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Nome: Serena Ammendola

Data di nascita: 23 giugno 1972

Nazionalità: Italiana

e-mail: serena.ammendola@uniroma2.it

Istruzione e carriera professionale

2022-oggi

Professore Associato di Microbiologia presso il Dipartimento di Biologia dell'Università di Roma Tor Vergata

2019-2022

Ricercatore presso il Dipartimento di Biologia dell'Università di Roma Tor Vergata.

2016

Abilitazione Scientifica Nazionale per Professore Associato, settore 05/I2 Microbiologia.

2004-2019

Post-doc e Ricercatore a Contratto presso il Dipartimento di Biologia, Università di Roma Tor Vergata (gruppo Prof. Andrea Battistoni)

2004

Dottorato di Ricerca in Biologia Cellulare e Molecolare, Università di Roma Tor Vergata

2001

Corso avanzato di genetica batterica, Cold Spring Harbor Laboratory (NY, USA)

1997

Laurea Magistrale in Biologia, Università di Roma Tor Vergata (110/110 e lode)

 

Principali linee di ricerca in corso

Meccanismi di regolazione dell’omeostasi dei metalli di transizione nei batteri patogeni, ed in particolare:

·       Caratterizzazione biochimica e funzionale dei sistemi di importo dello zinco in Salmonella enterica e Pseudomonas aeruginosa;

·       Analisi di applicazioni terapeutiche basate sull'interferenza dell'omeostasi dello zinco in batteri patogeni;

·       Ruolo dei metalli nelle interazioni Salmonella-pianta.

 

Pubblicazioni (ultimi 4 anni)

·      Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14(1):7526.

·      Secli V, Di Biagio C, Martini A, Michetti E, Pacello F, Ammendola S, Battistoni A. Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes 2023 Int J Mol Sci. 4;24(2):944.

·      Ammendola S, Micallef SA, Schikora A. Editorial: Dealing with unusual hosts and unconventional habitats: versatile strategies of Salmonella enterica. Front Microbiol. 2023;14:1342139.

·      Iacovelli F, Romeo A, Lattanzio P, Ammendola S, Battistoni A, La Frazia S, Vindigni G, Unida V, Biocca S, Gaziano R, Divizia M, Falconi M. Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations. 2023 Int J Mol Sci. 4;24(15):12432.

·      Ammendola S, Battistoni A. New Insights into the Role of Metals in Host-Pathogen Interactions 2022 Int J Mol Sci. 10;23(12):6483.

·      Visconti S, Astolfi ML, Battistoni A, Ammendola S. Impairment of the Zn/Cd detoxification systems affects the ability of Salmonella to colonize Arabidopsis thaliana. 2022 Front Microbiol. 22;13:975725.

·      Ammendola S, Secli V, Pacello F, Mastropasqua MC, Romão MA, Gomes CM, Battistoni A. Zinc-binding metallophores protect Pseudomonas aeruginosa from calprotectin-mediated metal starvation 2022 FEMS Microbiol Lett. 16;369(1)

·      Fiorillo, A., Battistoni, A., Ammendola, S., Secli, V., Rinaldo, S., Cutruzzola`, F., Demitri, N. & Ilari, A. Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa 2021. Acta Crystallogr D Struct Biol. 2021 1;77(Pt 11):1401-1410..

·      Ammendola S, Secli V, Pacello F, Bortolami M, Pandolfi F, Messore A, Di Santo R, Scipione L, Battistoni A. Salmonella Typhimurium and Pseudomonas aeruginosa Respond Differently to the Fe Chelator Deferiprone and to Some Novel Deferiprone Derivatives. 2021 Int. J. Mol.  Sci. Volume: 22, Issue: 19, pp 10217

·      Ammendola S*, Ciavardelli D , Consalvo A , Battistoni A. Cobalt can fully recover the phenotypes related to zinc deficiency in Salmonella Typhimurium. Metallomics. 2020 Dec 23;12(12):2021-2031.. *corresponding author

 

Attività editoriali

Guest editor per lo Special Issue "Transition Metals in the Host-Pathogen Interaction" in International Journal of Molecular Science, sezione "Molecular Microbiology".

Guest editor per il Research Topic "Dealing with unusual hosts and unconventional habitats: versatile strategies of Salmonella enterica" in Frontiers in Microbiology

Revisore per Frontiers in Microbiology, International Journal of Molecular Science, Microorganisms, Biological Trace Element Research, Antibiotics, Scientific Report, Gut Microbes

 

Affiliazioni a società scientifiche

2020/oggi

SIM - Società Italiana di Microbiologia

2023/oggi

SIMGBM - Società Italiana di Microbiologia e Biotecnologie Microbiche

2024/oggi

Microbiology Society

 

Attività didattiche

2021/oggi

Microbial Technology (M.Sc. Biotechnology – Università di Roma Tor Vergata)

Microbiologia Generale (B.S. Biotecnologie – Università di Roma o Vergata)

2019/2021

Microbial Technology (M.Sc. Biotechnology – Università di Roma Tor Vergata)

2016/2018

Methods for genetic modification of bacteria (M.Sc. Biotechnology – Università di Roma Tor Vergata)

 

Name: Serena Ammendola

Date of Birth: 23 June 1972

Nationality: Italian

e-mail: serena.ammendola@uniroma2.it

 

Education and Professional Career

2022-present

Associate Professor of Microbiology  at the Department of Biology of Tor Vergata University of Rome

2019-2022

Researcher at the Department of Biology of Tor Vergata University of Rome.

2016

National Scientific Habilitation for Associate Professor, sector 05/I2 Microbiology.

2004-2019

Post-doc and Contract Researcher at the Department of Biology, Tor Vergata University of Rome (Prof. Andrea Battistoni group)

2004

PhD in Cellular and Molecular Biology, Tor Vergata University of Rome

2001

Advanced Bacterial Genetics Course, Cold Spring Harbor Laboratory (NY, USA)

1997

Master Degree in Biology,  Tor Vergata University of Rome (110/110 cum laude)

 

Current Research

Regulatory mechanisms of transition metal homeostasis in pathogenic bacteria, focusing on:

·      Biochemical and functional characterization of zinc import systems in Salmonella enterica and Pseudomonas aeruginosa;

·      Analysis of therapeutic applications based on the interference of zinc homeostasis in pathogenic bacteria;

·      Role of metals in Salmonella -plant interactions.

 

Publications (last 4 years)

Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14(1):7526.

Secli V, Di Biagio C, Martini A, Michetti E, Pacello F, Ammendola S, Battistoni A. Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes 2023 Int J Mol Sci. 4;24(2):944.

Ammendola S, Micallef SA, Schikora A. Editorial: Dealing with unusual hosts and unconventional habitats: versatile strategies of Salmonella enterica. Front Microbiol. 2023;14:1342139.

Iacovelli F, Romeo A, Lattanzio P, Ammendola S, Battistoni A, La Frazia S, Vindigni G, Unida V, Biocca S, Gaziano R, Divizia M, Falconi M. Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations. 2023 Int J Mol Sci. 4;24(15):12432.

Ammendola S, Battistoni A. New Insights into the Role of Metals in Host-Pathogen Interactions 2022 Int J Mol Sci. 10;23(12):6483.

Visconti S, Astolfi ML, Battistoni A, Ammendola S. Impairment of the Zn/Cd detoxification systems affects the ability of Salmonella to colonize Arabidopsis thaliana. 2022 Front Microbiol. 22;13:975725.

Ammendola S, Secli V, Pacello F, Mastropasqua MC, Romão MA, Gomes CM, Battistoni A. Zinc-binding metallophores protect Pseudomonas aeruginosa from calprotectin-mediated metal starvation 2022 FEMS Microbiol Lett. 16;369(1)

Fiorillo, A., Battistoni, A., Ammendola, S., Secli, V., Rinaldo, S., Cutruzzola`, F., Demitri, N. & Ilari, A. Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa 2021. Acta Crystallogr D Struct Biol. 2021 1;77(Pt 11):1401-1410..

Ammendola S, Secli V, Pacello F, Bortolami M, Pandolfi F, Messore A, Di Santo R, Scipione L, Battistoni A. Salmonella Typhimurium and Pseudomonas aeruginosa Respond Differently to the Fe Chelator Deferiprone and to Some Novel Deferiprone Derivatives. 2021 Int. J. Mol.  Sci. Volume: 22, Issue: 19, pp 10217

Ammendola S*, Ciavardelli D , Consalvo A , Battistoni A. Cobalt can fully recover the phenotypes related to zinc deficiency in Salmonella Typhimurium. Metallomics. 2020 Dec 23;12(12):2021-2031.. *corresponding author

 

Editorial activities

Guest editorfor the Special Issue "Transition Metals in the Host-Pathogen Interaction" in International Journal of Molecular Science, section "Molecular Microbiology".

Guest Editorfor the Research Topic "Dealing with unusual hosts and unconventional habitats: versatile strategies of Salmonella enterica" in Frontiers in Microbiology

Reviewerfor Frontiers in Microbiology, International Journal of Molecular Science, Microorganisms, Biological Trace Element Research, Antibiotics, Scientific Report, Gut Microbes

 

Scientific society affiliation

2020/present

SIM - Società Italiana di Microbiologia

2023/present

SIMGBM - Società Italiana di Microbiologia e Biotecnologie Microbiche

2024/present

Microbiology Society

 

Teaching activities

2021/present

Microbial Technology (M.Sc. Biotechnology – University of Rome Tor Vergata)

General Microbiology (B.S. Biotecnology – University of Rome or Vergata)

2019/2021

Microbial Technology (M.Sc. Biotechnology – University of Rome Tor Vergata)

2016/2018

Methods for Genetic Modification of Bacteria (M.Sc. Biotechnology – University of Rome Tor Vergata)

 

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