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CURRICULUM VITAE ET STUDIORUM

Nome: Gianna Roscetti

Nata a: Roma

Data di nascita: 21 dicembre 1954

Cittadinanza: italiana

Diploma di Laurea: Scienze Biologiche

Formazione

27/6/1978: Diploma di Laurea in Scienze Biologiche, Universita' degli Studi di Roma, La Sapienza.

22/10/1982: Diploma di Specialista in Patologia Generale - Universita' degli Studi di Roma, La Sapienza.

Titoli di carriera

2/4/1990-1/2/2001: Funzionario Tecnico presso il Dipartimento di Medicina Sperimentale e Scienze Biochimiche e, dal 1998, presso il Dipartimento di Neuroscienze della Facolta’ di Medicina e Chirurgia - Universita' degli Studi di Roma, Tor Vergata.

1/2/2001 ad oggi: Ricercatore confermato presso il Dipartimento di Neuroscienze, poi Medicina dei Sistemi della Facolta’ di Medicina e Chirurgia - Universita' degli Studi di Roma, Tor Vergata.

Attivita' didattica

dal 1989 ad oggi: Modulo di Fisiologia Renale - Diploma di laurea in Medicina e Chirurgia - Universita' di Roma, Tor Vergata.

dal 1991 al 1996: Fisiologia dell'Apparato Urinario e Genitale Maschile - Scuola di Specializzazione in Urologia - Universita' di Roma, Tor Vergata.

Anno Accademico 2000/2001 e AA 2001-2002: Fisiologia Umana nel Corso di Laurea di I livello per Logopedisti.

Dall'Anno Accademico 2000-2001 fino all’AA 2012/2013: Fisiologia Umana - Corso di Laurea in Ingegneria Medica.

Anno Accademico 2001/2002 ad oggi: Fisiologia Umana - Corso di Laurea di I livello per Dietisti; Coordinatrice del Corso Integrato di Anatomo-Isto-Fisiologia per Dietisti.

Dal 2014-15: Fisiologia Umana nel 2 Tronco Comune

Attivita' di ricerca

Attualmente: presso il Dipartimento di Medicina dei Sistemi - Facolta’ di Medicina e Chirurgia, Universita’ di Roma, Tor Vergata svolge attivita’ di ricerca occupandosi in particolare dell’estrazione, caratterizzazione biochimica e isolamento di principi attivi da piante medicinali; del saggio di alcuni composti naturali cosi’ isolati su colture cellulari primarie e su cellule tumorali di linee nel quadro della ricerca sulla fitoterapia particolarmente in campo oncologico

L'attivita' di ricerca svolta e' attestata dall'elenco delle pubblicazioni che segue

GIANNA ROSCETTI - Pubblicazioni

1. O. Cherubini, V. De Marco, G. Roscetti, R. Possenti and L.G. Roda: In vitro interaction of opioid peptides with phospholipids: formation and characterization of complexes.-Int. J. Peptide Protein Res. 1984 Apr; 23(4):435-442

2. A. Caprioli, G. Donelli, V. Falbo, R. Possenti, L.G. Roda, G. Roscetti and F.M. Ruggeri: A cell division-active protein from E. coli.-Biochem. Biophys. Res. Comm. 1984 Jan; 118(2): 587-593

3. L.G. Roda, G. Roscetti, F. Venturelli, A. Tutino, E. Gilardi, F. Vita, B. Rapposelli: Idrolisi e controllo dell'idrolisi delle enkefaline periferiche.-Quaderni Marchigiani di Medicina 3, 145-152, 1985.

4. F. Venturelli, G. Roscetti, R. Possenti, F. Vita and L.G. Roda: Peripheral enkephalin hydrolysis in different animal species: a comparative study.-Neurochem. Res. 1985 Mar; 10(3): 333-342, .

5. G. Roscetti, R. Possenti, E. Bassano and L.G. Roda: Mechanisms of leu enkephalin hydrolysis in human plasma.-Neurochem. Res. 1985 Oct; 10(10): 1393-1404

6. F. Venturelli, E. Gilardi, G. Roscetti, G. Laugesen, P.F.A. Barra and L.G. Roda: Control mechanisms of peripheral enkephalin hydrolysis in mammalian plasma.-Compar. Biochem. Physiol. [C] 1986; 83(2): 307-311

7. L.G. Roda, G. Roscetti, R. Possenti, F. Venturelli and F. Vita: Control mechanisms in the enzyme hydrolysis of adrenal released enkephalins.-In: "Enkephalins and endorphins: stress and the immune system", Edited by N.P. Plotnikoff, R.E. Faith, A.J. Murgo, R.A. Good.-Plenum press, New York, p. 17-33, 1986.

8. C. Zona, G. Roscetti, F. Venturelli and L.G. Roda: Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin.-Pharmacol. Biochem. Behav. 1986 Apr; 24(4): 1031-1037

9. F. Vita, F. Venturelli, G. Roscetti and L.G. Roda: In vitro interaction of opioid peptides with phospholipids. III. the role of lipids.-Int. J. Peptide Protein Res. 1986 Sep; 28(3): 220-229

10. L.G. Roda, F. Venturelli and G. Roscetti: Hydrolysis and protection from hydrolysis of circulating enkephalins.-Compar. Biochem. Physiol. [C] 1986; 85(2): 449-454

11. F. Venturelli, G. Roscetti and L.G. Roda: Mechanisms protecting plasma peptides from enzyme hydrolysis: a comparative study.-Compar. Biochem. Physiol. [B] 1987; 87(3): 485-488

12. G. Roscetti, F. Venturelli and L.G. Roda: Enkephalin binding systems in human plasma III: comparative protection of different peptides.-Neurochem. Res. 1988 Mar; 13(3): 221-224

13. G. Roscetti, C.M. Ausiello, C. Palma, P. Gulla' and L.G. Roda: Enkephalin activity on antigen-induced proliferation of human peripheral blood mononucleate cells.-Int. J. Immunopharmacol. 1988; 10(7): 819-823

14. M. Marini, G. Roscetti, L. Bongiorno, A. Urbani and L.G. Roda: Hydrolysis and protection from hydrolysis of enkephalins in human plasma.-Neurochem. Res. 1990 Jan; 15(1): 61-67

15. M. D'Alagni, P. Gulla',L.G. Roda and G. Roscetti: In vitro interaction of the opioid peptides with phospholipids, IV: met-enkephalin versus leucine enkephalin.-Int. J. Peptide Prot. Res. 1990 Apr; 35(4): 328-335

16. G. Roscetti, L. Bongiorno, A. Urbani, M. Marini and L.G. Roda: Hydrolysis and binding of leucine enkephalin to lymphomic and erythroleukaemic cell lines.-Int. J. Immunopharmacol. 1990; 12(4): 391-396

17. M.L. Barbaccia, G. Roscetti, M. Trabucchi, C. Ambrosio and M. Massotti: Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces.-Eur. J. Pharmacol. 1992 Sep; 219(3): 485-486

18. G. Biggio, T. Cuccheddu, S. Floris, E. Sanna, M.L. Barbaccia, G. Roscetti, M. Serra and A. Concas: Stress and GABAergic transmission in the rat brain: the effect of carbon dioxide inhalation.-In: "Anxiety: Neurobiology, Clinic and Therapeutic Perspectives". (Eds.: M. Hamon, H. Ollat and M.H. Thiebot), John Libbey, vol. 232, p. 53-64, 1993

19. G. Roscetti, C. Ambrosio, M. Trabucchi, M. Massotti and M.L. Barbaccia: Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex.-Eur. J. Pharmacol. 1994 Sep; 269(1): 17-24

20. M.L. Barbaccia, G. Roscetti, M. Trabucchi, T. Cuccheddu, A. Concas and G. Biggio: Neurosteroids in the brain of handling- habituated and naive rats: effect of carbon dioxide inhalation.-Eur. J. Pharmacol. 1994 Aug; 261(3): 317-320

21. A. Concas, M.C. Mostallino, C. Perra, M.L. Barbaccia, G. Roscetti, R.H. Purdy and G. Biggio: Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylentetrazol or stress.-Br. J. Pharmacol. 1996 Jun; 118(4): 839-846 .

22. M.L. Barbaccia, G.Roscetti, M.Trabucchi, M.C.Mostallino, A.Concas, R.H.Purdy and G.Biggio: Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress.-Neuroendocrinology 1996 Feb; 63(2): 166-172

23. M.L.Barbaccia, G.Roscetti, F.Bolacchi, A.Concas, M.C.Mostallino, R.H.Purdy and G.Biggio: Stress induced increase in brain neuroactive steroids: antagonism by abecarnil.-Pharmacol. Biochem. Behav. 1996 May; 54(1): 205-210

24. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Perra C., Concas A. and Biggio G. Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain.-Neuropharmacology 1996; 35(9-10): 1299-1305

25. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Concas A. and Biggio G. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentration.-Br. J. Pharmacol. 1997 Apr; 120(8): 1582-1588

26. Roscetti G., Trabucchi M., Massotti M., Purdy R.H. and Barbaccia M.L. Modulation of neurosteroid synthesis/accumulation by L-ascorbic acid in rat brain tissue: inhibition by selected serotonin antagonists.-J. Neurochem. 1998 Sep; 71(3): 1108-1117

27. Roscetti G., Franzese O., Comandini A. and Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin-Phytotherapy Research 18, 66-72 (2004)

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CURRICULUM VITAE ET STUDIORUM

Name: Gianna Roscetti Born in Rome Date of Birth: 21 December 1954 Nationality: Italian Master Degree: Biological Sciences

Training 1973: High School Scientific Diploma 27/6/1978: Degree in Biological Sciences, University of Rome, La Sapienza. Apprenticeship: Istituto Zooprofilattico of Lazio and Tuscany, Rome and Policlinico Umberto I, University of Rome, La Sapienza

22/10/1982: Specialist Degree in General Pathology, University of Rome, La Sapienza 16-18/11/1987: IV Course of the School of Oncology and Biomedical Sciences, Cell cultures: basic techniques and applications in oncology, Villa Durazzo, S. Margherita Ligure (GE) 4-16/9/1992: International School of Neuroscience, 4th Course: Glia and Neuron-Glia Interactions, Fidia Research Foundation, Abano terme (PD) Academic Year 1995/96: 7th Course in Phytotherapy, University of Siena (SI) February 2002: registration to Italian Society of Phytotherapy October 2002: registration to Italian Society of Phytochemistry

February 9 and October 26, 2002: Course in New Uses of Medicinal Plants, University of Siena- Phytonutrients, the near nutrients in the diet and Plants, medicines and food: synergies and interactions October 9-10, 2002: School of Phytochemistry P.Ceccherelli Aloe: Recent Acquisitions, Riolo Terme (BO) September 28-30, 2006: School of Phytochemistry P. Ceccherelli Looking to the Green Gold, Perugia (PG) Career Titles 1979-1981: - supply teacher at state institutions of primary and secondary education - Winner of a competition to n.2 Assistant Biologist, Istituto Zooprofilattico of Lazio and Tuscany, Rome (Resolution 30/7/1979) - Winner of a competition at No. 3 scholarships, Instituto Zooprofilattico of Lombardia and Emilia, Brescia (BS)

1/7/1983-1/4/1990: Professional Training Course, National Research Council (exL285/77/350.0.2) 2/4/1990-1/2/2001: Graduate Technician Role (VIII level of functional status) Department of Experimental Medicine and Biochemical Science (since 1998, Department of Neurosciences) Faculty of Medicine and Surgery, University of Rome, Tor Vergata 1/2/2001 to date: Researcher at the Department of Neurosciences (then Systemic Medicine) Faculty of Medicine and Surgery, University of Rome, Tor Vergata Teaching Activities since 1989: Teachings activities in the course of Physiology, Faculty of Medicine and Surgery, University of Rome, Tor Vergata from 1991 to 1996: Annual cycles of seminars and examinations in the teaching of Physiology of the Urinary and Male Genital Apparatus, School of Specialization in Urology, University of Rome, Tor Vergata Academic Years 2000/2001 and 2001-2002: Teachings of Human Physiology, Bachelor’s Degree for Speech Pathology Academic Year 2000-2001 until 2006/2007: Teachings activities in Human Physiology, Degree in Bioengineering (Medical Engineering) Academic Year 2001/2002 to date: Teaching activities in Human Physiology, Bachelor’s Degree in Dietitian

Academic Years 2006-2007 to 2012: Teachings activities in Human Physiology, Degree in Bioengineering (Medical Engineering) Research Activities 1979-1981: post-graduate practical training: - at the Institute Zooprofilattico of Lazio and Tuscany, Rome, in the field of quality control and food fraud - At the University of Rome, La Sapienza, in the clinical field. 1982: at the Superior Institute of Health of Rome: research topic: study of a protein found in bacterial strains of E. coli with activity on mitotic division of Hela cells in culture. 1983: at the Technical Physiology chair (Faculty of Medicine and Surgery – University of Rome, La Sapienza): research topic: biochemical purification of E. coli protein.

1983-1990: at the Technical Physiology chair first and from 1984 at the Physiology chair of the Faculty of Medicine and Surgery – University of Rome, Tor Vergata: research themes: - opioid peptides, their enzymatic degradation and protection systems in human and animal plasma - opioid peptides in the dialogue between nervous system and immune system. 1991-1998: at the Pharmacology chair (Faculty of Medicine and Surgery – University of Rome, Tor Vergata): research themes: - role of neurosteroids in stress and in modulation of the GABAergic function – Blood steroids in elder diseases. Currently: at the Department of Systemic Medicine (Faculty of Medicine and Surgery, University of Rome, Tor Vergata): research activity addressing in particular to the extraction, isolation and biochemical characterization of active ingredients from medicinal plants of therapeuthic interest towards different field principally in oncology.  

GIANNA ROSCETTI - Publications   1. O. Cherubini, V. De Marco, G. Roscetti, R. Possenti and L.G. Roda: In vitro interaction of opioid peptides with phospholipids: formation and characterization of complexes.-Int. J. Peptide Protein Res. 1984 Apr; 23(4):435-442

2. A. Caprioli, G. Donelli, V. Falbo, R. Possenti, L.G. Roda, G. Roscetti and F.M. Ruggeri: A cell division-active protein from E. coli.-Biochem. Biophys. Res. Comm. 1984 Jan; 118(2): 587-593

3. L.G. Roda, G. Roscetti, F. Venturelli, A. Tutino, E. Gilardi, F. Vita, B. Rapposelli: Idrolisi e controllo dell'idrolisi delle enkefaline periferiche.-Quaderni Marchigiani di Medicina 3, 145-152, 1985.

4. F. Venturelli, G. Roscetti, R. Possenti, F. Vita and L.G. Roda: Peripheral enkephalin hydrolysis in different animal species: a comparative study.-Neurochem. Res. 1985 Mar; 10(3): 333-342, .

5. G. Roscetti, R. Possenti, E. Bassano and L.G. Roda: Mechanisms of leu enkephalin hydrolysis in human plasma.-Neurochem. Res. 1985 Oct; 10(10): 1393-1404

6. F. Venturelli, E. Gilardi, G. Roscetti, G. Laugesen, P.F.A. Barra and L.G. Roda: Control mechanisms of peripheral enkephalin hydrolysis in mammalian plasma.-Compar. Biochem. Physiol. [C] 1986; 83(2): 307-311

7. L.G. Roda, G. Roscetti, R. Possenti, F. Venturelli and F. Vita: Control mechanisms in the enzyme hydrolysis of adrenal released enkephalins.-In: "Enkephalins and endorphins: stress and the immune system", Edited by N.P. Plotnikoff, R.E. Faith, A.J. Murgo, R.A. Good.-Plenum press, New York, p. 17-33, 1986.

8. C. Zona, G. Roscetti, F. Venturelli and L.G. Roda: Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin.-Pharmacol. Biochem. Behav. 1986 Apr; 24(4): 1031-1037

9. F. Vita, F. Venturelli, G. Roscetti and L.G. Roda: In vitro interaction of opioid peptides with phospholipids. III. the role of lipids.-Int. J. Peptide Protein Res. 1986 Sep; 28(3): 220-229

10. L.G. Roda, F. Venturelli and G. Roscetti: Hydrolysis and protection from hydrolysis of circulating enkephalins.-Compar. Biochem. Physiol. [C] 1986; 85(2): 449-454

11. F. Venturelli, G. Roscetti and L.G. Roda: Mechanisms protecting plasma peptides from enzyme hydrolysis: a comparative study.-Compar. Biochem. Physiol. [B] 1987; 87(3): 485-488

12. G. Roscetti, F. Venturelli and L.G. Roda: Enkephalin binding systems in human plasma III: comparative protection of different peptides.-Neurochem. Res. 1988 Mar; 13(3): 221-224

13. G. Roscetti, C.M. Ausiello, C. Palma, P. Gulla' and L.G. Roda: Enkephalin activity on antigen-induced proliferation of human peripheral blood mononucleate cells.-Int. J. Immunopharmacol. 1988; 10(7): 819-823

14. M. Marini, G. Roscetti, L. Bongiorno, A. Urbani and L.G. Roda: Hydrolysis and protection from hydrolysis of enkephalins in human plasma.-Neurochem. Res. 1990 Jan; 15(1): 61-67

15. M. D'Alagni, P. Gulla',L.G. Roda and G. Roscetti: In vitro interaction of the opioid peptides with phospholipids, IV: met-enkephalin versus leucine enkephalin.-Int. J. Peptide Prot. Res. 1990 Apr; 35(4): 328-335

16. G. Roscetti, L. Bongiorno, A. Urbani, M. Marini and L.G. Roda: Hydrolysis and binding of leucine enkephalin to lymphomic and erythroleukaemic cell lines.-Int. J. Immunopharmacol. 1990; 12(4): 391-396

17. M.L. Barbaccia, G. Roscetti, M. Trabucchi, C. Ambrosio and M. Massotti: Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces.-Eur. J. Pharmacol. 1992 Sep; 219(3): 485-486

18. G. Biggio, T. Cuccheddu, S. Floris, E. Sanna, M.L. Barbaccia, G. Roscetti, M. Serra and A. Concas: Stress and GABAergic transmission in the rat brain: the effect of carbon dioxide inhalation.-In: "Anxiety: Neurobiology, Clinic and Therapeutic Perspectives". (Eds.: M. Hamon, H. Ollat and M.H. Thiebot), John Libbey, vol. 232, p. 53-64, 1993

19. G. Roscetti, C. Ambrosio, M. Trabucchi, M. Massotti and M.L. Barbaccia: Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex.-Eur. J. Pharmacol. 1994 Sep; 269(1): 17-24

20. M.L. Barbaccia, G. Roscetti, M. Trabucchi, T. Cuccheddu, A. Concas and G. Biggio: Neurosteroids in the brain of handling- habituated and naive rats: effect of carbon dioxide inhalation.-Eur. J. Pharmacol. 1994 Aug; 261(3): 317-320

21. A. Concas, M.C. Mostallino, C. Perra, M.L. Barbaccia, G. Roscetti, R.H. Purdy and G. Biggio: Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylentetrazol or stress.-Br. J. Pharmacol. 1996 Jun; 118(4): 839-846 .

22. M.L. Barbaccia, G.Roscetti, M.Trabucchi, M.C.Mostallino, A.Concas, R.H.Purdy and G.Biggio: Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress.-Neuroendocrinology 1996 Feb; 63(2): 166-172

23. M.L.Barbaccia, G.Roscetti, F.Bolacchi, A.Concas, M.C.Mostallino, R.H.Purdy and G.Biggio: Stress induced increase in brain neuroactive steroids: antagonism by abecarnil.-Pharmacol. Biochem. Behav. 1996 May; 54(1): 205-210

24. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Perra C., Concas A. and Biggio G. Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain.-Neuropharmacology 1996; 35(9-10): 1299-1305

25. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Concas A. and Biggio G. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentration.-Br. J. Pharmacol. 1997 Apr; 120(8): 1582-1588

26. Roscetti G., Trabucchi M., Massotti M., Purdy R.H. and Barbaccia M.L. Modulation of neurosteroid synthesis/accumulation by L-ascorbic acid in rat brain tissue: inhibition by selected serotonin antagonists.-J. Neurochem. 1998 Sep; 71(3): 1108-1117

27. Roscetti G., Franzese O., Comandini A. and Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin-Phytotherapy Research 18, 66-72 (2004)

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