Conti, Lucia Pacillo, Donato Amodio, Beatrice Rivalta, Mattia Moratti, Caterina Campoli, Daniele Zama, Ilaria Corsini, Carmela Giancotta, Stefania Bernardi, Samuele Naviglio, Maria Pia Cicalese, Marco Rabusin, Alessandro Aiuti, Caterina Cancrini, Marcello Lanari, Pierluigi Viale, Paolo Palma, Andrea Pession, Andrea Finocchi (Donato Amodio: corresponding author)

  1. Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait? Front. Immunol., 29 July 2022. https://doi.org/10.3389/fimmu.2022.919237

Maria Chiriaco*, Giorgiana Madalina Ursu*, Donato Amodio*, Nicola Cotugno*, Stefano Volpi, Francesco Berardinelli, Simone Pizzi, Cristina Cifaldi, Matteo Zoccolillo, Ignazia Prigione, Silvia Di Cesare, Carmela Giancotta, Elisa Anastasio, Beatrice Rivalta, Lucia Pacillo, Paola Zangari, Alessandro G. Fiocchi, Andrea Diociaiuti, Alessandro Bruselles, Francesca Pantaleoni, Andrea Ciolfi, Valentina D’Oria, Giuseppe Palumbo, Marco Gattorno, Maya El Hachem, Jean-Pierre de Villartay, Andrea Finocchi, Paolo Palma, Paolo Rossi, Marco Tartaglia, Alessandro Aiuti, Antonio Antoccia, Gigliola Di Matteo and Caterina Cancrini

  1. Secondary cytomegalovirus infections: How much do we still not know? Comparison of children with symptomatic congenital cytomegalovirus born to mothers with primary and secondary infection. Front. Pediatr., 19 July 2022. https://doi.org/10.3389/fped.2022.885926

Fabiola Scaramuzzino, Michela Di Pastena, Sara Chiurchiu, Lorenza Romani, Maia De Luca, Giulia Lucignani, Donato Amodio, Annalisa Seccia, Pasquale Marsella, Teresa Grimaldi Capitello, Daniela Longo, Paolo Palma, Laura Lancella, Stefania Bernardi, Paolo Rossi and Francesca Ippolita Calo Carducci

  1. Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History. Vaccines 2022, 10(7), 1136; https://doi.org/10.3390/vaccines10071136

Veronica Santilli, Emma Concetta Manno, Carmela Giancotta, Chiara Rossetti, Nicola Cotugno, Donato Amodio, Gioacchino Andrea Rotulo, Annalisa Deodati, Roberto Bianchi, Giulia Lucignani, Daniela Longo, Massimiliano Valeriani and Paolo Palma

  1. Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens. Vaccines 2022, 10(7), 1109; https://doi.org/10.3390/vaccines10071109

Nicola Cotugno, Enrica Franzese, Giulia Angelino, Donato Amodio, Erminia Francesca Romeo, Francesca Rea, Simona Faraci, Renato Tambucci, Elisa Profeti, Emma Concetta Manno, Veronica Santilli, Gioacchino Andrea Rotulo, Chiara Pighi, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Giuseppe Rubens Pascucci, Diletta Valentini, Alberto Villani, Paolo Rossi, Paola De Angelis and Paolo Palma

  1. Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment. Front. Immunol., 21 June 2022; https://doi.org/10.3389/fimmu.2022.891274

Beatrice Rivalta*, Donato Amodio*, Carmela Giancotta, Veronica Santilli, Lucia Pacillo, Paola Zangari, Nicola Cotugno, Emma Concetta Manno, Andrea Finocchi, Stefania Bernardi, Luna Colagrossi, Leonarda Gentile, Cristina Russo, Carlo Federico Perno, Paolo Rossi, Caterina Cancrini and Paolo Palma

  1. COVID-19 in children: From afterthought to unknown. Cell Reports Medicine, 2022, 3(3), 100558

Donato Amodio, Nicola Cotugno, Paolo Palma

  1. Perinatally HIV-infected adolescents and young adults demonstrate distinct BNT162b2 mRNA COVID-19 vaccine immunogenicity. Clin Infect Dis. 2022 Jun 23;ciac408. Doi: 10.1093/cid/ciac408

Elena Morrocchi, Chiara Pighi, Giuseppe Rubens Pascucci, Nicola Cotugno, Chiara Medri, Donato Amodio, Luna Colagrossi, Alessandra Ruggiero, Emma Concetta Manno, Chiara Casamento Tumeo, Stefania Bernardi, Kinga K Smolen, Carlo Federico Perno, Al Ozonoff, Paolo Rossi, Ofer Levy, Paolo Palma

  1. Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA Cells 2021, 10(10), 2541; doi: 10.3390/cells10102541

Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgi, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina, Rita Carsetti

  1. Humoral and cellular response following vaccination with BNT162b2 mRNA COVID-19 Vaccine in Patients affected by Primary Immunodeficiencies. Front. Immunol. | doi: 10.3389/fimmu.2021.727850

Donato Amodio, Alessandra Ruggiero, Mayla Sgrulletti, Chiara Pighi, Nicola Cotugno, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Cristina Russo, Salvatore Zaffina, Gigliola Di Matteo, Cristina Cifaldi, Silvia Di Cesare, Beatrice Rivalta, Lucia Pacillo, Veronica Santilli, Carmela Giancotta, Emma Concetta Manno, Marta Ciofi Degli Atti, Massimiliano Raponi, Paolo Rossi, Andrea Finocchi, Caterina Cancrini, Carlo Federico Perno, Viviana Moschese, Paolo Palma

  1. BNT162b2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed? Transplantation 2022; 106(2): e158-e160. doi: 10.1097/TP.0000000000003999

Nicola Cotugno, Chiara Pighi, Elena Morrocchi, Alessandra Ruggiero, Donato Amodio, Chiara Medri, Luna Colagrossi, Cristina Russo, Silvia Di Cesare, Veronica Santilli, Emma Concetta Manno, Paola Zangari, Carmela Giancotta, Stefania Bernardi, Luciana Nicolosi, Marta Ciofi Degli Atti, Massimiliano Raponi, Salvatore Zaffina, Sara Alfieri, Richard Kirk, Carlo Federico Perno, Paolo Rossi, Antonio Amodeo, Paolo Palma

  1. Clinical, immunological and molecular variability of RAG deficiency: a retrospective analysis of 22 RAG patients. J Clin Immunol. 2022 Jan;42(1):130-145. doi: 10.1007/s10875-021-01130-3.

Cristina Cifaldi*, Beatrice Rivalta*, Donato Amodio*, Algeri Mattia*, Lucia Pacillo, Silvia Di Cesare, Maria Chiriaco, Giorgiana Madalina Ursu, Nicola Cotugno, Carmela Giancotta, Emma C Manno, Veronica Santilli, Paola Zangari, Galaverna Federica, Giuseppe Palumbo, Pietro Merli, Paolo Palma, Paolo Rossi, Gigliola Di Matteo, Franco Locatelli, Andrea Finocchi, Caterina Cancrini

  1. TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different non-malignant disorders. Blood Adv. 2022 Jan 11;6(1):281-292. doi: 10.1182/bloodadvances.2021005628.

Pietro Merli, Daria Pagliara, Federica Galaverna, Giuseppina Li Pira, Marco Andreani, Giovanna Leone, Donato Amodio, Rita Maria Pinto, Alice Bertaina, Valentina Bertaina, Angela Mastronuzzi, Luisa Strocchio, Emilia Boccieri, Daniela Pende, Michela Falco, Matteo Di Nardo, Francesca Del Bufalo, Mattia Algeri, Franco Locatelli

  1. Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-Up. Front Pediatr. 2021 Aug 27;9:703853. doi: 10.3389/fped.2021.703853.

Beatrice Rivalta, Donato Amodio, Cinzia Milito, Maria Chiriaco, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Veronica Santilli, Lucia Pacillo, Cristina Cifaldi, Maria Giovanna Desimio, Margherita Doria, Isabella Quinti, Rita De Vito, Gigliola Di Matteo, Andrea Finocchi, Paolo Palma, Antonino Trizzino, Alberto Tommasini, Caterina Cancrini (Donato Amodio: corresponding author)

  1. Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology. Pediatr Allergy Immunol. 2021 Nov;32(8):1833-1842. doi: 10.1111/pai.13585.

Nicola Cotugno, Alessandra Ruggiero, Giuseppe Rubens Pascucci, Francesco Bonfante, Maria Raffaella Petrara, Chiara Pighi, Loredana Cifaldi, Paola Zangari, Stefania Bernardi, Laura Cursi, Veronica Santilli, Emma Concetta Manno, Donato Amodio, Giulia Linardos, Livia Piccioni, Maria Antonietta Barbieri, Daniela Perrotta, Andrea Campana, Daniele Donà, Carlo Giaquinto, CACTUS Study Team; Carlo Concato, Petter Brodin, Paolo Ross, Anita De Rossi, Paolo Palma

  1. Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome Patients. Front Immunol. 2021 Jun 1;12:669893. doi: 10.3389/fimmu.2021.669893.

Genni Enza Marcovecchio, Francesca Ferrua, Elena Fontana, Stefano Beretta, Marco Genua, Ileana Bortolomai, Anastasia Conti, Davide Montin, Maria Teresa Cascarano, Sonia Bergante, Veronica D'Oria, Alessandro Giamberti, Donato Amodio, Caterina Cancrini, Adriano Carotti, Raffaella Di Micco, Ivan Merelli, Marita Bosticardo, Anna Villa

  1. Gastric cancer, inflammatory bowel disease and polyautoimmunity in a 17-year-old boy: CTLA-4 deficiency successfully treated with Abatacept. Eur J Gastroenterol Hepatol . 2021 Dec 1;33(1S Suppl 1):e1051-e1056. doi: 10.1097/MEG.0000000000002185.

Giulia Angelino, Cristina Cifaldi, Paola Zangar, Silvia Di Cesare, Gigliola Di Matteo, Maria Chiriaco, Paola Francalanci, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Donato Amodio, Giorgiana Madalina Ursu, Arianna Bertocchini, Antonella Accinni, Alessandro Crocoli, Alessandro Inserra, Raffaele Cozza, Claudio Romano, Maria Licciardello, Martina Rinelli, Luigi Dall'Oglio, Caterina Cancrini, Paola De Angelis , Andrea Finocchi

  1. Initial Presenting Manifestations In 16,486 Patients With Inborn Erros Of Immunity Include Infectious And Noninfectious Manifestations J Allergy Clin Immunol. 2021 Nov;148(5):1332-1341.e5. doi: 10.1016/j.jaci.2021.04.015.

Julian Thalhammer, Gerhard Kindle, Alexandra Nieters, Stephan Rusch, Mikko R J Seppänen, Alain Fischer, Bodo Grimbacher, David Edgar, Matthew Buckland, Nizar Mahlaoui, Stephan Ehl, European Society for Immunodeficiencies Registry Working Party

  1. VIROLOGICAL AND IMMUNOLOGICAL FEATURES OF SARS-CoV-2 INFECTED CHILDREN DEVELOPING SPECIFIC AND NEUTRALIZING ANTIBODIES 2021 Mar 16;34(11):108852.  doi: 10.1016/j.celrep.2021.108852.

Nicola Cotugno, Alessandra Ruggiero, Francesco Bonfante, Maria Raffaella Petrara, Sonia Zicari, Giuseppe Rubens Pascucci, Paola Zangari, Maria Antonietta De Ioris, Veronica Santilli, E C Manno, Donato Amodio, Alessio Bortolami, Matteo Pagliari, Carlo Concato, Giulia Linardos, Andrea Campana, Daniele Donà, Carlo Giaquinto, CACTUS Study Team; Petter Brodin, Paolo Rossi, Anita De Rossi, Paolo Palma

  1. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19, Cell. 2020 Nov 12;183(4):968-981.e7. doi: 10.1016/j.cell.2020.09.016.

Camila Rosat Consiglio*, Nicola Cotugno*, Fabian Sardh*, Christian Pou*, Donato Amodio*, Lucie Rodriguez, Ziyang Tan, Sonia Zicari, Alessandra Ruggiero, Giuseppe Rubens Pascucci, Veronica Santilli, Tessa Campbell, Yenan Bryceson, Daniel Eriksson, Jun Wang, Alessandra Marchesi, Tadepally Lakshmikanth, Andrea Campana, Alberto Villani Paolo Rossi, CACTUS Study Team; Nils Landegren, Paolo Palma, Petter Brodin

  1. Artificial Intelligence Applied to in vitro Gene Expression Testing (IVIGET) to Predict Trivalent Inactivated Influenza Vaccine Immunogenicity in HIV Infected Children Front Immunol. 2020 Oct 5;11:559590. doi: 10.3389/fimmu.2020.559590.

Nicola Cotugno, Veronica Santilli, Giuseppe Rubens Pascucci, Emma Concetta Manno, Lesley De Armas, Suresh Pallikkuth, Annalisa Deodati, Donato Amodio, Paola Zangari, Sonia Zicari, Alessandra Ruggiero, Martina Fortin, Christina Bromley, Rajendra Pahwa, Paolo Rossi, Savita Pahwa, Paolo Palma 

  1. Consensus of the Italian Primary Immunodeficiency Network on Transition Management from Pediatric to Adult Care in Patients Affected with Childhood Onset Inborn Errors of Immunity. J Allergy Clin Immunol. 2020 Nov;146(5):967-983.  doi: 10.1016/j.jaci.2020.08.010.

Emilia Cirillo, Giuliana Giardino, Silvia Ricci, Viviana Moschese, Vassilios Lougaris, Francesca Conti, Chiara Azzari, Federica Barzaghi, Clementina Canessa, Baldassarre Martire, Raffaele Badolato, Laura Dotta, Annarosa Soresina, Caterina Cancrini, Andrea Finocchi, Davide Montin, Roberta Romano, Donato Amodio, Francesca Ferrua, Alberto Tommasini, Lucia Augusta Baselli, Rosa Maria Dellepiane, Agata Polizzi, Luciana Chessa, Antonio Marzollo, Maria Pia Cicalese, Maria Caterina Putti, Andrea Pession, Alessandro Aiuti, Franco Locatelli, Alessandro Plebani, Claudio Pignata

  1. Partial T cell defects and expanded CD56bright NK cells in an SCID patient carrying hypomorphic mutation in the IL2RG gene. Leukoc Biol. 2020 Aug;108(2):739-748. doi: 10.1002/JLB.5MA0220-239R.

Cristina Cifaldi, Nicola Cotugno, Silvia Di Cesare, Silvia Giliani, Gigliola Di Matteo, Donato Amodio, Eva Piano Mortari, Maria Chiriaco, Danilo Buonsenso, Paola Zangari, Daria Pagliara, Stefania Gaspari, Rita Carsetti, Paolo Palma, Andrea Finocchi, Franco Locatelli, Paolo Rossi, Margherita Doria, Caterina Cancrini

  1. How to dissect the plasticity of antigen-specific immune response: a tissue perspective. Amodio et al. Clin Exp Immunol. 2020 Feb;199(2):119-130. doi: 10.1111/cei.13386.

D Amodio, V Santilli, P Zangari, N Cotugno, E C Manno, S Rocca, P Rossi, C Cancrini, A Finocchi, A Chassiakos, C Petrovas, P Palma

  1. Phenotypical T Cell Differentiation Analysis: A Diagnostic and Predictive Tool in the Study of Primary Immunodeficiencies. Front Immunol. 2019 Nov 29;10:2735. doi: 10.3389/fimmu.2019.02735

Enrico Attardi, Silvia Di Cesare, Donato Amodio, Carmela Giancotta, Nicola Cotugno, Cristina Cifaldi, Maria Chiriaco, Paolo Palma, Andrea Finocchi, Gigliola Di Matteo, Paolo Rossi, Caterina Cancrini

  1. Novel Compound Heterozygous Mutations in IL-7 Receptor α Gene in a 15-Month-Old Girl Presenting With Thrombocytopenia, Normal T Cell Count and Maternal Engraftment. Front Immunol. 2019 Oct 30;10:2471. doi: 10.3389/fimmu.2019.02471

Paola Zangari, Cristina Cifaldi, Silvia Di Cesare, Gigliola Di Matteo, Maria Chiriaco, Donato Amodio, Nicola Cotugno, Maia De Luca, Cecilia Surace, Saverio Ladogana, Simone Gardini, Pietro Merli, Mattia Algeri, Paolo Rossi, Paolo Palma, Caterina Cancrini, Andrea Finocchi

  1.  Immunophenotype Anomalies Predict the Development of Autoimmune Cytopenia in 22q11.2 Deletion Syndrome. J Allergy Clin Immunol Pract. Sep-Oct 2019;7(7):2369-2376. doi: 10.1016/j.jaip.2019.03.014.

Davide Montin, Agostina Marolda, Francesco Licciardi, Francesca Robasto, Silvia Di Cesare, Emanuela Ricotti, Francesca Ferro, Giacomo Scaioli, Carmela Giancotta, Donato Amodio, Francesca Conti, Giuliana Giardino, Lucia Leonardi, Silvia Ricci, Stefano Volpi, Lucia Augusta Baselli, Chiara Azzari, Grazia Bossi, Rita Consolini, Rosa Maria Dellepiane, Marzia Duse, Marco Gattorno, Baldassarre Martire, Maria Caterina Putti, Annarosa Soresina, Alessandro Plebani, Ugo Ramenghi, Silvana Martino, Claudio Pignata, Caterina Cancrini

  1. OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines. J Immunol Res. 2019 Apr 28;2019:8732191. doi: 10.1155/2019/8732191.

Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J Pollard, Paolo Palma

  1. Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development. Front Immunol. 2019 Mar 15;10:447. doi: 10.3389/fimmu.2019.00447

Genni Enza Marcovecchio, Ileana Bortolomai, Francesca Ferrua, Elena Fontana, Luisa Imberti, Erika Conforti, Donato Amodio, Sonia Bergante, Giulia Macchiarulo, Veronica D'Oria, Francesca Conti, Silvia Di Cesare, Georgia Fousteri, Adriano Carotti, Alessandro Giamberti, Pietro Luigi Poliani, Luigi D Notarangelo, Caterina Cancrini, Anna Villa, Marita Bosticardo

  1. Distinct gut microbiota profile in ART-treated perinatally HIV-infected patients associated with cardiac and inflammatory biomarkers. AIDS. 2019 May 1;33(6):1001-1011. doi: 10.1097/QAD.0000000000002131.

Libera Sessa, Sofia Reddel, Emma Manno, Andrea Quagliariello, Nicola Cotugno, Federica Del Chierico, Donato Amodio, Claudia Capponi, Fabrizio Leone, Stefania Bernardi, Paolo Rossi, Lorenza Putignani, Paolo Palma

  1. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018 Jan 15;200(2):538-550. doi: 10.4049/jimmunol.1701312.

Donato Amodio, Nicola Cotugno, Giulia Macchiarulo, Salvatore Rocca, Yiannis Dimopoulos, Maria Rita Castrucci, Rita De Vito, Filippo M Tucci, Adrian B McDermott, Sandeep Narpala, Paolo Rossi, Richard A Koup, Paolo Palma, Constantinos Petrovas

  1. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infect Dis. 2017 Apr 24;17(1):302. doi: 10.1186/s12879-017-2396-7.

Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte, Luca Gramatica, Marco Ciabattini, Susanna Livadiotti, Paolo Rossi

  1. Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: a systematic review.” Ital J Pediatr. 2016 Apr 27;42:44. doi: 10.1186/s13052-016-0242-y.

Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Francesca Calò Carducci, Alessandro Jenkner, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Alessandra Simonetti, Elena Ferretti, Martina Della Corte, Luca Gramatica, Susanna Livadiotti, Paolo Rossi

  1. Expansion of actTreg cells inversely correlates with clinical severity in septic neonates” Journal of allergy and clinical immunology. J Allergy Clin Immunol. 2016 May;137(5):1617-1620.e6. doi: 10.1016/j.jaci.2015.10.048.

Eleonora Timperi, Laura Folgori, Donato Amodio, Maia De Luca, Sara Chiurchiù, Silvia Piconese, Silvia Di Cesare, Ilenia Pacella, Carmela Martire, Giulia Bonatti, Seila Perrone, Terenzio Boni, Genni Enza Marcovecchio, Antonino Reale, Francesco Parisi, Andrea Dotta, Vincenzo Barnaba, Paolo Rossi

  1. Pituicytoma and Cushing’s Disease in a 7-Year-Old Girl: A Mere Coincidence?” Pediatrics. 2015 Dec;136(6):e1632-6. doi: 10.1542/peds.2015-0638.

Paola Cambiaso, Donato Amodio, Emidio Procaccini, Daniela Longo, Stefania Galassi, Francesca Diomedi Camassei, Marco Cappa

  1. Serum Soluble ST2 as Diagnostic Marker of Systemic Inflammatory Reactive Syndrome of Bacterial Etiology in Children. Pediatr Infect Dis J. 2014 Feb;33(2):199-203. doi: 10.1097/INF.0000000000000030.

Francesca Ippolita Calò Carducci, Lelia Rotondi Aufiero, Laura Folgori, Anna Chiara Vittucci, Donato Amodio, Maia De Luca, Giuseppina Li Pira, Alberto Bergamini, Giuseppe Pontrelli, Andrea Finocchi, Patrizia D'Argenio

  1. Granulicatella bacteraemia in children: two cases and review of the literature. BMC Pediatr. 2013 Apr 22;13:61. doi: 10.1186/1471-2431-13-61.

Maia De Luca, Donato Amodio, Sara Chiurchiù, Maria Assunta Castelluzzo, Gabriele Rinelli, Paola Bernaschi, Francesca Ippolita Calò Carducci, Patrizia D'Argenio

  1. Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors. BMC Infect Dis. 2012 Jan 23;12:18. doi: 10.1186/1471-2334-12-18.

Giuseppe Pontrelli, Nicola Cotugno, Donato Amodio, Paola Zangari, Hyppolite K Tchidjou, Stefania Baldassari, Paolo Palma, Stefania Bernardi

  1. Fulminant Fusobacterium necrophorum meningitis in an immunocompetent adolescent. Pediatr Emerg Care. 2012 Jul;28(7):703-4. doi: 10.1097/PEC.0b013e31825d23fb.

Giulia Angelino, Nicoletta Cantarutti, Sara Chiurchiù, Donato Amodio, Maia De Luca, Laura Lancella, Luana Coltella, Cristina Russo, Andrea Finocchi

 

 

 

The European Society of immunodeficiencies ESID 2021 Online Symposium

 

 

 

Sindrome da delezione 22q11.2 – Sindrome di Digeorge - Sindrome velo-cardio-facciale

 

Presentation at National and International Meetings

 

 

PERSONAL SKILLS AND COMPTENCES

 

Pediatric Basic Life Support and Defibrillation” instructor from 2013

“Pediatric Advanced Life Support” provider

Informatic: Office, Pubmed, GraphPad, Imaris, EpiInfo, Illustrator, FlowJo, NIS, Leica suites, NPX Manager.

Cellular biology: Cells activation, Elisa, Flowcytometry, Confocal Microscopy, Histocytometry, Proteomic

 

Mother Tongue

Other Languages

 

 

 

Italian

 

English

Reading Skils

Writing Skills

Verbal Skills

 

 

Effective Operational Proficiency

 

Effective Operational Proficiency

 

Effective Operational Proficiency

 

 

 

 

Si dichiara che quanto riportato corrisponde a verità, ai sensi degli articoli 46 e 47 del D.P.R. 445 del 2000

 

I authorize the treatment of my personal data art. 13 GDPR (RU 2016/679).                      Donato Amodio

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