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E-mail

ID ORCID

enrica.bianchi@uniroma2.it

https://orcid.org/0000-0001-8124-7328

 

 

Esperienza professionale

• Date (da – a)

• Nome e indirizzo del datore di lavoro

Gennaio 2024 - attuale

Dipartimento di Biomedicina e prevenzione, Sezione di Istologia. Università degli studi di Roma “Tor Vergata”

• Tipo di impiego Principali mansioni e responsabilità

Ricercatore di tipo b

Attività di ricerca volta ad identificare e caratterizare interazioni tra proteine di membrana necessarie per la riproduzione.

• Date (da – a)

• Nome e indirizzo del datore di lavoro

Ottobre 2021- agosto 2023

Dipartimento di Biologia, Università di York, UK

• Tipo di impiego Principali mansioni e responsabilità

Research Fellow

Attività di ricerca riguardante l’identificazione di nuove interazioni tra proteine di membrana necessarie per la riproduzione, con particolare attenzione al ruolo svolto da proteine espresse sulla superficie cellulare di ovociti e spermatozoi.

• Date (da – a)

• Nome e indirizzo del datore di lavoro

Febbraio 2017- Settembre 2021

Wellcome Trust Sanger Institute, Cambridge, UK

• Tipo di impiego Principali mansioni e responsabilità

Staff scientist

Attività di ricerca volta a chiarire il ruolo del recettore ADGRD1 (Adhesion G Protein-Coupled Receptor D1) nel trasporto dell’embrione lungo le tube di Falloppio. Lo studio in un modelllo murino ha rivelato che il recettore ADGRD1 è essenziale affinchè l’embrione possa raggiungere l’utero e che esercita il suo ruolo regolando il flusso di fluido nell’ovidutto.

• Date (da – a)

• Nome e indirizzo del datore di lavoro

Maggio 2011- Gennaio 2017

Wellcome Trust Sanger Institute, Cambridge, UK

• Tipo di impiego Principali mansioni e responsabilità

Ricercatore post-dottorato

Attività di ricerca volta ad identificare nuove coppie di recettori coinvolte nell’interazione tra ovocita e spermatozoo. Nell’ambito di questo progetto è stata scoperta la prima coppia di recettori essenziali per la fecondazione nei mammiferi composta dalle proteine JUNO e IZUMO1.

• Date (da – a)

• Nome e indirizzo del

Novembre 2007 - Novembre 2009

Università di Roma Tor Vergata, Facoltà di Medicina e Chirurgia, Dipartimento

datore di lavoro

di Sanità Pubblica e Biologia Cellulare, Sezione di Anatomia.

• Tipo di impiego Principali mansioni e responsabilità

Assegno per la collaborazione ad attività di ricerca (post-dottorato)

Attività di ricerca nell’ambito del progetto: Ruolo della proteina Sam68 nelle cellule germinali murine

• Date (da – a) Nome e indirizzo del datore di lavoro

Maggio 2003 – Aprile 2004

Università degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Laboratorio di Immunologia, via San Giacomo 14, Bologna

• Tipo di impiego Principali mansioni e responsabilità

Collaborazione coordinata e continuativa

Attività di ricerca nell’ambito del progetto: espressione delle metallotioneine nei linfociti umani

• Date (da – a) Nome e indirizzo del datore di lavoro

Maggio 2001 – Aprile 2003

Università degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Laboratorio di Immunologia, via San Giacomo 14, Bologna.

• Tipo di impiego Principali mansioni e responsabilità

Borsa di studio

Attività di ricerca nell’ambito del progetto: Studio degli effetti dei campi elettromagnetici a bassa frequenza su sistemi cellulari in vitro tramite tecniche di biofisica e biologia molecolare

Istruzione e formazione

2004-2008

Università degli Studi di Roma Tor Vergata, Dipartimento di Sanità Pubblica e Biologia Cellulare, sezione di Anatomia.

Qualifica conseguita

Dottorato di ricerca in Scienze e biotecnologie della riproduzione e dello sviluppo.

Titolo della tesi: “Translational control of gene expression at the onset of embryogenesis”

• Data

2004

Abilitazione all’esercizio della professione di biologo

2000-2003

Università degli Studi di Bologna

Qualifica conseguita

Scuola di Specializzazione in Genetica applicata, Università di Bologna

Titolo della tesi: “Coesposizione alle RF (900 MHz) e ad un mutageno chimico. Studio degli effetti biologici sulla linea cellulare murina NIH3T3” Diploma di specializzazione conseguito con la votazione di 70/70 e lode

 

 

• Data

1995-1999

• Nome e tipo di istituto di istruzione o formazione

Corso di laurea in Scienze Biologiche, indirizzo morfologico-funzionale, Università degli studi di Bologna

Tesi sperimentale dal titolo: “Le lesioni traumatiche in popolazioni del passato” Laurea conseguita con la votazione di 110/110 e lode

 

 

Altre qualifiche

04/10/2022

Abilitazione Scientifica Nazionale alle funzioni di professore universitario di Seconda Fascia nel Settore Concorsuale 05/H2 – Istologia valida fino al 04/10/2033

Pubblicazioni

  1. Elofsson A, Han L, Bianchi E, Wright GJ, Jovine L (2024). Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse. eLife 13:RP93131 10.7554/eLife.93131.2
  2. Bianchi E, Jiménez-Movilla M, Cots-Rodríguez P, Viola C, Wright GJ (2024). No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1. Sci Adv. Feb 23;10(8):eadk6352.10.1126/sciadv.adk6352
  3. Bianchi E, Wright GJ (2023) Mammalian fertilization: does sperm IZUMO1 mediate fusion as well as adhesion? Journal of Cell Biology Feb 6;222(2):e202301035 10.1083/jcb.202301035
  4. Makieva S, Fraire-Zamora JJ, Mincheva M, Uraji J, Ali ZE, Ammar OF, Liperis G, Serdarogullari M, Bianchi E, Pettitt J, Sermon K, Bhattacharya S, Massarotti C (2023) #ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room? Human Reproduction Feb 1;38(2):324-32710.1093/humrep/deac265
  5. Bianchi E, Jimenez-Movilla M, Krauchunas AR (2022). Editorial: Fertilization in the spotlight: Dynamics and mechanisms of sperm-egg interaction. Frontiers in Cell and Developmental Biology Sep 8;10:993865 10.3389/fcell.2022.993865
  6. Stepanenko N, Wolk O, Bianchi E, Wright GJ, Schachter-Safrai N, Makedonski K, Ouro A, Ben-Meir A, Buganim Y, Goldblum A (2022). In Silico Docking Analysis for Blocking JUNO-IZUMO1 Interaction Identifies Two Small Molecules that Block In Vitro Fertilization Frontiers in Cell and Developmental Biology Apr 5;10:82462910.3389/fcell.2022.824629
  7. Bianchi E (2021). Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization Proc Natl Acad Sci 118(42):e2116001118. 10.1073/pnas.2116001118
  8. Bianchi E, Sun Y, Almansa-Ordonez A, Woods M, Goulding D, Martinez-Martin N, Wright GJ (2021). Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Nature Communications 12(1):1251.10.1038/s41467-021-21512-w
  9. Bianchi E, Wright GJ (2020) Find and fuse: Unsolved mysteries in sperm–egg recognition PLoS Biology 18(11): e3000953.doi.org/10.1371/journal.pbio.3000953
  10. Lamas-Toranzo I, Hamze JG, Bianchi E, Fernández-Fuertes B, Pérez-Cerezales S, Laguna-Barraza R, Fernández-González R, Lonergan P, Gutiérrez-Adán A, Wright GJ, Jiménez-Movilla M, Bermejo-Álvarez P. (2020). TMEM95 is a sperm membrane protein essential for mammalian fertilization. Elife 9:e53913.10.7554/eLife.53913
  11. Bianchi E, Wright GJ (2016). Sperm Meets Egg: The Genetics of Mammalian Fertilization. Annual Review of Genetics 50:93-111.10.1146/annurev-genet-121415-121834
  12. Nishimura K, Han L, Bianchi E, Wright GJ, de Sanctis D, Jovine L. (2016). The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins. Current Biology 26(14):R661-2.10.1016/j.cub.2016.06.028
  13. Han L, Nishimura K, Sadat Al Hosseini H, Bianchi E, Wright GJ, Jovine L. (2016). Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes. Current Biology 8;26(3):R100-1.10.1016/j.cub.2015.12.034
  14. Wright GJ, Bianchi E (2015). The challenges involved in elucidating the molecular basis of sperm-egg recognition in mammals and approaches to overcome them. Cell and Tissue Research 363(1):227-35.10.1007/s00441-015-2243-3
  15. Bianchi E, Wright GJ (2015). Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 370(1661):20140101. 10.1098/rstb.2014.0101
  16. Bianchi E, Wright GJ (2014). Izumo meets Juno: Preventing polyspermy in fertilization. Cell Cycle 13(13):2019–2020.10.4161/cc.29461
  17. Bianchi E, Doe B, Goulding D, Wright GJ (2014). Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature 508(7497):483-7.10.1038/nature13203
  18. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V (2012). FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. Oncogene 31(5):573-82. 10.1038/onc.2011.274
  19. Bianchi E, Sette C (2011). Post-transcriptional control of gene expression in mouse early embryo development: a view from the tip of the iceberg. Genes 2:345-359. 10.3390/genes2020345
  20. Bianchi E, Barbagallo F, Valeri C, Geremia R, Salustri A, De Felici M, Sette C. (2010). Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development. Human Molecular Genetics 19(24):4886-94.10.1093/hmg/ddq422
  21. Bianchi E, Geremia R, Sette C (2010). Expression of stemness markers in mouse parthenogenetic-diploid blastocysts is influenced by slight variation of activation protocol

adopted. In vitro cellular and Developmental Biology-Animal 46(7):619-23. 10.1007/s11626-010-9312-4

  1. Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C (2009). Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. The Journal of Cell Biology 185(2):235-49.10.1083/jcb.200811138
  2. Paronetto MP #, Bianchi E #, Geremia R, Sette C (2008). Dynamic expression of the RNA-binding     protein Sam68 during mouse pre-implantation development. Gene

Expression Patterns 8(5):311-322. #Equal contribution10.1016/j.gep.2008.01.005

  1. Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, Agostini C, Antolini A, Schiavoni A, Castellani G, Bersani F, Franceschi C (2004). In vitroexposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies on proliferation, apoptosis and mitochondrial membrane potential. Radiation Research 162(2):211-218. 10.1667/RR3209
  2. Capri M, Scarcella E, Bianchi E, Fumelli C, Mesirca P, Agostini C, Schuderer J, Kuster N, Franceschi C, Bersani F (2004). 1800 MHz radiofrequency (mobile phones, different GSM modulations) does not affect apoptosis and Hsp70 level in peripheral blood mononuclear cells from young and old donors. International Journal of Radiation Biology 80(6):389-397.10.1080/09553000410001702346
  3. Brasili P, Bianchi E, Ventrella AR (2004). Traumatic events and life-style in ancient Italian populations. Collegium Antropologicum 28(1):179-191.

Book Chapter:

Barchi M, Geremia R, Magliozzi R, Bianchi E (2009). Isolation and analyses of enriched populations of male mouse germ cells by sedimentation velocity: the centrifugal elutriation. Methods in Molecular Biology. Meiosis Volume 2, Cytological Methods, 558:299-321

Employment and Education

January 2024-

Research Fellow (Assistant Professor) at the University of Rome 'Tor Vergata'

October 2021-August 2023

Research Fellow at the Biology Department, University of York, UK.

2017-2021

Staff scientistat the Wellcome Trust Sanger Institute, Cambridge, UK.

2011-2017     

Post-doctoral fellow, Wellcome Trust Sanger Institute, Cambridge, UK.  Supervisor: Dr Gavin J Wright

2008-2009     

Post-doctoral fellow, University of Rome Tor Vergata, Italy

Supervisor: Professor Claudio Sette

2004-2008

PhDin Reproduction and Development, University of Rome “Tor Vergata”, Italy.

Thesis: “Translational control of gene expression at the onset of embryogenesis”

2001-2004  

Research fellow, University of Bologna, Department of Experimental Pathology

2000-2003

Applied Genetics,SpecialisationDegree, diploma cum laude, University of Bologna, Italy.

1994-1999

Laurea(BSc) in Biology, summa cum laude,University of Bologna, Italy.

Scientific activity

March 2021-March 2022 Guest Editor of the Research Topic ‘Fertilization in the Spotlight: Dynamics and Mechanisms of Sperm-Egg Interaction’ published in Frontiers in Cell and Developmental Biology.

Reviewer for the following scientific journals: Reproduction, Scientific Reports, Systems Biology in Reproductive Medicine, PNAS, Reproduction in Domestic Animals, Journal of Experimental Zoology part B-Molecular and Developmental Evolution, Journal of Animal Science and Biotechnology.

Reviewer for the Czech Science Foundation in 2016, 2017 and 2018.

Remote Referee for the ERC Starting Grant 2017.  

Abstract reviewer for the European Society of Human Reproduction and Embryology Annual Meetings from March 2020-ongoing.

International meetings

2024 Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE), Amsterdam, The Netherlands. 'Evidence for gamete recognition mechanisms in humans' (invited Speaker)

2023 EMBO Workshop on Mechanisms of membrane fusion, Göttingen, Germany. ‘Identification of a novel binding partner for the sperm protein IZUMO1’ (Invited speaker)2023 18th Women’s Health Congress, Bern, Switzerland. ‘JUNO-IZUMO1 and the intricacies of sperm-egg interaction’ (Invited speaker)

2021 Gametes meet in the time of Covid-19. Virtual conference replacing the Gordon Research Conference Fertilization and Activation of Development (Invited speaker)

2021 ESHRE Exchange Session at the 4th ALMER Annual meeting ‘Interaction of eggs and sperm during fertilization: recognition, membrane fusion and polyspermy block’ (Invited speaker)

2019 Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE), Vienna, Austria. ‘Breakthroughs in human fertilization’ (Invited speaker)

2018 Gordon Research Conference on mammalian reproduction ‘The orphan G-protein coupled receptor ADGRD1 is required for embryo transport in the mammalian oviduct’ (poster)

2017 Gordon Research Conference Fertilization and Activation of Development ‘The orphan G-protein coupled receptor ADGRD1 is required for oviductal embryo transport’ (poster)

2016 Society for Reproduction and Fertility Annual Conference ‘Investigating the role of the membrane receptor ADGRD1 in female fertility’ (poster)

2016 EMBO workshop Membrane fusion in health and disease ‘Development of a cell-based assay using split-GFP to identify novel fusogens involved in fertilization’ (poster)

2015 Gordon Research Seminar and Gordon Research Conference Fertilization and Activation of Development ‘Mammalian Gamete Recognition: Izumo1, Juno and Beyond’ (Invited speaker)

2015Society for the Study of Reproduction ‘Screening for new receptor-ligand pairs involved in mammalian gamete recognition’ (Poster)

2014 Society for the Study of Reproduction ‘Izumo meets its match: introducing Juno’ (invited speaker and Anita Payne New Perspectives in Reproductive Biology award)

2013 Gordon Research Conference on Fertilization and Activation of Development ‘Screening to identify an oocyte cell surface receptor for the essential sperm ligand, IZUMO1’ (poster)

Publications

  1. BianchiE, Wright GJ (2023) Mammalian fertilization: does sperm IZUMO1 mediate fusion as well as adhesion? JCB 10.1083/jcb.202301035
  2. Makieva S, Fraire-Zamora JJ, Mincheva M, Uraji J, Ali ZE, Ammar OF, Liperis G, Serdarogullari M, Bianchi E, Pettitt J, Sermon K, Bhattacharya S, Massarotti C (2022) #ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?Hum Reprod, deac26510.1093/humrep/deac265
  3. BianchiE, Jimenez-Movilla M, Krauchunas AR (2022). Editorial: Fertilization in the spotlight: Dynamics and mechanisms of sperm-egg interaction. Front Cell Dev Biol. Sep 8;10:993865  10.3389/fcell.2022.993865
  4. Stepanenko N, Wolk O, Bianchi E, Wright GJ, Schachter-Safrai N, Makedonski K, Ouro A, Ben-Meir A, Buganim Y, Goldblum A (2022). In Silico Docking Analysis for Blocking JUNO-IZUMO1 Interaction Identifies Two Small Molecules that Block In Vitro Fertilization Front. Cell Dev. Biol.Apr 5;10:82462910.3389/fcell.2022.824629
  5. Bianchi E(2021). Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization Proc Natl Acad Sci 118(42):e2116001118. 10.1073/pnas.2116001118
  6. Bianchi E, Sun Y, Almansa-Ordonez A, Woods M, Goulding D, Martinez-Martin N, Wright GJ (2021). Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Nat Commun12(1):1251. 10.1038/s41467-021-21512-w
  7. Bianchi E,Wright GJ (2020) Find and fuse: Unsolved mysteries in sperm–egg recognitionPLoS Biol18(11): e3000953. doi.org/10.1371/journal.pbio.3000953
  8. Lamas-Toranzo I, Hamze JG, Bianchi E, Fernández-Fuertes B, Pérez-Cerezales S, Laguna-Barraza R, Fernández-González R, Lonergan P, Gutiérrez-Adán A, Wright GJ, Jiménez-Movilla M, Bermejo-Álvarez P. (2020). TMEM95 is a sperm membrane protein essential for mammalian fertilization. Elife 9:e53913. 10.7554/eLife.53913
  9. Bianchi E, Wright GJ (2016). Sperm Meets Egg: The Genetics of Mammalian Fertilization.Annual Review of Genetics50:93-111. 10.1146/annurev-genet-121415-121834
  10. Nishimura K, Han L, Bianchi E, Wright GJ, de Sanctis D, Jovine L. (2016). The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins. Current Biology26(14):R661-2. 10.1016/j.cub.2016.06.028
  11. Han L, Nishimura K, Sadat Al Hosseini H, Bianchi E, Wright GJ, Jovine L. (2016). Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes. Current Biology8;26(3):R100-1. 10.1016/j.cub.2015.12.034
  12. Wright GJ, Bianchi E (2015). The challenges involved in elucidating the molecular basis of sperm-egg recognition in mammals and approaches to overcome them. Cell and Tissue Research363(1):227-35.10.1007/s00441-015-2243-3
  13. Bianchi E, Wright GJ (2015).Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 370(1661):20140101. 10.1098/rstb.2014.0101
  14. Bianchi E, Wright GJ (2014).Izumo meets Juno: Preventing polyspermy in fertilization. Cell Cycle13(13):2019–2020. 10.4161/cc.29461
  15. Bianchi E, Doe B, Goulding D, Wright GJ (2014).Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature508(7497):483-7. 10.1038/nature13203
  16. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V (2012). FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. Oncogene31(5):573-82. 10.1038/onc.2011.274
  17. Bianchi E, Sette C (2011). Post-transcriptional control of gene expression in mouse early embryo development: a view from the tip of the iceberg. Genes2:345-359. 10.3390/genes2020345
  18. Bianchi E, Barbagallo F, Valeri C, Geremia R, Salustri A, De Felici M, Sette C. (2010). Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development. Human Molecular Genetics 19(24):4886-94. 10.1093/hmg/ddq422
  19. Bianchi E, Geremia R, Sette C (2010). Expression of stemness markers in mouse parthenogenetic-diploid blastocysts is influenced by slight variation of activation protocol adopted.In vitro cellular and Developmental Biology-Animal 46(7):619-23. 10.1007/s11626-010-9312-4
  20. Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C (2009). Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis.The Journal of Cell Biology 185(2):235-49.10.1083/jcb.200811138
  21. Paronetto MP #, Bianchi E #, Geremia R, Sette C (2008). Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development.Gene Expression Patterns 8(5):311-322. # Equal contribution 10.1016/j.gep.2008.01.005
  22.  Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, Agostini C, Antolini A, Schiavoni A, Castellani G, Bersani F, Franceschi C (2004). In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies on proliferation, apoptosis and mitochondrial membrane potential. Radiation Research 162(2):211-218. 10.1667/RR3209
  23. Capri M, Scarcella E, Bianchi E, Fumelli C, Mesirca P, Agostini C, Schuderer J, Kuster N, Franceschi C, Bersani F (2004). 1800 MHz radiofrequency (mobile phones, different GSM modulations) does not affect apoptosis and Hsp70 level in peripheral blood mononuclear cells from young and old donors.International Journal of Radiation Biology 80(6):389-397. 10.1080/09553000410001702346
  24. Brasili P, Bianchi E, Ventrella AR (2004). Traumatic events and life-style in ancient Italian populations. Collegium Antropologicum28(1):179-191.

 

Book Chapter:

Barchi M, Geremia R, Magliozzi R, Bianchi E (2009). Isolation and analyses of enriched populations of male mouse germ cells by sedimentation velocity: the centrifugal elutriation. Methods in Molecular Biology. Meiosis Volume 2, Cytological Methods, 558:299-321

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